ライフサイエンスコーパス: curative

1 o prevent morbidity and mortality, it is not curative.

2 Antiretroviral therapy is not curative.

3 Thus, ART is not curative.

4 treat tachycardiomyopathy and is potentially curative.

5 many advances, current therapies are rarely curative.

6 average 6-year follow-up, treatment was not curative.

7 ith promising results, but have never proven curative.

8 n of novel targets that potentially would be curative.

9 bition by ruxolitinib, both of which are not curative.

10 ] 1.085, 99% CI 1.040-1.132; p<0.0001; NSCLC curative: 1.045, 1.013-1.079; p=0.00033; breast palliati

11 OR 2.326 99% CI 1.634-3.312; p<0.0001; NSCLC curative: 3.371, 1.554-7.316; p<0.0001; NSCLC palliative

12 versus those who were generally well (breast curative: 6.057, 1.333-27.513; p=0.0021; breast palliati

13 an liver predicts rapid HCC recurrence after curative ablation.

14 he only safe drug treatment with substantial curative activity against the filarial nematodes respons

15 vitro effects against T. brucei and in vivo curative activity in a mouse model of HAT.

16 in vivo properties and demonstrated in part curative activity in the Plasmodium berghei mouse model

17 as macrophages are required for synergistic curative activity.

18 Th2 ACT was also curative against B-cell lymphoma.

19 development process, allowed it to become a curative agent for type I tyrosinemia (T1T) and to enter

20 Cerebellar ataxias currently lack a curative agent.

21 ows progression of these diseases but is not curative and associated with notable toxicity at clinica

22 Because curative and eradicative therapy for HBV is not currentl

23 However, LT is not curative and only bone marrow transplantation (BMT) can

24 used in cancer treatment and in a number of curative and palliative regimens.

25 Comparing efficacies of phage-curative and prophylactic treatments in healthy immunoco

26 ichael Sofia, pioneers in the development of curative and safe therapies for the 170 million people w

27 ssion-free survival, but these drugs are not curative and therefore are reserved for patients with pr

28 gly increased JIA remission rates, it is not curative and up to 80% of patients flare upon treatment

29 bitor (TKI) therapy for human cancers is not curative, and relapse occurs owing to the continued pres

30 es will be critical for the future design of curative antiviral therapies against chronic hepatitis B

31 tudy of hepatitis B virus and development of curative antivirals are hampered by a scarcity of models

32 Although ASCT remains a potentially curative approach, these patients, particularly those wi

33 cells, and this reservoir has long hampered curative approaches.

34 dy immune clearance and test therapeutic and curative approaches.

35 entiviral infection and the effectiveness of curative approaches.

36 ponse rates in several lymphomas, but is not curative as monotherapy.

37 This approach is not curative, as some BRAF-mutated melanoma cells are intrin

38 However, TKI are not yet curative, because most patients retain leukemic stem cel

39 emia (GvL) effect, however, is the desirable curative benefit.

40 ellular level and can be exploited for broad curative benefit.

41 95% control limits; this included seven for curative breast cancer, four for palliative breast cance

42 tic stem cell (HSC) transplantation is often curative but is associated with significant comorbidity.

43 ulmonary endarterectomy (PEA) is potentially curative, but residual pulmonary hypertension following

44 e aimed to describe the cumulative burden of curative cancer therapy in a clinically assessed ageing

45 t of acute radiation exposure that can limit curative cancer treatment therapies and cause lethality

46 < 0.001), more likely to describe shift from curative care to organ donation as emotionally complex (

47 he most recent HF visited for vaccination or curative care.

48 se-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed pre

49 consecutive patients undergoing potentially curative CRC resection from a single institution (Januar

50 tients with CRCLM, resection seems not to be curative, despite its curative intent.

51 particles (NPs) can dramatically alter their curative/diagnostic abilities and medical outcomes.

52 s); combination with rituximab decreased the curative dose to 100 mug/kg (1 mug/kg drug equivalents).

53 C) islets can be implanted in these sites in curative doses.

54 Yet ART is not curative due to the persistence of CD4+ T-cell proviral

55 system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after

56 ption of Traditional Chinese Medicine, had a curative effect on scleroderma, a typical fibrotic disea

57 s) occurred in settings with near-perfect SP curative efficacy (>99%) based on the most recent estima

58 Compounds 15 and 17 further demonstrate curative efficacy in human melanoma and lung cancer xeno

59 The high curative efficacy of these ozonides was most often assoc

60 ot explain the presence or absence of either curative efficacy or in vivo toxicity.

