ライフサイエンスコーパス: culminate

1 FIS melting culminates 12,880 years ago synchronously with the start

2 This event culminated a half-century effort around the globe to dev

3 AP cell elongation forms a gradient culminating at the posterior of the embryo, consistent w

4 range of the spectrum, where solar radiation culminates, but also the emissivity of the ant in the mi

5 A steep increase occurs after the 1940s culminating during the 1970s, at the same time as the ma

6 f the haploid spermatozoon and oocyte is the culminating event in mammalian fertilization, enabling t

7 Fertilization, the culminating event in sexual reproduction, occurs when ha

8 Fertilization is the culminating event of sexual reproduction, which involves

9 se receptors initiates signaling events that culminate in an effective immune response.

10 ly that the YAP and Hippo signaling pathways culminate in an Mcl-1-regulated tumor survival pathway b

11 athogenic GC B cell and macrophage reactions culminate in antibody formation and TGF-beta secretion,

12 d inflammation, and lysosomal anomalies that culminate in behavioral and motor deficiencies.

13 The overall response to this stress may culminate in cardiac muscle atrophy.

14 s encompass many layers of regulation, which culminate in changes in accumulated transcript levels.

15 e-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major

16 ies of regulated structural transitions that culminate in delivery of the viral genetic material.

17 nslational fidelity defects of these mutants culminate in destabilization of selected mRNAs and short

18 eactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AA

19 rases (and other supporting components) that culminate in elevated [CO2] inside a chloroplastic Rubis

20 These defects culminate in excessive cell extrusion, enlargement of th

21 rs complex signal transduction cascades that culminate in expression of gene patterns that facilitate

22 This level of consensus could culminate in global coordination of incentives that stri

23 e, we analyze the degenerative sequelae that culminate in heart failure and death in this mouse model

24 ity at dentate gyrus-CA3 excitatory synapses culminate in impaired coding of new spatial information

25 These culminate in in situ XAS experiments that link structura

26 Reduced TET levels culminate in increased 5-methylcytosine, resulting in CT

27 The computations for object vision culminate in inferior temporal cortex (IT), but the func

28 ccur through a series of discrete steps that culminate in insertion of the new SPB into the nuclear e

29 behavior and callous-unemotional traits that culminate in later diagnoses of conduct disorder, antiso

30 Nondenaturing solvent conditions usually culminate in low ESI charge states.

31 Targeting the molecular pathways that culminate in lysis of neutrophils during CA-MRSA infecti

32 scade through communities, with effects that culminate in mass extinction.

33 e liver failure to develop sepsis, which may culminate in multiple organ failure and death.

34 nsduction of structural changes in MLKL that culminate in necroptosis.

35 rarchical genomic and regulatory states that culminate in neutrophil or macrophage specification in m

36 action and differentiation of myofibroblasts culminate in pathologic deposition of collagen.

37 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intrac

38 activate proper responses that will finally culminate in plant adaptations to optimize their growth

39 Persistent insulin secretion defects culminate in progressive deficits in beta-cell prolifera

40 phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the join

41 o endothelial cell (EC) permeability and may culminate in pulmonary edema, a devastating complication

42 These mechanisms culminate in reduction of paralytic signs of EAE.

43 ccessive episodes of stochastic accumulation culminate in repeated reversals of visual appearance.

44 These perturbations can culminate in significant morbidity and mortality, usuall

45 results highlight brainstem mechanisms that culminate in SSS at the level of the auditory cortex.

46 g synthetic strategies, some of the sections culminate in tables containing comparisons of various me

47 litical reorganization and depopulation that culminate in the abandonment of Cahokia and the surround

48 ents that produce cognitive deficits and can culminate in the development of epilepsy.

49 These processes culminate in the development of pulmonary hypertension,

50 s of S. aureus bloodstream infections, which culminate in the establishment of abscess lesions.

51 row ingression during early development that culminate in the formation of an epithelial sheet.

