ライフサイエンスコーパス: crystallography

1 bstrate recognition were elucidated by x-ray crystallography.

2 dated by surface plasmon resonance and X-ray crystallography.

3 pic methods, as well as single-crystal X-ray crystallography.

4 complex with the paxillin LD1 motif by X-ray crystallography.

5 ases, and their structural analysis by X-ray crystallography.

6 the duplex proximal to the triangle by X-ray crystallography.

7 elemental analysis, and, in one case, X-ray crystallography.

8 terized by NMR spectroscopy as well as X-ray crystallography.

9 at -35 degrees C and characterized by X-ray crystallography.

10 nes were established by single-crystal X-ray crystallography.

11 plane structural order as confirmed by X-ray crystallography.

12 tures determined by chemical-shift-based NMR crystallography.

13 of the key products were confirmed by X-ray crystallography.

14 vis, EPR, and ENDOR spectroscopies and X-ray crystallography.

15 1(alphabetagamma)0 using (3 + 1)-dimensional crystallography.

16 edicted binding modes were verified by X-ray crystallography.

17 res were determined by solution NMR or X-ray crystallography.

18 spectroscopy, protein engineering, and X-ray crystallography.

19 ompeting molecular models derived from x-ray crystallography.

20 es are determined using single-crystal X-ray crystallography.

21 s titration, and in the solid state by X-ray crystallography.

22 in complex structures well resolved by X-ray crystallography.

23 ed and discussed as a part of small molecule crystallography.

24 adium complexes, were characterized by X-ray crystallography.

25 evented structural characterization by X-ray crystallography.

26 s 183-238 and 292-317) not observed by X-ray crystallography.

27 complements techniques such as NMR and X-ray crystallography.

28 cular target, which was confirmed by SPR and crystallography.

29 m was confirmed through single-crystal X-ray crystallography.

30 ystals whose structure was revealed by X-ray crystallography.

31 re of one of the triads was deduced by X-ray crystallography.

32 vily on average atomic models extracted from crystallography.

33 coupled with in-vitro acetylation assays and crystallography.

34 terized by NMR spectroscopy, HRMS, and X-ray crystallography.

35 erroxidase sites determined earlier by X-ray crystallography.

36 int, and in the case of 1, 2, and 4-8, X-ray crystallography.

37 tures of key products are confirmed by X-ray crystallography.

38 ulted from structural perturbations by X-ray crystallography.

39 ution of a KasA-GSK3011724A complex by X-ray crystallography.

40 e active-site configuration as determined by crystallography.

41 s of 3FMTDZ and HETDZ were analyzed by X-ray crystallography.

42 characterized by NMR spectroscopy and X-ray crystallography.

43 )Bu, and 5-Cp* have been elucidated by X-ray crystallography.

44 packing motifs have been determined by X-ray crystallography.

45 and its stereochemistry established by X-ray crystallography.

46 chemical biology, solution biochemistry, and crystallography.

47 Structures of 1 and 2 are confirmed by X-ray crystallography.

48 unds were profiled using ITC, DSF, and X-ray crystallography.

49 e 3 RNA-dependent RNA polymerase using x-ray crystallography.

50 (3D) atomic structures are not accessible to crystallography.

51 thyldodecylamine N-oxide determined by X-ray crystallography.

52 R spectroscopy, mass spectrometry, and X-ray crystallography.

53 yridine derivatives was validated by protein crystallography.

54 V1 and its closely related AAV6, using X-ray crystallography.

55 as not had its structure determined by X-ray crystallography.

56 odels from electron cryomicroscopy and X-ray crystallography.

57 ctroscopy, computational analysis, and X-ray crystallography.

58 MR spectroscopy, DFT calculations, and X-ray crystallography.

59 s, which is most commonly performed by X-ray crystallography.

60 benzene-metal adducts characterized by X-ray crystallography.

