ライフサイエンスコーパス: cyclase

1 sized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

2 eports that CO2 directly stimulates adenylyl cyclase.

3 ying potassium channels, as well as adenylyl cyclase.

4 apparent affinity with its target guanylate cyclase.

5 Gbetagamma, Akt, NOS, and soluble guanylate cyclase.

6 ical agents involving activation of adenylyl cyclase.

7 from beta-adrenergic receptors to adenylate cyclase.

8 l nitric oxide synthase and soluble guanylyl cyclase.

9 nse requires mechanisms upstream of adenylyl cyclase.

10 ting of the haem moiety of soluble guanylate cyclase.

11 y, we hypothesize that AMP inhibits adenylyl cyclase.

12 tly related to promoting dimerization of the cyclase.

13 ued by pharmacological blockade of adenylate cyclase.

14 ncoupled respiration downstream of adenylate cyclase.

15 up with the known L. clavatum alpha-onocerin cyclases.

16 PS) and activating Ca(2+) regulated adenylyl cyclases.

17 P-gated cation channels and distal guanylate cyclases.

18 domain of a human retinal membrane guanylyl cyclase 1 (RetGC1) linked to autosomal dominant cone-rod

19 2+)-sensitive activation of retinal guanylyl cyclase 1 (RetGC1).

20 Nitric Oxide Synthase 3 [NOS3] and Guanylate Cyclase 1, Soluble, Alpha 3 [GUCY1A3]) with a range of h

21 nd GCAP2) to their membrane target guanylate cyclase 1.

22 mes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

23 ), reduced the RD3 apparent affinity for the cyclase 180-700-fold.

24 Three SNPs within adenylate cyclase 2 (ADCY2) showed the same direction of the inter

25 s, as the endogenous ligand for the guanylyl cyclase 2C receptor has revealed a new system in the reg

26 Adenylate cyclase 3 (Adcy3) has been shown to colocalize with the

27 l ciliary cAMP level is a result of adenylyl cyclase 5 and 6 activity that depends on ciliary phospha

28 Adenylate cyclase 5 catalyzes the production of cyclic AMP, which

29 rons of ADCY5, a gene that encodes adenylate cyclase 5.

30 the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

31 ubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed.

32 omal cell-derived factor 1 (SDF1), adenylate cyclase 7 (ADCY7), and p21 protein-activated kinase 1 (P

33 th known (TSHR, GNAS) or presumed (adenylate cyclase 9 [ADCY9]) alterations in cAMP pathway genes.

34 ascular outcomes are determined by adenylate cyclase 9 gene polymorphisms.

35 for the rs1967309 polymorphism in adenylate cyclase 9.

36 However, both inhibition of adenylate cyclase A (ACA) with SQ22536 and incubation of a tempera

37 ylate (c-di-GMP), synthesized by diguanylate cyclase A (DgcA), induces stalk formation.

38 type natriuretic peptide (BNP) is a guanylyl cyclase A (GC-A) agonist.

39 or (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent study has shown that many APDs affect

40 wn that NPs, via their cGMP-forming guanylyl cyclase-A (GC-A) receptor and cGMP-dependent kinase I (c

41 Guanylyl cyclase-A (GC-A) signaling, a natriuretic peptide recept

42 Guanylyl cyclase-A (GC-A), the transmembrane cGMP-producing recep

43 the reaction mechanism of the spirotetronate cyclase AbyU, an enzyme shown here to be a bona fide nat

44 Adenylyl cyclase (AC) activity relies on multiple effectors actin

45 prostaglandin E2 (PGE2) stimulates adenylyl cyclase (AC) and attenuates the increase in intracellula

46 SA requires continuing activity of adenylyl cyclase (AC) and cAMP-dependent protein kinase (PKA), as

47 soluble guanylyl cyclase (sGC) or adenylate cyclase (AC) specific inhibitors.

48 mans has recently implicated type 3 adenylyl cyclase (AC3; ADCY3) in MDD.

49 ll occurred in mutants lacking the adenylate cyclases ACG or ACR, or the cAMP phosphodiesterase RegA.

50 s synthesized by nine transmembrane adenylyl cyclases (ACs) and one soluble AC (sAC).

