ライフサイエンスコーパス: crystallographic analysis

1 es that was unambiguously confirmed by X-ray crystallographic analysis.

2 nd 2D NMR experiments and confirmed by X-ray crystallographic analysis.

3 tion of natural proteins to facilitate X-ray crystallographic analysis.

4 pts an octahedral geometry as shown by X-ray crystallographic analysis.

5 leic acid structure, we undertook a detailed crystallographic analysis.

6 or nuclear magnetic resonance (NMR) or X-ray crystallographic analysis.

7 solute configurations were assigned by X-ray crystallographic analysis.

8 ture of one complex was established by X-ray crystallographic analysis.

9 ranging from 58 nM to 0.8 pM was chosen for crystallographic analysis.

10 e of 7k with p38alpha was confirmed by X-ray crystallographic analysis.

11 The structure of 1 was determined by X-ray crystallographic analysis.

12 to trap acyl-enzyme intermediates for X-ray crystallographic analysis.

13 N,N-dimethylamino biphenyl ligands by X-ray crystallographic analysis.

14 nctions was unambiguously confirmed by X-ray crystallographic analysis.

15 MR and IR spectroscopy, base hydrolysis, and crystallographic analysis.

16 netic and equilibrium binding parameters and crystallographic analysis.

17 istry was unequivocally established by X-ray crystallographic analysis.

18 nterface and confirmed the design with X-ray crystallographic analysis.

19 ss an (aS)-configurated biaryl axis by X-ray crystallographic analysis.

20 is mutant, evidence for which is provided by crystallographic analysis.

21 diastereomer occurred as confirmed by X-ray crystallographic analysis.

22 of miliusate was further confirmed by X-ray crystallographic analysis.

23 tional significance that extend recent x-ray crystallographic analysis.

24 lidate the dimer interface proposed by prior crystallographic analysis.

25 itions for flash-freezing crystals for X-ray crystallographic analysis.

26 multidomain proteins that are not suited to crystallographic analysis.

27 olution experiments, overcoming the need for crystallographic analysis.

28 s been investigated by biochemical and X-ray crystallographic analysis.

29 e efforts, a MutS.ATP.DNA complex has eluded crystallographic analysis.

30 ture of the product was elucidated via X-ray crystallographic analysis.

31 forms a GTP-bound complex stable enough for crystallographic analysis.

32 raphy (TLC), and in the solid state by X-ray crystallographic analysis.

33 design applications as well as an adjunct to crystallographic analysis.

34 -Michael product (30) was confirmed by X-ray crystallographic analysis.

35 rocess was unambiguously determined by X-ray crystallographic analysis.

36 ic transformation and characterized by X-ray crystallographic analysis.

37 or working as NAD isostere as ascertained by crystallographic analysis.

38 tative products have been confirmed by X-ray crystallographic analysis.

39 errin A was unambiguously confirmed by X-ray crystallographic analysis.

40 ative ease of expression, and amenability to crystallographic analysis.

41 51 enzyme, an observation confirmed by X-ray crystallographic analysis.

42 als of the above proteins suitable for X-ray crystallographic analysis.

43 Turning to crystallographic analysis, a 2.35 A resolution structure

44 X-ray crystallographic analysis allowed the quantification of

45 le quinone anion radicals suitable for X-ray crystallographic analysis allows for the first time thei

46 This same crystallographic analysis also indicates the morphologie

47 This same crystallographic analysis also reveals the identity of t

48 tive demethylation reaction was captured via crystallographic analysis and analyzed via single-crysta

49 se complexes could be characterized by X-ray crystallographic analysis and employed as catalysts for

50 X-Ray crystallographic analysis and first principles calculati

51 X-ray crystallographic analysis and solution NMR studies verif

52 However, an early crystallographic analysis and some of the more recent so

53 Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of co

54 Using ligand binding assays, crystallographic analysis, and all atom MD simulations,

55 By using NMR spectroscopy, X-ray crystallographic analysis, and density functional theory

56 rized previously both structurally, by x-ray crystallographic analysis, and energetically, by scannin

57 thiones is unambiguously determined by X-ray crystallographic analysis, and this is used to correct e

58 protocol described here, has been useful for crystallographic analysis, and will be valuable for stud

59 were confirmed through single-crystal X-ray crystallographic analysis, arise from sequential inter/i

60 erfering device (SQUID), FT Raman, and X-ray crystallographic analysis, assisted by unrestricted symm

61 ient absorption spectroscopy (TA), and X-ray crystallographic analysis, assisted by unrestricted symm

62 acyl-enzyme complex stable enough for X-ray crystallographic analysis at pH 5.

