ライフサイエンスコーパス: cure

1 ecular markers from days 8 to 42 (defined as cure).

2 and there is still no known possibility of a cure.

3 red further surgical intervention to achieve cure.

4 al lung disease with dismal prognosis and no cure.

5 opathy, a debilitating disease without known cure.

6 roaches to treatment must eradicate LSCs for cure.

7 not always suitable for providing a radical cure.

8 me for the plastic to penetrate the bone and cure.

9 y opportunity to reach surgery and potential cure.

10 -1 in resting CD4(+) T lymphocytes precludes cure.

11 linical studies relevant to achieving an HIV cure.

12 nfection for which there remains no feasible cure.

13 licates investigation of the barriers to HIV cure.

14 of BRCA1 activity and indicating a potential cure.

15 ffective treatment strategies to achieve HIV cure.

16 servoir and contribute to a functional HIV-1 cure.

17 mentation of promising strategies for an HIV cure.

18 on, and inevitably represent a bottleneck to cure.

19 memory CD4(+) T cells, creating a barrier to cure.

20 lead to long-term ART-free HIV remission or cure.

21 d testing for sustained HIV remission and/or cure.

22 sign of clinical trials aimed at hepatitis B cure.

23 develop treatments that could lead to an HIV cure.

24 haracteristics compatible with a single-dose cure.

25 aziliensis and reduced IL-1beta levels after cure.

26 with the ultimate goal of achieving an HIV-1 cure.

27 nt survival, but there remains no definitive cure.

28 w measurable clinical advances toward an HIV cure.

29 ajor barrier for the development of an HIV-1 cure.

30 py (cART) represents a major obstacle toward cure.

31 rapeutically targeted for a functional HIV-1 cure.

32 ctivity, and the potential for a single dose cure.

33 line, ART was initiated, and TB successfully cured.

34 Overall, 191 (83%) patients were cured.

35 s treated before the first year of life were cured.

36 reviously undiagnosed advanced disease to be cured.

37 roves responses and predominantly results in cures.

38 tant cancer cells is a major barrier to full cures.

39 Only the anti-CD27/CD20 combination provided cures.

40 uperior antitumor efficacy and even complete cures.

41 f crosslinking, gel time, degree and rate of curing.

42 and the weaker the variant, the greater the curing.

43 performed 0, 1, 3, 5, and 10 min after light curing.

44 30 KHz) during and up to 10 min after light curing.

45 g these assays and ultimately as a "proof of cure."

46 Optimal dosing of PRIT plus venetoclax cured 100% of mice with no detectable toxicity.

47 The primary endpoint was sustained clinical cure 30 days after end of treatment (day 55 for extended

48 the bispecific outperformed the SA approach, curing 35% more mice overall (P < .004).

49 creting human proinsulin and interleukin-10, cured 66% of mice with new-onset diabetes, which is comp

50 The primary outcome was clinical cure 7 to 10 days after the end of treatment.

51 F) were significantly less likely to achieve cure (90%) compared to nonblack patients (99%).

52 duce adverse events, prolonged survival, and cured a fraction of glioma-bearing mice.

53 the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in t

54 tion, thus separating filament cleavage from curing activities.

55 The curing activity of Hsp104 thus constitutes an antiprion

56 Virologic or complete cure additionally includes loss of HBV covalently closed

57 in P. falciparum-infected mice, providing a cure after four oral doses.

58 fective host immunity and accelerate the HIV cure agenda.

59 uidance to therapeutic approaches in the HIV cure agenda.

60 crobial drugs have been viewed as miraculous cure-alls for the past 80 years, increasing antimicrobia

61 Hazard ratio (HR) for presumed cure among those treated with povidone-iodine (vs antibi

62 d after treatment to determine frequency of cure and assess select normal tissues for treatment-rela

63 eatments to decipher the origin of the rapid cure and to evaluate the possibility of further reducing

64 ty of natural products, versus products from cured and processed material, in this Review.

65 h a faceted liquid compartment, which can be cured and purified to yield colloidal polyhedra.

66 rto usually been embedded in plastic blocks, cured and sectioned with a tungsten carbide knife to obt

67 6 [24-120] days) with a 1-year success rate (cured and surviving) of 88% and a 5.9% risk of relapse (

68 Science can provide cures and improve health, and it can also make us more h

69 ding Marfan syndrome (MFS), currently lack a cure, and causative mutations have been identified for o

70 All patients were cured, and no further cases were identified after trimet

71 g for disease progression with the intent to cure) appears to be safe and has become the preferred ap

72 informed pathogenetic understanding, but no cure as yet exists.

