ライフサイエンスコーパス: cultured cell

1 ts Nf1 RasGAP activity in vivo as it does in cultured cells.

2 lpha MAPK-induced BACE1 protein reduction in cultured cells.

3 nd stoichiometry in rat liver microsomes and cultured cells.

4 ently tagged clathrin coat components within cultured cells.

5 racellular vimentin and keratin filaments in cultured cells.

6 o 0.9 Hz after stimulation with 30 mM KCl in cultured cells.

7 ) strain A2MC2 induces type I interferons in cultured cells.

8 resistant to chemotherapeutic agents than 2D-cultured cells.

9 istance against random mutation was shown in cultured cells.

10 sed LRRK2-induced cytoplasmic aggregation in cultured cells.

11 HERV-K ENV imparts broad species tropism in cultured cells.

12 h mechanisms similar to those established in cultured cells.

13 expressed in adult Muller glia increased in cultured cells.

14 2 plays in its localization and stability in cultured cells.

15 system can restrict the JCPyV life cycle in cultured cells.

16 ormation in vivo, in contrast to findings in cultured cells.

17 ow yield functional folding of cone PDE6C in cultured cells.

18 7 reverse HOXC10-mediated drug resistance in cultured cells.

19 pig, ferret, and rabbit and in two types of cultured cells.

20 n and cell boundaries is a common feature of cultured cells.

21 lity and inhibitory activities reported with cultured cells.

22 ne expression patterns and protein levels in cultured cells.

23 mimicked the effects of enzyme inhibition in cultured cells.

24 g of the regulation of glucose metabolism in cultured cells.

25 oxicity and reduced LRRK2 kinase activity in cultured cells.

26 d that of infectious EBOV and MARV in tissue cultured cells.

27 ortening upon long-term chemical exposure in cultured cells.

28 lopmental time points, dissected tissues and cultured cells.

29 negatively regulate YAP1 activity in tissue-cultured cells.

30 in the same species, in tissue sections and cultured cells.

31 fficult to study because HBV does not infect cultured cells.

32 take of recombinant AAV serotype 2 (AAV2) in cultured cells.

33 tin (mHTT) mediates its nuclear exclusion in cultured cells.

34 type during serial amplification passages in cultured cells.

35 specificity observed in vivo was retained in cultured cells.

36 s, as evidenced in various animal models and cultured cells.

37 man renalase 3'-UTR (untranslated region) in cultured cells.

38 hesions, and active beta1-integrin levels in cultured cells.

39 ered and shown to inhibit virus infection in cultured cells.

40 vercome by adaptation of the virus in tissue-cultured cells.

41 n with sonically prepared cell-free virus in cultured cells.

42 a model that induces protein aggregation in cultured cells.

43 been able to overcome these blocks in tissue-cultured cells.

44 currence of soluble CL-12 shed from in vitro cultured cells.

45 or the secretion of exosome-like vesicles in cultured cells.

46 bodies binding to alphaIIbbeta3 expressed in cultured cells.

47 ith p11, diminishes the calcium responses in cultured cells.

48 various stages of the disease as well as in cultured cells.

49 y compound glycosylation and growth phase of cultured cells.

50 ginine methylation in a range of primary and cultured cells.

51 e through the TCA cycle in mouse tissues and cultured cells.

52 M), both of which inhibit CYB5R3 activity in cultured cells.

53 rate of diversification can be controlled in cultured cells.

54 protein and lipid delivery to nascent NR in cultured cells.

55 netic, genomic or other biological assays in cultured cells.

56 -1 in vitro and inhibits MOAP-1 stability in cultured cells.

57 egy of serial passage in nonhost animals and cultured cells.

58 en used to transfer constructs directly into cultured cells.

59 mes modulates the length of primary cilia in cultured cells.

60 re is much lower in human neurons than other cultured cells.

61 e most potent ones were not acutely toxic to cultured cells.

62 ies of the PSP extracts were investigated in cultured cells.

63 ects MKK and NLRP1B cleavage in vitro and in cultured cells.

