ライフサイエンスコーパス: cyano

1 ps, including keto, imino, ester, ether, and cyano.

2 blockade with D3R antagonist trans-N-4-2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethylcyclohexy

3 p unexpectedly found that N-[(1r,4r)-4-[2-(7-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexy

4 g as C-C-S building blocks produce 5-amino-4-cyano-1,2,3-thiadiazoles exclusively.

5 example: The reported 1.643 A C-C bond in 5-cyano-1,3-dehydroadamantane was redetermined and "only"

6 ute for the construction of functionalized 2-cyano-1,4-diketones has been established from the nucleo

7 Now, a series of six novel 6-amino-5-cyano-1,4-disubstituted-2(1H)-pyrimidinones 5a-5f and tw

8 molecular Pauson-Khand reactions of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched

9 -tolyl-2(1H)-pyrimidinone (5b) and 6-amino-5-cyano-1-(naphthalen-1-yl)-4-p-tolyl-2(1H)-pyrimidinone (

10 2-Cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[2-(phenylsulfanyl

11 ean-1,12-dien-30-oate (CF3DODA-Me) contain 2-cyano-1-en-3-one and 2-trifluoromethyl-1-en-3-one moieti

12 The rotational barriers of 6-amino-5-cyano-1-o-tolyl-4-p-tolyl-2(1H)-pyrimidinone (5b) and 6-

13 nished 2,2'-bipyrroles as well as 5,5'-bis(5-cyano-1-pyrrolines), depending on the reaction condition

14 (+)-2-Cyano-1-{[trans-(1S,3S)-3-(1H-imidazol-4-yl)cyclopentyl]

15 denosine analogs in this class identified 1'-cyano-2'-C-methyl 4-aza-7,9-dideaza adenosine as a poten

16 GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleosid

17 The nucleoside analog 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosyl-cytosine

18 1'-Cyano-2'-deoxyuridine (CNdU) and related molecules may p

19 1'-Cyano-2'-deoxyuridine (CNdU) is a nanomolar competitive

20 able to sugar-protected 6-cyanouridine and 6-cyano-2'-deoxyuridine without the protection at the N(3)

21 ase of compound 2a and 3,4-trans-1-benzoyl-4-cyano-2,3-(6-bromotetrahydroisoquinoline)tetrahydropyraz

22 l % catalyst to afford 3,4-trans-1-benzoyl-4-cyano-2,3-(tetrahydroisoquinoline)tetrahydropyrazole (2a

23 R,4S)-1 affords (+)-(2R,3R)-2-carbomethoxy-3-cyano-2,3-diphenyl-butane 2 with two adjacent stereogeni

24 t bacterial abundance, metabolic activity (5-cyano-2,3-ditolyl tetrazolium chloride (CTC+) cells), an

25 In contrast to the other epithionitriles, 1-cyano-2,3-epithiopropane is highly reactive.

26 Here, we characterized the reactivity of 1-cyano-2,3-epithiopropane under aqueous heat treatment co

27 The epithionitriles, 1-cyano-2,3-epithiopropane, in particular, and 1-cyano-3,4

28 o-alpha-cyanocinnamic acid (ClCCA) and alpha-cyano-2,4-difluorocinnamic acid (DiFCCA) matrixes.

29 hexasubstituted (+)-(2R,4S)-2-carbomethoxy-4-cyano-2,4-diphenyl-3-pentanone 1.

30 of a protected 2,6-disubstituted phenol to 4-cyano-2,6-dimethylphenol, which is an intermediate in th

31 scribe a protocol for the reaction between 1-cyano-2-((trimethylsilyl)methyl)allyl acetate and a seri

32 Ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino)acetate (o-Nosyl

33 Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY

34 Most importantly, byproducts Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] and 4-nitrobenzenesulfoni

35 table analogue of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (6,

36 mily inhibitors [ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate (H

37 oate (4a and 17) and (E)- and (Z)-diethyl (1-cyano-2-heptenyl)phosphate (21a and 21b) with organocupr

38 ((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283), reveal striking conf

39 atalyst conditions using n-Bu4NBr afforded 2-cyano-2-siloxyvinylallenes via a tandem process that inv

40 abolic stability afforded N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-s