61 R spectroscopy, mass spectrometry, and X-ray crystallography.

62 elasticity, temperature, and grain boundary crystallography.

63 try, small-angle X-ray scattering, and X-ray crystallography.

64 erized by spectroscopic studies and by X-ray crystallography.

65 nt affinities was evidenced by NMR and X-ray crystallography.

66 polarisation axis determined by the material crystallography.

67 d on the basis of NMR spectroscopy and X-ray crystallography.

68 n spectroscopy, stopped-flow, NMR, and X-ray crystallography.

69 tom in a crystal structure determined by NMR crystallography.

70 lculations, and, in the case of 4a, by X-ray crystallography.

71 dicted to be small and is not discernible by crystallography.

72 characterized by NMR spectroscopy and X-ray crystallography.

73 ng for its structural determination by X-ray crystallography.

74 icroED and potentially by serial femtosecond crystallography.

75 Ku80 at 4.3 angstrom resolution using x-ray crystallography.

76 and below the Pc core, as confirmed by X-ray crystallography.

77 cryo-electron microscopy and 3.8 A by X-ray crystallography.

78 utility for compounds not amenable to x-ray crystallography.

79 and determine its X-ray structure by racemic crystallography.

80 ) are characterized using (1)H NMR and X-ray crystallography.

81 de by using site-directed mutagenesis, X-ray crystallography, (11)B NMR, and computational analysis.

82 In addition, X-ray crystallography, (57)Fe Mossbauer spectroscopy, and EPR

83 Serial X-ray crystallography allows macromolecular structure determin

84 difficulties of crystallizing RNA for X-ray crystallography along with extensive chemical shift over

85 X-ray crystallography analysis of intermediate 15 confirmed it

86 g microcrystals for serial femtosecond X-ray crystallography analysis that enables studies of challen

87 r-subunit disulfide bonds, and show by X-ray crystallography and by binding to a panel of human antib

88 characterized the PRORP2 structure by X-ray crystallography and by small-angle X-ray scattering in s

89 The surface crystallography and chemistry of a LaAlO3 single crystal

90 Here, we have used X-ray crystallography and computational modeling to examine th

91 Here, we combine X-ray crystallography and crosslinking mass spectrometry to ou

92 active form of human ORC determined by X-ray crystallography and cryo-electron microscopy.

93 onventional structural methods such as X-ray crystallography and cryo-transmission electron microscop

94 Several studies with protein crystallography and cryoelectron microscopy have shed li

95 ion of protonation states enabled by neutron crystallography and density functional theory calculatio

96 NMR measurements, in combination with X-ray crystallography and DFT calculations, can reliably disse

97 ng ligands, have been characterized by X-ray crystallography and DFT calculations.

98 the discrepancy between structural data from crystallography and electron microscopy (EM), we show th

99 A combined in situ crystallography and electron spin-state study to probe t

100 L40 and CL59 complexes with gHgL using X-ray crystallography and EM to identify their epitope locatio

101 and cell functional studies, involving X-ray crystallography and EM, we show that PA41 recognizes a s

102 report the low pH characterization by X-ray crystallography and EPR spectroscopy of the nitrogenase

103 tures that are particularly important in MOF crystallography and have a large impact on the quality a

104 The stereochemistry was assigned by crystallography and HPLC for both product manifolds.

105 the core of the complex determined by X-ray crystallography and identify a broader interface.

106 m albumin was investigated by means of X-ray crystallography and inductively coupled plasma mass spec

107 fully designed ligands using high-resolution crystallography and isothermal titration calorimetry.

108 viously been reported to be dependent on its crystallography and its interaction with the substrate.

109 Protein crystallography and mass spectrometry confirmed a chemos

110 Co-crystallography and molecular dynamics simulation analys

111 Through X-ray crystallography and molecular dynamics studies, we show

112 urally analyze these protein complexes using crystallography and molecular modeling.