64 docin through cis- and trans-associations in cultured cells.

65 processing of pri-mir-30c-1 in vitro and in cultured cells.

66 orylation and an increase in Abeta levels in cultured cells.

67 ,000-fold MECP2 up-regulation from the Xi in cultured cells.

68 ructures containing the small GTPase Rab8 in cultured cells.

69 ring was classified by Hodgkin's criteria in cultured cells, 18% displayed tonic class 1 excitability

70 ent gene expression with 40-fold contrast in cultured cells, 32-fold in subcutaneous mouse tissue, an

71 FBS-cultured cells also showed higher MsgA and NanA activity

72 ough LpdA is translocated inefficiently into cultured cells, an L. pneumophila DeltalpdA mutant displ

73 the RNAs synthesized in abortively infected cultured cells and a human skin lesion by next-generatio

74 thermore, FBS transcripts can be taken up by cultured cells and affect the results of highly sensitiv

75 irected mutagenesis, mouse inoculation (from cultured cells and after cohabitation), monitoring of ba

76 TDP-43-containing material derived from both cultured cells and ALS patient brain lysate.

77 ANGPTL2 can increase NOTCH activation in cultured cells and ANGPTL receptor interacted with NOTCH

78 ction of monogenic neuromuscular diseases in cultured cells and animal models.

79 With demonstrated utility in both cultured cells and animals, this mRNA delivery technolog

80 ent ~70-nanometer lateral resolution in both cultured cells and brain tissue, performing three-color

81 Following translocation into cultured cells and clustering by intimin, Tir Y474 is ph

82 ted LPS-induced paracellular permeability in cultured cells and enhanced expression of the adherens j

83 p53-independent fashion, as observed both in cultured cells and growing tumors in mice.

84 e exhibiting Cl-13 wild-type-like fitness in cultured cells and immunocompromised mice.

85 down-regulated were assessed for function in cultured cells and in a transgenic mouse.

86 ral genome promote viral RNA accumulation in cultured cells and in animal models of HCV infection.

87 hondrial and nuclear translocation of p53 in cultured cells and in APP/PS1 mice.

88 Hypoxia induced expression of KIT in cultured cells and in human colon tumor xenografts and t

89 2O3 exposure increased MTHFD1 SUMOylation in cultured cells and in in vitro SUMOylation reactions, an

90 llel with enhanced mitochondrial function in cultured cells and in leukocytes extracted from healthy

91 e to elevated beta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prol

92 logical and immunological characteristics in cultured cells and in mice.

93 T promoted SiO2 NP-induced apoptosis both in cultured cells and in mouse lung tissue.

94 In cultured cells and in samples from patients, HEV produce

95 In cultured cells and in transgenic mice, deficiency in end

96 its efficacy in blocking HCV replication in cultured cells and in treatment of patients with HCV inf

97 sphorylated downstream of AngII signaling in cultured cells and in vitro by PKC and PKA.

98 te the amyloid-like fibril formation both in cultured cells and in vitro.

99 nscriptionally regulated by SKP2 in vitro in cultured cells and in vivo in mouse models.

100 dented telomere-specific DDR inactivation in cultured cells and in vivo in mouse tissues.

101 (G93A) uncovers a survival defect ex vivo in cultured cells and in vivo in tissues lacking Aptx.

102 rties of FABP5-expressing carcinoma cells in cultured cells and in vivo.

103 Loss of function in cultured cells and in zebrafish unexpectedly leads to in

104 broadly localized to the plasma membrane of cultured cells and intact blood vessels in the inner ret

105 as well as single-molecule precision in both cultured cells and intact brain tissue.

106 We noted specific subsets of RBPs in cultured cells and leaves and a comparison of Arabidopsi

107 dard 96-well plate with the ability to image cultured cells and membrane-bound microbeads in twelve i

108 the mitochondrial oxygen consumption rate of cultured cells and mice.

109 nd identification of sialoglycoproteins from cultured cells and model organisms.