73 The efficacy outcomes included clinical cure at 24 hours and time to last unformed stool.

74 Clinical cure at 24 hours occurred in 81.4%, 78.3%, and 74.8% of

75 come than those who achieved microbiological cure at 6 days in the Mycotic Ulcer Treatment Trial I (M

76 ained clinical response, defined as clinical cure at the end of treatment and no recurrence within 30

77 The primary endpoint was clinical cure at the test-of-cure visit (21-25 days after randomi

78 Each approach cured at least 75% of mice at the highest radiation dose

79 r precursors with block copolymer templates, curing at 140-180 degrees C, and calcination to remove t

80 Presently, there is no cure available to treat those infected or prevent future

81 They could be 3D printed and cured both in air and under water.

82 ivity than either Ca-Hsp104 or Sp-Hsp104, it cures both the weak and strong variants, whereas Ca-Hsp1

83 ted disease, in which young patients will be cured but bear the consequences of adverse effects for d

84 ng antimycobacterial treatment and following cure by 6 months of antibiotics.

85 en and reduce treatment time to relapse-free cure by 75%.

86 ssive infiltration, making it difficultly to cure by surgery.

87 Primary hyperparathyroidism can be cured by removal of the parathyroid gland or glands but

88 spontaneously in an hsp104(T160M) strain are cured by restoration of just normal levels of the WT Hsp

89 [PSI+] arising in the absence of Siw14p are cured by restoring normal levels of the protein.

90 leukemia (APL) patients can be definitively cured by the combination of two targeted therapies: reti

91 g and weak [PSI(+)] variants are among those cured by this process.

92 Therefore, curing by Hsp104 overexpression depends on both the trim

93 will therefore be necessary to eradicate and cure cancer.

94 nd create public health benefits on par with curing cancer.

95 anuloma-independent action that enables self-cure (CCL5), and (vi) may have no role in responsiveness

96 Instead, a functional cure characterized by sustained loss of hepatitis B surf

97 Curing CHC was associated with a reduction in MR among c

98 iral diseases, which may open a new venue to cure chronic hepatitis B.

99 available antivirals can suppress but rarely cure chronic infections.

100 ceftazidime-avibactam group were clinically cured, compared with 270 (73.0%) of 370 patients in the

101 When we are not able to cure, correct, or mitigate the cause of conditions such

102 The primary endpoint was serological cure, defined as a two-dilution decrease in rapid plasma

103 riori in the per-protocol group was clinical cure, defined as absence of these clinical failure crite

104 The ability of Tr1 cells to cure diabetes in NOD mice required IL-10 signaling, as T

105 been achieved to harness nature's ability to cure diseased tissues and organs.

106 ntly there are no drugs available that could cure diseases induced by them.

107 r the Bayonne ham is directly related to its curing due to the salt used in process coming from the n

108 ponses could potentially be leveraged in HIV cure efforts if epitope escape and lack of sustained eff

109 in two pairwise combinations: iES vs EG and cured ES (cES, where Cardinium was removed with antibiot

110 The test-of-cure evaluation was conducted 25 to 31 days after the fi

111 iciency, will continue to expand options for cure even in these most difficult to treat patients.

112 ation and hypervascularization, for which no cure exists.

113 continued to propagate after composite light curing finished.

114 Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (all

115 A cure for CHC was associated with an MRR of 0.64 (95% CI,

116 urrently, there is no effective treatment or cure for epidermolysis bullosa, but bone marrow transpla

117 eption of liver transplantation, there is no cure for hemophilia, which is currently managed by preem

118 The search for a cure for HIV infection has highlighted the need for incr

119 ABTRACT: Establishing a cure for HIV is hindered by the persistence of latently

120 common inherited anemias, with no effective cure for most patients.

121 ars from discontinuation provides hope for a cure for some patients.

122 ightforward and simple solution to provide a cure for T1D is immensely attractive but entails at leas

123 experience, looking ahead to the chance of a cure for these disorders.

124 There is no cure for this disease and current treatment modalities f

125 A logical cure for type 1 diabetes (T1D) involves replacing the lo

126 Although there is no known cure for Type 2 diabetes, early diagnosis and interventi

127 or a complete understanding of, and eventual cure for, these childhood epilepsy syndromes.

128 but has fallen short of delivering effective cures for complex human diseases with complicated causes

129 Identifying cures for long-term problems of a complex developmental

130 t, and as yet unsolved, challenge to develop cures for this disease.