41 on of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A1

42 2-Substituted 1,4-benzodioxanes, such as 2-cyano-, 2-methoxycarbonyl-, 2-aminocarbonyl-, and 2-form

43 penoids such as bardoxolone methyl (methyl-2-cyano 3,12-dioxooleano-1,9-dien-28-oate; CDDO-Me) (4) ar

44 Compound 21 [N-(4'-cyano-3'-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonam

45 y related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate [bardoxolone-meth

46 In addition, 2-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-ethyl a

47 iterpenoids, bardoxolone methyl (BARD) and 2-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-ethyl a

48 the non-steroidal anti-inflammatory drug, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid-ethyl am

49 ministration of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-C28-methyl ester (CD

50 to apoptosis induced by PPARgamma agonists 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and 1

51 Our previous work demonstrates that the 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and i

52 The anticancer agent 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and i

53 ether derivatives of the triterpenoid (TP) 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO; CDDO-

54 ap1 expression or by the reactive compound 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester

55 The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and i

56 extensively used octocrylene (2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, OCT) was frequently fou

57 we have demonstrated that N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-

58 gs to those of the related epithionitriles 1-cyano-3,4-epithiobutane and 1-cyano-4,5-epithiopentane.

59 ano-2,3-epithiopropane, in particular, and 1-cyano-3,4-epithiobutane, are important, but yet underest

60 Focused library development of our lead 2-cyano-3-(1-(3-(dimethylamino)propyl)-2-methyl-1H-indol-3

61 naling [aurintricarboxylic acid (ATA), (E)-2-cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenami

62 ent with the JAK/STAT inhibitor AG490 [(E)-2-cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenami

63 f the new molecules, compounds 2-75 [4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-th

64 xoheptyl)benzamide] and 1005 [(E)-3-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-th

65 activation of Nrf2 by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9 (11)-dien-28-oyl]imidazole l

66 h as isopropylidenemalononitrile and ethyl 2-cyano-3-methyl-2-butenoate underwent the phospha-Michael

67 derived from [Ir(cod)Cl]2, allyl acetate, 4-cyano-3-nitro-benzoic acid, and (R)-MeO-BIPHEP catalyzes

68 m C,O-benzoate derived from allyl acetate, 4-cyano-3-nitrobenzoic acid and (S)-SEGPHOS delivers produ

69 yst generated in situ from [Ir(cod)Cl](2), 4-cyano-3-nitrobenzoic acid and the chiral phosphine ligan

70 atalyst (R)-I derived from [Ir(cod)Cl](2), 4-cyano-3-nitrobenzoic acid, (R)-SEGPHOS, and allyl acetat

71 complex (S)-I derived from [Ir(cod)Cl](2), 4-cyano-3-nitrobenzoic acid, allyl acetate, and (S)-SEGPHO

72 m C,O-benzoate derived from allyl acetate, 4-cyano-3-nitrobenzoic acid, and (R)-SEGPHOS delivers prod

73 ecific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the

74 s observed, including direct comparison of 3-cyano-, 3-nitro-, and 3-phenyl-substituted BF2 formazana

75 Mitsunobu chemistry afforded 6-cyano (35) and 6-azido (36) analogues of GlcN-(Cbz), and

76 ginal coumarin dyes has been replaced by the cyano(4-nitrophenyl)methylene moiety.

77 he magnetic field-aligned nematic phase of 4-cyano-4'-n-pentylbiphenyl (5CB) at 295 K.

78 In this system, 4-cyano-4'-pentyl biphenyl (5CB) was doped with a sulfur-

79 tudied in the nematic liquid crystal (NLC) 4-cyano-4'-pentylbiphenyl (5CB): Both point and ring topol

80 cterizing the orientations of nematic LCs (4-cyano-4'-pentylbiphenyl and TL205 (a mixture of mesogens

81 e interface between air and the nematic LC 4-cyano-4'-pentylbiphenyl create quadrupolar distortions i

82 ecules such as squalane, polyisoprene, and 4-cyano-4'-pentylbiphenyl into a nanocrystal suspension, t

83 midines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in tu

84 tron-withdrawing group, 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF), with a tri

85 thionitriles 1-cyano-3,4-epithiobutane and 1-cyano-4,5-epithiopentane.

