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1 uires dimerization, which is induced by 2'3' cyclic GMP-AMP (cGAMP) produced by the cGAMP synthase in
2 Ab and TH responses than the mammalian 2'3'-cyclic GMP-AMP (cGAMP), and generated better protection
3 lso required for the inhibition of the 2',3'-cyclic GMP-AMP (cGAMP)-dependent immune responses during
5 endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response an
7 ble to bind c-di-AMP and with lower affinity cyclic GMP-AMP (3'3'-cGAMP) but not c-di-GMP or 2'3'-cGA
8 or 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2
9 Additionally, we determined that STING and cyclic GMP-AMP synthase (cGAS) are important to engage t
10 future autoimmune therapies.Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucle
12 clic GMP-AMP, a second messenger produced by cyclic GMP-AMP synthase (cGAS) as well as RNA ligands an
16 w DNA-activated pathway involving the enzyme cyclic GMP-AMP synthase (cGAS) was described and potenti
18 been shown to bind cytosolic DNA to generate cyclic GMP-AMP, which binds to the signaling adaptor sti
20 y, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for
25 signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of in
26 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP) in vitro from adenosine tripho
27 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates
28 erferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interfe
29 s active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces c
30 Here, we report the discovery of a class of cyclic GMP-AMP synthase inhibitors identified by a high-
31 mical analyses showed enhanced generation of cyclic GMP-AMP, STING aggregation, and TANK-binding kina
33 toward understanding the biological roles of cyclic GMP-AMP synthase and can serve as a molecular sca
34 onships and we present crystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibi
35 lso show expression of the antiviral protein cyclic GMP-AMP synthase (cGAS) in neuronal SH-SY5Y cells
36 ndent of the cytosolic nucleic acid receptor cyclic GMP-AMP (cGAMP) synthase (cGAS), but cGAS neverth
37 infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the secon
40 pase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta
42 n of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) produces the se
43 S2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation
45 tigated the roles of the putative DNA sensor cyclic GMP-AMP synthase (cGas), as well as the downstrea
46 ustering highlights the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) as
47 rom activation of the cytoplasmic DNA sensor cyclic GMP-AMP synthase by a nucleic acid substrate of T
48 demonstrate that knocking out the DNA sensor cyclic GMP-AMP synthase completely abrogates spontaneous
49 upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP synthase (cGAS), the innate immune adapto
50 s a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS), which catalyzes
51 recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in pro
52 data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-indu
53 We report that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activati
54 racellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon ga
55 y, we report that the cytosolic DNA sensors, cyclic GMP-AMP synthase (cGAS) and Ifi204, are both requ
56 e immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interfer
59 ieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious p
60 unological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.
61 caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-T
62 epigenetic silencing of either STING or the cyclic GMP-AMP synthase, which generates STING-activatin
63 ntle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of int
64 cleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of do
65 acid-inducible gene I (RIG-I) in response to cyclic GMP-AMP, a second messenger produced by cyclic GM
66 sponses to human CMV that are dependent upon cyclic GMP-AMP synthase (cGAS), STING, and interferon re
67 ere triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon re
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