ライフサイエンスコーパス: culminate in

1 rezizaane sesquiterpenes are reported, which culminated in a formal total synthesis of the neurotroph

2 al innovation in Triassic stem-group mammals culminated in a global adaptive radiation of crown-group

3 These events culminated in a more rapid starvation-induced autophagy

4 enultimate glacial termination (T-II), which culminated in a sea-level highstand during the last inte

5 A strategy has been developed that culminated in a stereoselective total synthesis of the t

6 topoietic cell transplantation have recently culminated in a successful merger: the development and c

7 Increased circulatory GH culminated in a switch in whole body fuel metabolism and

8 the Tc17 differentiation program during GVHD culminates in a highly plastic, hyperinflammatory, poorl

9 ly postnatal life wherein partial amputation culminates in a localized regeneration instead of global

10 s, the programs associated with T cell aging culminates in a maladaptive response that directly contr

11 (ICE), the accessibility of the naphthoates culminates in a new synthesis of anthraquinones and dias

12 suggesting that mPFC-BLA circuit maturation culminates in a period of exuberant GABAergic transmissi

13 rather broad time scale and how this process culminates in a structural signal that is responsible fo

14 V pathophysiology, prognosis, and therapies, culminating in a 2-part document describing consensus re

15 orylation capacity and increased ROS levels, culminating in a bioenergetic catastrophe.

16 g: 1) the evolution of training requirements culminating in a competency-based curriculum; 2) the dev

17 articipants were included in 2 groups each), culminating in a consensus meeting attended by experts (

18 unting protein synthesis and mTOR signaling, culminating in a decline of Mcl-1.

19 postdoctoral years in biology at Hopkins and culminating in a faculty position in biological sciences

20 r the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect

21 been translated to a small molecule paradigm culminating in a highly (Z)-selective, catalytic isomeri

22 of carbon nucleophiles to C-alkynyl imines, culminating in a highly syn-selective catalytic asymmetr

23 th are steadily recruited to the centrosome, culminating in a peak in MTOC function in metaphase.

24 second-generation route to key spirocycle 9, culminating in a practical synthesis of the axinellamine

25 Culminating in a scalable, rapid, high-yielding, and ope

26 2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectan

27 nsion of the Pacific subtropical anticyclone culminating in A.D. 1140-1260 opened an anomalous climat

28 gions and peripheral-autonomic body systems, culminating in accurate emotion discrimination.

29 tion and integrity decline rapidly with age, culminating in activity-dependent, non-apoptotic cell de

30 eurodegenerations, the pathogenic mechanisms culminating in ALS phenotypes begin much earlier in life

31 d differential expression of VEGF-A isoforms culminates in alterations in gonadotroph function opposi

32 MAPK and NF-kappaBp65 activation, ultimately culminating in amelioration of excess collagen synthesis

33 se receptors initiates signaling events that culminate in an effective immune response.

34 ly that the YAP and Hippo signaling pathways culminate in an Mcl-1-regulated tumor survival pathway b

35 n reproductive medicine and cryobiology have culminated in an increased interest in fertility preserv

36 This culminates in an extremely poor clinical outcome.

37 oral and spatial control of gene expression, culminating in an asymmetric cell division yielding dist

38 the rates of the paternal PAR or autosomes, culminating in an elevated chromosome-wide rate.

39 athogenic GC B cell and macrophage reactions culminate in antibody formation and TGF-beta secretion,

40 RI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects.

41 ear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion.

42 ading and autophagic degradation of NBK/Bik, culminating in apoptosis.

43 ng to the leakage of lysosomal contents that culminates in apoptotic cell death.

44 rylation and its membrane translocation that culminates in augmented autophagy with concomitant G2/M

45 d inflammation, and lysosomal anomalies that culminate in behavioral and motor deficiencies.

46 g protein-like 1), leads to retinal diseases culminating in blindness.

47 The overall response to this stress may culminate in cardiac muscle atrophy.

48 volved in mechanisms downstream of PLCbeta1b culminating in cardiomyocyte hypertrophy, and that the h

49 ndergo a complex series of interactions that culminate in cell fusion.

