ライフサイエンスコーパス: cycle

1 ntered throughout its tick-mammal infectious cycle.

2 in Rhode Island sediments over the seasonal cycle.

3 the external world thanks to the light/dark cycle.

4 e passage to the succeding stage of the cell cycle.

5 lenged the prevailing view of the ocean iron cycle.

6 molecule modulators of the Hsp70 allosteric cycle.

7 ajor gateway in the global geochemical water cycle.

8 sis dynamometer using the cold-start unified cycle.

9 he force-generating step in the cross-bridge cycle.

10 y, mid, and late S phase of the mitotic cell cycle.

11 t life-history stages across the annual life cycle.

12 cycles with capacity fade of only 0.001% per cycle.

13 biosynthesis through to the mammalian visual cycle.

14 ll entry, and other stages of the viral life cycle.

15 ametocyte development in the subsequent cell cycle.

16 tion are changed during an entire algal life cycle.

17 ncorporated in the mammalian genome per cell cycle.

18 abolism, oxidative stress response, and cell cycle.

19 t require IMPalpha/beta1 in their infectious cycle.

20 ceptors and distinct modulations of the cell cycle.

21 as a considerable impact on the wider carbon cycle.

22 jejuni factors essential throughout its life cycle.

23 netics to model a minimal eight-state ATPase cycle.

24 ales and females and across the reproductive cycle.

25 al binary fission but undergo unconventional cycles.

26 bacteriophages play essential roles in life cycles.

27 elow Tmix, over multiple heating and cooling cycles.

28 4% increase in resistance after 4000 bending cycles.

29 n days 1, 8, 15, and 22) in 28 day treatment cycles.

30 to inosine modifications in retroviral life cycles.

31 e DDR during the course of their replicative cycles.

32 ologic and nonhematologic toxicity than HDAC cycles.

33 hydro-refugia through orbital-scale climate cycles.

34 to RNA occurred in just one to a few wet-dry cycles.

35 m (CBB) and reverse tricaboxylic acid (rTCA) cycles.

36 6 mg/km on weeks 1 and 2 of 3-week repeated cycles.

37 oes a series of breakage-fusion-bridge (BFB) cycles.

38 ross ontogeny in organisms with complex life cycles.

39 volved in hair fiber morphogenesis during HF cycling.

40 part by fungal respiration and/or iron redox cycling.

41 photosynthesis on Pacific AMZ biogeochemical cycling.

42 ab ozogamicin (starting dose 1.8 mg/m(2) per cycle [0.8 mg/m(2) on day 1; 0.5 mg/m(2) on days 8 and 1

43 ected from patients before treatment (day 1, cycle 1) or after treatment (after 2 cycles) for epigeno

44 13 patients received treatment cycle 2; ten (77%) of the 13 achieved a response.

45 es in the cytokinin receptors mediating cell cycle activation in feeding sites induced by BCN and RKN

46 protein that is itself inhibited by the cell-cycle activator, their interaction network presents a re

47 on networks, composed of phase-specific cell-cycle activators and inhibitors.

48 Precise control of the cell cycle allows for timely repair of genetic material prior

49 escribe herein its structure and replicative cycle, along with genomic analysis and genomic compariso

50 with anti-alpha-tubulin antibodies and cell cycle analysis indicated that tubulin and/or microtubule

51 tress, but impaired tricarboxylic acid (TCA) cycle anaplerosis, macromolecule production, and redox h

52 population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts t

53 Topologically, these flow states are a limit cycle and a quasiperiodic solution on a two-torus, respe

54 eak (DSB) repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of

55 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progressio

56 or cells of the retina from exiting the cell cycle and differentiating.

57 In striking contrast, the regulation of cell-cycle and differentiation gene programs by MEF2C was ant

58 In this overview, we review the EBV life cycle and discuss our current understanding of the immun

59 nergy production components, including Krebs cycle and electron transport genes, decreased by 43% +/-

60 Transcriptional targets include cell cycle and epigenetic regulators (e.g., Foxo3, Plk1, Mycn

61 way delays cells in the G1 phase of the cell cycle and improves cell survival in response to growth-i

62 ase (PDH) is the main regulator of the Krebs cycle and is located upstream of the electron transport

63 aracteristics, explained its complex disease cycle and its ability to spread locally or over long dis

64 n sphingolipids, indicate that both the urea cycle and nitric oxide pathways are dysregulated at earl

65 essed in bone marrow ECs regulated HSPC cell cycle and quiescence during regeneration.