52 es induces a variety of chemical events that culminate in the nucleation and growth of metal nanocrys

53 coordination of many endocrine factors that culminate in the production of mature, viable gametes.

54 ver, the intracellular molecular events that culminate in tolerance and functional competency of educ

55 o facilitate pathogen-host interactions that culminate in toxin delivery.

56 rezizaane sesquiterpenes are reported, which culminated in a formal total synthesis of the neurotroph

57 al innovation in Triassic stem-group mammals culminated in a global adaptive radiation of crown-group

58 These events culminated in a more rapid starvation-induced autophagy

59 enultimate glacial termination (T-II), which culminated in a sea-level highstand during the last inte

60 A strategy has been developed that culminated in a stereoselective total synthesis of the t

61 Increased circulatory GH culminated in a switch in whole body fuel metabolism and

62 cal changes that developed over 2-4 days and culminated in cell death.

63 contributed to immunological signaling that culminated in colon inflammation.

64 he seismic network captured an eruption that culminated in explosive acoustic signals where lava erup

65 These structural and mechanistic insights culminated in GSK065(C1) and GSK366(C2), molecules suita

66 This culminated in increased DNA damage already at 20 weeks o

67 This work culminated in numerous companies identifying potent sele

68 ion of this unique crown-color signal likely culminated in premating isolation of the hybrid species

69 thrombosis in the pulmonary microvasculature culminated in right ventricular dysfunction.

70 ptors are the differentiating features which culminated in selection of 5al for further development.

71 ata, MD runs in the absence of Ca(2+) and Ax culminated in target binding site closure.

72 The work described herein culminated in the 2014 FDA approval of suvorexant as a f

73 corporates the use of the GRADE methodology, culminated in the 2015 CoSTR publication, which in turn

74 These deleterious effects culminated in the activation of the mitochondrial apopto

75 ies made in the cyclic nucleotide field that culminated in the advent of PDE5 inhibitors that treat e

76 ts to generate such semi-synthetic organisms culminated in the creation of a strain of Escherichia co

77 decade, which has, in my own field of study, culminated in the determination of ribosome structure at

78 rocyclic core residues and N-acyl side chain culminated in the development of 26, which shows potent

79 This paper traces the research path that culminated in the development of this drug.

80 stress, transport, and secondary metabolism culminated in the differentiation zone.

81 ting point for a drug discovery program that culminated in the discovery of 103 (AZD1979).

82 These studies culminated in the discovery of 6-(4-amino-4-methylpiperi

83 rsible covalent drug discovery program which culminated in the discovery of compound 34 (PRN1371), a

84 Iteration of these efforts culminated in the discovery of MK-2640, and its in vitro

85 Chemical optimization of 3 using SBDD culminated in the discovery of the potent and selective

86 veral episodes of intense volcanic activity, culminated in the effusive flank eruption of August 2014

87 to alkyl and aryl groups, additional efforts culminated in the expansion of the scope of the substitu

88 These efforts have culminated in the first successful biomimetic catalyst c

89 etric approach to these alkaloids, which has culminated in the first total syntheses of (-)-2(S)-cath

90 This medicinal chemistry effort culminated in the identification of 52, a potent and hig

91 This work culminated in the identification of a simplified tris-ba

92 This work culminated in the identification of compound 30 (AZD7986

93 aryl appendage improved oral absorption and culminated in the identification of indole acid, PF-0640

94 f properties related to drug metabolism then culminated in the identification of the clinical candida

95 protein pair mediating this event in mammals culminated in the identification of the glycosylphosphat

96 ironmental change and biologic turnover that culminated in the marine and terrestrial mass extinction

97 Research on elicitins culminated in the recent cloning of the elicitin respons

98 ptimization in the pyridopyrimidinone series culminated in the selection of compound 3 (RG7800), the

99 These efforts have culminated in the simultaneous approval by the US Food a

100 ) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion.