50 cal changes that developed over 2-4 days and culminated in cell death.

51 ing accompanied by cell-cycle activation and culminating in cell death was also observed in 1 degrees

52 of p27 and PUMA in a panel of cancer cells, culminating in cell death.

53 xic accumulation of maltose-1-phosphate that culminates in cellular death.

54 s encompass many layers of regulation, which culminate in changes in accumulated transcript levels.

55 gen I, by hepatic stellate cells (HSCs) that culminates in cirrhosis.

56 d pattern of PAD-mediated deimination events culminating in citrullination of R502/R510.

57 rost thawed in response to climatic warming, culminating in collapse of the peat domes.

58 contributed to immunological signaling that culminated in colon inflammation.

59 The process of testis regression culminates in complete degeneration of the seminiferous

60 interactions (P(Het) 0.0003-6.3 x 10(-12)), culminating in contrasting estimates of trait variance e

61 , a process analogous to ubiquitination that culminates in covalent attachment of the ubiquitin-like

62 trigger caspase-1 or caspase-11 activation, culminating in cytokine secretion and obliteration of th

63 da-5) initiates multiple signaling cascades, culminating in cytotoxicity and type I IFN production in

64 e-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major

65 : 3500 boys and leads to muscle dysfunction culminating in death due to respiratory or cardiac failu

66 opment of various SMN replacement strategies culminating, in December 2016, in the approval of the fi

67 and expression of c-fos in BMMs (p < 0.01), culminating in decreased NFATc1 protein expression and t

68 damage, and impaired cell cycle progression, culminating in defective terminal differentiation and an

69 ies of regulated structural transitions that culminate in delivery of the viral genetic material.

70 oner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+), yet the identi

71 nslational fidelity defects of these mutants culminate in destabilization of selected mRNAs and short

72 ive interaction between rhizobia and legumes culminating in development of functional root nodules ha

73 accumulate activated, autoreactive T cells, culminating in development of multi-organ autoimmunity a

74 eactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AA

75 r IL5 expression by CXCR2+ lung neutrophils, culminating in early lung injury.

76 The molt culminates in ecdysis, an ordered sequence of behaviors

77 rases (and other supporting components) that culminate in elevated [CO2] inside a chloroplastic Rubis

78 imprints on the DNA sequence of tumours, and culminating in empirical evidence from NGS data that wel

79 Global nuclear condensation, culminating in enucleation during terminal erythropoiesi

80 ion of IL-6 increases cortical excitability, culminating in epileptiform discharges in vitro and spon

81 Infiltration of infected leukocytes culminates in establishment of a brain niche for Human I

82 These defects culminate in excessive cell extrusion, enlargement of th

83 That cancer-driven alteration of WWP1 culminates in excessive TbetaRI degradation and attenuat

84 he seismic network captured an eruption that culminated in explosive acoustic signals where lava erup

85 rs complex signal transduction cascades that culminate in expression of gene patterns that facilitate

86 an sulfate results in neurological symptoms, culminating in extensive neurodegeneration and early dea

87 els an accelerating disease progression that culminates in failure of mitochondrial energy production

88 (systole) in aged animals, where their loss culminates in fibrillatory cardiac arrest.

89 ls by a complex differentiation process that culminates in fusion of mononuclear osteoclast precursor

90 acts as the first step in a series of events culminating in fusion with the host cell membrane and tr

91 GPCR)-like protein Smoothened into cilia and culminates in gene transcription via the Gli family of t

92 This level of consensus could culminate in global coordination of incentives that stri

93 owledged to reflect glomerular damage, which culminates in glomerulosclerosis and proteinuria.

94 These structural and mechanistic insights culminated in GSK065(C1) and GSK366(C2), molecules suita

95 ar1 membrane binding is elevated, ultimately culminating in GTP hydrolysis, which may destabilize the

96 trant tumours with OCCC-like histopathology, culminating in haemorrhagic ascites and a median surviva

97 e, we analyze the degenerative sequelae that culminate in heart failure and death in this mouse model

98 rogressive and severe diastolic dysfunction, culminating in heart failure.

