ライフサイエンスコーパス: cumbersome

1 curve (PAP/AUC) is the gold standard but is cumbersome.

2 enic viruses or bacteria tend to be slow and cumbersome.

3 modifications in living cells is complex and cumbersome.

4 ous agent and its use in plasmapheris is too cumbersome.

5 asurement of plasma C2 glucose enrichment is cumbersome.

6 s in a given enzyme preparation are slow and cumbersome.

7 detecting accelerated muscle proteolysis are cumbersome.

8 reassortment by more traditional methods is cumbersome.

9 assessing kidney function, is expensive and cumbersome.

10 luating this function are either invasive or cumbersome.

11 ids is well established, it is laborious and cumbersome.

12 lele states by allele sequencing is slow and cumbersome.

13 specificity and low sensitivity and are also cumbersome.

14 that sometimes are excessively intrusive and cumbersome.

15 nteractions, where genetic analysis is often cumbersome.

16 d genetic manipulations become difficult and cumbersome.

17 e to the allergen, but is time-consuming and cumbersome.

18 ll fusion mechanistic studies are especially cumbersome.

19 tion in the histopathology laboratories more cumbersome.

20 ion of the common and efficient reagents are cumbersome.

21 eedingly rare and methods to purify them are cumbersome.

22 -cell fusion mechanistic studies are notably cumbersome.

23 a new natural or synthetic inhibitor can be cumbersome.

24 ng those data in downstream analyses remains cumbersome.

25 parate databases makes information discovery cumbersome.

26 ic, requires many washing steps, making it a cumbersome addition to a high throughput workflow.

27 biomedical applicability is hindered by its cumbersome administration, since NO is unstable especial

28 rdous chemicals were hindered by complex and cumbersome administrative burdens, data limitations, vul

29 ide a more rapid and possibly less toxic and cumbersome alternative to traditional G-CSF-based mobili

30 rrent methods used to titer many viruses are cumbersome and are not amenable to handling large number

31 External air connectors can be cumbersome and are real-estate intensive.

32 Human clinical studies are cumbersome and are thwarted by the extent of investigati

33 s evolved into an expensive, time consuming, cumbersome and bureaucratic process involving multiple i

34 teractions since labeling small molecules is cumbersome and can affect binding.

35 otoresponsive, which makes their preparation cumbersome and can markedly hamper their performance.

36 to identify DNaseI hypersensitive sites are cumbersome and can only be applied to short stretches of

37 teraction (GxE) meta-analysis studies can be cumbersome and challenging.

38 sequences to depict the fistula in detail is cumbersome and confusing for the clinicians to interpret

39 rrelated with the angle measured on the more cumbersome and costly full-limb radiograph.

40 irus vaccine could abolish the need for this cumbersome and costly process and would also enhance our

41 l function has traditionally been limited by cumbersome and costly techniques and the involvement of

42 In vitro mutagenesis is cumbersome and costly: probing all residues in a protein

43 from radiolabeled inositol, making the assay cumbersome and difficult to automate.

44 gs; however, in vitro manipulation of DCs is cumbersome and difficult to control, resulting in vaccin

45 eas calculations of hot carrier dynamics are cumbersome and dominated by empirical approaches.

46 in a case-by-case fashion, but this becomes cumbersome and error prone if genes show a huge abundanc

47 cardiography), beacuse current platforms are cumbersome and expensive for individual physician use.

48 lly, the preoperative workup is logistically cumbersome and expensive given the need for separate car

49 Cancer vaccines typically depend on cumbersome and expensive manipulation of cells in the la

50 t femtomoles of target DNA without employing cumbersome and expensive optics, light sources, or photo

51 mobility models today depend on detailed but cumbersome and expensive travel surveys for their calibr

52 e not only time consuming, but they are also cumbersome and expensive.