113 Consistent with prior X-ray crystallography and NMR results, the N-terminal domain c

114 Both crystallography and NMR support a specific electrostatic

115 scaffold with respect to DYRK1A using X-ray crystallography and NMR techniques.

116 ctly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance (primary

117 While X-ray crystallography and nuclear magnetic resonance spectrosc

118 Using crystallography and other approaches, we show how the EG

119 NMR and CD spectroscopy, as well as by X-ray crystallography and quantum chemical calculations.

120 laser, we performed picosecond time-resolved crystallography and show that the hydroxybenzylidene imi

121 Here we use X-ray crystallography and single-molecule fluorescence resonan

122 Here, we use the combination of X-ray crystallography and single-molecule FRET analysis to rev

123 inking coupled with mass spectrometry, X-ray crystallography and single-particle electron microscopy.

124 a conveyor belt drive that is optimized for crystallography and spectroscopy measurements of photoch

125 centered radical has been confirmed by X-ray crystallography and SQUID magnetometry.

126 Here, we used X-ray crystallography and surface plasmon resonance spectrosco

127 uctural and biophysical studies of hTS using crystallography and thermal shift assay and provided the

128 e in the ground state, as evidenced by X-ray crystallography and transient absorption spectroscopies.

129 ere, we capture the translocation process by crystallography and unguided molecular dynamics simulati

130 he IgG1 CH3 homodimer was evidenced by X-ray crystallography and used to engineer examples of bsAbs f

131 teins were determined by quasi-racemic X-ray crystallography and were similar to wild-type ShK.

132 ally investigated both experimentally (X-ray crystallography) and theoretically (DFT calculations).

133 ibition kinetics, mass spectrometry, protein crystallography, and antiviral activity in infected huma

134 are fully characterized, including by X-ray crystallography, and are compared to the "blue solution"

135 nding assays, in structural studies by x-ray crystallography, and by site-directed mutagenesis.

136 mbered ring was examined using spectroscopy, crystallography, and computation.

137 olid-state nuclear magnetic resonance, X-ray crystallography, and computational chemistry-to interrog

138 by NMR spectroscopy, IR spectroscopy, X-ray crystallography, and computational methods.

139 optical absorption, EPR spectroscopy, X-ray crystallography, and DFT calculations.

140 ithin these materials is elucidated by X-ray crystallography, and it is shown that cooperative diffus

141 irst to utilize direct binding assays, X-ray crystallography, and modeling, to pinpoint factors that

142 competition and SPR assays, high-resolution crystallography, and mutational analyses to characterize

143 steady-state kinetics, high resolution X-ray crystallography, and quantum chemical calculations.

144 MR relaxation dispersion measurements, X-ray crystallography, and structure-based chemical shift pred

145 c pocket of the enzyme were characterized by crystallography, and the results provide further insight

146 data we collected by room-temperature serial crystallography are of comparable quality to cryo-crysta

147 can circumvent some of the problems of x-ray crystallography as a pipeline for obtaining the required

148 Here, we demonstrate that serial millisecond crystallography at a synchrotron beamline equipped with

149 s BinAB solved de novo by serial-femtosecond crystallography at an X-ray free-electron laser.

150 Serial crystallography at last generation X-ray synchrotron sou

151 X-ray crystallography at X-ray free-electron laser sources is

152 We report a method for serial X-ray crystallography at X-ray free-electron lasers (XFELs), w

153 has been extensively characterized by X-ray crystallography, biochemical and biophysical experiments

154 Protein crystallography, biophysical affinity determination and

155 e an inhibitor envelope that is invisible to crystallography, but is dynamically accessible by small

156 Neutron crystallography, carried out for the first time on a pro

157 guided by structural information from X-ray crystallography, computational studies, and NMR solution

158 eans of ligand-based NMR spectroscopy, X-ray crystallography, computer simulations, and isothermal ti