86 Starting from the previously identified 3-cyano-4,6-diphenyl-pyridines, we chemically modified thi

87 d with the RAFT chain transfer agent (CTA) 4-cyano-4-(ethylsulfanylthiocarbonylsulfanyl) pentanoic ac

88 elective androgen receptor modulator, (S)-(7-cyano-4-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydrocyclopent

89 h various polysaccharide/protein ratios by 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP)

90 ation curves of standard peptides with alpha-cyano-4-hdydroxycinnamic acid as a matrix.

91 te shuttle by administering 100 microM alpha-cyano-4-hydroxy-cinnamate (4-CIN), a dose that blocks th

92 th PR(4)(+) cations and ferulate (FA), alpha-cyano-4-hydroxycinnamate (CHCA), and 2,5-dihydroxybenzoa

93 er to the pyruvate transport inhibitor alpha-cyano-4-hydroxycinnamate.

94 r of mitochondrial pyruvate transport, alpha-cyano-4-hydroxycinnamate.

95 sulation of an anticancer therapeutic, alpha-cyano-4-hydroxycinnamic acid (alpha-CHC), and subsequent

96 did two other commonly used matrixes, alpha-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxyben

97 on to its well-established predecessor alpha-cyano-4-hydroxycinnamic acid (CHCA) is significantly dep

98 d applying layers of finely ground dry alpha-cyano-4-hydroxycinnamic acid (CHCA) to the surface of ti

99 Two ILs derived from alpha-cyano-4-hydroxycinnamic acid (CHCA) were synthesized and

100 nzoic acid (DHB), sinapinic acid (SA), alpha-cyano-4-hydroxycinnamic acid (CHCA), 2,6-dihydroxyacetph

101 nzoic acid (DHB), 4-nitroaniline (NA), alpha-cyano-4-hydroxycinnamic acid (CHCA), and sinapic acid (S

102 spectrometry (MS) bacteria profiling, alpha-cyano-4-hydroxycinnamic acid (CHCA), sinapinic acid (SA)

103 s, 2,5-dihydroxybenzoic acid (DHB) and alpha-cyano-4-hydroxycinnamic acid (CHCA).

104 D(4)-alpha-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthe

105 es 2,5-dihydroxybenzoic acid (DHB) and alpha-cyano-4-hydroxycinnamic acid (HCCA) as well as five halo

106 5-dihydroxybenzoic acid + pyridine and alpha-cyano-4-hydroxycinnamic acid + butylamine) were investig

107 Comparisons with other UV matrixes (alpha-cyano-4-hydroxycinnamic acid and sinapinic acid) and ion

108 ation of TBA (tributylamine) and CHCA (alpha-Cyano-4-hydroxycinnamic acid) as extraction solvent.

109 DHB (2,5-dihydroxybenzoic acid), CHCA (alpha-cyano-4-hydroxycinnamic acid), and 2-mercaptobenzothiazo

110 mparison to classical matrices such as alpha-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid,

111 Finally, we showed that alpha-cyano-4-hydroxycinnamic acid, a classic inhibitor for mo

112 imination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform

113 -2(1H)-pyrimidinones 5a-5f and two 6-amino-5-cyano-4-p-tolyl-1-substituted-2(1H)-pyrimidinethiones 6a

114 N-(2-((3-Cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-3-methoxybe

115 was obtained with the fluorescent substrate cyano(6-methoxy-naphthalen-2-yl)methyl glycidyl carbonat

116 N-{trans-3-[(5-Cyano-6-methylpyridin-2-yl)oxy]-2,2,4,4-tetramethylcyclo

117 he utility of our approach, we synthesized 2-cyano-7-(N,N-diethylamino)pyrene (3), a pyrene analogue

118 es of 3 are compared to those of DMABN and 2-cyano-7-(N,N-dimethylamino)-4,5,9,10-tetrahydropyrene, a

119 yzes the reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ(0)) to 7-aminomethyl-7-deazag

120 mplex, involving the initial production of 7-cyano-7-deazaguanine (preQ(0)), an advanced precursor th

121 nine (CDG) into its corresponding nitrile, 7-cyano-7-deazaguanine (preQ0 ).