66 totoxic effects upon Caco-2 cells (MTT, cell cycle and reactive oxygen species (ROS)) were evaluated

67 aller pool of OPCs results from altered cell cycle and reduced cell proliferation.

68 llulose degradation is central to the carbon cycle and renewable biotechnologies.

69 here, is a major component of the hydrologic cycle and surface energy balance.

70 hospholipid metabolism is linked to the cell cycle and that changes in membrane composition can facil

71 ions across different portions of the annual cycle and understanding the effects of variation in weat

72 apacity retention after 400 charge/discharge cycles and a capacity of 1.2 mAh/cm(2) in a carbonate-ba

73 e an integral part of Earth's biogeochemical cycles and a promising resource for the synthesis of ren

74 re similar to Vip(-/-) mice under light-dark cycles and only somewhat worse in constant conditions.

75 xposed that directly reflect ultradian sleep cycles and replicate the dynamics of laboratory sleep pa

76 S-acylation/deacylation cycles and vesicular transport are critical for an adequ

77 understanding of global carbon and nitrogen cycling and a reduction in the uncertainty of carbon-cli

78 ca and has potential to dramatically alter C cycling and accumulation in these ecosystems.

79 es in ecosystem functioning, global nutrient cycling and climate regulation, but are declining in the

80 nigral afferents is essential for the normal cycling and maintenance of neural stem cells (NSCs) in t

81 e critical for plant fitness, biogeochemical cycling and other processes.

82 ale evidence for changing conditions of iron cycling and stability of iron minerals it does not provi

83 as vitamin metabolism, the citric acid (TCA) cycle, and amino acid metabolism.

84 f pathways mediating energy metabolism, cell cycle, and B cell receptor signaling.

85 excitations persisting for nearly 1 billion cycles, and for their low optical nonlinearity.

86 anti-atoms accumulated from five consecutive cycles.Antihydrogen studies are important in testing the

87 interventions as part of an integrated life cycle approach to development.

88 lly forced systems and show that, when limit cycles are considered, a transient structure, so-called

89 The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but l

90 tion, essential steps in the Plasmodium life cycle, are targets of existing antimalarials.

91 roliferation/viability and by promoting cell-cycle arrest and apoptosis.

92 6, which together induces autophagy and cell cycle arrest and benefits virus replication.

93 UV-induced PAF also activates cell cycle arrest and disrupts DNA repair, in part by increas

94 ter mechanism involves p38-dependent G1 cell-cycle arrest and subsequent intrinsic mitochondrial apop

95 that CDK4/6 inhibition failed to induce cell-cycle arrest or senescence.

96 RR inhibitor 3-AP actively induces PEL cell cycle arrest through inhibiting the activity of the nucl

97 er cells by inducing both apoptosis and cell cycle arrest, and that reducing DHX33 levels through sho

98 wever, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor c

99 and later antagonizes TGFbeta-mediated cell cycle arrest, yet remains critical for the pathological,

100 target genes that induce apoptosis and cell-cycle arrest.

101 ell proliferation through initiation of cell cycle arrest.

102 Unlike animals, plants can pause their life cycle as dormant seeds.

103 e results establish circadian clock and cell cycle as interdependent coupled oscillators and identify

104 rom categories including metabolism and cell cycle, as well as RNA- and protein-modifying enzymes tha

105 equences of N limitation in coupled nutrient cycles, as well as modeling and forecasting nutrient con

106 mvent the limitations of scenario-based life cycle assessment (LCA), we develop a multiobjective opti

107 We present a Life Cycle Assessment of coal-fired electricity generation th

108 ase, the biochemical step in myosin's ATPase cycle associated with force generation and the conversio

109 Crucially, abolishing cell cycle asynchrony consistently disrupted the spindle orie

110 n/graphene-SeS2 full cell is 81% after 1,500 cycles at 268 mA gSeS2(-1).

