ライフサイエンスコーパス: crystal-induced

1 In normal mice, urate crystals induced a 10-fold increase (P < 0.01) in pouch

2 In mIL-8RH(-/-) mice, urate crystals induced a proteinaceous leukocyte-poor exudate

3 s leukocyte-poor exudate at 4 hours, despite crystal-induced activation of resident cells (documented

4 ital microscopy in models of IRI and oxalate crystal-induced acute kidney injury.

5 deficiency of RIPK3 or MLKL prevents oxalate crystal-induced acute kidney injury.

6 d calcium entry/IL-8 axis is involved in MSU crystal-induced aggregated NET formation, but MRS2578 co

7 hogenesis of both osteoarthritis and calcium crystal-induced arthritis and our limited ability to acc

8 ill hasten understanding of the pathology of crystal-induced arthritis and provide new therapies.

9 ons, such as ischemia reperfusion injury and crystal-induced arthritis, as well as with chronic disea

10 m pyrophosphate dihydrate and hydroxyapatite crystal-induced arthritis.

11 ve unveiled mechanisms in the development of crystal-induced arthritis.

12 ponent C6 to determine if MAC mediated urate crystal-induced arthritis.

13 a more effective management of other common crystal-induced arthritis.

14 The crystal-induced arthropathies are characterized by self-

15 ons that have stimulated renewed interest in crystal-induced arthropathies.

16 ations presage advances in the management of crystal-induced arthropathies.

17 al therapeutic targets for management of the crystal-induced arthropathies.

18 tion of gout is described as an inflammatory crystal-induced arthropathy that afflicts peripheral joi

19 ralization agent and a specific inhibitor of crystal-induced biologic effects.

20 trum of a 5-MHz fundamental frequency quartz crystal induced by a water-miscible room-temperature ion

21 e we further elucidate the mechanisms of BCP crystal-induced cell activation as BCP crystals activate

22 stals and the signal transduction pathway of crystal-induced cell activation offer a unique opportuni

23 Previous work suggested that BCP crystal-induced cell activation required intracellular c

24 ineating the mechanism of calcium-containing crystal-induced cell activation: (1) the identification

25 namide, an inhibitor for human MLKL suppress crystal-induced cell death in human renal progenitor cel

26 activator of MAPKs, significantly inhibited crystal-induced cell proliferation, suggesting that the

27 esent study, we found that calcium phosphate crystals induced cell death in human aortic vascular smo

28 stream of PKC and p44/42 MAPK to mediate BCP crystal-induced cellular responses.

29 ith TLR2-blocking Ab suppressed CPPD and MSU crystal-induced chondrocyte release of NO, an inflammato

30 IPK3 and MLKL are molecular targets to limit crystal-induced cytotoxicity, tissue injury and organ fa

31 vation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation.

32 Attenuated MSU crystal-induced IL-1beta release in CD14(-/-) BMDMs was

33 crystalline inflammasome activators, cystine crystal-induced IL-1beta secretion required activation o

34 pecies, and potassium efflux reduced cystine crystal-induced IL-1beta secretion.

35 activation and microbial ligand-, DAMP-, and crystal-induced IL-1beta secretion.

36 ERK-2 pathway was essential for MSU and CPPD crystal-induced IL-8 mRNA expression, whereas the p38 pa

37 Finally, crystal-induced IL-8 promoter activation was mediated by

38 n of cryopyrin plays a role in mediating MSU crystal-induced inflammation in this model.

39 al models have implicated a general model of crystal-induced inflammation involving innate immunity t

40 occult crystalline disease who, by virtue of crystal-induced inflammation, require more aggressive an

41 LRR) domain of cryopyrin is required for MSU crystal-induced inflammation.

42 l role for interleukin-1 inhibition in urate crystal-induced inflammation.

43 fic role of macrophage TG2 expression in MSU crystal-induced inflammation.

44 en recently identified as mediators of acute crystal-induced inflammation.

45 tabolites, and immune cells that account for crystal-induced inflammation.

46 (PMN) in monosodium urate monohydrate (MSU) crystal-induced inflammation.

47 also observed in a model of monosodium urate crystals-induced inflammation.

48 MSU crystal-induced inflammatory responses were comparably a

49 of AGDV into closed alphaIIbbeta3 headpiece crystals induced intermediate states similarly to RGDSP.

50 development of specific calcium crystals and crystal-induced intracellular changes.

51 An attenuated rise in MSU crystal-induced joint effusion levels of IL-8 also was o

52 trophils (P < 0.05) but not monocytes in MSU crystal-induced knee synovial fluid from C6-deficient an

53 Last, MSU crystal-induced leukocyte influx at 6 h was reduced by a

54 Several details of crystal-induced macrophage activation were recently unco

55 and potentially therapeutic function against crystal-induced membranolysis is also discussed.

56 rk on calcium pyrophosphate dihydrate (CPPD) crystal-induced membranolysis, we demonstrate, using the

57 le of crystal endocytosis and dissolution in crystal-induced metalloproteinase synthesis and mitogene

58 MSU and CPPD crystal-induced mitogen-activated protein kinase (MAPK)

59 confirm the role of protein kinase C in BCP crystal-induced mitogenesis in human fibroblasts.

60 role of TNF alpha was then studied in an MSU crystal-induced monarthritis model, in the presence or a

61 In the MSU crystal-induced monarthritis model, TNF alpha blockade w

62 The detailed mechanism of MSU crystal-induced NET formation remains unknown.

63 annel inhibitor (SK&F96365) also reduced MSU crystal-induced NET release.

64 Analogously, monosodium urate crystal-induced neutrophil migration to the tibiofemural

65 matory effects on LPS, ox-LDL or cholesterol crystal-induced NF-kappaB, c-jun and p38 activation, as

66 n was associated with increased CPPD and MSU crystal-induced NO release.

67 We studied MSU crystal-induced peritonitis in TG2-/- and congenic TG2+/

68 influx and cytokine production in a model of crystal-induced peritonitis, and these effects were abse

69 ial cold autoinflammatory syndrome and urate crystal-induced peritonitis.

70 learance of apoptotic neutrophils during MSU crystal-induced peritonitis.

71 MSU crystal-induced production of interleukin-1beta (IL-1bet

72 ddition, T cells and cholesterol monohydrate crystals induced proinflammatory gene expression in the

73 ative mutant of p38 MAP kinase abolishes COM crystal-induced re-initiation of DNA synthesis.

74 ver, we find that stimulation with liposomes/crystals induced reactive oxygen species-dependent calci

75 ) crystals are common in osteoarthritis, the crystal-induced signal transduction pathways in human fi

76 he MAPK pathway is a significant mediator of crystal-induced signals.

77 Both crystals induced the binding of nuclear factor kappaB (N

78 MSU crystals induced TNFalpha, IL-1beta, and IL-6 (but not I

79 Both crystals induced transcriptional activation of the IL-8

80 covery of superconductivity in Sb2Se3 single crystal induced via pressure.