131 kely to increase the probability of clinical cure from infection and suppress the emergence of resist

132 The mice cured from ReACT also developed immunological memory aga

133 ere more prevalent in isolates from the "not-cured" group.

134 loin, dry fermented sausage, cooked ham, dry-cured ham and minced meat) by trained assessors.

135 Sensory and nutritional properties of dry-cured ham can be negatively affected due to oxidative mo

136 Excessive proteolysis during dry-cured ham processing may lead to high adhesiveness and c

137 s are generated during the processing of dry-cured ham that can be affected by post-translational mod

138 or moderate boar taint compound levels (dry-cured ham) occurred.

139 lysis phenomena during the processing of dry-cured ham.

140 in those peptides generated in 12-months dry-cured hams.

141 rigin of world famous brands of European dry-cured hams.

142 by medicine and society on intervention and cure has sometimes come at the expense of good end-of-li

143 New antiviral treatments can cure HCV in the majority of patients, but a vaccine rema

144 Indeed, curing HCV infection with an oral medication is now real

145 es has been paramount to the VA's success in curing HCV infection.

146 Efforts to cure HIV are hampered by limited characterization of the

147 can prevent disease progression, it does not cure HIV infection.

148 ed interest in using antibodies to treat and cure HIV infection.

149 It is not yet possible to cure HIV infection.

150 in HIV-1 positive individuals have failed to cure HIV-1 infection.

151 nfected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this lig

152 ells (rCD4 cells), posing a major barrier to curing HIV-1 infection.

153 common with ART and is the major barrier to curing HIV-1 infection.

154 emory CD4(+) T cells is the major barrier to curing HIV-1 infection.

155 hat type I IFN modulation will be pivotal to cure human chronic infections, cancer, or autoimmune dis

156 detect the volatile compound profile of dry-cured Iberian ham from pigs fattened on acorn and pastur

157 surface antigen seroclearance) and complete cure (ie, eradication of covalently closed circular DNA)

158 To achieve functional cure (ie, HBV surface antigen seroclearance) and complet

159 of macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during

160 o determine the SLT strategy's potential for cure in R&T HCC patients, and to identify predictors for

161 is still the most promising modality for HBV cure in the future.

162 of hepatology for the past 25 years, and its cure in the majority of treated patients is one of the g

163 Median interval to presumed cure in the Philippines was 7 days for povidone-iodine a

164 apeutics to achieve functional and virologic cure in various phases of HBV infection.

165 (77.4%) of 257 participants were clinically cured in the ceftazidime-avibactam group, compared with

166 i) outperformed arterolane itself, producing cures in mice after a single oral exposure.

167 ctive value (94.3%-100.0%) for late clinical cure, including among hospitalized patients.

168 The shells were photo-cured individually, on-the-fly, with precisely-actuated,

169 d programs to optimally prevent, detect, and cure infection.

170 ovirus and rotavirus, in both preventing and curing infection.

171 Curing infections increasingly requires antimicrobials t

172 controlled micro-extrusion and subsequently cured into complex geometries.

173 inherited neurodegenerative disorder, and no cure is available currently.

174 No definitive cure is available for OI and to develop novel drug thera

175 A model assuming that rapid cure is due to a drug effect of generating non-infectiou

176 uring treatment of myeloid malignancies, and cure is only rarely achieved.

177 ften effective in defined molecular subsets, cure is rare and resistance is common.

178 HBV functional cure is sustained hepatitis B surface antigen loss and a

179 Hsp104 deficiency curing is a result of failure to cleave the Sup35p amylo

180 This normal-level Hsp104 curing is promoted by Sti1p, Hsp90, and Sis1p, proteins

181 04(T160M) can propagate [PSI(+)], but cannot cure it by overproduction, thus separating filament clea

182 tention and symbolizes current confidence in curing it.

183 Moreover, infecting mice with the LRV1-cured Leishmania guyanensis (LgyLRV1(-) ) strain of para

184 temperature-sensitive liposomes can reliably cure local cancer in mouse models.

185 Modern cancer therapy has successfully cured many cancers and converted a terminal illness into

186 and good final mechanical properties of the cured materials.

187 l delivery of HMGN1 with low dose of Cytoxan cured mice bearing small (slashed circle approximately 0

188 Notably, cured mice were resistant to rechallenge not only by WEH

189 f anti-CTLA-4, anti-PD-1, and G47Delta-mIL12 cured most mice in two glioma models.