159 X-ray crystallography confirmed TFG binding to Zn(2+) in the d

160 spray ionization mass spectrometry and X-ray crystallography confirmed the formation of the predicted

161 X-ray crystallography confirms that the structures overall, an

162 X-ray crystallography confirms they have the fluorite structur

163 structural information available from X-ray crystallography, cryo-EM methods can provide useful comp

164 e minimum number and lengths of helices from crystallography, cryoelectron microscopy, or in vivo cro

165 ism of transport with a combination of X-ray crystallography, cysteine accessibility, and solution sp

166 X-ray crystallography determined that this enzyme is a hexamer

167 tion, and UV-vis spectroscopy; ESI-MS; X-ray crystallography; DFT calculations; reactivity, stereoche

168 , small-angle x-ray scattering (SAXS), x-ray crystallography, electron microscopy, and two-hybrid ana

169 on complex from Escherichia coli using X-ray crystallography, electron microscopy, double electron-el

170 of the Cu(II) corresponding complex by X-ray crystallography, EPR, and XAS spectroscopic methods.

171 Protein X-ray crystallography established that 3-unsubstituted 2,4-oxa

172 The time resolution for serial synchrotron crystallography experiments has been limited to millisec

173 o of which have been isolated in independent crystallography experiments.

174 lights the utility of small-molecule racemic crystallography for obtaining elusive structures of coor

175 In particular, while X-ray crystallography has been a staple of structural biology

176 X-ray crystallography has been applied to the structural analy

177 of the 3D printed mounts for single crystal crystallography has been demonstrated through their use

178 Crystallography has been fundamental to the development

179 of spectroscopy, computational modeling, and crystallography has identified the structures of key int

180 Although crystallography has shed light on the mechanism of mC fl

181 Furthermore, crystallography has the potential to provide information

182 Neutron crystallography has the unique ability of visualizing th

183 from Staphylococcus aureus obtained by X-ray crystallography have shed light on fine details of drug

184 Cryo-electron microscopy and X-ray crystallography have shown that the pre- and postfusion

185 X-ray crystallography, HDX-MS and SPR analysis confirmed that

186 ages were characterized by synchrotron X-ray crystallography, high-resolution mass spectrometry, and

187 ic regions that proved unresolvable by X-ray crystallography in homologous receptors.

188 The use of protein crystallography in structure-guided drug discovery emerg

189 the X-ray structure of ShK toxin by racemic crystallography, in the course of which we discovered th

190 own to possess a novel binding mode by X-ray crystallography, in which the triazolo N1 atom coordinat

191 NMR and crystallography indicate that a phosphoserine, but not a

192 NMR and IR spectroscopy and X-ray crystallography indicate that each alkyl ligand contains

193 geometric frustration remarks that classical crystallography is inadequate to describe systems with c

194 f an allenyl radical by single crystal X-ray crystallography is reported.

195 yzing dynamics of crystalline proteins.X-ray crystallography is the main method for protein structure

196 X-ray crystallography is the predominant source of structural

197 Molecular replacement in X-ray crystallography is the prime method for establishing str

198 llosteric mechanisms of rat PheH using X-ray crystallography, isothermal titration calorimetry (ITC),

199 Here, using X-ray crystallography, isothermal titration calorimetry, confo

200 explains the likely cause of conflict in the crystallography models.

201 Here we show, using X-ray crystallography, molecular dynamics simulations and in v

202 Here we used glycan arrays, STD NMR, X-ray crystallography, mutagenesis and binding assays to deter

203 approach involving protein expression, X-ray crystallography, mutagenesis experiments and molecular s

204 Here, we combine X-ray crystallography, native mass spectrometry, single-channe

205 Here we used crystallography, NMR dynamics, kinetics, and mass spectr

206 anism underlying these dynamics, using X-ray crystallography, NMR spectroscopy, and ab initio quantum

207 enerally static structures produced by X-ray crystallography, NMR spectroscopy, and cryo electron mic