99 priate to perform germline gene editing that culminates in human pregnancy.

100 This effort culminated in identification of LEO 29102 (20), a potent

101 ne-based potent and selective ALK inhibitors culminating in identification of the investigational cli

102 Manipulating this cellular circuit culminating in IL-2 production could have clinical benef

103 ntestinal epithelial signaling pathways that culminate in immune activation as well as the role of th

104 ity at dentate gyrus-CA3 excitatory synapses culminate in impaired coding of new spatial information

105 yte adhesion and ameliorated lung pathology, culminating in improved survival.

106 expansion and CAR T cell antitumor efficacy, culminating in improvement in survival in a syngeneic mo

107 These culminate in in situ XAS experiments that link structura

108 Reduced TET levels culminate in increased 5-methylcytosine, resulting in CT

109 t behavioral outcomes that could potentially culminate in increased drug use.

110 This culminated in increased DNA damage already at 20 weeks o

111 creased expression of key CHOP target genes, culminating in increased cell death in response to stres

112 ertical LIV realigned the cell cytoskeleton, culminating in increased cell stiffness.

113 kening of the intestinal epithelial barrier, culminating in increased colonic inflammation and accele

114 ocyte lengthening load, and atrial function, culminating in increased LV filling pressures.

115 o most abundant PDK isoforms, PDK2 and PDK3, culminating in increased PDH activation in mutant cells.

116 tions of vessels accumulate throughout life, culminating in increased risk of developing CVD.

117 y stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)

118 eregulation of early development checkpoints culminating in inefficient differentiation of CD4(+)CD8(

119 The computations for object vision culminate in inferior temporal cortex (IT), but the func

120 sea-ice development and ice volume increase, culminating in initiation of the extensive Northern Hemi

121 ccur through a series of discrete steps that culminate in insertion of the new SPB into the nuclear e

122 nal revascularization begins as inflammation culminates in ischemic retinopathies.

123 This strategy culminates in isolation of the first formal Ce horizonta

124 NA damage responses (DDRs) at the telomeres, culminating in karyotypic alterations with massive array

125 behavior and callous-unemotional traits that culminate in later diagnoses of conduct disorder, antiso

126 a specific context to auxin response maxima culminating in leaf primordia initiation.

127 nocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis.

128 gain a better understanding of the processes culminating in liver failure and cancer and to prioritiz

129 sts were accompanied by rising diastolic Ca, culminating in long pauses dominated by Ca waves.

130 Nondenaturing solvent conditions usually culminate in low ESI charge states.

131 Targeting the molecular pathways that culminate in lysis of neutrophils during CA-MRSA infecti

132 The cascade that culminates in macrometastases is thought to be mediated

133 which it activates a signaling cascade that culminates in many of the functional outcomes attributed

134 scade through communities, with effects that culminate in mass extinction.

135 ssive vascular disorganization and leakiness culminating in massive ascites.

136 al machinery in pancreatic cancer cells, and culminates in mda-7/IL-24-mediated toxicity.

137 ase, triggering a proteolytic cascade, which culminates in more ECM degradation.

138 avian crown group) explosively diversified, culminating in more than 10,000 species distributed worl

139 e liver failure to develop sepsis, which may culminate in multiple organ failure and death.

140 ionate host response to infection that often culminates in multiple organ failure.

141 ice held a value stream analysis in FY 2013, culminating in multiple rapid process improvement worksh

142 gressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 mon

143 nsduction of structural changes in MLKL that culminate in necroptosis.

144 oss, and reactive oxygen species production, culminating in necrotic cell death.

145 stress-induced glutamate excitotoxicity that culminates in neuron injury and manifests as re-experien

146 eurons induces both apoptosis and autophagy, culminating in neuron death.

147 n leads to a myriad of cellular dysfunctions culminating in neuronal loss and consequent motor, cogni

148 ponses and initiates signaling cascades that culminate in neutrophil lysis will provide insights prer

149 rarchical genomic and regulatory states that culminate in neutrophil or macrophage specification in m

150 This work culminated in numerous companies identifying potent sele

151 GA leads to defects in metabolic homeostasis culminating in obesity and insulin resistance.

152 transitions to eight weeks of research, and culminates in one week at the Rosetta annual conference.

