ライフサイエンスコーパス: cyclic GMP

1 uires dimerization, which is induced by 2'3' cyclic GMP-AMP (cGAMP) produced by the cGAMP synthase in

2 lso required for the inhibition of the 2',3'-cyclic GMP-AMP (cGAMP)-dependent immune responses during

3 Ab and TH responses than the mammalian 2'3'-cyclic GMP-AMP (cGAMP), and generated better protection

4 Bacterial bis-(3'-5') cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second

5 A cyclic GMP analog, 8-bromo-cyclic GMP, increased endogen

6 LY-83583 (10 microM; F(2,18)=3.46; P<0.01; a cyclic GMP lowering agent), there is no effect of ODQ (a

7 ANP, as determined by Western analysis and a cyclic GMP assay.

8 of the secondary messenger cyclic GMP and a cyclic GMP-activated Ca(2+)-conducting channel in the Pe

9 Simultaneous infusion of bradykinin and a cyclic GMP-specific phosphodiesterase inhibitor, zaprina

10 nd mitochondrial OXPHOS gene expression in a cyclic GMP-dependent manner.

11 regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synt

12 pothesis is that NO leads to activation of a cyclic GMP (cGMP)-activated phosphodiesterase (PDE II) a

13 ) regulatory subunit, whereas injection of a cyclic GMP dependent protein kinase inhibitory peptide h

14 s polymorphism is determined by alleles of a cyclic GMP-dependent protein kinase gene; rovers are at

15 Wang et al. now report on a cyclic GMP-AMP adjuvant, the natural stimulator of inter

16 feeding by antagonizing signalling through a cyclic GMP-gated ion channel encoded by tax-2 and tax-4.

17 endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response an

18 VEGF by these two gas molecules occurs via a cyclic GMP-mediated pathway.

19 tosol of human monocytes binds and activates cyclic GMP-AMP synthase (cGAS).

20 ble to bind c-di-AMP and with lower affinity cyclic GMP-AMP (3'3'-cGAMP) but not c-di-GMP or 2'3'-cGA

21 Ca(2+), InsP3, InsP4, GTPgammaS, cyclic AMP, cyclic GMP, ATP, and ADP) activated 3-pS channels in ins

22 ate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase were undetectable, although

23 identified endothelin-2, interleukin-6, and cyclic GMP-dependent protein kinase II as novel targets

24 iminished agonist-induced Akt activation and cyclic GMP production.

25 inase activity and restored NOS activity and cyclic GMP levels in O vessels to those of Y.

26 creased in O rings, whereas NOS activity and cyclic GMP levels were decreased.

27 hosphotriester derivatives of cyclic AMP and cyclic GMP are described, where the additional group on

28 hippocampus that breaks down cyclic AMP and cyclic GMP.

29 in intracellular concentrations of Ca2+ and cyclic GMP in response to activation of the Wnt/Frizzled

30 Calcium (Ca2+) and cyclic GMP (cGMP) subserve antagonistic functions that a

31 odiesterases (PDEs), by hydrolyzing cAMP and cyclic GMP, regulate the amplitude, duration, and compar

32 characterized by a deficiency of LV cNOS and cyclic GMP levels.

33 or 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2

34 significant increase in GTN denitration and cyclic GMP accumulation, whereas mitochondrial overexpre

35 undles Rac1, Rac2, cyclic AMP-dependent, and cyclic GMP-dependent protein kinases in close proximity

36 lase (GC), which synthesizes cyclic GMP, and cyclic GMP-dependent protein kinase (PKG).

37 C, cyclic AMP-dependent protein kinase, and cyclic GMP-dependent protein kinase were not capable of

38 neurotransmitter release, neurotoxicity, and cyclic GMP elevations.

39 ein kinase mediator of nitric oxide (NO) and cyclic GMP (cGMP) signaling, the cGMP-dependent protein

40 lic AMP-dependent protein kinase A (PKA) and cyclic GMP-dependent protein kinase I (PKGI), induces th

41 Additionally, we determined that STING and cyclic GMP-AMP synthase (cGAS) are important to engage t

42 future autoimmune therapies.Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucle

43 eased activation of eNOS and NO bioactivity (cyclic GMP).

44 ed concentration-dependent reduction of both cyclic GMP production and relaxations to DEA-NONOate.

45 The isolated cNMP domain of XC_0249 bound cyclic GMP and a structure-function analysis, directed b

46 Similar to diazoxide, exposure to 8-Br-cyclic GMP antagonized the PGE(2)-induced increase in ex

47 The effects of 8-Br-cyclic GMP could be reversed by exposure to glibenclamid

48 ion of sensory neurons were affected by 8-Br-cyclic GMP.

49 t ileum smooth muscle (ileum) and by 8-bromo-cyclic GMP (100 microM) in alpha-toxin-permeabilized ile

50 ein kinase (0.5 microM) activated by 8-bromo-cyclic GMP (50 microM) phosphorylated recombinant teloki

51 The nonhydrolyzable analog 8-bromo-cyclic GMP (8-Br-cGMP) potently inhibited activation of

52 ylthio)-cyclic GMP (8-pCPT-cGMP), or 8-bromo-cyclic GMP (8-Br-cGMP) responded normally to glutamate o

53 of soluble guanylyl cyclase because 8-bromo-cyclic GMP activated PI3 kinase and the soluble guanylyl

54 ormylmethionylleucylphenylalanine or 8-bromo-cyclic GMP activates either cyclic AMP-dependent or cycl

55 d by protein kinase G activated with 8-bromo-cyclic GMP and by a high (*)NO flux ( approximately 112

56 ng pathway; addition of the analogue 8-bromo-cyclic GMP did not induce the HO-1 transcript, and the s

57 yclic GMP-dependent kinase activator 8-bromo-cyclic GMP had similar effects on PI3-kinase activity, c

58 se (LY83583) or protein kinase G (Rp-8-bromo-cyclic GMP or KT5823), the response to ATP was restored.