190 ll responses, improved TH17 differentiation, cured mucocutaneous candidiasis, and maintained remissio

191 g high-throughput screens, we identify prion-curing mutants and engineer "anti-prion drives" that rev

192 heir oncologist's treatment goal was not "to cure my cancer." Conclusion Prognostic awareness is rela

193 Among the participants who were initially cured, new infections at 1 month of follow-up were less

194 fied intention-to-treat population, clinical cure occurred in 189 (76.2%) of 248 participants in the

195 ake new seeds, whereas Hsp104 overproduction curing occurs by a different mechanism.

196 ML) may be relevant for long-term control or cure of CML.

197 antiviral agents (DAA) provide an effective cure of HCV infection without risk of allograft rejectio

198 mbers of HIV DNA-containing cells.IMPORTANCE Cure of HIV infection requires an intervention that redu

199 nterruption and is a central obstacle to the cure of HIV infection.

200 sue on Advances in Prevention, Treatment and Cure of HIV/AIDS, Guest Editors Steven Deeks, Sharon Lew

201 eservoir cells, which may lead to a complete cure of HIV/AIDS.

202 Cure of Human Immunodeficiency Virus (HIV) infection rem

203 proteins identified were to be correlated to cure of infection, this would be a major advance.

204 effective than a single 1g dose at achieving cure of M. genitalium urethritis and importantly did not

205 ediated therapies for solid organ tolerance, cure of non-malignant hematological disease, and HIV res

206 ession of advanced s.c. tumors, resulting in cure of some mice and development of immunological memor

207 c islets are ultimate goals for the complete cure of type 1 diabetes (T1D).

208 tion termination factor eRF3 (Sup35), can be cured of its infectious conformation by overexpression o

209 years), 21 of 25 patients survived and were cured of underlying immunodeficiency.

210 usly implicated in the Hsp104 overproduction curing of [PSI(+)].

211 We demonstrate that both curing of [URE3] and enhancement of [PSI(+) ] in the pre

212 Early microbiological cure on culture is a predictor of clinical response to t

213 and no medication has been clearly proven to cure or delay the progression of AD.

214 ks with LDV/SOF, of whom all had outcomes of cure or relapse without loss to follow-up.

215 In the quest for a functional cure or the eradication of HIV infection, it is necessar

216 by aspiring leaders, and how contempt can be cured or at least mitigated.

217 <1% died during TB treatment and 89.5% were cured or completed treatment.

218 tified specific genes associated with a "not-cured" outcome that should be validated in future studie

219 QOD followed by every-third-day dosing were cured (P = .03).

220 ot be viewed as inevitably fatal, and can be cured, particularly if detected and treated at an early

221 treatment in this historically difficult-to-cure patient population.

222 the other hand, there is a concern that the cured patient with decompensated cirrhosis will find the

223 e this regimen to be recommended for radical cure patients would not require testing for G6PDd in are

224 torically considered "difficult to treat and cure patients," additional benefits have been documented

225 ak of KA in Babar El Fugara (Sudan), 5.7% of cured patients displayed relapses, with familial cluster

226 after catheter ablation (CA) in apparently "cured" patients could optimize long-term follow-up and m

227 the microstructural changes upon exposure of cured Portland cement with an artificially engineered le

228 tervals from start of treatment to "presumed cure" (primary outcome measure, defined as a closed epit

229 idised peptides generated throughout the dry-curing process (0, 2, 3.5, 5, 6.5 and 9months), focusing

230 Also dry-curing proved a promising technique for masking boar tai

231 ost newly arising [URE3] variants but do not cure [PSI(+)], even after overexpression.

232 The cure rate (ie, polymerase chain reaction-corrected adequ

233 In conclusion, the rapid cure rate achieved with these combinations is largely di

234 py in the intention-to-treat population, the cure rate among participants in the clindamycin group wa

235 16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs.

236 ants [81.7%], respectively; P=0.73), and the cure rate in each active-treatment group was higher than

237 use a variant of survival analysis known as cure rate modelling to differentiate factors that influe

238 The cure rate was comparable at day 42 in the ITT population

239 isoniazid-resistant tuberculosis had a high cure rate, the cases of recurrence and acquired drug res

240 Intention-to-treat analysis showed initial cure rates (2 months after treatment) of 22.2% (6 of 27)

241 dihydroartemisinin-piperaquine by increasing cure rates and thereby slowing resistance development.