110 Using cultured cells and mouse skeletal muscle, we show that T

111 of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be c

112 expressed ribosomal protein genes in single cultured cells and mouse thymus sections, revealing cell

113 hundreds of ADP-ribosylated proteins in both cultured cells and mouse tissues.

114 e feedback loop of the Hippo pathway in both cultured cells and mouse tissues.

115 Both cultured cells and mouse xenografts grow in an environme

116 e show that pALT(INK4a/b) is present in both cultured cells and naked mole rat tissues but is absent

117 lation and silencing upon differentiation in cultured cells and native epiblast.

118 Eya-So transcriptional output in vivo and in cultured cells and on meta analysis of their chromatin o

119 pproximately 7-kDa cytoplasmic C terminus in cultured cells and purified from Escherichia coli The al

120 ion of GLUT4, MEF2A, PGC-1alpha and HDAC5 in cultured cells and skeletal muscle of Wistar rats.

121 We use different types of animal tissues and cultured cells and test the performance of the method un

122 diates aggregation of otherwise non-adherent cultured cells and that loss of Ihog activity disrupts w

123 p to 4-fold, as shown by molecular assays in cultured cells and the use of a fluorescent reporter in

124 d on the introduction of random mutations in cultured cells and the use of nuclear transfer to genera

125 tion and RNA dynamics has been successful in cultured cells and tissues of vertebrates but is challen

126 LCMV/TransS showed slower growth kinetics in cultured cells and was highly attenuated in vivo in a mo

127 sS exhibited reduced viral multiplication in cultured cells and was highly attenuated in vivo while c

128 ucose transporters and glycolytic enzymes in cultured cells and xenograft tumors.

129 protective against mitochondrial toxicity in cultured cells and zebrafish models.

130 tein stability as demonstrated in zebrafish, cultured cells and, notably, in mitral valve interstitia

131 0.3 Hz, respectively, for adrenal slices and cultured cells) and increased up to 0.9 Hz after stimula

132 ibe key findings in human postmortem brains, cultured cells, and animal models of disease that suppor

133 expression of adipocyte marker genes in the cultured cells, and shRNA knockdown of PPFP eliminated t

134 dolosa induced a robust cytokine response in cultured cells, and this effect was dependent on the fla

135 Elevated Trib3 reduces Parkin expression in cultured cells; and in the SNpc of PD patients, Parkin l

136 Influenza vaccines propagated in cultured cells are approved for use in humans, but their

137 For instance, because cultured cells are constantly under oxidative stress, as

138 and expand Ag-specific memory B cells; these cultured cells are highly effective in presenting Ag to

139 es, but differences in CA between tumors and cultured cells are uncharacterized.

140 Cultured cells are widely used in mechanistic studies of

141 We found that overexpression of PKCgamma in cultured cells, as well as in vitro incubation of PKCgam

142 downstream signaling, and inhibit growth of cultured cells, as well as recruit immune effector cells

143 In cultured cells, ATF4 induces transcriptional expression

144 mucosal surfaces and actin-rich pedestals on cultured cells, both of which are dependent on the type

145 Experiments in cultured cells, brain slices, and in living mice demonst

146 his virus replicates with normal kinetics in cultured cells but displays a dramatically enhanced abil

147 ffected the kinetics of VEEV accumulation in cultured cells but strongly inhibited its pathogenesis i

148 C) exhibited Cl-13-like growth properties in cultured cells, but in contrast to Cl-13, rCl-13/LASV-GP

149 RNA and lipids in single organelles of live cultured cells by biomolecular component analysis using

150 pacity for efficient productive infection of cultured cells by herpes simplex virus 1 has made it a p

151 he IP receptor in podocytes was confirmed in cultured cells by immunoblotting and quantitative real-t

152 ation of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to

153 Here we demonstrate this approach in cultured cells by monitoring a viral infection and the c

154 gical inhibition of Hsc70 ATPase activity in cultured cells by the drug VER155008 prevents this chape

155 e show that PIM1 is modified in vitro and in cultured cells by the Small ubiquitin-like modifier (SUM