51 detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodiesterases (PDEs) since their

52 he presence of at least 15 distinct adenylyl cyclases (ACs).

53 n shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate P

54 Pituitary adenylate cyclase activating polypeptide (PACAP) is an excitatory

55 s of blocking glutamate, pituitary adenylate cyclase activating polypeptide, and microglia in the RVL

56 s, such as glutamate and pituitary adenylate cyclase activating polypeptide, whose expression is incr

57 art, human RPS23RG1 interacts with adenylate cyclase, activating PKA/CREB, and inhibiting GSK-3.

58 The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in the bed nu

59 cent work indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) plays an importan

60 idence suggests that the pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1 receptor sys

61 Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its

62 The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a pot

63 o acid substitution p.L176F in the guanylate cyclase-activating protein 1 (GCAP1).

64 We tested direct binding of guanylate cyclase-activating proteins (GCAP1 and GCAP2) to their m

65 talytic activity and stimulation by guanylyl cyclase-activating proteins (GCAPs).

66 ects of both nitric oxide-sensitive guanylyl cyclase activation and inhibition of the cGMP-degrading

67 kade by JD-5037 results in stronger adenylyl cyclase activation compared to rimonabant and it is a be

68 ogenitors transform in response to adenylate cyclase activation from being UCP1 negative to being UCP

69 and NOS stimulation and subsequent guanylyl cyclase activation that probably occurred in pericytes.

70 ress this question, including specificity of cyclase activation, tuned binding constants of effector

71 l stimulation of cAMP generation by adenylyl cyclases (activation phase) and cAMP hydrolysis by phosp

72 stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by inhibitors

73 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosolic localiz

74 we demonstrated that forskolin, an adenylyl cyclase activator, significantly increased the frequency

75 n Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodiesterase inhibitors, and mo

76 knockout of the ANP receptor with guanylate cyclase activity (betaGC-A-KO).

77 biosensor was used to screen for diadenylate cyclase activity and confirmed the enzymatic activity of

78 nt fluorescence-based assays to measure ADPR cyclase activity in Arabidopsis and found that this acti

79 osphorylation of NPR2 decreases its guanylyl cyclase activity in growth plate chondrocytes in living

80 ield, CB1b is a potent regulator of adenylyl cyclase activity in peripheral metabolic tissues.

81 ve cyaB homolog) was shown to have adenylate cyclase activity in vitro; however, mutants with mutatio

82 Therefore, the guanylate cyclase activity of BRI1 is modulated by the kinase whil

83 to determine whether the low levels of ADPR cyclase activity reported in Arabidopsis are indicative

84 between catalytic domain complementation and cyclase activity upon stimulation with forskolin and Gal

85 enlandia affinis that displayed weak peptide cyclase activity, despite having a similar structural fo

86 ounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Colly behav

87 To investigate the regulation of the cyclase activity, we isolated the guanylyl cyclase domai

88 ein exhibits robust light-dependent guanylyl cyclase activity, whereas a truncated form lacking the 1

89 ls through effects on transmembrane adenylyl cyclase activity.

90 nsistent with the impairment of Mg-proto MME cyclase activity.

91 ved motifs required for farnesyl diphosphate cyclase activity.

92 t, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to

93 essenger synthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

94 RET) sensor that functions both as a soluble cyclase and a reporter of complementation within the cat

95 as G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but some alte

96 al renal tubule), possibly through adenylate cyclase and cyclic AMP signaling and a cytoplasmic heat-

97 th an activity that is dependent on both the cyclase and HD nuclease domains of the Cas10 subunit, su

98 y be a link between the catalytic state of a cyclase and its physical contact with an effector.

99 ed by neuronal activity via soluble adenylyl cyclase and protein kinase A (PKA) signaling.

100 ress a mutated PTH1R that activates adenylyl cyclase and protein kinase A (PKA) via Gsalpha but not p

101 promote CFTR opening by activating adenylate cyclase and we show that Ca(2+)-stimulated type I adenyl

102 by the balance of cAMP synthesis by adenylyl cyclases and degradation by phosphodiesterases (PDEs).