208 The new cages were characterized using X-ray crystallography, NMR spectroscopy, and mass spectrometry

209 countered also by other established methods (crystallography, NMR) for the study of membrane proteins

210 ohexane, a series of studies including X-ray crystallography, NOE measurements, and DFT calculations

211 Freeze-trapping x-ray crystallography, nuclear magnetic resonance, and computa

212 In serial femtosecond crystallography of biological objects-an application of

213 X-ray crystallography of DNA gyrase-DNA complexes shows the co

214 Here we combined x-ray crystallography of Pcore with small angle x-ray scatteri

215 The crystallography of supramolecular host-guest complexes i

216 ectivity were rationalized by means of X-ray crystallography of the adducts of hCA II with several 4-

217 y labeling, hydrogen-deuterium exchange, and crystallography of the ligand-binding ectodomain to esta

218 However, X-ray crystallography of these intermediates is severely hampe

219 ed full characterization (including by X-ray crystallography) of PAHs containing one or more appended

220 road, weak, and often invisible, while X-ray crystallography only provides information on fully order

221 mendous challenges for structural studies by crystallography or solution NMR spectroscopy.

222 robed by molecular dynamics (MD) and protein crystallography (PC) if these endogenous ligands affect

223 X-ray crystallography provided GPCR molecular architectures, w

224 Serial femtosecond crystallography requires reliable and efficient delivery

225 X-ray crystallography revealed a binding site at the GluN1-Glu

226 X-ray crystallography revealed that both inhibitors bind L2 by

227 tify progressable chemical matter, and X-ray crystallography revealed the location of binding in a pr

228 ft calculations, NMR spectroscopy, and X-ray crystallography revealed the strong effect of the fusion

229 determined at 2.30 A resolution using X-ray crystallography, revealed that the overall architecture

230 X-ray crystallography reveals that binding of SPAA-based inhib

231 X-ray crystallography reveals that SJB7 resides in the ligand-

232 X-ray crystallography reveals that the macrocyclic beta-sheet

233 By combination of X-ray crystallography, SAXS and EM, together with biochemical

234 rystal characterized by single crystal X-ray crystallography (sc-XRD), Au279(SPh-tBu)84 named Faradau

235 Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on the

236 2.3 A, obtained by serial femtosecond X-ray crystallography (SFX) with an X-ray free electron laser.

237 cessfully engineer porosities, second phase, crystallography shear-planes and oxygen vacancies during

238 opy, small-angle x-ray scattering, and x-ray crystallography show that 10 designs spanning three dist

239 Binding studies and x-ray crystallography showed that NLPs form complexes with ter

240 Synechocystis sp. PCC6803 obtained by X-ray crystallography showed two juxtaposed FAD molecules per

241 he binding mode of 5 was examined with x-ray crystallography, showing that the only change compared t

242 X-ray crystallography shows that X2-Ph crystallizes into a den

243 of CshA, derived from a combination of X-ray crystallography, small angle X-ray scattering, and compl

244 Here we report time-lapse X-ray crystallography snapshots of catalytic events during gap

245 and dynamics of GPCRs, as determined through crystallography, spectroscopy, and computer simulations.

246 Mutagenesis, biochemical, and X-ray crystallography studies demonstrate that the epitope is

247 IX from conventional/film cryo-EM and X-ray crystallography studies have caused confusion.

248 Crystallography studies indicate that HJV can simultaneo

249 Crystallography studies on Naa60 were unable to resolve

250 cryo-electron microscopy (cryo-EM) and X-ray crystallography studies, but discrepancies exist concern

251 zed compounds was further confirmed by X-ray crystallography studies.