101 l account of our strategies and tactics that culminated in the total synthesis of ajudazol B, the mos

102 These studies culminated in useful and path-pointing structure-activit

103 the Tc17 differentiation program during GVHD culminates in a highly plastic, hyperinflammatory, poorl

104 ly postnatal life wherein partial amputation culminates in a localized regeneration instead of global

105 s, the programs associated with T cell aging culminates in a maladaptive response that directly contr

106 (ICE), the accessibility of the naphthoates culminates in a new synthesis of anthraquinones and dias

107 suggesting that mPFC-BLA circuit maturation culminates in a period of exuberant GABAergic transmissi

108 rather broad time scale and how this process culminates in a structural signal that is responsible fo

109 d differential expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposi

110 This culminates in an extremely poor clinical outcome.

111 ng to the leakage of lysosomal contents that culminates in apoptotic cell death.

112 rylation and its membrane translocation that culminates in augmented autophagy with concomitant G2/M

113 xic accumulation of maltose-1-phosphate that culminates in cellular death.

114 gen I, by hepatic stellate cells (HSCs) that culminates in cirrhosis.

115 The process of testis regression culminates in complete degeneration of the seminiferous

116 , a process analogous to ubiquitination that culminates in covalent attachment of the ubiquitin-like

117 oner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+), yet the identi

118 The molt culminates in ecdysis, an ordered sequence of behaviors

119 Infiltration of infected leukocytes culminates in establishment of a brain niche for Human I

120 That cancer-driven alteration of WWP1 culminates in excessive TbetaRI degradation and attenuat

121 els an accelerating disease progression that culminates in failure of mitochondrial energy production

122 (systole) in aged animals, where their loss culminates in fibrillatory cardiac arrest.

123 ls by a complex differentiation process that culminates in fusion of mononuclear osteoclast precursor

124 GPCR)-like protein Smoothened into cilia and culminates in gene transcription via the Gli family of t

125 owledged to reflect glomerular damage, which culminates in glomerulosclerosis and proteinuria.

126 priate to perform germline gene editing that culminates in human pregnancy.

127 nal revascularization begins as inflammation culminates in ischemic retinopathies.

128 This strategy culminates in isolation of the first formal Ce horizonta

129 The cascade that culminates in macrometastases is thought to be mediated

130 which it activates a signaling cascade that culminates in many of the functional outcomes attributed

131 al machinery in pancreatic cancer cells, and culminates in mda-7/IL-24-mediated toxicity.

132 ase, triggering a proteolytic cascade, which culminates in more ECM degradation.

133 ionate host response to infection that often culminates in multiple organ failure.

134 stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experien

135 transitions to eight weeks of research, and culminates in one week at the Rosetta annual conference.

136 Our theoretical model culminates in phase diagrams that accurately predict the

137 s a renal tubule injury-like response, which culminates in progressive tubulointerstitial fibrosis (T

138 ge in a stereotyped "dance," that this dance culminates in proper spindle positioning and orientation

139 ained during childhood, and its reactivation culminates in puberty initiation.

140 tims exhibit local or systemic reaction that culminates in pulmonary oedema, potentially leading to d

141 steoclasts activity and bone turnover, which culminates in reduced bone mass, similar to cases of pos

142 rtrophy, and progressive renal injury, which culminates in reduced renal function.

143 This translational control culminates in reprogramming of the transcriptome to faci

144 drives the cystic lung remodeling that often culminates in respiratory failure.

145 active Rac1 is lost in FRET experiments and culminates in shunting migration in a fibrous fibronecti

146 highly conserved neurohormonal cascade that culminates in systemic secretion of glucocorticoids.

147 idues, causing a domino chain of events that culminates in target binding site closure.

148 in and triggers intracellular signaling that culminates in the cleavage of the extracellular domain o

149 itrogen-fixing soil bacteria called rhizobia culminates in the development of root nodules, where rhi

150 our synthetic forays toward picrinine, which culminates in the first total synthesis of this long-sta

151 This evolutionary process culminates in the formation of metastases, which is the

152 between leguminous plants and soil rhizobia culminates in the formation of nitrogen-fixing organs ca

153 Hematopoiesis culminates in the production of functionally heterogeneo

154 Acute hepatitis C virus (HCV) infection culminates in viral persistence in the majority of cases

155 V pathophysiology, prognosis, and therapies, culminating in a 2-part document describing consensus re

156 orylation capacity and increased ROS levels, culminating in a bioenergetic catastrophe.