53 Execution of such advice can be cumbersome and expensive.

54 ics of pair-wise screening has resulted in a cumbersome and incomplete application of this method to

55 and by autoradiography using film, which is cumbersome and increases the cost of generating the radi

56 Unfortunately, cumbersome and inefficient radioiodination procedures ha

57 (GM) counter, although this procedure can be cumbersome and inexact.

58 Traditional serotyping methods are cumbersome and insufficient for detecting multiple serot

59 e the older DNA hydrolysis protocol which is cumbersome and labor intensive, this new protocol is ide

60 dentification of pairing antibodies is often cumbersome and labor-intensive even with the use of desi

61 imulations, these models are computationally cumbersome and limit analytical insight into the mechani

62 nt bioassay used to measure BioA activity is cumbersome and low throughput.

63 ng sites of transcription factors tend to be cumbersome and not adaptable to high throughput.

64 Because pulsed Doppler is cumbersome and often inappropriate for color flow comput

65 sis to be performed without the need for the cumbersome and problematic enhanced sensitivity cell.

66 ases, but the standard method is protracted, cumbersome and prone to error.

67 rrent system of GME financing is complex and cumbersome and relies almost exclusively on government s

68 Conventional methods for determining HMF are cumbersome and require expensive equipment or hazardous

69 Both methods are cumbersome and require the use of expensive reagents.

70 ence of genomic DNA of analogous sequence is cumbersome and requires implementation of critical contr

71 aria model system Plasmodium yoelii has been cumbersome and requires terminal procedures.

72 on in high dimensions is often very complex, cumbersome and slow.

73 high performance liquid chromatography, are cumbersome and slow.

74 serum samples that were required by the more cumbersome and subjective IFA testing to <20%.

75 thesis of specific bioactive HS structures a cumbersome and tedious undertaking that requires laborio

76 hnical aspects of this procedure become less cumbersome and the patient population increases, it is v

77 Currently available indexes are cumbersome and therefore seldom used.

78 photoreceptor activity in living humans was cumbersome and time consuming.

79 in structures, these tools are generally too cumbersome and time-consuming for examining multiple sup

80 'shopping around' using different methods: a cumbersome and time-consuming practice.

81 the quantitative analysis of IAA has been a cumbersome and time-consuming process that does not lend

82 However, these existing methods are cumbersome and time-consuming, and none measures all of

83 completing the required design steps can be cumbersome and time-consuming.

84 ough conventional microbiological methods is cumbersome and time-consuming.

85 ever, literature syntheses of the ligand are cumbersome and typically lead to low yields.

86 to completion we are left with inefficient, cumbersome, and costly macroscale processes and supporti

87 ore sensitive than culture, more rapid, less cumbersome, and more cost-effective than the available P

88 intravenous chemotherapy regimens are toxic, cumbersome, and negatively affect patients' quality of l

89 basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immuno

90 id chromatography, which are time-consuming, cumbersome, and sometimes inaccurate due to the incomple

91 for identifying these organisms are slow and cumbersome, and there is increasing need for more rapid

92 assays are immunologically based and require cumbersome antibody immobilization chemistries, thereby

93 alues equal to those of the more technically cumbersome antigenemia assay.

94 e ESwab method is a more accessible and less cumbersome approach to corneal culturing for ophthalmolo

95 sequences to tag an endogenous gene is still cumbersome as it requires the synthesis or cloning of ho

96 mation is highly condensed, these views grow cumbersome as larger numbers of genomes are added.

97 uction, without the need for the common, but cumbersome, azeotropic drying of (18)F, can now be accom

98 oteins enrichment from biological samples is cumbersome because of their low abundance.

99 for in vivo evaluation of antiandrogens are cumbersome because they rely on physiologic end points,

100 delivering this combination of molecules is cumbersome, because of the opposing supramolecular host

101 ication of this preexisting variation may be cumbersome, because potentially beneficial alleles are t

102 Ex vivo techniques are more cumbersome but safer, because all genetic manipulations

103 ression of the construct without the need of cumbersome chemical labeling.

