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1 rated that in analogy to cyclic urea, cyclic cyanoguanidines also displace the unique structural wate
2 re studies of the HIV PR complex with cyclic cyanoguanidine demonstrated that in analogy to cyclic ur
5 zamides with N-(substituted-pyridin-3-yl)-N'-cyanoguanidines furnished N-{2,2-dichloro-1-[N'-(substit
8 tructure-activity relationship of the cyclic cyanoguanidines is compared with that of the correspondi
10 found that bioisosteric replacement of the N-cyanoguanidine moiety of pinacidil (1, Figure 1) with a
11 lockers, the sulfonylurea glyburide, and the cyanoguanidine N-[1-(3-chlorophenyl)cyclobutyl]-N'-cyano
13 as strongly influencing inhibition, with the cyanoguanidine side chain of cimetidine and tiotidine ha
14 We disclose the design of a novel series of cyanoguanidines that are potent (IC(50) approximately 10
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