252 An X-ray crystallography study of the rabbit muscle GPb inhibitor

253 X-ray crystallography suggests that the unpaired electrons are

254 As shown through binding studies and crystallography, the engineered monomer retained the sam

255 In macromolecular crystallography, the rigorous detection of changed state

256 eptide, whose structure can be determined by crystallography, the structural description of the apoCa

257 tructure of NGF has been determined by X-ray crystallography, the structural details for proNGF remai

258 Employing X-ray crystallography, the structure of these domains was firs

259 Here, we make use of NMR crystallography-the synergistic combination of solid-sta

260 ed and holo-ACPP-bound forms solved by X-ray crystallography to 2.05and 4.10A, respectively, revealed

261 lexed with ritonavir was determined by X-ray crystallography to a limiting resolution of 2.91 A.

262 Here, we have used x-ray crystallography to analyze the location of Cy3 and Cy5 o

263 Here the authors use time-lapse X-ray crystallography to capture the states of pol micro durin

264 aden the applicability of serial femtosecond crystallography to challenging projects for which only l

265 o yield a high-resolution structure by X-ray crystallography to date.

266 its substrate octane was determined by X-ray crystallography to define features of the active site th

267 We used X-ray crystallography to describe the accurate binding mode of

268 nto how this occurs, here we have used X-ray crystallography to describe the structures of pre- and p

269 e a combination of enzyme kinetics and X-ray crystallography to generate a structure-kinetic relation

270 Interest in applications of protein crystallography to medicine was evident, as the first hi

271 tructure determination was succeeded by cryo-crystallography to mitigate radiation damage.

272 ed room-temperature joint X-ray/neutron (XN) crystallography to obtain an atomic-resolution structure

273 ial of 'mix-and-inject' time-resolved serial crystallography to study biochemically important interac

274 mistry, density functional theory (DFT), and crystallography to understand the effect of cyclization

275 Nevertheless, the use of SAXS and X-ray crystallography together to inspect PAH structure provid

276 We also reveal by crystallography two distinct dimer interfaces in the BTN

277 ely to be involved in neuroprotection, using crystallography under noble gas pressure, mostly at room

278 sent several examples which show that serial crystallography using high-viscosity injectors can also

279 tion transfer difference (STD)-NMR and X-ray crystallography using oligosaccharides obtained by synth

280 studied in detail by a combination of X-ray crystallography, UV-vis and fluorescence spectroscopy as

281 e routinely collected at synchrotrons.Serial crystallography was developed for protein crystal data c

282 Using x-ray crystallography, we determined the crystal structures of

283 Using kinetics and time-lapse crystallography, we evaluated how a model DNA polymerase

284 MR spectroscopy, mass spectrometry and X-ray crystallography, we now report a unified picture that ex

285 Here, using X-ray crystallography, we present for the first time structure

286 Using X-ray crystallography, we show that Cdt1 contains two winged-h

287 Here, using genetic analysis and X-ray crystallography, we show that MamO has a degenerate acti

288 Using time-resolved x-ray crystallography, we show that the phosphoryltransfer rea

289 Using x-ray crystallography, we solved the structure of the human SU

290 troscopy, native mass-spectrometry and X-ray crystallography, we studied how bundle formation was aff

291 (13)C, and (31)P NMR spectroscopy and X-ray crystallography, we suspect that this ATRA-active specie

292 for protein structure determination is X-ray crystallography which relies on the availability of high

293 Here the authors use neutron crystallography, which allows the visualization of the p

294 ufficient production of the enzyme for X-ray crystallography, which reveals the structural architectu

295 were able to confirm the structure by X-ray crystallography, while only one did not crystallize.

296 e receptor, determined by serial femtosecond crystallography with an X-ray free-electron laser.

297 Thus, combining X-ray crystallography with carbohydrate molecular modeling res

298 cales from atoms to cells by combining X-ray crystallography with electron cryotomography and sub-nan

299 rized in the Ir(V) state, including by X-ray crystallography, XPS, and DFT calculations, all of which

300 g DNA shape information extracted from X-ray crystallography (XRC) data or Molecular Dynamics (MD) si