156 However, cultured cells can acquire resistance to K5Is, indicativ

157 Next, we show that the damping rate of cultured cells can be changed in a dose-dependent fashio

158 Knockdown of LACTB2 in cultured cells caused a moderate but significant accumul

159 We show that in cultured cells, chromatin decompaction by the nucleosome

160 In contrast, recent work that employed cultured cells claimed that only PrP(C) with sialylo-GPI

161 y more embedded ribonucleotides than that of cultured cells, consistent with the high ratio of ribonu

162 t displayed altered substrate specificity in cultured cells, consistent with the idea that SUMOylatio

163 mal aggregation in NHFs-cultured cells, MWFs-cultured cells contain more and bigger lysosomal accumul

164 The cultured cells contained HPV-16, formed colonies in soft

165 sion of contractile smooth muscle markers in cultured cells could be partially or completely represse

166 ansgenic Drosophila, providing evidence that cultured cell cytoneme analysis is predictive of in vivo

167 Here, we introduce a fixation method whereby cultured cell cytonemes can be preserved for imaging stu

168 n results in premature ciliary resorption in cultured cells dependent on function of the tubulin deac

169 For example, SARS-CoV infection of cultured cells depends on endosomal acid pH-dependent pr

170 irmed the cell-based observations using both cultured cell-derived and patient-derived xenograft stud

171 Asc restoration in cultured cells dramatically altered their stress respons

172 beta oligomers (oAbeta) from hAPP-expressing cultured cells, EE prevented several morphological featu

173 hromosome could be selectively eliminated in cultured cells, embryos, and tissues in vivo.

174 Experiments in cultured cells established biochemical assays for disass

175 Recently, cultured cell experiments identified human MX2 as a key

176 hat are elicited by brief pulses of light to cultured cells expressing melanopsin and to neurons-expr

177 In cultured cells, expression of both the mutant SDR9C7 pro

178 idarum, a starter population was passaged in cultured cells for 28 generations without standard infec

179 We demonstrate that cultured cells form multiple nanotubes that mediate inte

180 Cultured cells from both diseases have similar sensitivi

181 We cultured cells from healthy gastric tissues, single-sort

182 In mice lacking CPEB1 and in cultured cells from which CPEB has been depleted, random

183 In cultured cells, Fucci(CA) produced a sharp triple color-

184 A wealth of information about senescence in cultured cells has been acquired over the past half cent

185 Work in cultured cells has established a wide array of functions

186 Genetic engineering of model organisms and cultured cells has for decades provided important insigh

187 Although cultured cells have facilitated investigations of lncRNA

188 While studies of cultured cells have led to new insights into biological

189 Consistent with the results in cultured cells, hepatic levels of Insig-2 mRNA were enha

190 detected for 14 days after MOCV infection of cultured cells; however, there was little change in the

191 HIF target gene expression both in mice and cultured cells in a manner that was at least in part ind

192 hase kinase-3beta inhibitor for 3 days, then cultured cells in renal epithelial growth medium to indu

193 organization and dynamics are controlled in cultured cells in vitro However, our understanding of mi

194 ibrils display cytotoxic capabilities toward cultured cells in vitro, with oligomers producing elevat

195 ents were also done ex vivo and with primary cultured cells in vitro.

196 ng machines have been studied extensively in cultured cells; in contrast, remarkably little is known

197 requirements to achieve lytic replication in cultured cells included (i) either in vitro cultures of

198 Sterol depletion in cultured cells increased flux through the Bloch pathway,

199 ngly, acute knockdown of Clcc1 expression in cultured cells increases sensitivity to ER stress.

200 ormal protein distributions were reversed in cultured cells incubated with SB216763, a small molecule

201 ce for deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DN

202 In cultured cells, indoxyl sulfate and p-cresol sulfate act

203 Overexpression of Aurora B in cultured cells induces defective chromosome segregation

204 , ruzasvir, velpatasvir, and pibrentasvir in cultured cells infected with HCV recombinants expressing

205 In cultured cells, infectivity and cytokine induction were

206 embrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltr

207 encephalitis in mice, and its replication in cultured cells is inhibited by the zinc finger antiviral

208 RQC recruitment to the ER in cultured cells is stimulated by translation stalling.

209 We hypothesized that cultured cells lack one or more factors required for the

210 Overexpression of CK1epsilon in cultured cells led to increased tau phosphorylation at m

211 curred at the same human loci within a given cultured cell line.

