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1 , including challenging beta-diaryl and beta-cyclic.
2 r of isomeric compounds, both aliphatics and cyclics.
4 ee energies for the Diels-Alder reactions of cyclic 1-azadienes are 10-14 kcal mol(-1) higher than th
6 are 10-14 kcal mol(-1) higher than those of cyclic 2-azadienes, and the reaction free energies are 1
7 erization to afford the resulting poly(3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate)s with low
8 A thymidine-derived bicyclic monomer, 3',5'-cyclic 3-(3-butenyl) thymidine ethylphosphate, was synth
12 asic studies exploring the importance of the cyclic adenosine monophosphate (cAMP) cascade in major d
13 A) R-subunit through formation of a PDE-PKAR-cyclic adenosine monophosphate (cAMP) complex (the termi
14 4 phosphodiesterase (PDE4) and elevation of cyclic adenosine monophosphate (cAMP) has emerged as a p
17 pression of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenos
18 nscriptional activity and phosphorylation of cyclic adenosine monophosphate response element binding
19 nvestigated the functional regulation of the cyclic adenosine monophosphate response element binding
20 roximal promoter region as well as increased cyclic adenosine monophosphate response element-mediated
21 ; cyclic adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase
22 echanism of ICAM-4 activation occurs via the cyclic adenosine monophosphate-protein kinase A (cAMP-PK
23 d adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca(2+)-mobilizing messenge
25 ) to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating several processes including calc
26 or weakly electron-donating groups (31-73%); cyclic aliphatic substrates provide low yields (24-38%).
28 ,2-azaborole derivative 2 was converted to a cyclic (alkyl) (amino)carbene (cAAC) via 1,2-hydrogen mi
31 ld procedure for the construction of (hetero)cyclic alpha,beta-unsaturated carboxylic acids from 1,6-
33 th alpha-substituted five- to seven-membered cyclic amines proceeds very efficiently to provide high
34 In cardiomyocytes and smooth muscle cells, cyclic AMP (cAMP) and subsequent calcium (Ca(2+)) fluxes
35 RATIONALE: Although the second messenger cyclic AMP (cAMP) is physiologically beneficial in the h
41 lase in vitro, and the cAMP analogue 8-bromo-cyclic AMP partially rescued the circadian phenotype in
43 ceptor gamma coactivator 1alpha (PGC1alpha), cyclic AMP-responsive element binding protein binding pr
45 Here, we optimized the protein misfolding cyclic amplification (PMCA) assay for highly efficient d
46 onversion in vitro assay, protein misfolding cyclic amplification (PMCA), by using experimental scrap
50 d that there are strong interactions between cyclic and noncyclic alternative electron transport and
51 the epoxide, a zero-order dependence on the cyclic anhydride, and a first-order dependence on the ca
53 8; 95% CI, 1.34-2.64) and tricyclic or other cyclic antidepressants (absolute risk, 0.89 per 10000 pe
58 ore usually extremely challenging to predict cyclic behaviour and fatigue life under a realistic load
64 lls, these Ca(2+) oscillations are caused by cyclic Ca(2+) release from the sarcoplasmic reticulum, a
65 vities for catalyzing conversion of CO2 into cyclic carbonate (conversion >95% at 100 degrees C and 1
67 atoid arthritis (RA), especially more severe cyclic-citrullinated peptide antibody-positive (anti-CCP
69 most important tools for the construction of cyclic compounds in organic synthesis, since these react
74 irreversible damage to microstructure during cyclic deformation, leading to cyclic responses that are
76 reptomyces sp. Svetamycins A-D, F, and G are cyclic depsipeptides, whereas svetamycin E is a linear a
77 teractions between the PMDI units in the two cyclic derivatives under reducing conditions, as determi
81 nown that intracellular levels of the signal cyclic-di-GMP increase upon surface adhesion and that th
82 nts for the feedback between mechanosensors, cyclic-di-GMP signaling, and production of adhesive poly
85 otein NspS and the transmembrane bis-(3'-5') cyclic diguanosine monophosphate (c-di-GMP) phosphodiest
87 tetrameric form of the second messenger, 3-5 cyclic diguanylic acid (c-di-GMP) to the master represso
88 ar secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital
89 d in the cytosol by cGAS, which produces the cyclic dinucleotide (CDN) second messenger cGAMP to acti
90 exciting adjuvant target due to its role in cyclic dinucleotide (CDN)-driven anti-viral immunity; ho
91 on following treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting that the STI
94 sm via activation of the recently discovered cyclic dinucleotide synthetase cGAS and the cyclic dinuc
98 iled to fully activate chlororespiration and cyclic electron flow due to a more oxidized state of the
99 the deletion of NdbC increases the amount of cyclic electron transfer, possibly via the NDH-12 comple
103 ding is substantiated using three classes of cyclic game models through stability analysis, Monte Car
106 acilitate the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme.