103 r understand how dynamic networks of sibling cyclases and effector proteins result in sensible output

104 r proteins, and physical interaction between cyclases and effectors.

105 he stability and/or trafficking of guanylate cyclases and maintaining ER and mitochondrial homeostasi

106 s belonging to a broad family of diguanylate cyclases and phosphodiesterases to highlight their speci

107 emical biology, focusing mainly on terpenoid cyclases and related prenyltransferases for which X-ray

108 s a catalytic center diagnostic for guanylyl cyclases and the recombinant AtPNP-R1 is capable of cata

109 on to accommodate the emergence of adenylate cyclases and thus the signaling molecule 3',5'-cAMP.

110 1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice.

111 lation and inactivation of the NPR2 guanylyl cyclase, and cGMP hydrolysis is increased by activation

112 rrents in Xenopus laevis oocytes by adenylyl cyclase- and protein kinase A (PKA)-dependent mechanisms

113 its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a kn

114 et al. show that different forms of adenylyl cyclase are activated at the plasma membrane versus endo

115 ugation, whereas other class III nucleotidyl cyclases are functional dimers.

116 e-integral and soluble adenylyl and guanylyl cyclases, are central components in a wide range of sign

117 The role of the terpenoid cyclase as a template for catalysis is paramount to its

118 n of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transforming pr

119 e natriuretic peptide activation of guanylyl cyclase B (GC-B), also known as natriuretic peptide rece

120 r C-type natriuretic peptide (CNP), guanylyl cyclase B (GC-B, also known as Npr2 or NPR-B), increase

121 We make an argument for adenylyl cyclases being central to the formation and maintenance

122 through the introgression of a lycopene beta-cyclase (beta-Cyc) allele from a Solanum galapagense bac

123 Swapping cyclases between cyanobacteria and purple phototrophic b

124 inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these t

125 se (AMPK) via direct inhibition of adenylate cyclase by AMP.

126 Blockade of adenylate cyclase by its inhibitor reversed PGE2-mediated NLRP3 in

127 Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguan

128 racrine hormones of the intestinal guanylate cyclase C (GUCY2C) receptor.

129 f the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracr

130 Guanylyl cyclase C (GUCY2C), a membrane-bound guanylyl cyclase ex

131 (Ad5) combination regimen targeting guanylyl cyclase C (GUCY2C), a receptor expressed by intestinal m

132 reacting with the human endogenous guanylate cyclase C receptor ligands.

133 activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding protein (

134 c inhibitory action of GnIH on the adenylate cyclase/cAMP/protein kinase A pathway, suggesting a comm

135 anding how a cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a

136 r sulfurreducens showed it is a dinucleotide cyclase capable of switching the major cyclic dinucleoti

137 trated to contain a biosynthetic operon with cyclases capable of producing the universal GA precursor

138 ive kinase and also encapsulates a guanylate cyclase catalytic centre.

139 and on delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the cytosol, g

140 Terpenoid cyclases catalyze the most complex chemical reactions in

141 e: poly(ADP-ribose) polymerases, ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIRT1-7).

142 The nitric oxide-sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling p

143 tablishing a catalytically competent dimeric cyclase conformation.

144 A guanylate cyclase construct containing the juxta-membrane and kina

145 drastin, or terretonin structural classes by cyclase-controlled rearrangement pathways.

146 Adenylate cyclases convert intra- and extracellular stimuli into a

147 get cells by binding to specialized guanylyl cyclase-coupled receptors, resulting in cGMP generation.

148 he efficacy of soluble/particulate guanylate cyclase coupling to cGMP in cardiac dysautonomia.

149 ic portion of the membrane-integral adenylyl cyclase Cya from Mycobacterium intracellulare in a nucle

150 (PSY) and chromoplast-specific lycopene beta-cyclase (CYCB) alleles.

151 efective in the fruit-enhanced lycopene beta-cyclase (CYCB).

152 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggested that cA

153 nactivation of a gene coding for diadenylate cyclase (DAC), a c-di-AMP producing enzyme, resulted in

154 ncluding the gene coding for the diadenylate cyclase DacA.