61 atopoietic cell transplant (allo-HCT) can be curative for certain hematologic malignancies, but the r

62 Hematopoietic cell transplantation (HCT) is curative for FA-related marrow failure or leukemia, but

63 tly, this immunotherapeutic regimen was also curative for large established mouse Renca and EG7 tumor

64 lized PC, as surgery alone is unlikely to be curative for most patients.

65 Surgery is potentially curative for primary nonmetastatic extremity soft tissue

66 repeats can be lead compounds for restoring curative FXN levels.

67 erived OVA-expressing mouse melanomas resist curative immunotherapy with either adoptive transfer of

68 the immune-checkpoint inhibitor anti-PD1 was curative in all of the treated mice.

69 pennies and that we have had since 1945) is curative in early stages.

70 These molecules are curative in mice at a single, low dose and show activity

71 The SLT strategy is curative in only 56% of cases.

72 setting, requiring further investigation in curative indications.

73 stage cancer ( P = .035), those treated with curative intent ( P = .003), and those with a lower CD4

74 Locoregional therapy with curative intent (CLRT) followed by salvage liver transpl

75 tumors were more likely to be treatable with curative intent (Dukes' A: 13/26, 50%; Dukes' B: 32/81,

76 care: during treatment, after treatment with curative intent (survivorship), and after diagnosis with

77 ancer and enter an era in which surgery with curative intent actually fulfills this goal on a much mo

78 with comorbidities can undergo therapy with curative intent and achieve successful long-term outcome

79 Of these, 15 were treated with curative intent due to the presence of locoregional dise

80 or marrow transplantation (BMT) is used with curative intent for hematologic malignancies.

81 ave provided better therapeutic options with curative intent potential for some locoregional therapie

82 Primary rectal cancer patients undergoing curative intent proctectomy at our institution between 2

83 3 weeks, both administered concurrently with curative intent radiotherapy in patients with LAHNSCC.

84 e survival (CDFS) for patients who underwent curative intent surgery for adrenocortical carcinoma (AC

85 gery for exocrine pancreatic malignancy with curative intent were identified from a prospective datab

86 ma undergoing upfront surgical resection for curative intent were identified in the National Cancer D

87 diagnosed from 2000 to 2012 and treated with curative intent were included from the United States and

88 gery for early-stage disease (presumably for curative intent), the outcomes were far worse (13.1, 18.

89 cancer and patients with NSCLC treated with curative intent, and decreased with age for patients rec

90 asis of these data, active surveillance with curative intent, in which active treatment is delayed un

91 recurrence after primary PCa treatment with curative intent, three or fewer extracranial metastatic

92 , with 35 new localized cancers treated with curative intent.

93 urgical local therapy to the liver mass with curative intent.

94 after colorectal cancer (CRC) resection with curative intent.

95 t high risk of recurrence after surgery with curative intent.

96 was performed for all patients treated with curative intent.

97 fter the treatment of colorectal cancer with curative intent.

98 ection seems not to be curative, despite its curative intent.

99 rrent chemoradiotherapy or radiotherapy with curative intent.

100 wly diagnosed HIV-cHL should be managed with curative intent.

101 e therapy of carboplatin and paclitaxel with curative intent.

102 mized between open and MI esophagectomy with curative intent.

103 inal irradiation and had been treated with a curative intent.

104 ly one of 15 (7%) patients who had undergone curative-intent ablation, surgery, or liver transplantat

105 nostic for lethal prostate cancer both after curative-intent prostatectomy and in a watchful waiting

106 Patients who underwent NAT followed by curative-intent resection were matched by propensity sco

107 total of 68,463 eligible patients underwent curative-intent surgery and filled opioid prescriptions.

108 stitutional cohort of patients who underwent curative-intent surgery for ACC at 13 major institutions

109 ictors of survival and recurrence risk after curative-intent surgery for ACC were selected to create

110 e identified patients with cancer undergoing curative-intent surgery from 2010 to 2014.

111 the risk of new persistent opioid use after curative-intent surgery, identify risk factors, and desc

112 plication in patients with cancer undergoing curative-intent surgery.

113 ncer center included all patients undergoing curative-intent total gastrectomy for gastric adenocarci

114 In total, 120 patients underwent curative-intent total gastrectomy for stage I through II

115 ated with tripled normalized costs following curative-intent total gastrectomy.

116 Curative intervention is possible if colorectal cancer i

117 cumulative incidence of reclassification and curative intervention.

118 l inform design of vaccines for use in HIV-1 curative interventions.