107 eloping an in vivo imaging system to measure cyclic GMP production in intact tibia, we show that FGF-
111 ntle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of int
112 S2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation
113 infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the secon
114 pase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta
115 ieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious p
117 e immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interfer
119 endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response an
120 unological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.
121 caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-T
124 gnal amplifier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cy
127 sterase 3B (PDE3B), and a membrane-permeable cyclic guanosine monophosphate (cGMP) analog on KATP cha
131 d channel from Caenorhabditis elegans in the cyclic guanosine monophosphate (cGMP)-bound open state.
132 ns, whereas the response to ascr#3 relies on cyclic guanosine monophosphate (cGMP)-gated channels and
133 ecutively with H2(17)O to yield a mixture of cyclic H-phosphonates labeled with (17)O and (18)O.
136 to screen a SICLOPPS library of 3.2 million cyclic hexapeptides for inhibitors of this protein-prote
137 Here we report a general approach to design cyclic homo-oligomers that employs a new residue-pair-tr
138 me of the rich dynamical properties of these cyclic Hopfield systems, including the ability of popula
139 8 by total synthesis, analogues based on the cyclic inosine 5'-diphosphate ribose (cIDPR) template we
140 the pericyclic path facilitates trapping of cyclic intermediate by a variety of further reactions an
141 f three peptide ligands (i.e., cyclic-RGDFC, cyclic-isoDGRFC, and CisoDGRC), which have different bin
148 ic simulations and variable-strain-amplitude cyclic loading experiments at stress amplitudes lower th
151 The enantioselective desymmetrization of cyclic meso-anhydrides with benzyl trifluoroborates unde
152 orted the hypothesis that the strained 3',5'-cyclic monomer can promote ring-opening polymerization t
153 hloro-phenylthio)-2'-O-methyladenosine-3', 5-cyclic monophosphate-AM (8-pCPT-AM) induces autophosphor
155 ovide a comprehensive view of the changes in cyclic mRNA accumulation occurring in these different sy
163 the successful identification of novel 3',5'-cyclic nucleotide phosphodiesterase (PDE) inhibitors, co
165 membrane binding required the high-affinity cyclic nucleotide-binding (CNB) and Ras association doma
166 compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP senso
168 ia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a d
170 tor (NMDAR) and hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels play in this noci
172 rmeation through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and contributes
178 wledge, this is the first observation of non-cyclic-nucleotide small molecules with agonist propertie
180 arboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding domain interacts directly with
181 icle electron cryo-microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis eleg
182 ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide m
185 catalysts has been tested for ethenolysis of cyclic olefins toward the goal of selectively forming al
186 mplex, its Cas10 subunit converts ATP into a cyclic oligoadenylate product, which allosterically acti
190 ains a challenging task to assemble NPs into cyclic one-dimensional (1D) shapes, such as rings and fr
192 rse profiles of cell cycle, as well as other cyclic or circadian processes (e.g., in liver), on singl
194 the first time, cyclic triazanes, a class of cyclic organic compounds sequentially bearing three all-
195 ntified in the KP, representing a noticeable cyclic pattern with a periodicity of around 1000 years.