155 Listeria monocytogenes, the sole diadenylate cyclase, DacA, is essential in rich, but not synthetic m

156 -type Brucella or the low-c-di-GMP guanylate cyclase DeltacgsB mutant.

157 by planktonic PAO1 requires the diguanylate cyclase (DGC) SadC, previously identified as a regulator

158 The role of this region in cyclase dimerization has been a subject of debate.

159 e corresponding regions of human nucleotidyl cyclases disrupt the normal helical domain structure.

160 e cyclase activity, we isolated the guanylyl cyclase domain from Escherichia coli with (GCwCCRho) and

161 a helical region that precedes the catalytic cyclase domain.

162 ng a type I rhodopsin domain with a guanylyl cyclase domain.

163 This reaction is catalyzed by two unrelated cyclase enzymes using different chemistries.

164 Cyclase enzymes weave simple polyprenyl chains into the

165 yclase C (GUCY2C), a membrane-bound guanylyl cyclase expressed in intestinal epithelial cells, binds

166 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAADP and cA

167 GMP-stimulated phosphodiesterases, adenylate cyclases, FhlA) domain that binds BCAAs and a winged hel

168 ies aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.

169 plants and is instead related to a lycopene cyclase from photosynthetic bacteria(3).

170 by expression of a light-activated adenylate cyclase from the ACA promoter and exposure to light, ind

171 RhoGC is a rhodopsin (Rho)-guanylyl cyclase (GC) gene fusion molecule that is central to zoo

172 ) is critical in the regulation of guanylate cyclase (GC) signaling and photoreceptor cell survival.

173 ation is required for activation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, by cardiac

174 ripherin/rds; however, the retinal guanylate cyclases GC1 and GC2 were severely affected in the Reep6

175 from its receptor, the NO-sensitive guanylyl cyclase (GC1).

176 hosphodiesterase (PDE6) and retinal guanylyl cyclases (GCs), and mutations in genes that disrupt cGMP

177 tivation of receptor enzymes called guanylyl cyclases (GCs).

178 ensory receptor, the receptor-type guanylate cyclase GCY-9, to cilia in chemosensory neurons of the n

179 bitors of an NRE-localized receptor-guanylyl-cyclase, GCY-8, which synthesizes cyclic guanosine monop

180 ain or a strain overexpressing a diguanylate cyclase gene lost viability upon toluene shock.

181 udy, we recombined a more potent diguanylate cyclase gene, VCA0848, into a nonreplicating adenovirus

182 y genes, including hns and vieA, diguanylate cyclase genes, and genes belonging to the lysR and gntR

183 rotein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> neuritogenic cAMP sensor-Rapgef2 --

184 rotein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response element-bindi

185 These neurons express the soluble guanylate cyclase Gucy1b2 and the cation channel Trpc2.

186 riociguat, a stimulator of soluble guanylate cyclase, has proven efficacious.

187 ough mutations within this region in various cyclases have been linked to genetic diseases, the molec

188 of additional standalone [Formula: see text]-cyclases have been reported as potential Diels-Alderases

189 ith significant similarity to the known ADPR cyclases have been reported in any plant genome database

190 tica eudoraenol synthase is an oxidosqualene cyclase homologous to bacterial lanosterol synthases and

191 FP, the Chp system, FimL, FimV and adenylate cyclase homologs, suggesting that surface sensing may be

192 of odorant receptors (ORs) leads to adenylyl cyclase III activation, cAMP increase, and opening of cy

193 data delineate three classes of O2-dependent cyclase in chlorophototrophic organisms from higher plan

194 y to inhibit RetGC1 and co-localize with the cyclase in co-transfected cells.

195 AcsF is the cyclase in Rvi.

196 re unable to identify a functional adenylate cyclase in S. aureus and only detected 2',3'-cAMP but no

197 with the RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-bromo-cyclic A

198 erated a duodecuple mutant of 12 diguanylate cyclases in V. cholerae.

199 ase while cGMP, the product of the guanylate cyclase, in turn inhibits BRI1 kinase activity.

200 Nucleotidyl cyclases, including membrane-integral and soluble adenyl

201 oteins with all Galphai/o subunits, adenylyl cyclase inhibition, and beta arrestin recruitment.