111 introduces no addition time to the scan duty cycle but generates MS/MS spectra rich in b/y-type and c

112 is inhibited during the G1 phase of the cell cycle, but both pathways are active in the S and G2 phas

113 y trafficking to support their intracellular cycle, but knowledge of these pathogenic processes is li

114 e kinase (AK) throughout its active reaction cycle by characterization of complexes containing AK and

115 ce of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1 nuclear localizati

116 amined the individual steps in the transport cycle by recording transporter-associated currents: the

117 ides might have driven the patients' bipolar cycles, by periodically entraining the circadian pacemak

118 The N(tz) ADP(+) /N(tz) ADPH cycle can be monitored in real time by fluorescence spec

119 It was found that velocity recovery cycles can distinguish whether a sympathetic nerve fibre

120 Slow-cycling cells with high Notch activity and histone demet

121 ty of ATR inhibition to abrogate the G2 cell cycle checkpoint both contributed to the synergistic ind

122 We showed here that E7 abrogated the G1 cell cycle checkpoint under hypoxia and analyzed key cell cyc

123 d to the liver and a higher median number of cycles (close to 12).

124 GCs reentrain faster to a delayed light/dark cycle compared with mice expressing virally encoded WT m

125 In this regard, the evolution of life cycle complexity promotes phenotypic diversity.

126 these incubations shed new light on nitrogen cycling complexity and possible factors underlying varia

127 Standardized respiratory cycles consisted of a deep standardized inspiration foll

128 Although size-related C cycle contributions did not vary systematically across t

129 Loss of cell-cycle control is a hallmark of human cancer.

130 etinal differentiation independently of cell-cycle defects.

131 ogression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mo

132 eg (nasal area, 1,700 cells/mm(2) ), and 4.2 cycles/deg (horizontal streak, 250 cells/mm(2) ).

133 deg (temporal area, 1,800 cells/mm(2) ), 7.7 cycles/deg (nasal area, 1,700 cells/mm(2) ), and 4.2 cyc

134 upper limits of spatial resolving power of 8 cycles/deg (temporal area, 1,800 cells/mm(2) ), 7.7 cycl

135 re, we investigate size control and the cell cycle dependence of bacterial growth using multigenerati

136 s in combination with chemical double-mutant cycles (DMCs) have been used to study the competition of

137 antify anthropogenic impacts on the nitrogen cycle do not explicitly consider nitrate stored in the v

138 rations fluctuate over the estrous/menstrual cycle, dynamically modulating estrogen receptor (ER) exp

139 mplex, a rate-controlling tricarboxylic acid cycle enzyme.

140 w these larger fluctuations in archaeal cell cycle events contribute to cell size variability and con

141 ro accumulation that, in turn, promotes cell cycle exit.

142 At least six miRNAs show cycling expression levels within the pigment dispersing

143 Future work on glaciation-weathering-carbon cycle feedbacks should consider weathering of trace sulf

144 ssociated effects on biodiversity and carbon-cycle feedbacks to climate change.

145 tween serum E2 levels and pLTF expression in cycling female rats.

146 This is because ER-Golgi-cycling FKBP proteins contain a C-terminal KDEL-like seq

147 0.5 mg/m(2) on days 8 and 15 of a 21-28 day cycle for </=6 cycles]) or standard care (either fludara

148 The turnover-limiting step in the catalytic cycle for hydroboration of the internal alkene is insert

149 (day 1, cycle 1) or after treatment (after 2 cycles) for epigenomic and transcriptomic profiling usin

150 15 through 18, and 22 through 25 of a 28-day cycle, for 12 weeks.

151 in acutely infected mice, extending the life cycle from 24 h to 40 h.

152 essential for H3K9me2 demethylation at cell cycle gene loci.

153 luding WNT/beta-catenin alterations and cell-cycle-gene (CDK4 and CDK6) mutations.

154 loss of chromatin accessibility around cell cycle genes during postnatal maturation.

155 sing a suite of stress response and nutrient cycling genes to fix carbon under the fluctuating condit

156 ng coal-based electricity with net-zero life-cycle GHG.