153 pulmonary bypass (CPB) provokes inflammation culminating in organ dysfunction and increased mortality

154 action and differentiation of myofibroblasts culminate in pathologic deposition of collagen.

155 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intrac

156 ton-type process involving exposed iron ions culminating in peroxide initiated free-radical formation

157 Our theoretical model culminates in phase diagrams that accurately predict the

158 nd other stimuli trigger a signaling cascade culminating in phosphoinositide-phospholipase C (PLC) ac

159 us subcellular compartments is demonstrated, culminating in photoinduced labelling within live cells.

160 echanism via a light-triggered redox cascade culminating in photooxidation of a yet unknown substrate

161 ulatory subunit of PKA (PRKAR1alpha) content culminating in PKA-site dependent phosphorylation of car

162 activate proper responses that will finally culminate in plant adaptations to optimize their growth

163 ube) and the maternal tissues of the flower, culminating in precise pollen tube guidance to the femal

164 ion of this unique crown-color signal likely culminated in premating isolation of the hybrid species

165 BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degen

166 Persistent insulin secretion defects culminate in progressive deficits in beta-cell prolifera

167 phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the join

168 s a renal tubule injury-like response, which culminates in progressive tubulointerstitial fibrosis (T

169 TIR domains results in downstream signaling culminating in proinflammatory cytokine production.

170 ge in a stereotyped "dance," that this dance culminates in proper spindle positioning and orientation

171 sative agent of chronic prostatitis possibly culminating in prostate cancer, is reduced in SFM of ESR

172 ained during childhood, and its reactivation culminates in puberty initiation.

173 o endothelial cell (EC) permeability and may culminate in pulmonary edema, a devastating complication

174 tims exhibit local or systemic reaction that culminates in pulmonary oedema, potentially leading to d

175 steoclasts activity and bone turnover, which culminates in reduced bone mass, similar to cases of pos

176 rtrophy, and progressive renal injury, which culminates in reduced renal function.

177 flammation leads to macrophage reprogramming culminating in reduced proinflammatory and increased ant

178 These mechanisms culminate in reduction of paralytic signs of EAE.

179 llen tube with egg adjoining synergid cells, culminating in release of two sperm cells and their fusi

180 ccessive episodes of stochastic accumulation culminate in repeated reversals of visual appearance.

181 This translational control culminates in reprogramming of the transcriptome to faci

182 drives the cystic lung remodeling that often culminates in respiratory failure.

183 thrombosis in the pulmonary microvasculature culminated in right ventricular dysfunction.

184 during the two decade long Rome process now culminating in Rome IV.

185 ructural and functional decline with ageing, culminating in sarcopenia.

186 rease excitatory drive into the hippocampus, culminating in seizure activity and SUDEP.

187 ptors are the differentiating features which culminated in selection of 5al for further development.

188 in initiation of its autocatalytic activity, culminating in self-cleavage that generates catalyticall

189 Th1/Th2 imbalance impacts childhood immunity culminating in sensitivity to allergic reactions, suscep

190 a phenotypic roadmap of disease progression culminating in serially transplantable leukemia.

191 ntially and spatially choreographed program, culminating in seven spatially arranged unilineage proge

192 These studies culminate in showing that a single GnT residue, Y627, is

193 active Rac1 is lost in FRET experiments and culminates in shunting migration in a fibrous fibronecti

194 These perturbations can culminate in significant morbidity and mortality, usuall

195 n physical activity or food consumption, all culminating in significantly reduced weight gain and adi

196 levels and activation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal

197 results highlight brainstem mechanisms that culminate in SSS at the level of the auditory cortex.

198 e of significant pathology in other tissues, culminating in stroke and severe neurological deficits w

199 d vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor growth and prolonged sur

200 y IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.

201 highly conserved neurohormonal cascade that culminates in systemic secretion of glucocorticoids.