212 ion, rCl-13(GPC/VGKS) grew to high titers in cultured cell lines and in immunodeficient mice.

213 ier studies focused on xenograft models with cultured cell lines and involved ectopic expression of E

214 Studies with cultured cell lines and primary embryonic cells showed t

215 nthetic yeast centromeric plasmids (YCps) to cultured cell lines at rates similar to that of 12 kb YC

216 studying the effect of anti-cancer drugs in cultured cell lines by monitoring phosphatidylserine tra

217 to produce vaccines by adaptation of ASFV to cultured cell lines have been made.

218 We further cultured cell lines specific for four SIV-derived epitop

219 We have shown previously in cultured cell lines that Bok interacts strongly with ino

220 We found that in cultured cell lines, FAM92A colocalizes with Cby1 at the

221 sed chromatin organization studies have used cultured cell lines, limiting their generalizability.

222 or 16,698 single cells from a combination of cultured cell lines, primate frontal cortex tissue and t

223 In cultured cell lines, the EXT1 and EXT2 enzymes, initiati

224 ariations in cell-cycle requirements between cultured cell lines, we generated knockouts across cell

225 as project for 11 punctate proteins in three cultured cell lines.

226 the Republic of Georgia (ASFV-G) to grow in cultured cell lines.

227 rter plasmids into Huh7, BNL-1ME, and HEK293 cultured cell lines.

228 on gene expression have been well studied in cultured cells, little is known about its functions in i

229 In cultured cells, loss of JAM-A caused an approximately 30

230 Serum steroids and cultured cell media androgens were measured with liquid

231 As have made targeted mutagenesis routine in cultured cells, mice, zebrafish and other model systems.

232 Using a cultured cell model of erythroid differentiation, deplet

233 ate partners interacted both in vitro and in cultured cell models.

234 CFCs such as (i) 'cobblestone' morphology of cultured cell monolayers; (ii) acetylated low-density li

235 tochondrialand lysosomal aggregation in NHFs-cultured cells, MWFs-cultured cells contain more and big

236 In zebrafish and cultured cells, NCOA4 plays an essential role in erythro

237 and the basal body in different tissues and cultured cells of Drosophila melanogaster, highlighting

238 Cultured cells of Eschscholzia californica (Papaveraceae

239 -active frustule biosilica was isolated from cultured cells of the marine diatom Pinnularia sp. and f

240 Expression in cultured cells of these APOL1 risk variants, commonly re

241 ia physically interact and cross-regulate in cultured cells, our work indicates that a conserved EXC-

242 In cultured cells, overexpressed Smad3 is sufficient to ind

243 Functional analysis in cultured cells overexpressing FLAG-tagged wild-type or m

244 ased the incidence of inclusion formation in cultured cells overexpressing P23H rod opsin, and increa

245 Furthermore, in cultured cells, overexpression of N22A mutant OTUB1 impa

246 0.04, significantly less acidic than that in cultured cells (p < 0.001), and responded to inhibition

247 tial for binding to beta-Catenin in vitro In cultured cells, phosphorylation of specific serine resid

248 also show that association rates measured in cultured cells predict the extent of internalization of

249 s capable of interaction with poly(A) RNA in cultured cells, primarily mediated by the N-terminal reg

250 hitectures and similar fine structures to 2D-cultured cells, providing a pathway to enable our unders

251 In cultured cells, Rbpr2 localized to membranes and promote

252 In contrast, overexpression of SORLA in cultured cells reduced the abundance of endogenous calci

253 observe that the baseline state of untreated cultured cells relative to untreated rat liver shows str

254 Cultured cells repopulated tracheal scaffolds in a heter

255 However, mutagenized cultured cells require cloning to yield homogeneous popu

256 Cultured cells require the actions of growth factors to

257 WH by siRNA in Drosophila, mouse, and human cultured cells results in DNA damage with strand breaks

258 iption (TPRT) and mobilized efficiently in a cultured cell retrotransposition assay.