157 g: 1) the evolution of training requirements culminating in a competency-based curriculum; 2) the dev

158 articipants were included in 2 groups each), culminating in a consensus meeting attended by experts (

159 unting protein synthesis and mTOR signaling, culminating in a decline of Mcl-1.

160 r the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect

161 been translated to a small molecule paradigm culminating in a highly (Z)-selective, catalytic isomeri

162 of carbon nucleophiles to C-alkynyl imines, culminating in a highly syn-selective catalytic asymmetr

163 th are steadily recruited to the centrosome, culminating in a peak in MTOC function in metaphase.

164 Culminating in a scalable, rapid, high-yielding, and ope

165 2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectan

166 nsion of the Pacific subtropical anticyclone culminating in A.D. 1140-1260 opened an anomalous climat

167 gions and peripheral-autonomic body systems, culminating in accurate emotion discrimination.

168 tion and integrity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell de

169 MAPK and NF-kappaBp65 activation, ultimately culminating in amelioration of excess collagen synthesis

170 oral and spatial control of gene expression, culminating in an asymmetric cell division yielding dist

171 the rates of the paternal PAR or autosomes, culminating in an elevated chromosome-wide rate.

172 ear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion.

173 g protein-like 1), leads to retinal diseases culminating in blindness.

174 ing accompanied by cell-cycle activation and culminating in cell death was also observed in 1 degrees

175 of p27 and PUMA in a panel of cancer cells, culminating in cell death.

176 d pattern of PAD-mediated deimination events culminating in citrullination of R502/R510.

177 rost thawed in response to climatic warming, culminating in collapse of the peat domes.

178 interactions (P(Het) 0.0003-6.3 x 10(-12)), culminating in contrasting estimates of trait variance e

179 da-5) initiates multiple signaling cascades, culminating in cytotoxicity and type I IFN production in

180 : 3500 boys and leads to muscle dysfunction culminating in death due to respiratory or cardiac failu

181 and expression of c-fos in BMMs (p < 0.01), culminating in decreased NFATc1 protein expression and t

182 ive interaction between rhizobia and legumes culminating in development of functional root nodules ha

183 r IL5 expression by CXCR2+ lung neutrophils, culminating in early lung injury.

184 imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that wel

185 Global nuclear condensation, culminating in enucleation during terminal erythropoiesi

186 ion of IL-6 increases cortical excitability, culminating in epileptiform discharges in vitro and spon

187 an sulfate results in neurological symptoms, culminating in extensive neurodegeneration and early dea

188 acts as the first step in a series of events culminating in fusion with the host cell membrane and tr

189 ar1 membrane binding is elevated, ultimately culminating in GTP hydrolysis, which may destabilize the

190 trant tumours with OCCC-like histopathology, culminating in haemorrhagic ascites and a median surviva

191 rogressive and severe diastolic dysfunction, culminating in heart failure.

192 ne-based potent and selective ALK inhibitors culminating in identification of the investigational cli

193 Manipulating this cellular circuit culminating in IL-2 production could have clinical benef

194 yte adhesion and ameliorated lung pathology, culminating in improved survival.

195 expansion and CAR T cell antitumor efficacy, culminating in improvement in survival in a syngeneic mo

196 creased expression of key CHOP target genes, culminating in increased cell death in response to stres

197 ertical LIV realigned the cell cytoskeleton, culminating in increased cell stiffness.

198 kening of the intestinal epithelial barrier, culminating in increased colonic inflammation and accele

199 ocyte lengthening load, and atrial function, culminating in increased LV filling pressures.

200 o most abundant PDK isoforms, PDK2 and PDK3, culminating in increased PDH activation in mutant cells.