119 burden in macrophages that may contribute to curative interventions.

120 ould not want" (88% agreement) and "advanced curative/life-prolonging treatments that are not consist

121 ns of nonbeneficial treatment were "advanced curative/life-prolonging treatments that would almost ce

122 , thymic Foxp3(+) Treg cells orchestrate the curative mechanisms of IT.

123 New, curative medicines are needed urgently.

124 ier against the widespread use of HSCTs as a curative modality.

125 which could bridge the practice gap between curative models of care and palliative care.

126 Because of the toxicity and non-curative nature of systemic therapy, some of these patie

127 four for palliative breast cancer, five for curative NSCLC, and seven for palliative NSCLC.

128 r patients receiving palliative SACT (breast curative: odds ratio [OR] 1.085, 99% CI 1.040-1.132; p<0

129 The only curative option for CMML remains allogeneic stem cell tr

130 application of liver surgery, still the main curative option for liver cancer.

131 scopically negative margins remains the main curative option for pancreatic cancer; however, in pract

132 ietic stem cell transplantation was the only curative option for Wiskott-Aldrich syndrome (WAS).

133 However, IT AmBd remains the only known curative option in the management of CM.

134 Liver resection and transplantation provide curative options for patients with HCC beyond Milan crit

135 ) patients ineligible for the only potential curative options for this malignancy-tumor resection or

136 t 2 lines of chemotherapy and had no further curative options.

137 for patients receiving their first reported curative or palliative SACT versus those who received SA

138 disease and mortality in children but is not curative owing to the early generation of a latent reser

139 ion a treatable illness; however, ART is not curative owing to the persistence of replication-compete

140 ated, time-limited combination regimens with curative potential for patients with B-cell lymphomas.

141 is the only treatment with proved long-term curative potential in patients with allergic disease.

142 The impact of implementing curative programs on HIV epidemics has not been consider

143 Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurre

144 veterinary drugs are used for preventive and curative purposes to treat animals.

145 Even after potentially curative R0 resection, patients with pancreatic ductal a

146 eactivation following immunosuppression, and curative rates were higher than with benznidazole.

147 Current HIV therapy is not curative regardless of how soon after infection it is in

148 Despite the subsequent development of a curative regimen for this disease, tuberculosis remains

149 f tolerability prevented delivery of a fully curative regimen in the stage 2 mouse model and thus fur

150 In our simulations, curative regimes had limited impact on HIV incidence if

151 dictor of OS in patients with CRC undergoing curative resection and appears to be superior to pre-exi

152 ents with colorectal cancer (CRC) undergoing curative resection and to compare it to established biom

153 ents with rectal adenocarcinoma suitable for curative resection conducted at 29 sites across 10 count

154 stinal tract metastases undergoing complete, curative resection derived the greatest benefit, with a

155 identify patients who underwent potentially curative resection for GE junction and gastric adenocarc

156 Eligible patients were scheduled to undergo curative resection for hepatobiliary and gastrointestina

157 The data of 19 patients who had curative resection for pancreatic adenocarcinoma of the

158 study identified 202 patients who underwent curative resection of CLMs between January 1, 2008, and

159 re (mGPS) in patients undergoing potentially curative resection of colorectal cancer (CRC).

160 s outcome in patients undergoing potentially curative resection of CRC.

161 Purpose After curative resection of gastric or gastroesophageal juncti

162 Conclusion After a curative resection of gastric or gastroesophageal juncti

163 d May 2009, 546 patients who had undergone a curative resection of stage IB through IV (M0) gastric o

164 or 1) with liver metastases not suitable for curative resection or ablation were randomly assigned (1

165 colorectal cancer (CRC) patients who undergo curative resection subsequently experience tumor recurre

166 ents identified, 1623 patients who underwent curative resection were deemed eligible for inclusion.

167 Consenting patients (n = 15) scheduled for curative resection were enrolled in a clinical trial eva

168 After curative resection, patients were randomly assigned to r

169 ents with rectal adenocarcinoma suitable for curative resection, robotic-assisted laparoscopic surger

170 trinsic potential for early recurrence after curative resection.

171 re powerful new medicines, offering hope for curative responses in patients with cancer.

172 approaches to improve treatment outcomes and curative responses in patients.

173 cer therapies in order to achieve durable or curative responses in patients.

174 cy is generally desirable, because it offers curative results.