104 SAL stereoisomers on a chiral column without cumbersome chiral derivatization to unstable SAL diaster

105 olographic rendering can be achieved without cumbersome circuitry and with only a single transducer,

106 rge fragments of DNA and numerous, and often cumbersome, cloning steps.

107 tem nucleus defined by genetic lineage and a cumbersome combination of markers.

108 le user orientation and its prerequisite and cumbersome combination of mouse and keyboard for navigat

109 eby reducing the need for time-consuming and cumbersome confirmatory plaque-reduction neutralization

110 First-generation devices consisted of large, cumbersome consoles requiring patient immobilization and

111 However, it is cumbersome, costly, and associated with considerable tox

112 ed for organizing and interpreting otherwise cumbersome data sets when extremely large numbers of ful

113 usually tackled by implementing unattractive cumbersome designs.

114 method for determining the activity has been cumbersome due to the use of a site-specifically (3)H-la

115 es for electrochemical detection without any cumbersome electrode surface functionalization procedure

116 atomic absorption spectrometry but with less cumbersome equipment and freedom from calibration.

117 Cumbersome, expensive and time consuming detection techn

118 sor is fully electronic and requires neither cumbersome, expensive optics nor high voltage power supp

119 fucosylation, such strategies are often too cumbersome, expensive, and time-consuming for routine N-

120 rface receptors and their ligands is often a cumbersome, expensive, and time-consuming process that l

121 cted great attention by mitigating otherwise cumbersome experimental implementation constraints.

122 ge part to the requirement for prohibitively cumbersome experimental procedures and daunting analytic

123 s to provide a ready alternative to the more cumbersome femtomolar electrochemical assays described t

124 PA) to replace the more costly, wasteful and cumbersome filter binding assay and demonstrate its util

125 However, LC-MS/MS proved cumbersome for analyzing multiple samples because it req

126 logy remains insufficiently accurate and too cumbersome for continuous ICP monitoring.

127 arations has been well characterized, but is cumbersome for drug discovery.

128 A is impractical, variably reproducible, and cumbersome for large epidemiologic studies and for clini

129 However, the determination of log P is cumbersome for non-UV-active compounds.

130 Wired technology can be cumbersome for patient monitoring and can restrict the b

131 rologously express membrane proteins, can be cumbersome for screening and expression of multiple cons

132 based assay is useful, but this technique is cumbersome for TDP2 inhibitor screening.

133 ion, fluorescence labeling and mutations are cumbersome for the whole ribosome but readily applicable

134 eing comparable to a well-optimized but more cumbersome gas chromatography-mass spectrometry (GC-MS)

135 ient cell factories has been impaired by the cumbersome genetic tools that are currently available fo

136 e to DNA sequencing or other, more costly or cumbersome genotyping approaches.

137 A) because of significantly lower cost, less cumbersome handling, smaller delivery catheters, and sup

138 plotypes have not been determined because of cumbersome haplotyping workflows that require fractions

139 Standard traditional techniques are slow and cumbersome, highlighting the pressing need for evoking a

140 wide temperature range without the need for cumbersome humidification and pressurization.

141 are inoperable above 100 degrees C, require cumbersome humidification systems, and suffer from fuel

142 nalyzing associated loci and variants can be cumbersome if data is not given in a form amenable to pa

143 urface of microtiter wells that replaces the cumbersome immunoprecipitation method, (iii) a 96-well p

144 cro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thu

145 ers, because achievement of hyperemia can be cumbersome in daily clinical practice.

146 studying regulatory interactions, but remain cumbersome in most model organisms.

147 complex genetic interaction analysis remains cumbersome in this diploid pathogen.

148 imited numbers of animals; alternative, less cumbersome in vivo models are desirable.

149 rent methods of monitoring breathing require cumbersome, inconvenient, and often expensive devices; t

150 ethods used to detect mitophagy in vivo were cumbersome, insensitive and difficult to quantify.

151 brary bead processors eliminates potentially cumbersome instrumentation engineering challenges and is

152 is process has been hampered by the need for cumbersome isolation of intact genomes before transfer.