198 pic breast MDA-MB-231 tumors showed that the cyclic peptide preferentially accumulates in tumor (2 h
199 y asparaginyl endopeptidases (AEPs) into the cyclic peptide SFTI-1 (sunflower trypsin inhibitor-1) an
200 hyl-lysine or methylated arginine results in cyclic peptide substrates, indicating that KDM4s may act
201 sing this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide
202 To address this gap, a genetically encoded cyclic peptide was designed based on the sonic hedgehog
204 the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammat
205 mposed of two self-complementary alpha,gamma-cyclic peptides bearing a Zn porphyrin cap that is used
207 ables the emergence of extensively different cyclic peptides through short mutational paths based on
208 can be applied to synthesize both linear and cyclic peptides, as well as peptides composed of natural
212 -end of cleaved RNA(3'-rA) consists of 2',3'-cyclic phosphate which protects RNA(3'-rA) from ligation
213 ehydrocoupling of primary phosphines to form cyclic phosphine rings and the first example of a non-me
214 human ortholog, we show that yeast Usb1 has cyclic phosphodiesterase activity that leaves a terminal
217 al enzyme that repairs RNA breaks with 2',3'-cyclic-PO4 and 5'-OH ends inflicted during tRNA splicing
218 t depolymerization of the transient polymer, cyclic poly(phthalaldehyde) (cPPA), exhibited a SICA eff
221 crown-6 until his retirement to synthesis of cyclic polyethers and evaluation of their metal ion comp
222 tly, we reported that treating patients with cyclic pyranopterin monophosphate (cPMP) is a successful
223 gas-phase synthesis of this hitherto elusive cyclic radical species 1,2,4,7-cyclooctatetraenyl via a
224 imaging to monitor the phase evolution upon cyclic rapid laser heating and cooling mimicking the dir
225 elf and must be regulated dynamically during cyclic re-entry to ensure efficient affinity-based selec
226 , we report a history-independent and stable cyclic response in bulk copper samples that contain high
227 ucture during cyclic deformation, leading to cyclic responses that are unstable (hardening or softeni
228 aman spectra of three peptide ligands (i.e., cyclic-RGDFC, cyclic-isoDGRFC, and CisoDGRC), which have
232 of the imidazole ring of 1 and four-membered cyclic silylene (4) via insertion of a silicon(I) atom o
236 e high charge storage capacity but with poor cyclic stability due to structural damage occurring duri
239 conductivity, 300% increase in water uptake, cyclic strain amplitudes of 0.15% for 0.1 Hz excitation
240 ents and structures are caused by fatigue at cyclic stress amplitudes much lower than the tensile str
242 Exposure of cultured fibroblasts to uniaxial cyclic stretch results in an actin stress fiber reinforc
243 eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of beta,gamma-u
245 mation of quaternary carbon stereocenters in cyclic systems have been documented, the construction of
249 Based on DFT calculations, an eight-membered cyclic transition state involving coordination of the li
250 ich proceed in a concerted fashion through a cyclic transition state-are among the most powerful synt
251 ewis acids, we prepared, for the first time, cyclic triazanes, a class of cyclic organic compounds se
252 nd symmetry reduction upon cupriphication of cyclic trinuclear trigonal-planar gold(I) complexes are
254 ethylcyclopentasiloxane (D5, C10H30O5Si5), a cyclic volatile methyl siloxane (cVMS) found in consumer
259 iting amorphous manganese dioxide layers via cyclic voltammetry (CV) and electroless deposition (ED).
260 different terminations was determined using cyclic voltammetry (CV) and scanning electrochemical mic
267 an be monitored in real time using fast-scan cyclic voltammetry (FSCV) coupled with carbon-fiber micr
269 that an increasing magnitude of response in cyclic voltammetry and chronoamperometry correlates with
274 phine borane amino ester was investigated by cyclic voltammetry and spectroelectrochemistry after con
276 static intermittent titration technique, and cyclic voltammetry at varied scan rates, the NVPF-NTP sh
279 nalyzer were also compared with the standard cyclic voltammetry instrument and found in agreement wit
282 del is validated using chronoamperometry and cyclic voltammetry of an ideal outer-sphere redox probe,
283 sking damage to the SECM probe, we implement cyclic voltammetry probe approach surfaces (CV-PASs), co
286 he binding events were studied by monitoring cyclic voltammetry signals and the developed nanosensor
290 ty (linear sweep voltammetry) and stability (cyclic voltammetry) with respect to the HER in acidic co
292 y steady-state and transient spectroscopies, cyclic voltammetry, and electron paramagnetic resonance
293 efully studied by steady-state spectroscopy, cyclic voltammetry, differential scanning calorimetry, s
295 nvestigated by UV-visible spectrophotometry, cyclic voltammetry, mass spectrometry, and products asse
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