175 with pathologically proven HNSCC undergoing curative RT at a single academic cancer referral center

176 temic relapse of disease may be eligible for curative salvage surgery, but the benefit of this surger

177 tions in the context of its application as a curative (seizure freedom) or palliative (seizure reduct

178 pharmacologic management of SS, both in the curative setting, where the standard approach is wide su

179 a are important, given that ibrutinib is not curative, so clinicians will increasingly encounter pati

180 HIV curative strategies currently under development aim to e

181 prone to become pharmacological targets for curative strategies in adult patients.SIGNIFICANCE STATE

182 prone to become pharmacological targets for curative strategies in adults.

183 ed to be targeted therapeutically for future curative strategies in MDSs.

184 tation of human immunodeficiency virus (HIV) curative strategies is the limited ability to sensitivel

185 As many HIV curative strategies require cART interruption to determi

186 of HIV persistence and the implementation of curative strategies would benefit from animal models tha

187 cells need to be identified for potentially curative strategies.

188 otentially important for HIV therapeutic and curative strategies.IMPORTANCE Approximately 1% of peopl

189 MVI-positive undergoing preoperative CRT and curative surgery between Jan 2006 and Jan 2012 were incl

190 orectal cancer (CRC) patients is modified by curative surgery for a potential application in the onco

191 AIMS: Recommendations for surveillance after curative surgery for colorectal cancer (CRC) include a 1

192 ores of 0 or 1 who had undergone potentially curative surgery for histologically proven stage III or

193 mic at the time of diagnosis, and apparently curative surgery is followed at a later date by tumor re

194 dvanced basal cell carcinoma not amenable to curative surgery or radiation or metastatic basal cell c

195 ent and, for some variables, persisted after curative surgery.

196 lue of factors for being offered potentially curative surgery.

197 atients with asymptomatic pHPT who underwent curative surgery.

198 Adoptive immunotherapy is a potentially curative therapeutic approach for patients with advanced

199 extensively, with the aim of developing new curative therapeutic approaches based on LSC eradication

200 atients diagnosed at an advanced stage where curative therapeutic options are lacking.

201 Thus, we have developed a curative therapeutic vaccination regimen dubbed 'TheraVa

202 lobal health concern, and the development of curative therapeutics is urgently needed.

203 n early stage are candidates for potentially curative therapies (local ablation, resection, or transp

204 Curative therapies are most successful when cancer is di

205 resent a path forward for the development of curative therapies for the majority of cancer patients.

206 Novel curative therapies using genetic transfer of normal glob

207 The safety of any new curative therapies will be paramount given the excellent

208 taking decisions on efficient preventive and curative therapies.

209 tion of this cell population is required for curative therapies.

210 of virus cell entry and open new avenues for curative therapies.

211 /E7 vaccines already in clinical trials into curative therapies.

212 Curative therapy for cancer patients with advanced-stage

213 Despite intensive efforts in recent years, a curative therapy for cutaneous T-cell lymphoma (CTCL) ha

214 bone marrow transplantation (allo-BMT) is a curative therapy for hematological malignancies, but is

215 transplantation (allo-HSCT) is a potentially curative therapy for hematological malignancies.

216 Solid organ transplantation is a curative therapy for hundreds of thousands of patients w

217 tic stem cell transplantation is a potential curative therapy for malignant and nonmalignant diseases

218 etic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, c

219 HSCT represents a curative therapy for patients with MYSM1 deficiency.

220 c cell transplantation is, to date, the only curative therapy for SCD, but its application is limited

221 Additionally, HSCT has been a curative therapy for several nonmalignant hematologic di

222 se (NCDB), we examined patients who received curative therapy for the following sites: oral tongue, o

223 marrow transplantation is currently the only curative therapy for the hematopoietic complications of

224 Nevertheless, curative therapy has remained elusive for important path

225 No curative therapy is currently available for AGU.

226 No curative therapy presently exists.

227 ions with potential to reduce anti-Wolbachia curative therapy times to between one and two weeks.

228 mediate or high grade, for which no standard curative therapy was available, an Eastern Cooperative O

229 transplantation (HCT) has been considered a curative therapy, but the procedure has inherent complic

230 To obtain curative therapy, other effective agents, based on HL bi

231 Curative therapy, thanks to insights into the molecular

232 isease with high public health burden and no curative therapy.

233 an 85% of adults worldwide with no permanent curative therapy.

234 istant urothelial carcinoma has no uniformly curative therapy.

235 epresents a significant clinical obstacle to curative therapy.

236 cell transplantation might be a potentially curative therapy.

237 Bone marrow transplantation is the only curative therapy.

238 applies to patients with MT-GCT treated with curative therapy.

239 the epileptogenic focus represents the only curative therapy.