157 lity and greening trend of the global carbon cycle given their mean lower productivity when compared

158 history and therefore whether the phosphorus cycle has consistently modulated biospheric productivity

159 licles to produce the human 28-day menstrual cycle hormone profile, which controls human female repro

160 ns emerge as a driver with dominant global C cycle impacts only in the most recent three millennia.

161 the exact magnitude of the resulting carbon cycle impacts remains to be confirmed, the radiocarbon d

162 may have a substantial influence on the life-cycle impacts.

163 ansitions so that completion of a mechanical cycle in a direction in which work is done on the enviro

164 F inhibited completion of the HCV infectious cycle in hepatoma cells and HFLCs in a dose-dependent an

165 malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of

166 ated with cell death and impacts on the cell cycle in three dinoflagellate species (Prorocentrum mini

167 skull size and body mass throughout the full cycle in wild recaptured shrews (Sorex araneus).

168 The palladium complex was reused up to four cycles in an open-flask condition.

169 l coupling of viral and cellular replication cycles in both photoautotrophic and heterotrophic bacter

170 eatment, and management of relapse/remission cycles in multiple sclerosis patients by providing infor

171 terferon (IFN) pathways, which enforced cell cycling in quiescent HSPCs, resulting in their apoptotic

172 led with a rapid transient rise in glutamate cycling in the medial prefronal cortex (mPFC) of awake r

173 cators to elucidate the complexity of carbon cycling in these ecosystems.

174 and PELDOR measurements along the transport cycle indicate that McjD does not undergo major conforma

175 Here we report data for the eight-cycle induction period, up to week 24.

176 in part by expression of the p16(INK4a) cell-cycle inhibitor.

177 anaplerotic refilling of tricarboxylic acid cycle intermediates in mouse brain during ischemic strok

178 nucleotides, but an increase in TCA and urea cycle intermediates.

179 A fuller understanding of the virus life cycle is important to aid control strategies.

180 ation between E2 and ChlR1 in the HPV16 life cycle is unresolved.

181 regulating PD-L1 protein stability by a cell cycle kinase and reveals the potential for using combina

182 Viability and cell cycle kinetics were measured by using flow cytometry.

183 oculum, plant population size and nodulation cycle length.

184 e of achieving a high energy density, a long cycle life and an excellent power density, has the poten

185 otential ( approximately 0.025 V) for a long cycle life.

186 es and centuries during glacial-interglacial cycles, likely causing rapid regional replacement of bio

187 g genes and down-regulation of the G2/M cell-cycle marker gene, CYCB1;1 TCP20 and NLP6&7 also support

188 itogens and accompanied by induction of cell-cycle markers, including phosphorylation of the retinobl

189 usly been shown to be modulated by the Krebs cycle metabolite citrate in Escherichia coli.

190 ressing KDM5B in response to dosing with TCA cycle metabolite pro-drug esters, suggesting that the hi

191 oxidative phosphorylation and changes in TCA cycle metabolites, as well as decreased mitochondrial me

192 pressed during only one stage of the estrous cycle (metestrus).

193 al and idler pulses to generate 33 muJ, 0.88-cycle, multi-gigawatt pulses centred at 4.2 mum, which

194 Most abortive cycling occurs in the slower phase (>10 s), when stalled

195 stematically controlled by changing the duty cycle of alternating current (AC) magnetic field during

196 iation and susceptibility for the full lytic cycle of HCMV.

197 formation for further understanding the life cycle of HCV and its interaction with the host cells.

198 ts) are signalling molecules that induce the cycle of some Staphylococcal pathogenicity islands (SaPI

199 It has long been thought that the life cycle of Streptomyces bacteria encompasses three develop

200 epresent a key bottleneck in the demographic cycle of trees, efforts to predict the long-term effects

201 nvolved-field (IF)-RT to more intensive four cycles of ABVD plus 30 Gy IF-RT was confirmed with 10-ye

202 All patients received two cycles of ATO therapy during consolidation 1, an additio

203 predicted probability of conceiving after 6 cycles of attempt (61%; 95% CI, 46%-74%) compared with w

204 al values (62%; 95% CI, 58%-66%) or after 12 cycles of attempt (70% [95% CI, 54%-80%] vs 76% [95% CI,

205 two-dimensional optical lattice that enables cycles of compression to increase the density, followed