202 g synthetic strategies, some of the sections culminate in tables containing comparisons of various me

203 ata, MD runs in the absence of Ca(2+) and Ax culminated in target binding site closure.

204 idues, causing a domino chain of events that culminates in target binding site closure.

205 ts are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs.

206 s of the unfolded protein response (UPR) and culminating in terminal UPR activation.

207 litical reorganization and depopulation that culminate in the abandonment of Cahokia and the surround

208 ents that produce cognitive deficits and can culminate in the development of epilepsy.

209 These processes culminate in the development of pulmonary hypertension,

210 s of S. aureus bloodstream infections, which culminate in the establishment of abscess lesions.

211 row ingression during early development that culminate in the formation of an epithelial sheet.

212 es induces a variety of chemical events that culminate in the nucleation and growth of metal nanocrys

213 coordination of many endocrine factors that culminate in the production of mature, viable gametes.

214 The work described herein culminated in the 2014 FDA approval of suvorexant as a f

215 corporates the use of the GRADE methodology, culminated in the 2015 CoSTR publication, which in turn

216 These deleterious effects culminated in the activation of the mitochondrial apopto

217 ies made in the cyclic nucleotide field that culminated in the advent of PDE5 inhibitors that treat e

218 ed with an increasing evidence base that has culminated in the concept of the brain-gut axis.

219 ts to generate such semi-synthetic organisms culminated in the creation of a strain of Escherichia co

220 decade, which has, in my own field of study, culminated in the determination of ribosome structure at

221 rocyclic core residues and N-acyl side chain culminated in the development of 26, which shows potent

222 y an overview of the intellectual basis that culminated in the development of Mo-based diolates and s

223 This paper traces the research path that culminated in the development of this drug.

224 stress, transport, and secondary metabolism culminated in the differentiation zone.

225 ting point for a drug discovery program that culminated in the discovery of 103 (AZD1979).

226 These studies culminated in the discovery of 6-(4-amino-4-methylpiperi

227 rsible covalent drug discovery program which culminated in the discovery of compound 34 (PRN1371), a

228 Chemical synthesis of about 25 derivatives culminated in the discovery of compounds 11d (type I1/2)

229 Iteration of these efforts culminated in the discovery of MK-2640, and its in vitro

230 Chemical optimization of 3 using SBDD culminated in the discovery of the potent and selective

231 veral episodes of intense volcanic activity, culminated in the effusive flank eruption of August 2014

232 to alkyl and aryl groups, additional efforts culminated in the expansion of the scope of the substitu

233 These efforts have culminated in the first successful biomimetic catalyst c

234 etric approach to these alkaloids, which has culminated in the first total syntheses of (-)-2(S)-cath

235 This medicinal chemistry effort culminated in the identification of 52, a potent and hig

236 This work culminated in the identification of a simplified tris-ba

237 This work culminated in the identification of compound 30 (AZD7986

238 This work culminated in the identification of GS-9973, 68, a highl

239 aryl appendage improved oral absorption and culminated in the identification of indole acid, PF-0640

240 f properties related to drug metabolism then culminated in the identification of the clinical candida

241 protein pair mediating this event in mammals culminated in the identification of the glycosylphosphat

242 ironmental change and biologic turnover that culminated in the marine and terrestrial mass extinction

243 This focus has culminated in the now well-established multistage mutati

244 Research on elicitins culminated in the recent cloning of the elicitin respons

245 ptimization in the pyridopyrimidinone series culminated in the selection of compound 3 (RG7800), the

246 These efforts have culminated in the simultaneous approval by the US Food a

247 ) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion.