122 In nature, QueF converts 7-cyano-7-deazaguanine (preQ0) into 7-aminomethyl-7-deazag

123 glycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and DNA metabolis

124 the 1.53-A crystal structure of the enzyme 7-cyano-7-deazaguanine reductase (QueF) from Vibrio choler

125 fer of four protons (and electrons) to the 7-cyano-7-deazaguanine substrate.

126 rmation of the native substrates NADPH and 7-cyano-7-deazaguanine.

127 ting Plk1 with a small molecule inhibitor (5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide) or

128 cid (AP-5) and AMPA/KA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) acted on RGCs

129 onal EPSPs as well as a local injection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and (2R)-amino

130 ionotropic glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and DL-2-amino

131 tra-LC co-injection of the AMPA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the gap-ju

132 th, although the non-NMDA receptor blocker 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) at a concentra

133 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a partial ago

134 ly reduced by the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whereas this

135 The AMPA/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 microM) abo

136 n ionotropic glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 200 microm) to

137 er the non-selective AMPAR/KAR antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 4 nmol) or the

138 preparations, blockade of this region with 6-cyano-7-nitroquinoxaline-2,3-dione and (2R)-amino-5-phos

139 ven extremely low efficacy ligands such as 6-cyano-7-nitroquinoxaline-2,3-dione can produce a full lo

140 ed an endovascular embolization with N-butyl-cyano-acrylate (NBCA) glue.

141 rform an endovascular treatment with N-butyl-cyano-acrylate (NBCA) glue.

142 The cyano adducts were characterized by UV-vis, EPR, and END

143 applied to the synthesis of an antiviral 4'-cyano adenosine analogue from a commercial precursor usi

144 protein via vibrational spectroscopy, using cyano-alanine residues to form the anesthetic binding ca

145 enerated carbon-palladium bond to a tethered cyano/aldehyde group.

146 teroaryl group at the beta-position of alpha-cyano aliphatic acids for the first time.

147 ryl-, silyl-, and alkyl-capped alkynyl alpha-cyano alkanone systems to the corresponding highly funct

148 In addition, the alpha-cyano-alpha-ketocyclopropane products are demonstrated t

149 lyzed arylation of C(sp(3))-H bonds in alpha-cyano-alpha-methyl aliphatic amides is achieved in the p

150 protocol for the synthesis of arylated alpha-cyano amides.

151 possessing other functional groups including cyano, amino, trifluoromethyl, and phenol, coupled with

152 nds to form channels that are decorated with cyano and amide groups.

153 rotein, due in part to the small size of the cyano and ethynyl groups.

154 energy surfaces (PESs) for the reactions of cyano and ethynyl radicals with styrene and N-methyleneb

155 the highest potencies were achieved for the cyano and hydroxyiminomethyl substituents, with TPI valu

156 arboxamido, trimethylammonium as well as the cyano and methoxy moieties with interesting inhibitory a

157 Cyano and thiocyano groups have received attention as IR

158 oups, such as the ester, aryl ketone, nitro, cyano, and amide functions.

159 e resulting XFs carry dibutylamino, pyridyl, cyano, and diphenylamino residues on their styryl arms t

160 ester, chloro, trifluoromethyl, bromo, iodo, cyano, and fluoro groups, are tolerated.

161 nge of deactivating groups including acetyl, cyano, and nitro groups.

162 ve groups like alkyl and aryl esters, amide, cyano, and the carbon-carbon double bond survive the rea

163 an alternative structural difference between cyano- and iodocuprates, which is in agreement with the

164 f both similar and different reactivities of cyano- and iodocuprates.

165 alities decorating the pores vary from polar cyano- and nitro- groups to nonpolar alkyl groups.

166 d even simple nucleophiles, such as azido or cyano anions, react with unexpected stereo- or regiosele

167 NH and methyl, alkyl, aralkyl, vinyl, cyano, aryl and N-heteroaryl, acyl, carbamoyl, alkoxycar

168 ron-withdrawing groups (EWGs) like nitro and cyano at the phenyl ring, leading to absorption in the g

169 ematic variation of the number and nature of cyano-based acceptor TCNE and TCNQ units on the photophy

170 f MPC by the pharmacological inhibitor alpha-cyano-beta-(1-phenylindol-3-yl)-acrylate (UK5099) result

171 of the metastable photomagnetic phase in the cyano-bridged 3D network Cs(2)Cu(7)[Mo(CN)(8)](4).