153 Slow and cumbersome laboratory diagnostics for Mycobacterium tube

154 methods for BPA exposure assessment rely on cumbersome laboratory instrumentation with high capital

155 , current assays for DNA-protein adducts are cumbersome, limiting both mechanistic studies and transl

156 No cumbersome liquid junction based reference element is ut

157 ng magnetic-device elements without applying cumbersome magnetic fields.

158 ively complex, requiring the user to perform cumbersome maneuvers and time-consuming image manipulati

159 not to be confined to the tedious growth and cumbersome manipulation of molecular crystals-which gene

160 res that can be used to classify tissue is a cumbersome manual process which limits this technology f

161 lyze cytosine-5 methylation patterns require cumbersome manual techniques that employ gel electrophor

162 nt volumes and regurgitant fractions without cumbersome measurements.

163 sum) in pears does not necessarily require a cumbersome method involving cleavage to DMA.

164 etion defects observed previously using more cumbersome methodology.

165 been partially alleviated by the use of more cumbersome methods such as three-dimensional confocal mi

166 ternatives to substitute for the traditional cumbersome methods.

167 les, such as aromatic amines, onto sluggish (cumbersome) Michael acceptors without any promoter or wo

168 ng remains a challenge, primarily due to the cumbersome, multi-step synthesis processes conventionall

169 In current form, however, FIAs can be cumbersome, multistep procedures and often lack versatil

170 programs has been limited by the lengthy and cumbersome nature of current chemotherapeutic regimens.

171 t leprosy are difficult to obtain due to the cumbersome nature of the conventional drug susceptibilit

172 used in paraffin sections, thereby obviating cumbersome oil red O staining of frozen sections.

173 , these techniques are either experimentally cumbersome or applicable to a limited set of experimenta

174 Current GCPII in vitro activity assays are cumbersome or have limited sensitivity.

175 ormatics tools do not scale accordingly, are cumbersome, or require extensive support from bioinforma

176 avirus virion production has been limited to cumbersome organotypic cultures and mouse xenografts.

177 s in men, but until recently it has required cumbersome parenteral administration.

178 he first inhibitors studied were hampered by cumbersome pharmacokinetics and a general lack of potenc

179 luding limited cell sources and the need for cumbersome pre-processing steps (for example, isolation,

180 the decay process in these systems is a very cumbersome problem, either because of very complicated o

181 ed to create mutations, gene targeting, is a cumbersome process.

182 apping as gapped alignment, which results in cumbersome processing times and a biased sampling of STR

183 dendritic cell-based vaccination methods are cumbersome, promising results from clinical trials in pa

184 d disease state, are typically monitored via cumbersome, reagent-intensive assays that require relati

185 requires multiple ligation steps and remains cumbersome relative to more conventional deep-sequencing

186 ve transmission electronic microscopy, often cumbersome, remains as the 'gold standard' for dispersio

187 olicy can lack transparency and is sometimes cumbersome, requiring the intervention of a Senior Ethic

188 The need for cumbersome RNA purification is circumvented in our assay

189 e directly detected simultaneously, avoiding cumbersome sample preparation procedures in conventional

190 e substantially context dependent, requiring cumbersome screening to identify the optimal site for st

191 mary procedure, which involves a lengthy and cumbersome second-order (in wave-amplitude) calculation

192 Conventional approaches often rely on cumbersome, semi-quantitative amplification of target DN

193 e performed conveniently at home, and avoids cumbersome shipping and storage procedures.

194 still involve impractical solutions such as cumbersome signal calibration processes and substantial

195 ipotent cells (iPSCs) into neurons are often cumbersome, slow, and variable.

196 ns tested, thus eliminating the need for the cumbersome spheroplast-proteinase K method for topology

197 With this approach, the cumbersome step of 18C purification has been eliminated.

198 This would bypass the cumbersome step of having to evolve mutant synthetases a

199 e one-pot synthesis procedure eliminates the cumbersome steps of protecting/deprotecting amino or hyd

200 Most gene expression methods often involve cumbersome steps or use expensive facilities.

201 ect method uses the whole AH suspension, the cumbersome steps used by traditional methods are not req

202 nal methods which involve time-consuming and cumbersome strip comparisons obtained with series of tri

203 ltiplexed Western blots are possible without cumbersome stripping and reprobing steps.