240 thritis is a common, complex disease with no curative therapy.

241 he subset that received guideline-concordant curative treatment (hazard ratio, 2.63; 95% CI, 1.05 to

242 Improved testing and linkage could increase curative treatment access.

243 to a higher probability of benefiting from a curative treatment and so a higher survival probability.

244 life expectancy in patients who had received curative treatment and whose hypercortisolism remained i

245 ly recommended and an extended indication of curative treatment by HSCT should be considered.

246 nd pharmacodynamic models more predictive of curative treatment durations are set forth.

247 ansplantation (HCT) represents a potentially curative treatment for a variety of hematologic malignan

248 Allergen immunotherapy (AIT) is the only curative treatment for allergy.

249 There is still no curative treatment for Duchenne muscular dystrophy (DMD)

250 transplantation (allo-HCT) is a potentially curative treatment for hematologic and immunologic disea

251 cquired liver diseases and could represent a curative treatment for hemophilia A.

252 Despite the availability of curative treatment for hepatitis C virus (HCV) infection

253 Surgical resection is the only curative treatment for pancreatic and periampullary canc

254 Curative treatment for patients with advanced head and n

255 Treatment selection for men undergoing curative treatment for prostate cancer is often a challe

256 anscription, suggesting that even apparently curative treatment for PTB may not eradicate all of the

257 There is currently no curative treatment for this disorder.

258 Allergen-specific immunotherapy is the only curative treatment for type I allergy.

259 stem cell (HSC) transplantation represents a curative treatment for various hematological disorders.

260 ng breast cancer care from diagnosis through curative treatment into survivorship, and metastatic dis

261 anges over time for those who survived since curative treatment is unknown.

262 cessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible.

263 cell transplantation (HSCT) remains the only curative treatment of FA patients with MDS or AML.

264 ne and tafenoquine) are used for the radical curative treatment of Plasmodium vivax malaria and can c

265 or combination therapy has failed to offer a curative treatment option, most likely because these pat

266 ent brentuximab vedotin may be a potentially curative treatment option.

267 itor crizotinib in patients who had no known curative treatment options at diagnosis or with relapsed

268 n indolent cancer, with effective but rarely curative treatment options.

269 Currently, curative treatment trials for Alzheimer's disease (AD) h

270 lower dose than required to achieve the same curative treatment without MDNPs.

271 esection is regarded as the only potentially curative treatment, and adjuvant chemotherapy with gemci

272 nefits, defined as early tumor detection and curative treatment, and surveillance-related physical ha

273 Patients were stratified by curative treatment, geography, Child-Pugh status, and re

274 n oesophageal cancer that was unsuitable for curative treatment, symptomatic dysphagia, Eastern Coope

275 In the absence of curative treatment, the management of pre-eclampsia invo

276 ed patients who stand to benefit most from a curative treatment.

277 mber of days from diagnosis to initiation of curative treatment.

278 ognoses, limited therapeutic options, and no curative treatment.

279 ed patients with a non-ICU policy or with no curative treatment.

280 crine disorder for which surgery is the only curative treatment.

281 hypopharynx, or larynx undergoing first-line curative treatment.

282 does not appear to be a contraindication to curative treatment.

283 reatment course including current first-line curative treatment: liver resection, radiofrequency abla

284 with only one third of patients eligible for curative treatments and very limited survival benefits w

285 rogeneity is critical for the development of curative treatments as the failure to eliminate therapy-

286 patients within Milan criteria submitted to curative treatments did not show any difference in survi

287 ctory to available therapies or for which no curative treatments existed.

288 Surgery and radiation continue to be curative treatments for localized disease but have adver

289 Resistance to therapy and lack of curative treatments for metastatic breast cancer suggest

290 liver transplantation (CLT) are potentially curative treatments for patients with hepatocellular car

291 successful remission; however, there are no curative treatments for tumors that have progressed beyo

292 Socioeconomic factors affect selection of curative treatments in HL.

293 m earlier diagnosis and access to first-line curative treatments, among which RFA provided the best v

294 In spite of great advances in the design of curative treatments, most patients currently receive pal

295 ffective than benznidazole and nifurtimox as curative treatments, particularly for acute stage infect

296 ing the past 20 y, but we are still far from curative treatments.

297 for chronically infected individuals are not curative, underscoring the need for a better understandi

298 The SLT strategy is successful or curative when patients are recurrence free following pri

299 The best compounds were found to be curative with all mice surviving a Plasmodium berghei in

300 Excision was curative without recurrence.