259 phenotyping analysis of FGF-10 mobilized and cultured cells revealed expression of the MSC markers CD

260 xpressed functional VAP-1, and evaluation of cultured cells revealed that sVAP-1 promotes leukocyte m

261 In cultured cells, RGNs on-target editing activity had been

262 HSV infection in these cultured cells shows the properties expected for a laten

263 Here, we report that in SPECC1L-knockdown cultured cells, staining of canonical adherens junction

264 35Pro]) and the REEP6.1 frameshift mutant in cultured cells suggest that these changes destabilize th

265 defect in vitro and could not be passaged in cultured cells, suggesting an essential role for the ORF

266 d from host cells in response to bacteria in cultured cell systems and in the intestine in vivo Uric

267 This is observed in cultured cell systems, as well as in clinical trials in

268 In cultured cells, tacrolimus inhibited dephosphorylation o

269 In cultured cells, TBK1 associates with and activates mTORC

270 ce from experiments conducted in vivo and in cultured cells that indicates aldosterone and vasopressi

271 lated in Abcc5(-/-) tissues were depleted in cultured cells that overexpressed human ABCC5.

272 ignificantly decreased the viral RNA load in cultured cells that were infected with viruses of the fa

273 In cultured cells, the mutations reduced the DNA binding af

274 s by analyzing LZA element function in human cultured cells; the LZA element-mediated transcriptional

275 In cultured cells, this capacity is tightly aligned to phos

276 t Pik3ca induces centrosome amplification in cultured cells (through a pathway involving AKT, ROCK an

277 inolevulinic acid (ALA) treatment of mice or cultured cells to bypass the rate-limiting enzyme in hep

278 lain elevated CA in vivo because exposure of cultured cells to hypoxia or mimicking hypoxia pharmacol

279 Sample preparation takes 3 d from cultured cells to pooled libraries.

280 well-established model systems ranging from cultured cells to simple organisms and to mice and plant

281 In cultured cells, treatment with sunitinib and erlotinib,

282 saying short CREs in a limited repertoire of cultured cell types.

283 ene expression, both in diabetic mice and in cultured cells under hyperglycemic and proinflammatory c

284 Most cultured cells used for biomedical research are cultured

285 with PRC1, PRC2, and H3K27me3 in embryos and cultured cells using ChIP-seq (chromatin immunoprecipita

286 sociated AAA+ ATPase VPS4 on EV release from cultured cells using two methods for EV recovery, differ

287 pair resolution during HIV-1 replication in cultured cells using vectors that force template switchi

288 In cultured cells, we found that corin activation was inhib

289 High levels of RSV F expression in cultured cells were observed with rHPIV1-C(Delta170)-F1,

290 infection and GP-mediated membrane fusion in cultured cells were remarkably suppressed by treatment w

291 tophagy has been defined based on studies in cultured cells where M. tuberculosis co-localizes with a

292 latory activity of GPC6 was also observed in cultured cells, where this GPC increased the binding of

293 induced aggregation of alpha-syn*A53T-YFP in cultured cells, whereas none of six Parkinson's disease

294 describes how to identify the active RBPs in cultured cells, whereas this Protocol Extension also ena

295 as validated for targeting lysosomes in live cultured cells, which enabled identification and subsequ

296 ectron battery by stimulating a monolayer of cultured cells, which fluoresces a calcium ion wave at a

297 antly increased MMPs expression in 3D vs. 2D cultured cells, while pharmacological inhibition of MMPs

298 cifically addressed whether nonproliferating cultured cells will sense the presence of microgravity i

299 Importantly, treatment of porcine cultured cells with Ad5-poIRF7/3(5D) inhibited the repli

300 ools for the efficient delivery of mRNA into cultured cells would advance many areas of research, and