202 the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein kinase A a

203 SAN4825, an ADP-ribosyl cyclase inhibitor that reduces cADPR and NAADP synthesis

204 ither a Ca(2+) channel blocker or a guanylyl cyclase inhibitor.

205 In addition to L-NAME, the guanylyl cyclase inhibitors ODQ and thrombospondin-1 also abated

206 y incorporated a Vibrio cholerae diguanylate cyclase into an adenovirus vaccine, fostering production

207 ding sites formed by distant portions of the cyclase intracellular domain.

208 (93) profoundly reduced RD3 affinity for the cyclase, irrespective of their relative helix propensiti

209 The SadC diguanylate cyclase is associated with this patho-adaptive transitio

210 show that Ca(2+)-stimulated type I adenylate cyclase is expressed in the developing human lung.

211 acking one of the two NO-sensitive guanylate cyclase isoforms [NO-GC1 knockout (KO) or NO-GC2 KO].

212 of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal in the cy

213 rast, in Lycopodium clavatum, two sequential cyclases, LcLCC and LcLCD, are required to produce alpha

214 erent protein families including unknown and cyclase-like proteins.

215 as dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to behavioral

216 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region.

217 ates that this domain is an integral part of cyclase machinery across protein families and species.

218 as well as Gi inhibition of type 1 adenylyl cyclase may underlie the experimental observations.

219 meable 8Br-cAMP under inhibition of adenylyl cyclase-mediated cAMP production by MDL 12330A.

220 nce GABA release through a soluble guanylate cyclase-mediated pathway.

221 by further increases in LOX and allene oxide cyclase mRNA and protein levels.

222 e identified and characterized a diadenylate cyclase, named CdaA, in S. mutans.

223 eved by expressing the nisA structural gene, cyclase (nisC) and dehydratase (nisB), together with an

224 activates the NO-sensitive soluble guanylate cyclase (NO-GC, sGC) and triggers intracellular signalin

225 thological differentiation via the guanylate cyclase NPR2 (natriuretic peptide receptor 2) and not th

226 s at the Fe(2+) centres of soluble guanylate cyclase or cytochrome c oxidase.

227 either failed to prevent RD3 binding to the cyclase or had a much smaller effect.

228 MP and activate PKA (activators of adenylate cyclase or inhibitors of phosphodiesterase 4) promoted d

229 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB phosphoryla

230 tome analysis of the roots, an oxidosqualene cyclase, OsONS1, was identified that produces alpha-onoc

231 ypothesized that a photoactivatable adenylyl cyclase (PAC) can be employed to modulate cAMP in beta-c

232 tor constitutively activates the Gs/adenylyl cyclase pathway in various cell types, including neurons

233 cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and receptor tyros

234 ox gene Emx1 is expressed in three guanylate cyclase(+) populations, two located in the MOE and the t

235 tors couple to G-protein activating adenylyl cyclase, producing cAMP.

236 ic oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vaso

237 gelatinosus, whereas alphaproteobacterial cyclases require a newly discovered protein that we term

238 d the functionality of CfcR as a diguanylate cyclase requires the multisensor CHASE3/GAF hybrid histi

239 rs of NO synthase (NOS) and soluble guanylyl cyclase, respectively, abolished tadalafil induction of

240 rmal expression of retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC cat

241 We show that AFD-specific receptor guanylyl cyclases (rGCs) are instructive for thermosensation.

242 ces, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cycl

243 , the cAMP-producing enzyme soluble adenylyl cyclase (sAC) is expressed in pigment cells, and its inh

244 expression and activity of soluble adenylyl cyclase (sAC), an evolutionarily conserved bicarbonate s

245 ce in the flagellum is the soluble adenylate cyclase (SACY).

246 to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are

247 resulting in activation of soluble guanylate cyclase (sGC) and cGMP-mediated vasodilation.