172 8)] magnetic system gives two enantiomorphic cyano-bridged chains, {[Co(II)((S,S)-iPr-Pybox)(MeOH)](3

173 The nonphotomagnetic cyano-bridged Fe(II)-Nb(IV) coordination polymer {[Fe(II

174 and in the construction of high-dimensional cyano-bridged materials exhibiting higher ordering tempe

175 metalated nitrile nucleophile species (alpha-cyano carbanion analogues), is a key step of the mechani

176 Aromatic cyano, chloro, and bromo functionalities are tolerated b

177 matographic separation was performed using a cyano (CN) column for both 25(OH)D(3) and 25(OH)D(2).

178 s substituted by a barrierless addition of a cyano (CN) radical, this newly proposed mechanism can ev

179 ovalent silicon atom, i.e. shifting from the cyano (CN) to the silicon nitride (SiN) radical, has a d

180 we also explored the aurophilic anchor group cyano (CN), amino (NH2), thiol (SH), and 4-pyridyl (PY).

181 the same X(2)Sigma(+) electronic structure - cyano (CN), boron monoxide (BO), silicon nitride (SiN),

182 fically incorporated carbon-deuterium (C-D), cyano (CN), thiocyanate (SCN), and azide (N3) "transpare

183 three-periodic (framework) p, d, and f metal cyano complexes or cyanometallates, i.e. coordination co

184 5-Cyano compounds are especially potent and selective rat

185 um salts was obtained from the corresponding cyano compounds or nitriles by reaction with anhydrous H

186 diazo ester in the process, leading to alpha-cyano cycloprop(en)ylcarboxylates in high yields and ste

187 g the bromine substituent for a nitro (NHQ), cyano (CyHQ), or chloro (CHQ) or exchanging the hydroxy

188 s tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.

189 ives allowed the alternative use of an alpha-cyano diazo ester in the process, leading to alpha-cyano

190 phonates was developed by employing an alpha-cyano diazophosphonate and Rh(2)(S-IBAZ)(4) as chiral ca

191 Here, we describe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group,

192 tivity relationships of this novel series of cyano ester dihydropyridines that resulted in R6 substit

193 es a variety of functional groups, including cyano, ester, aldehyde, and ketone groups, occurs under

194 of oxygen and subsequent deprotection of the cyano ethyl phosphoester afforded the target compounds i

195 In comparison with the isoelectronic cyano-ethylene system, the cyanoethylene (C(2)H(3)CN) is

196 electfluor-mediated coupling of the BPin and cyano functionalities to annulate a new five-membered ri

197 ans with both a tetra-substituted carbon and cyano functionality are accessed by the newly developed

198 roved the structural equivalence of iodo and cyano Gilman cuprates and their subsequential intermedia

199 rporation of alkyl copper in iodo but not in cyano Gilman cuprates during the reaction.

200 onger electron withdrawing groups (triflate, cyano) give oligomers for which misfolded states are und

201 ion of a hydrophobic substituent next to the cyano group and aminoquinoline methylation considerably

202 ubstitution of the guanidine group with an N-cyano group and replacement of guanidine with amidine, p

203 A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to

204 e, the replacement of the carbon atom in the cyano group by an isovalent silicon atom has a pronounce

205 scribe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group, including its synt

206 Iterative transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terp

207 molecular dynamics simulations show that the cyano group is exposed to solvent and forms hydrogen bon

208 triple bond]N) fluorescence is high when the cyano group is hydrogen bonded and low when it is not.

209 Hydrogen bonding to the cyano group is known to play a major role in modulating

210 The more strongly electron-accepting cyano group is predicted to shift the transitions of dia

211 Replacement of the iminium motif by a cyano group is well tolerated and gives an additional de

212 Introducing an electron-deficient p-cyano group on the B-phenyl substituent creates a twiste

213 lectivity are mediated by the binding of the cyano group to a new auxiliary pocket in nNOS.