63 e sites of these enzymes are the same within crystallographic analysis, but residues in the second-sp

64 Crystallographic analysis classifies CIP-boxes into two

65 The crystallographic analysis complemented by sensitive sequ

66 We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and N

67 EPR spectroscopy and crystallographic analysis confirm a common active-site s

68 Subsequent crystallographic analysis confirmed the single-crystal-t

69 Crystallographic analysis confirmed the structure of [KC

70 The crystallographic analysis confirms that the small organi

71 The X-ray crystallographic analysis confirms that while CIP and CI

72 Furthermore, crystallographic analysis demonstrated atomic accuracy t

73 Crystallographic analysis demonstrated that the Crwn-THF

74 X-ray crystallographic analysis details rearrangements in the

75 re comprehensively characterized by means of crystallographic analysis, determination of pK(a) values

76 inst single-chain Fv antibodies obtained via crystallographic analysis/engineering and against commer

77 tivities, confirmed where necessary by X-ray crystallographic analysis, establish the capability of s

78 insights provide simple and accurate optical crystallographic analysis for liquid-dispersed nanomater

79 onal (2D) NMR methods and confirmed by X-ray crystallographic analysis has an unusual 3H-benzo[d]pyrr

80 on the tertiary assembly of these proteins; crystallographic analysis has revealed that the two cyto

81 An X-ray crystallographic analysis has shown the compound to be a

82 More importantly, the crystallographic analysis illustrated for the first time

83 he use of kinetic isotope effects (KIEs) and crystallographic analysis, in conjunction with structure

84 Analytical ultracentrifugation and crystallographic analysis indicate that the resulting VC

85 mic and activity measurements, together with crystallographic analysis, indicate that binding of AANA

86 Here, this local crystallographic analysis is applied to the in-situ-grow

87 tisubunit complexes like photosystem II when crystallographic analysis is of insufficient resolution

88 The portion of FANCE defined by our crystallographic analysis is sufficient for interaction

89 The focus of this X-ray crystallographic analysis is the third enzyme in the pat

90 Based on the crystallographic analysis, MS data, and biochemical anal

91 lative configuration was determined by X-ray crystallographic analysis), no particular difference was

92 X-ray crystallographic analysis of 1-acetyl-4-benzyl-2-(thiazo

93 Crystallographic analysis of 17 different complexes of H

94 ecules within the O(2) channel, we performed crystallographic analysis of 19 Xe laden crystals freeze

95 X-ray crystallographic analysis of 1b indicates the H3CAl(C6F5

96 Small-molecule X-ray crystallographic analysis of 20 established the C-4 S st

97 Crystallographic analysis of 2G12 I19R in complex with M

98 X-ray crystallographic analysis of 3 unveils its ability to se

99 Crystallographic analysis of 35 different peptide sequen

100 backbone NH of Met109 was confirmed by X-ray crystallographic analysis of 3a bound to p38alpha.

101 the intermediates were confirmed by an X-ray crystallographic analysis of 43.

102 X-ray crystallographic analysis of 5 established that the chai

103 Added corroboration was gained from a crystallographic analysis of 8.

104 X-ray crystallographic analysis of 9, 1,4-dimethoxy-2,5-bis(2-

105 X-ray crystallographic analysis of [3H]BF(4) revealed a highly

106 ted by 2D NMR methods and confirmed by X-ray crystallographic analysis of a bromo derivative.

107 X-ray crystallographic analysis of a closely related chromium

108 Crystallographic analysis of a complex between mammalian

109 site of the lipid molecule on KcsA by X-ray crystallographic analysis of a complex of KcsA with a mo

110 Using high-resolution X-ray crystallographic analysis of a DNA polymerase that catal

111 Here, we present an X-ray crystallographic analysis of a four-component complex co

112 eta-fold that was not observed in an earlier crystallographic analysis of a less stable version of th

113 Crystallographic analysis of a nearly inactive W149A-sub

114 Crystallographic analysis of a pair of analogous nonpola

115 with affinity similar to that of gp120, and crystallographic analysis of a scaffold bound to b12 rev