242 The difference in clinical cure rates between the groups was -0.80% (95% CI, -7.1%

243 Definitive chemoradiation results in high cure rates but causes long-term toxicity and may represe

244 he most common childhood cancer, and despite cure rates exceeding 90% in children, it remains an impo

245 DAAs became available in January 2014, with cure rates exceeding 90%; only 51 000 veterans in VA car

246 Purpose Improvement of cure rates for patients treated with allogeneic hematopo

247 ormed a logistic meta-regression analysis of cure rates from all falciparum malaria treatment trials

248 Hepatitis C virus (HCV) cure rates have been similar in patients with and withou

249 ate the real-world ability of achieving high cure rates using patient navigation care models.

250 The results have implications for HIV cure regimens based on stem cell transplantation.

251 lished a cohort optimised for prevention and cure research.

252 ic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleatio

253 ercentage of transferred globin necessary to cure SCD is currently not known.

254 ers toward better defining hepatitis B virus cure should occur in parallel with development of novel

255 ich requires no further modification/ex-situ curing step.

256 will provide insight into further studies of cure strategies inspired by the Berlin patient.IMPORTANC

257 Here we review leading HIV cure strategies that harness cell-mediated control again

258 nted for the in vivo evaluation of novel HIV cure strategies.

259 ction with T cell-activating agents in HIV-1 cure strategies.

260 irs underscore challenges in developing 'HIV cure' strategies targeting multiple sources of virus pro

261 is crucial for designing the prevention and curing strategy of cancer.

262 tomical patency) and subjective (symptomatic cure) success rates within the duration of follow-up.

263 individuals with KA who never relapsed after cure, suggesting incomplete penetrance of AGMO deficienc

264 By varying curing temperature and resin formulation, the clear tren

265 cological options for type 2 diabetes do not cure the disease.

266 ation is an attractive therapeutic option to cure the injured heart and prevent heart failure.

267 progression of liver diseases, they fail to cure the viral infection.

268 riants, whereas Ca-Hsp104 and Sp-Hsp104 only cure the weak variants.

269 any chaperones and other cellular components cure the yeast prions [PSI(+)] (formed by Sup35p) or [UR

270 Deficiency or overproduction of Hsp104 cures the [PSI(+)] prion.

271 matopoietic stem cell transplantation (HSCT) cures the T-lymphocyte, B-lymphocyte, and natural killer

272 ith a combination of F8-TNF and doxorubicin, curing the majority of treated animals (29/37).

273 sity achieved in the focal region allows for curing the material quickly, while the brief duration of

274 There are currently no options for curing this infection.

275 sors is more challenging due to their longer curing times.

276 ay include cryogenic fuel-filling, and shell curing, to produce ready-to-use IFE targets.

277 In the absence of a cure, treatment comprises absolute avoidance measures.

278 chemotherapy era, including the inability to cure tuberculosis, high mortality, and the need for alte

279 ic amine (BA) development in "muxama", a dry-cured tuna muscle product, as affected by salt content,

280 nergistically increased mouse survival time, curing up to 10%.

281 ents at end of induction who are essentially cured using current chemotherapy and identifying MRD at

282 ry endpoint was clinical cure at the test-of-cure visit (21-25 days after randomisation).

283 The median follow-up time after cure was 11 months, during which 44 (30%) patients relap

284 (27/27) and the success rate of symptomatic cure was 92.6% (25/27).

285 ment was well tolerated, and 100% histologic cure was achieved in 9 of 9 assessable animals without d

286 Microbiological cure was determined for men with M. genitalium urethriti

287 ished if the proportion of patients who were cured was higher for artemether plus lumefantrine than f

288 nd safety of primaquine regimens for radical cure, we undertook a randomized controlled trial in Ethi

289 Proportions cured were also similar between the groups in the intent

290 ith acute myeloid leukemia (AML) can only be cured when allogeneic hematopoietic stem-cell transplant

291 Gy would lead to a high probability of tumor cure while being well tolerated by nude mice bearing sub

292 INTERPRETATION: The rate of cure with a fixed-dose combination of ledipasvir-sofosbu

293 HCV infection can progress to treatment and cure with rates comparable to ambulatory care settings,

294 , and high IPSS-R score have a low chance of cure with standard HSCT and consideration should be give

295 the risk and determinants of HCC in patients cured with DAA.

296 Four patients were cured with IS treatment tapering only.

297 psed metastatic germ cell tumor (GCT) can be cured with second-line and even third-line regimens.

298 Most small GISTs are cured with surgery.

299 herapies with ART could result in functional cure within 2-10 years rather than several decades on AR

300 sp104 homolog in vitro, and is essential for curing yeast prions by Hsp104 overexpression in vivo.