201 tions of vessels accumulate throughout life, culminating in increased risk of developing CVD.

202 y stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)

203 eregulation of early development checkpoints culminating in inefficient differentiation of CD4(+)CD8(

204 NA damage responses (DDRs) at the telomeres, culminating in karyotypic alterations with massive array

205 a specific context to auxin response maxima culminating in leaf primordia initiation.

206 nocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis.

207 gain a better understanding of the processes culminating in liver failure and cancer and to prioritiz

208 sts were accompanied by rising diastolic Ca, culminating in long pauses dominated by Ca waves.

209 ssive vascular disorganization and leakiness culminating in massive ascites.

210 avian crown group) explosively diversified, culminating in more than 10,000 species distributed worl

211 ice held a value stream analysis in FY 2013, culminating in multiple rapid process improvement worksh

212 gressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 mon

213 oss, and reactive oxygen species production, culminating in necrotic cell death.

214 eurons induces both apoptosis and autophagy, culminating in neuron death.

215 GA leads to defects in metabolic homeostasis culminating in obesity and insulin resistance.

216 pulmonary bypass (CPB) provokes inflammation culminating in organ dysfunction and increased mortality

217 ton-type process involving exposed iron ions culminating in peroxide initiated free-radical formation

218 nd other stimuli trigger a signaling cascade culminating in phosphoinositide-phospholipase C (PLC) ac

219 us subcellular compartments is demonstrated, culminating in photoinduced labelling within live cells.

220 echanism via a light-triggered redox cascade culminating in photooxidation of a yet unknown substrate

221 ulatory subunit of PKA (PRKAR1alpha) content culminating in PKA-site dependent phosphorylation of car

222 ube) and the maternal tissues of the flower, culminating in precise pollen tube guidance to the femal

223 BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degen

224 TIR domains results in downstream signaling culminating in proinflammatory cytokine production.

225 sative agent of chronic prostatitis possibly culminating in prostate cancer, is reduced in SFM of ESR

226 flammation leads to macrophage reprogramming culminating in reduced proinflammatory and increased ant

227 during the two decade long Rome process now culminating in Rome IV.

228 ructural and functional decline with ageing, culminating in sarcopenia.

229 rease excitatory drive into the hippocampus, culminating in seizure activity and SUDEP.

230 in initiation of its autocatalytic activity, culminating in self-cleavage that generates catalyticall

231 Th1/Th2 imbalance impacts childhood immunity culminating in sensitivity to allergic reactions, suscep

232 a phenotypic roadmap of disease progression culminating in serially transplantable leukemia.

233 ntially and spatially choreographed program, culminating in seven spatially arranged unilineage proge

234 n physical activity or food consumption, all culminating in significantly reduced weight gain and adi

235 levels and activation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal

236 e of significant pathology in other tissues, culminating in stroke and severe neurological deficits w

237 d vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor growth and prolonged sur

238 y IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.

239 ts are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

240 s of the unfolded protein response (UPR) and culminating in terminal UPR activation.

241 aptic, cellular, and network-level function, culminating in the aberrant encoding of spatial informat

242 (ROCK) and myosin light chain kinase (MLCK), culminating in the activation of non-muscle myosin IIA (

243 riggers a series of distinct receptor states culminating in the active Metarhodopsin II (Meta II) sta

244 gh time is a key feature of human evolution, culminating in the advanced capacity for ecosystem engin

245 However, the signal transduction pathways culminating in the biological consequences of VEGF signa

246 gnificantly to "hit-to-lead" design efforts, culminating in the creation of potent and selective inhi

247 ents in potency and NaV subtype selectivity, culminating in the design of [Ala5,Phe6,Leu26,Arg28]GpTx

248 totype for transition from bench to bedside, culminating in the development and clinical implementati

249 ted through an in silico screening campaign, culminating in the discovery of an additional RAD52 inhi

250 ty against two LAR subtype cell line models, culminating in the discovery of compound 30 (CIDD-006710