214 romophore containing an electron-withdrawing cyano group to delocalize negative charge from the chrom

215 ich then undergo smooth cycloaddition with a cyano group to generate the desired fused 1,2,3-triazole

216 rated that C-H bonds can be activated by the cyano group under high pressure, but at room temperature

217 formed by combining the electron-withdrawing cyano group with thiophene or benzothiadiazole units.

218 , a(u), b(1g), and b(2u), all located at the cyano group) with pi*-orbitals of the ring systems.

219 hydrogen bonding interactions involving the cyano group, and its fluorescence quantum yield increase

220 of TO is replaced by an electron withdrawing cyano group, which was expected to decrease the suscepti

221 e ring opening, the unusual migration of the cyano group.

222 eraction observed in this study was with the cyano group.

223 eactive azadienophiles including unactivated cyano groups and heterosubstituted imine derivatives suc

224 s featuring the participation of unactivated cyano groups as enophile and dienophile cycloaddition pa

225 n of the peptide/protein upon removal of the cyano groups from the derived bisthiocyanate.

226 observation that NHC-boryl radicals abstract cyano groups from various organic nitriles has been parl

227 ine 5 to a dinitrile 7, 8, or 9 with the two cyano groups in 1,3 or 1,4 distance.

228 ximum rates confirm that sequestering of the cyano groups occurs concomitantly with the development o

229 rformance is further enhanced by introducing cyano groups to the CoPc molecule.

230 s that are activated by electron-withdrawing cyano groups.

231 ther, dimethylamino, trifluoromethyl, ester, cyano, halide, hydroxyl, and silyl functionalities compa

232 A wide variety of functional groups (nitro, cyano, halo, alkyl, amido, and thioether) was tolerated,

233 ) ) coupling method using boronic esters and cyano heteroarenes under flow conditions.

234 amino-group(s) directly linked to a pulling cyano, imino, or phosphoimino group, as well as those in

235 s) and increases the basicity of the pulling cyano, imino, or phosphoimino group.

236 dition of both the CN and OTf groups of aryl(cyano)iodonium triflates to alkynes is described.

237 de range of functional groups such as ester, cyano, keto, and nitro.

238 eta-cyano-L-alanine, demonstrating that beta-cyano-L-alanine nitrilase activity can have a significan

239 ing plants to grow in concentrations of beta-cyano-L-alanine that would otherwise prove lethal.

240 rilase that catalyses the hydrolysis of beta-cyano-L-alanine, a nitrile common in the plant environme

241 reased growth in high concentrations of beta-cyano-L-alanine, but also resulted in increased root elo

242 elongation in the absence of exogenous beta-cyano-L-alanine, demonstrating that beta-cyano-L-alanine

243 In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to asp

244 1-(SS) and 1-(RR) are paramagnets with cyano-mediated Co(II)-W(V) magnetic couplings that lead

245 nd unpaired electron to the nitrogens of the cyano moieties and also, notably, to the silicon atoms o

246 r (SET) that is uniform from 4-methoxy- to 4-cyano-N,N-dimethylanilines.

247 ethyl]phenyl}-2-hydroxy-benzamide (CPPHA), 3-cyano-N-(1, 3-diphenyl-1H-prazol-5-yl)benzamide (CDPPB),

248 r the mGluR5 positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) or CDPPB.

249 ed, as both the systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)

250 ors (mGluR5) positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)

251 Pharmacological treatments with 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, a posit

252 3; 3, X = H; 4, X = Br) photosensitized by 3-cyano-N-methylquinolinium perchlorate (3-CN-NMQ(+)) has

253 ion of the parent sulfoxides sensitized by 3-cyano-N-methylquinolinium perchlorate (3-CN-NMQ(+)ClO4(-

254 using bis(pinacolato)diboron (B2Pin2) and N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as reag

255 n of bis(pinacolato)diboron (B2 pin2 ) and N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) to a br

256 loying the electrophilic cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) as the cyano

257 ough N-directed ortho C-H activation using N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent

258 of alkenylboronic acids with delta- or gamma-cyano-N-tosylhydrazones.