116 Crystallographic analysis of a Sec23/24-Sar1 prebudding

117 X-ray crystallographic analysis of a series of halide catenane

118 DD-transpeptidase active site--discovered by crystallographic analysis of a soluble construct of PBP2

119 Based on the crystallographic analysis of a urea-checkpoint kinase 1

120 We report electron and X-ray crystallographic analysis of a variety of specimens asse

121 The recent crystallographic analysis of A2AAR agonists and antagoni

122 Crystallographic analysis of ACs with known inhibitors r

123 By using crystallographic analysis of adaptor-Fis1 complexes, we

124 X-Ray crystallographic analysis of addition product 2 and aldo

125 steric inhibitors, a finding rationalized by crystallographic analysis of allosterically inhibited L-

126 However, crystallographic analysis of an interfacially impaired p

127 d catalytic activity was elucidated by X-ray crystallographic analysis of an isolated Au(iii)-activat

128 Crystallographic analysis of an R343V complex with 1,2-D

129 this specificity with biochemical and X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 complexes

130 Kinetic characterization and crystallographic analysis of BsTrpRS allowed us to probe

131 cture than had been supposed on the basis of crystallographic analysis of canonical tRNAs.

132 However, crystallographic analysis of CBM22-2 complexes shows Trp

133 Spectroscopic analysis in solution and X-ray crystallographic analysis of cocrystals of pyrene and NA

134 Crystallographic analysis of DB884 bound to an AATT site

135 X-ray crystallographic analysis of DB921 bound to -AATT- in d(

136 X-ray crystallographic analysis of DB921 bound to AATT shows t

137 X-ray crystallographic analysis of derivatives of (+)-anti- an

138 X-ray crystallographic analysis of DHR38 reveals the absence o

139 As this segment was not resolved in previous crystallographic analysis of E1 and LTag hexameric helic

140 Previous crystallographic analysis of Escherichia coli GlpG, an i

141 Crystallographic analysis of Fab alone or in complex wit

142 Our studies represent the first crystallographic analysis of GATA zinc fingers bound to

143 Crystallographic analysis of geranylgeranyl diphosphate

144 Crystallographic analysis of GSHKT10 and GSHKT13 (harbor

145 X-ray crystallographic analysis of H90Q dehalogenase complexed

146 Together with biochemical and crystallographic analysis of HD deletion mutants, we sho

147 We report crystallographic analysis of hETHE1 in complex with iron

148 Here we report the x-ray crystallographic analysis of human galactose mutarotase

149 X-ray crystallographic analysis of II revealed a rare trans-ch

150 toward this goal by setting the stage for a crystallographic analysis of inactivated Cg10062.

151 nimized insulin receptors (IRs) have enabled crystallographic analysis of insulin-bound "micro-recept

152 NMR and crystallographic analysis of IPSEDeltaNLS, a monomeric I

153 the native sodium and potassium forms, and a crystallographic analysis of it complexed with an O. nov

154 by NMR and MS methods coupled with an X-ray crystallographic analysis of its Fe-complex.

155 uorenyl group in 19b was determined by X-ray crystallographic analysis of its N-oxide derivative (23b

156 Crystallographic analysis of KIAA1718 Jumonji domain in

157 Traditionally, crystallographic analysis of macromolecules has depended

158 Crystallographic analysis of mammalian importin alpha1 i

159 Here, through electron-crystallographic analysis of membrane-embedded proteins,

160 Crystallographic analysis of nearly intact Src kinases i

161 ency to form fibrils were coupled with X-ray crystallographic analysis of nine TTR.ligand complexes.

162 X-ray crystallographic analysis of octafluoro-9,10-bis[(trimet

163 X-ray crystallographic analysis of one of the new inhibitors b

164 Crystallographic analysis of one of these analogues boun

165 X-ray crystallographic analysis of one such inhibitor in compl

166 lysozyme, and has been employed for routine crystallographic analysis of organic and inorganic mater

167 Recent crystallographic analysis of p66/p51 human immunodeficie

168 arison of these data with electron and X-ray crystallographic analysis of photosystem II indicates th

169 Crystallographic analysis of PR ligand binding domain co

170 Through crystallographic analysis of protein mutants incapable o

171 utilized molecular modeling based upon X-ray crystallographic analysis of renin's active site to desi

172 rminants were established based on the X-ray crystallographic analysis of representative compounds bo

173 An X-ray crystallographic analysis of representative Ph(2)P(E)- a

174 X-ray crystallographic analysis of representative structures r

175 X-ray crystallographic analysis of ribosomes from streptomycin

176 NMR experiments, DFT calculations and X-ray crystallographic analysis of Sc(3)N@C(78) derivative 1a.

177 Computational chemistry and X-ray crystallographic analysis of selected member compounds c

178 Crystallographic analysis of seven anthranilic acid deri

179 X-ray crystallographic analysis of several cis,cis,cis,cis-[4.

180 Crystallographic analysis of several large RNAs revealed

181 Crystallographic analysis of several {UO(2)[TAM(HOPO)(2)

182 pplication of LCP techniques to enable X-ray crystallographic analysis of single-pass TM interactions