206 of docetaxel plus capecitabine followed by 3 cycles of cyclophosphamide, epirubicin, and capecitabine

207 received 3 cycles of docetaxel followed by 3 cycles of cyclophosphamide, epirubicin, and fluorouracil

208 About half received 3 cycles of docetaxel followed by 3 cycles of cyclophospha

209 cil (T+CEF), while the other half received 3 cycles of docetaxel plus capecitabine followed by 3 cycl

210 follow-up, 98 months), noninferiority of two cycles of doxorubicin, bleomycin, vinblastine, dacarbazi

211 y fiber spikes to repetitive theta-frequency cycles of granule cell activity.SIGNIFICANCE STATEMENT L

212 Although the structures and chemomechanical cycles of motor proteins have been extensively investiga

213 elapsed/refractory MM (RRMM) received 28-day cycles of pembrolizumab, 200 mg IV every 2 weeks, pomali

214 andomly assigned in a 1:1 ratio to up to six cycles of pemetrexed and cisplatin plus nintedanib (200

215 Several cycles of repetitive exposure of cells to 0.1 g/L nZVI i

216 st response to infection and the replicative cycles of several viruses.

217 Multiple cycles of switching, controllable in real time, are poss

218 nsed on the conjugate pad and the dispensing cycles of the capture DNA probes on the test-zone), the

219 mplete tumor regression was observed after 4 cycles of therapy.

220 25 ALD cycles of TiO2 growth are found to be the optimized para

221 ory HL received 2 (cohort 1) or 3 (cohort 2) cycles of weekly BV; PET-negative patients (Deauville sc

222 cytoplasmic conductivity that depends on the cycling of cytoplasmic K(+) levels.

223 een suggested that sea-salt-induced chemical cycling of Hg (through 'atmospheric mercury depletion ev

224 sm for a direct influence of the respiratory cycle on memory function.

225 ural progenitor cell (NPC) reenters the cell cycle or exits and differentiates are pivotal for genera

226 hways responsible for each phase of the hair cycle, or elucidate which proteolysis products from kera

227 ial distributions, affecting annual/seasonal cycles, or altering disease incidence and severity.

228 days 8 and 15 of a 21-28 day cycle for </=6 cycles]) or standard care (either fludarabine plus cytar

229 on between the two motor domains keeps their cycles out of phase in order to stimulate directional mo

230 o reconstruct the dynamics of the phosphorus cycle over the past 3.5 billion years, it remains uncert

231 ndent regulation of pre- and post-Start cell-cycle periods rather than the consequence of an underlyi

232 hat GSCs can reversibly transition to a slow-cycling, persistent state in response to targeted kinase

233 high proportion of cells in a quiescent cell cycle phase as assessed in wounds, tumors, and aorta.

234 hotosynthetic and respiratory capacity, cell-cycle phase, and environmental condition.

235 curring during hormonally distinct menstrual cycle phases.

236 le about the ecology of chytrids, their life cycles, phylogeny, host specificity and range.

237 Unexpectedly, in the rapid cell cycles preceding the midblastula transition, a defined t

238 ed from hysterectomy specimens from normally cycling premenopausal women with uterine fibroids, who w

239 AP2-G expression during this 'commitment cycle' prepares gene expression in nascent merozoites to

240 ons non-cell-autonomously to facilitate cell-cycle progression and stem cell proliferation.

241 comes have been attributed to increased cell cycle progression and the development of genomic instabi

242 Furthermore, we show that growth and cell cycle progression are arrested in cells infected with va

243 ongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cyc

244 Cell cycle progression in mammals is strictly controlled by a

245 Instead, we showed that mycobacterial cell-cycle progression is regulated by an unprecedented mecha

246 proliferation rather than for allowing cell-cycle progression itself and must be regulated dynamical

247 indirect regulator of transcription and cell cycle progression through the regulation of specific mRN

248 ia and is important for cell signaling, cell cycle progression, polarity, and motility.

249 s involved in both circadian timing and life cycle progression.

250 egulation, cellular growth control, and cell-cycle progression.

251 ional blockade of genes associated with cell cycle progression.

252 necessary for kinetochore assembly and cell-cycle progression.