248 Epigenetic regulation of soluble guanylate cyclase (sGC) beta1 in breast cancer cells.

249 e coordination in purified soluble guanylate cyclase (sGC) by time-resolved spectroscopy in a time ra

250 RATIONALE: Soluble guanylate cyclase (sGC) heme iron, in its oxidized state (Fe(3+)),

251 10 mumol l(-1) , n = 6) or soluble guanylate cyclase (sGC) inhibitor ODQ (1H-[1,2,4]oxadiazolo[4,3-a]

252 Soluble guanylate cyclase (sGC) is a heterodimer composed of alpha and bet

253 Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a hig

254 in this pathway, including soluble guanylyl cyclase (sGC) itself, the NO -activated form of sGC, and

255 in the above effects using soluble guanylyl cyclase (sGC) or adenylate cyclase (AC) specific inhibit

256 The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduc

257 s the alpha1 subunit of the soluble guanylyl cyclase (sGC), a key enzyme in the nitric oxide/cGMP sig

258 Soluble guanylate cyclase (sGC), a key enzyme of the nitric oxide signalin

259 c oxide synthase (nNOS) and soluble guanylyl cyclase (sGC), and can be mimicked by the nitric oxide (

260 rway smooth muscle enzyme, soluble guanylate cyclase (sGC).

261 Soluble guanylate cyclases (sGCs) are gas-binding proteins that control di

262 Significance statement: Soluble guanylate cyclases (sGCs) control essential and diverse physiologi

263 EA) who were receiving the soluble guanylate cyclase stimulator riociguat.

264 hodiesterase-5 inhibitors, soluble guanylate cyclase stimulators, prostacyclin analogues, and prostac

265 the encoded protein, Galphaolf, an adenylyl-cyclase-stimulatory G-protein highly enriched in striata

266 Here, I review key advances in terpenoid cyclase structural and chemical biology, focusing mainly

267 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio of terpenoid cyclase

268 lase structural biology: a trio of terpenoid cyclase structures reported together in 1997 were the fi

269 nosus These results indicate that Ycf54 is a cyclase subunit in oxygenic phototrophs, and that differ

270 ocial amoebae reveal the presence of terpene cyclases (TCs) in these organisms.

271 yme to a specific, light-stimulated adenylyl cyclase that catalyzes the formation of cAMP from ATP.

272 iridoid synthase (OeISY), an unusual terpene cyclase that couples an NAD (P)H-dependent 1,4-reduction

273 is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleos

274 vity has the characteristics of a nucleotide cyclase that is activated by nitric oxide to increase cA

275 -AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiesterase (PD

276 l signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behavior

277 taining enzymes were shown to be diguanylate cyclases that produce cyclic di-GMP (cdiG), a second mes

278 the expected presence of class II diterpene cyclases that produce the intermediate copalyl diphospha

279 Adenylyl cyclases, the enzymatic source of cAMP production, are k

280 otein alpha subunits that activate adenylate cyclase, thereby serving as crucial mediators of intrace

281 (sAC) in addition to transmembrane adenylyl cyclases (tmACs).

282 ategy that uses a photoactivatable adenylate cyclase to achieve real-time regulation of cAMP and the

283 CD99 signals through soluble adenylyl cyclase to activate PKA to trigger ongoing targeted recy

284 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenesis.

285 terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GABA release

286 Adenylate cyclase toxin (ACT or CyaA) plays a crucial role in resp

287 Adenylate cyclase toxin (ACT) is a critical factor in establishing

288 The adenylate cyclase toxin (ACT) is a multifunctional virulence facto

289 ssis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host cells to a

290 oping cough, secretes and releases adenylate cyclase toxin (ACT), which is a protein bacterial toxin

291 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immun

292 Adenylate cyclase translocation assays revealed 13 proteins were s

293 Here we utilized the bacterial adenylate cyclase two-hybrid method and carried out a saturation m

294 to the full-length membrane-bound guanylate cyclase type 1.

295 Adenylyl cyclase type 5 knockout (AC5KO) mice have increased long

296 Adenylyl cyclase type 9 (AC9) is found tightly associated with th

297 ive site, which requires dimerization of the cyclase, was formed even when Met(823) or Arg(822) was m

298 Stimulation of endogenous adenylate cyclase with forskolin or inhibition of phosphodiesteras

299 or cADPR synthesis or that a homolog of ADPR cyclase with low similarity might exist in plants.

300 to different regions on the target guanylate cyclase with submicromolar affinity (apparent KD-values