259 Substitution with hydroxy, cyano, nitro, acetamido, and fluoro led to high inhibito

260 at 70 degrees C with bromoarenes containing cyano, nitro, ester, keto, fluoro, enolizable hydrogen,

261 of the amino acid, such as trifluoromethyl, cyano, nitro, ferrocenyl, boronato, or azido.

262 f about 6 A depth beyond the nitro oxygen or cyano nitrogen tip.

263 )12, cyanocycloheptatetraene 13, and finally cyano(phenyl)carbene (3)14 as evaluated by IR spectrosco

264 The FTLSs indicate that p-cyano phenylalanine incorporated at two positions is eng

265 he same linear dependence is observed with p-cyano phenylalanine, cyanylated cysteine, or cyanylated

266 his goal, isotopically labeled p-((13)C(15)N-cyano)phenylalanine was synthesized, site-selectively in

267 We demonstrate that cyano-phenylalanine (Phe(CN)) can be utilized to probe t

268 hing vibration of an unnatural amino acid, p-cyano-phenylalanine, to directly probe how TMAO affects

269 o[b,d]pyr an-3-yl]-2-methyl-propanoic acid 3-cyano-propyl ester (AM7438), showed picomolar affinity f

270 oal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structur

271 f an aryl sulfone as a replacement for the 3-cyano pyridyl group.

272 Silicon nitride (SiN) and the cyano radical (CN) are isoelectronic; however, their che

273 ompared to the isoelectronic reaction of the cyano radical (CN) with acetylene, the replacement of th

274 nitrogen atom to the acetylene molecule, the cyano radical adds barrierlessly with the carbon atom fo

275 double bond of ethylene; in comparison, the cyano radical adds via its carbon atom.

276 ons of ethylene with silicon nitride and the cyano radical, the silaisonitrile over the silanitrile a

277 s and also the distinct differences with the cyano radical-ethylene system.

278 he elementary reactions of ethynyl (CCH) and cyano radicals (CN) with unsaturated hydrocarbons.

279 Cyano radicals and excited carbon monoxide molecules in

280 bundant vinyl cyanide and its radical or via cyano radicals reacting with 1,3-butadiene.

281 -N-phenyl-p-toluenesulfonamide (NCTS) as the cyano source, efficient decarboxylative cyanation chemis

282 te [2](2-) to be an unusual high-spin Co(II)-cyano species (S = 3/2), while IR, EXAFS, and EPR spectr

283 Functionalization of tetracene with cyano substituents yields a more stable chromophore with

284 eveloped due to ICT in the moderately stable cyano substituted enolate intermediate.

285 tones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl beta-positi

286 vatives RNC: under heating conditions gave a cyano-substituted boronium [L2PhBCN]BF4 5 and a 2-borany

287 and B-H hydride donors transfer hydride to a cyano-substituted carbon of DDQ is supported by quantum-

288 mechanism can even lead to the formation of cyano-substituted naphthalene cores in the interstellar

289 Here, we focus on thiacloprid, a widely used cyano-substituted neonicotinoid thought to be less toxic

290 ,beta-unsaturated alpha-cyanoketones gives 5-cyano-substituted pyrimidines.

291 The key step involves a cyano-substituted TMM cycloaddition, which proceeds in n

292 work, benzannulation together with terminal cyano-substitution was demonstrated to be an efficient a

293 Furthermore, chloro, fluoro, or cyano substitutions on the 4- and 6-positions of the ind

294 iotin was attached to the surface in a mixed cyano-terminated silane monolayer.

295 (iii) A web service, the CYANO-VECTOR assembly portal, which was built to organiz

296 atility in the mechanism by which it removes cyano versus alkyl ligands in cobalamin.

297 ial discussion about a special reactivity of cyano- versus iodocuprates concentrated on the existence

298 bearing various substituents (chloro, bromo, cyano, vinyl, phenyl, carbethoxy, nitro, etc.) followed

299 nking reaction is possible via ligation of a cyano-vinyl carbazole nucleoside with an opposite thymin

300 nalities such as chloro, bromo, hydroxy, and cyano were also amenable to the developed reaction.

301 ons of four pyridinium salts (4-phenyl and 4-cyano with N-methoxy and N-ethoxy substituents) led to a