251 antibacterial activity in vitro and in vivo, culminating in the discovery of unprecedented substituen

252 s, both during wakefulness and during sleep, culminating in the distribution of information to additi

253 owed by early embryonic patterning genes and culminating in the emergence of a signature reminiscent

254 y a substantial decline across the boundary, culminating in the extinction of several important clade

255 is and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pan

256 ull account on the development of a strategy culminating in the first total synthesis of the architec

257 moting HF proliferation and differentiation, culminating in the formation of benign HF tumors and a c

258 sequential stages of TLS maturation in LSCC culminating in the formation of germinal centers (GC).

259 pollen tube cell and the receptive synergid, culminating in the lysis of both interaction partners.

260 CAIX-NF-kappaB-G-CSF cellular signaling axis culminating in the mobilization of granulocytic MDSCs to

261 XN3 abundance may reflect a complex response culminating in the modulation of specific components of

262 tokinesis is the last step of cell division, culminating in the physical separation of daughter cells

263 m India's unsatisfactory health-care system, culminating in the present government's promise to expan

264 in (LBD) published in 1998, and in many ways culminating in the publication of the full-length struct

265 that TNFalpha signaling, acting in pathways culminating in the redistribution of NF-kappaB and FoxA1

266 ded with drier positive PNA-like conditions, culminating in the staggered abandonment of many major N

267 to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyop

268 n with a range of simple and complex dienes, culminating in the synthesis of 6,6-spirocyclic ring sys

269 ding rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in

270 of this strategy was successfully realized, culminating in the synthesis of oridamycin A and oridamy

271 basal bodies at distinct stages of assembly, culminating in their asymmetric enrichment at specific t

272 ology, and platelet production and function, culminating in thrombocytopenia and platelet dysfunction

273 RP load were not always mutually beneficial, culminating in trade-offs among multiple Lake Erie phosp

274 ctivation of the Raf/MEK/ERK kinase cascade, culminating in upregulation of CDK1 with subsequent SAMH

275 ting a local renin-angiotensin system (RAS), culminating in ventricular fibrillation.

276 ons of calves latently infected with BoHV-1, culminating in virus shedding and transmission.

277 cell death, but also release toxic proteins culminating in widespread proteolysis, nucleolysis, and

278 opment of various SMN replacement strategies culminating, in December 2016, in the approval of the fi

279 ous design flexibility in the quantum regime culminating most recently in the demonstration of few qu

280 pattern becomes gradually more expansive and culminates when another rewarding flower is found.

281 cts with diabetes mellitus in particular, to culminate with arguments pro and con and a practical ris

282 leton-mediated FA growth and maturation thus culminate with FA traction oscillation to drive efficien

283 elt, crustal thickening began at 240 Ma and culminated with 60-70-km-thick crust at 215 Ma.

284 rity in order to improve intrinsic clearance culminated with the discovery of purinone 27 (AM-0902),

285 This effort culminated with the identification of a series of orally

286 The interaction culminates with a collapse of B. graminis haustoria, the

287 uage's usage and capabilities; the main text culminates with a final project in structural bioinforma

288 RNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival.

289 This integrated pathway culminates with the direct phosphorylation of the crucia

290 This article culminates with the discovery of our first clinical cand

291 tion of arterial markers, is observed, which culminates with the generation of the supraintestinal ar

292 RP biogenesis culminates with the joining of two large subcomplexes, t

293 As such, our framework culminates with the novel aggregation method, cell-centr

294 erol depletion triggers a signaling cascade, culminating with contraction impairment and myofibril di

295 itions, beginning with spore germination and culminating with establishment of a systemic infection.

296 physiological and epigenetic adaptations and culminating with slower long-lasting genetic ones.

297 ic hematopoiesis occurs in successive waves, culminating with the emergence of hematopoietic stem cel

298 is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion

299 th rates in batch cultures during log phase, culminating with the onset of stationary phase.

300 ticipants for validation at each site, and a culminating workshop with representatives from all 5 tri