253 gation, and increased the expression of cell cycle-promoting cyclin proteins, without enhancing metas

254 tential pathway involved, expression of cell cycle proteins was assessed.

255 Here we report a high-energy sub-cycle pulse synthesiser based on a mid-infrared optical

256 An inclusive theory for population cycles, ranging from ecosystem-level to demographic mode

257 in the absence of conventional transcription cycles, RBCs maintain a circadian rhythm in membrane ele

258 s, primarily in the break phase of an LF-ISO cycle, reduce the intensity of the following active phas

259 Mcl-1 was cell cycle-regulated during HR, with its expression peaking i

260 Thus, Ki-67 expression varies due to cell-cycle regulation, but it remains a reliable readout for

261 ermore, one pathway that is involved in cell cycle regulation, REACTOME_CHROMOSOME _MAINTENANCE, was

262 eckpoint under hypoxia and analyzed key cell cycle related proteins for their potential role in this

263 results suggest that overexpression of cell-cycle-related genes are a characteristic of proliferatio

264 is study, we determine the functions of cell cycle-related kinase (CDK20) in radiochemoresistance.

265 t shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on sp

266 models are complicated theories where limit cycles represent an idealized Red Queen, and therefore c

267 iration are a key component of global carbon cycling, resulting in the transfer of 40-70 Pg carbon fr

268 ression in late events during the viral life cycle, RNA-Seq was carried out on triplicate differentia

269 y four proteins to accomplish the viral life cycle, so each arenavirus protein likely plays unappreci

270 omethanesulfonyl)imide) and realize the best cycling stability among all reported Mg/S batteries by s

271 in the order of 850 Wh L(-1) with excellent cycling stability.

272 ime qPCR has confirmed the differential life-cycle stage expression of a set of selected lincRNAs.

273 Using the device, we obtain cell-cycle statistics for C. elegans vulval development, a pa

274 This study reviewed 147 life cycle studies, with 28 found suitable for harmonizing fo

275 ne, with additional roles in the replication cycle such as viral assembly.

276 e responses to HFS throughout the light-dark cycle suggests uncoupling of hypothalamic responses invo

277 ic tumor dynamics to inform on/off treatment cycles, suppresses proliferation of androgen-independent

278 reated or untreated with androgen after cell-cycle synchronization.

279 ) was a key enzyme in its tricarboxylic acid cycle (TCA) pathway.

280 ent methyl NMR analysis of the BiP chaperone cycle that reveals surprising conformational heterogenei

281 ts on both plant N pools and rates of soil N cycling that were independent of those of species richne

282 of methyl-6-adenosine in distinct viral life cycles, the role of 2' O-methyl modifications in RNA sta

283 s known about tipping of oscillations (limit cycles) though this dynamics are the typical response of

284 itive result in phase 1, the median baseline cycle-threshold values (higher values indicate lower RNA

285 PEN3 and other defense proteins continuously cycle through the TGN and that timely exit of these prot

286 We demonstrate that Si(OH)4 cycling through the Holocene alternates between being pr

287 in grass rats transferred from a light/dark cycle to constant darkness and aroused in early night or

288 r Glu through a truncated tricarboxylic acid cycle under hypoglycemic conditions.

289 al of organic micropollutants from the water cycle, understanding the processes during activated slud

290 ral placebo capsules (2.5 mg/day) for 28-day cycles, until disease progression or unacceptable toxici

291 combination of M6620 and topotecan in 3-week cycles using 3 + 3 dose escalation.

292 ent global simulations that exhibit magnetic cycles varying systematically with stellar rotation and

293 Flow cytometry analysis indicated the cell cycle was arrested at the G2 phase after FAM83H-AS1 knoc

294 r cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration

295 CLARA cycles were associated with higher hematologic and nonhe

296 e disease during chemotherapy (four to eight cycles) were randomly assigned one to one to lapatinib o

297 species during a longer period of the annual cycle, which may create additional opportunities for spe

298 non-fixing bacteria during serial nodulation cycles with a probability that is function of initial in

299 within 100 s) and sustain more than 10,000 cycles with capacity fade of only 0.001% per cycle.

300 ations of DRN(DA) activity across sleep-wake cycles with highest activity during wakefulness.