204 ers are complex and often require costly and cumbersome structural components to support system weigh

205 Based on absence of cumbersome surface immobilization and wash steps for car

206 limited due to their relative insolubility, cumbersome synthesis/purification, toxic side effects, a

207 eliable and fit-for-purpose models remains a cumbersome task due to the inherent complexity of biolog

208 ctrochemical microscopy (SECM) is a slow and cumbersome task that often results in untimely electrode

209 We wanted to determine a more rapid and less cumbersome technique to supplement this method for deter

210 The method is simple and avoids the use of cumbersome techniques associated with enzymatic treatmen

211 rmore, it is a far more rapid assay and less cumbersome than western blotting, lending itself more re

212 ed accurate GFR methodology is expensive and cumbersome; therefore, estimates of GFR based on serum c

213 ugh the last aromatization step proved to be cumbersome, this work unfolds a unique route to access i

214 omise for B-cell malignancies, production is cumbersome; thus, targeting a common antigen on malignan

215 However, these methods are cumbersome, time consuming and cost-prohibitive.

216 ost methods used to measure BER activity are cumbersome, time consuming and, for the most part, only

217 for recognition of TGs, among them, most are cumbersome, time-consuming, require sample pre-treatment

218 responsive measure of disability, but it is cumbersome to administer and has a limited content valid

219 e contribution to mortality risk but are too cumbersome to be readily applied in clinical practice.

220 reconstructions are powerful, they are still cumbersome to build and, because of the complexity of me

221 ion can act, yet fine-scale linkage maps are cumbersome to construct.

222 ever, with currently available vectors it is cumbersome to create multiple, stable, unmarked chromoso

223 s (NO/nucleophile adducts-NONOates) are less cumbersome to deliver and may offer clinical advantage c

224 Although it is extremely expensive and cumbersome to deploy large-scale radiofrequency phased a

225 However, it is cumbersome to identify functional motifs within enhancer

226 In the past, these methods have been cumbersome to implement and modify.

227 However, it is cumbersome to implement clinically given the large numbe

228 ion is central to cellular bioenergetics but cumbersome to measure.

229 d liver diseases in the United States may be cumbersome to obtain because they are scattered in multi

230 -resolution separations, such formats can be cumbersome to parallelize for single-cell analysis.

231 With existing approaches, it is cumbersome to perform multiplexed blots in which several

232 the bromo and fluoro analogues that are more cumbersome to prepare or are not readily available.

233 unreported tetracycline derivatives that are cumbersome to prepare through traditional methods.

234 l tricarbonyl compounds, which are otherwise cumbersome to prepare.

235 o far have employed optical systems that are cumbersome to scale to even a few tens of qubits.

236 ts become increasingly abundant, making them cumbersome to store and analyze on local servers.

237 However, these models remain expensive and cumbersome to use for large-scale preclinical drug testi

238 inadequate display of insertions and can be cumbersome to use on large datasets.

239 ns of predictive rules are more accurate but cumbersome to use, and therefore of limited clinical use

240 s in taking medication in the 1960s but were cumbersome to use.

241 hindered by increased genomic complexity and cumbersome transgenic assays.

242 easuring the degree of lung inflammation and cumbersome treatment protocols.

243 tethered to bulky control systems, and have cumbersome user interfaces, which all render commerciali

244 and adenocarcinoma (ADCA) of the lung can be cumbersome using established methods.

245 tudies of RNA-protein interactions are quite cumbersome using traditional methods.

246 he process of loading high-density gels less cumbersome while the associated time and errors are redu

247 ixture of an asymmetric reduction eliminates cumbersome work-up protocols and minimizes analysis time