183 Crystallographic analysis of SynAPSK in complex with eit

184 Through crystallographic analysis of SynCAM 2, we identified wit

185 X-ray crystallographic analysis of the 2.45 A LCAT-27C3 comple

186 critical differences are highlighted in the crystallographic analysis of the A. oryzae structure: (i

187 Crystallographic analysis of the alpha-hydroxy and alpha

188 Crystallographic analysis of the assembly unit reveals a

189 We have addressed these questions through crystallographic analysis of the Atm1/ABCB7/HMT1/ABCB6 o

190 rectly correlate binding interactions with a crystallographic analysis of the binding mechanism.

191 Crystallographic analysis of the bound form of five muta

192 pecificity is achieved, we carried out x-ray crystallographic analysis of the capsid protein domain b

193 Crystallographic analysis of the CC at 2.4 A resolution

194 X-ray crystallographic analysis of the Cdc42-RhoGDI complex su

195 X-ray crystallographic analysis of the complex [(eta 3-PhCHCHC

196 Crystallographic analysis of the complex formed between

197 Furthermore, crystallographic analysis of the complex with a modified

198 a functional immuno-precipitation assay, and crystallographic analysis of the complexes of the virus

199 hesized and the structures assigned by X-ray crystallographic analysis of the corresponding Boc-prote

200 pared and its structure established by X-ray crystallographic analysis of the corresponding Cbz-prote

201 Single-crystal X-ray crystallographic analysis of the dimeric diaminopyridazi

202 Crystallographic analysis of the EDC-cross-linked comple

203 Crystallographic analysis of the enzyme in free, acarbos

204 X-ray crystallographic analysis of the ERAP2 392K allele sugge

205 Recent progress in crystallographic analysis of the Escherichia coli rhombo

206 YA/J6 (IgG3, kappa) has been investigated by crystallographic analysis of the Fab domain and its two

207 xylappaconitine from condelphine, with X-ray crystallographic analysis of the former clarifying the N

208 Crystallographic analysis of the free ectodomain has def

209 Crystallographic analysis of the GluR2 LBD core has reve

210 In combination with a crystallographic analysis of the GluRIIB ligand binding

211 Crystallographic analysis of the hNCRD demonstrated a no

212 X-ray crystallographic analysis of the homotrimer showed that

213 Crystallographic analysis of the human neck+CRD complexe

214 We rationalized this effect by crystallographic analysis of the IgG1 Fc F241A mutant, d

215 These findings set the stage for a crystallographic analysis of the inactived enzyme to del

216 Crystallographic analysis of the interaction between bis

217 termination of NOE interactions and an X-ray crystallographic analysis of the latter product.

218 Crystallographic analysis of the lead compound bound to

219 X-ray crystallographic analysis of the liganded enzyme has sho

220 form and the structure established by X-ray crystallographic analysis of the methyl ester hydrochlor

221 A detailed crystallographic analysis of the mutant structures sugge

222 X-ray crystallographic analysis of the N(3)-thiophenylpropiony

223 Crystallographic analysis of the NHR2-N2B complex reveal

224 A high-resolution crystallographic analysis of the nitrogenase MoFe-protei

225 t recent advances in the field have been the crystallographic analysis of the oxidase and the use of

226 X-ray crystallographic analysis of the particles without the o

227 Crystallographic analysis of the pSP-D fragment complexe

228 Crystallographic analysis of the Saccharomyces cerevisia

229 An important advance has been the crystallographic analysis of the Sar1-Sec23/24 complex.

230 Crystallographic analysis of the shCD38:8-amino-N9-butyl

231 X-ray crystallographic analysis of the structure of SHP2 in co

232 X-ray crystallographic analysis of the supermacrocyclic struct

233 Crystallographic analysis of the T790M mutant shows how

234 Crystallographic analysis of the Taq MutS.DNA.ABF comple

235 ne of these geometries agrees with the X-ray crystallographic analysis of the thermodynamic conformat

236 ple interactions are integrated, we combined crystallographic analysis of the third and fourth PE pai

237 annot phosphorylate PtdIns(4,5)P2 Therefore, crystallographic analysis of the yeast and plant enzymes

238 Crystallographic analysis of these chromophores reveals

239 An X-ray crystallographic analysis of these complexes suggests th

240 X-ray crystallographic analysis of these compounds demonstrate

241 X-ray crystallographic analysis of these scaffold nucleoporins

242 X-ray crystallographic analysis of this hybrid-type intermedia

243 iew will highlight what we have learned from crystallographic analysis of this important protein fami

244 Crystallographic analysis of this region revealed a pair

245 heir stereochemistry was elucidated by X-ray crystallographic analysis of tosylate derivatives.