248 l account of our strategies and tactics that culminated in the total synthesis of ajudazol B, the mos

249 in and triggers intracellular signaling that culminates in the cleavage of the extracellular domain o

250 itrogen-fixing soil bacteria called rhizobia culminates in the development of root nodules, where rhi

251 our synthetic forays toward picrinine, which culminates in the first total synthesis of this long-sta

252 This evolutionary process culminates in the formation of metastases, which is the

253 between leguminous plants and soil rhizobia culminates in the formation of nitrogen-fixing organs ca

254 Hematopoiesis culminates in the production of functionally heterogeneo

255 aptic, cellular, and network-level function, culminating in the aberrant encoding of spatial informat

256 (ROCK) and myosin light chain kinase (MLCK), culminating in the activation of non-muscle myosin IIA (

257 riggers a series of distinct receptor states culminating in the active Metarhodopsin II (Meta II) sta

258 gh time is a key feature of human evolution, culminating in the advanced capacity for ecosystem engin

259 However, the signal transduction pathways culminating in the biological consequences of VEGF signa

260 mprehensive framework for a theory of change culminating in the change strategy of "learning from the

261 gnificantly to "hit-to-lead" design efforts, culminating in the creation of potent and selective inhi

262 ents in potency and NaV subtype selectivity, culminating in the design of [Ala5,Phe6,Leu26,Arg28]GpTx

263 totype for transition from bench to bedside, culminating in the development and clinical implementati

264 ted through an in silico screening campaign, culminating in the discovery of an additional RAD52 inhi

265 ty against two LAR subtype cell line models, culminating in the discovery of compound 30 (CIDD-006710

266 antibacterial activity in vitro and in vivo, culminating in the discovery of unprecedented substituen

267 s, both during wakefulness and during sleep, culminating in the distribution of information to additi

268 owed by early embryonic patterning genes and culminating in the emergence of a signature reminiscent

269 y a substantial decline across the boundary, culminating in the extinction of several important clade

270 is and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pan

271 ull account on the development of a strategy culminating in the first total synthesis of the architec

272 moting HF proliferation and differentiation, culminating in the formation of benign HF tumors and a c

273 sequential stages of TLS maturation in LSCC culminating in the formation of germinal centers (GC).

274 lecule disruptors of the GK-GKRP interaction culminating in the identification of 1 (AMG-1694).

275 pollen tube cell and the receptive synergid, culminating in the lysis of both interaction partners.

276 CAIX-NF-kappaB-G-CSF cellular signaling axis culminating in the mobilization of granulocytic MDSCs to

277 XN3 abundance may reflect a complex response culminating in the modulation of specific components of

278 tokinesis is the last step of cell division, culminating in the physical separation of daughter cells

279 m India's unsatisfactory health-care system, culminating in the present government's promise to expan

280 ble for extracellular nucleotide hydrolysis, culminating in the production of immunosuppressive adeno

281 in (LBD) published in 1998, and in many ways culminating in the publication of the full-length struct

282 that TNFalpha signaling, acting in pathways culminating in the redistribution of NF-kappaB and FoxA1

283 ded with drier positive PNA-like conditions, culminating in the staggered abandonment of many major N

284 to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyop

285 n with a range of simple and complex dienes, culminating in the synthesis of 6,6-spirocyclic ring sys

286 ding rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in

287 of this strategy was successfully realized, culminating in the synthesis of oridamycin A and oridamy

288 oxidase phase in the laboratory is reported, culminating in the total synthesis of taxuyunnanine D, i

289 basal bodies at distinct stages of assembly, culminating in their asymmetric enrichment at specific t

290 ology, and platelet production and function, culminating in thrombocytopenia and platelet dysfunction

291 ver, the intracellular molecular events that culminate in tolerance and functional competency of educ

292 o facilitate pathogen-host interactions that culminate in toxin delivery.

293 RP load were not always mutually beneficial, culminating in trade-offs among multiple Lake Erie phosp

294 multiple mechanisms, and its overexpression culminates in tumorigenesis.

295 ctivation of the Raf/MEK/ERK kinase cascade, culminating in upregulation of CDK1 with subsequent SAMH

296 These studies culminated in useful and path-pointing structure-activit

297 ting a local renin-angiotensin system (RAS), culminating in ventricular fibrillation.

298 Acute hepatitis C virus (HCV) infection culminates in viral persistence in the majority of cases

299 ons of calves latently infected with BoHV-1, culminating in virus shedding and transmission.

300 cell death, but also release toxic proteins culminating in widespread proteolysis, nucleolysis, and