246 From an electron crystallographic analysis of two-dimensional crystals of

247 tein purification, and high-resolution x-ray crystallographic analysis of tyvelose epimerase from Sal

248 Crystallographic analysis of wild-type ECAO structures,

249 X-ray crystallographic analysis on six [2]rotaxanes and two [3

250 In addition, single-crystal X-ray crystallographic analysis on the most reactive derivativ

251 Because eukaryotic BATs are recalcitrant to crystallographic analysis, our understanding of the mech

252 Crystallographic analysis provided insights into the inh

253 Our crystallographic analysis provides a detailed view into

254 ght (MALDI-TOF) mass spectrometry, and X-ray crystallographic analysis reveal a bimetallic structure

255 with multi-angle laser light scattering and crystallographic analysis reveal that a DNA-binding frag

256 Our crystallographic analysis revealed a monomeric enzyme wh

257 Previously, X-ray crystallographic analysis revealed a network of contacts

258 X-ray crystallographic analysis revealed that Abeta42 binding

259 Recent crystallographic analysis revealed that dimerization is

260 Crystallographic analysis revealed that pyridine-palladi

261 Crystallographic analysis revealed that SB-590885 stabil

262 Our previous crystallographic analysis revealed that the active site

263 Crystallographic analysis revealed that the nicotinamide

264 Crystallographic analysis reveals architectural features

265 X-ray crystallographic analysis reveals interesting conformati

266 X-ray crystallographic analysis reveals that 12 adopts a simil

267 Our crystallographic analysis reveals that PLSCR1 NLS binds

268 Crystallographic analysis reveals that the only signific

269 Crystallographic analysis reveals that the overall struc

270 The crystallographic analysis reveals that the thiolate liga

271 X-ray crystallographic analysis reveals that these type II inh

272 Crystallographic analysis reveals the formation of a sta

273 d, proton, and carbon NMR spectra, and X-ray crystallographic analysis reveals the nitroso groups pos

274 X-ray crystallographic analysis reveals the Zr and Hf complexe

275 Crystallographic analysis showed a plane of symmetry tha

276 Crystallographic analysis showed that W136A mutation did

277 Crystallographic analysis shows that 3 forms a chiral cl

278 Crystallographic analysis shows that [H1](0) retains the

279 Crystallographic analysis shows that Et4N[H3(BAr(F)3)2]

280 Crystallographic analysis shows that splaying between th

281 Crystallographic analysis shows that the concomitant cen

282 X-ray crystallographic analysis shows that the DPX-26 has a de

283 X-ray crystallographic analysis shows that these sites adopt d

284 ogy-dependent polymorphism using an in-depth crystallographic analysis that correlates high-resolutio

285 Here, we demonstrate using spectroscopic and crystallographic analysis that human PARP-1 has a third

286 primary adduct and established through X-ray crystallographic analysis that the adduct is the product

287 From X-ray crystallographic analysis, the molecular analogues Lu[CH

288 As shown by crystallographic analysis, the phosphonate moiety is hig

289 the designed protein was confirmed by X-ray crystallographic analysis: The remodeled loop adopts a c

290 and purification, and high resolution x-ray crystallographic analysis to 1.44 A of wild-type DesIV c

291 used multiple solution state techniques and crystallographic analysis to investigate the importance

292 The crystallographic analysis unambiguously elucidated that

293 The crystallographic analysis unexpectedly revealed the bind

294 Our crystallographic analysis unveiled the exact position of

295 Crystallographic analysis using a labeled RNA oligonucle

296 repare single crystals suitable for accurate crystallographic analysis was missing.

297 talline photochromism phenomena of 10, X-ray crystallographic analysis was performed, revealing a sig

298 As well as full X-ray crystallographic analysis, we studied the reactivity of

299 ctural assignments for 2 and 3 through X-ray crystallographic analysis, which revealed an interesting

300 photolabeling experiments, as well as X-ray crystallographic analysis with a protein prenyltransfera