59 ctive catalytic subunit of PKG-I, or 8-bromo-cyclic GMP stimulated RGS translocation.

60 A cyclic GMP analog, 8-bromo-cyclic GMP, increased endogenous AChR aggregation in emb

61 loss was correlated with the loss of 8-bromo-cyclic GMP-induced calcium desensitization.

62 ormylmethionylleucylphenylalanine or 8-bromo-cyclic GMP.

63 oprusside) or the cyclic GMP analog, 8-bromo-cyclic GMP.

64 te to the nucleus upon activation by 8-bromo-cyclic GMP.

65 , we applied the cyclic-GMP analogue 8-Bromo-cyclic-GMP (8-Br-cGMP) onto neurones in the ventrobasal

66 Cyclic AMP is not involved, but cyclic GMP is a likely candidate since the protein kinas

67 Furthermore, eNOS bioactivity assayed by cyclic GMP levels was significantly reduced by CRP.

68 ly comes under a further level of control by cyclic GMP-dependent protein kinase and that its activat

69 Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formatio

70 These genes were also induced by cyclic GMP (cGMP) and cyclic ADP-ribose, two molecules t

71 ophase arrest in the oocyte is maintained by cyclic GMP from the surrounding granulosa cells that dif

72 tosis was receptor-dependent and mediated by cyclic GMP: the effect was mimicked by 8-bromo-cGMP, a m

73 clic GMP-AMP, a second messenger produced by cyclic GMP-AMP synthase (cGAS) as well as RNA ligands an

74 in vivo phosphorylation of TXA2 receptors by cyclic GMP was demonstrated from 32P-labeled cells treat

75 The channel also can be regulated by cyclic GMP.

76 Cellular signaling by cyclic GMP (cGMP) regulates MMP-9 dynamics in various ce

77 ls its effect is enhanced synergistically by cyclic GMP (cGMP) through an unknown mechanism.

78 mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contri

79 m L-arginine treatment will increase cardiac cyclic GMP production and modify left ventricular (LV) p

80 The effects of the mitogens on cellular cyclic GMP are fully explained by a direct and stable in

81 e RhoA/Rho-kinase and nitric oxide (NO)/cGMP/cyclic GMP-dependent kinase (cGKI) pathways, myosin ligh

82 r cells dialyzed with 8-(4-chlorophenylthio)-cyclic GMP (8-pCPT-cGMP), or 8-bromo-cyclic GMP (8-Br-cG

83 d with T. gondii with 8-(4-chlorophenylthio)-cyclic GMP (CPT-cGMP), a membrane-permeable, nonhydrolyz

84 nerally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pathway.

85 ated through Ca2+-dependent guanylyl cyclase-cyclic GMP-protein kinase G signaling pathway.

86 Activation of the guanylyl cyclase-cyclic GMP-protein-kinase-G system with nitroprusside or

87 GUC2B]; gene name NPR2) produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligand,

88 (1) It controls the hormonally dependent cyclic GMP production in the kidney and the adrenal glan

89 We also determined cyclic GMP levels in tumors and normal brain, with or wi

90 Upon binding double-stranded DNA, cyclic GMP-AMP synthase synthesizes a cyclic dinucleotid

91 photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate ph

92 PRKG1 encodes cyclic GMP-dependent protein kinase 1, which is involved

93 Endogenous cyclic GMP concentrations of transfected or stable cells

94 Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to indu

95 w DNA-activated pathway involving the enzyme cyclic GMP-AMP synthase (cGAS) was described and potenti

96 ind or stimulate the target/effector enzyme (cyclic GMP phosphodiesterase).

97 e series targeting the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG).

98 that a functional KH domain is essential for cyclic GMP production.

99 ch as opsin (RHO), the beta-subunit gene for cyclic GMP phosphodiesterase (PDE6B), and RDS/peripherin

100 nucleotidyl cyclase domain, is required for cyclic GMP synthesis.

101 nt studies have also revealed a key role for cyclic GMP-AMP synthase (cGAS) in STING activation.

102 We show here that K-Ras is a substrate for cyclic GMP-dependent protein kinases (PKGs).

103 gnal amplifier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cy

104 eath (dnd1) mutant, which lacks a functional cyclic GMP-activated cell membrane Ca(2+)-conducting cha

105 yclase (GC), we investigated the role of GC, cyclic GMP (cGMP), and cGMP-activated protein kinase (PK

106 been shown to bind cytosolic DNA to generate cyclic GMP-AMP, which binds to the signaling adaptor sti

107 erase type 5A (PDE5A) selectively hydrolyzes cyclic GMP.

108 Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger tr

109 y, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for

110 tial expression and down-regulation of IFNs, cyclic GMP, and nuclear factor kappa B isoforms.

111 Purified XC_0250 was active in cyclic GMP synthesis in vitro.

112 electrical signals in response to changes in cyclic GMP concentration during phototransduction.

113 ansfer (FRET) imaging reveals the changes in cyclic GMP in response to Wnt5a predominate about the ce

114 Mice genetically deficient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3,

115 ole of the GC kinase homology (KH) domain in cyclic GMP production by GC1, the major cyclase in photo

116 stimulation decrease and, thereby, a drop in cyclic GMP concentration and membrane voltage.

117 rt suggests that a BR-dependent elevation in cyclic GMP may be involved in the Ca(2+) signaling casca

118 data are consistent with a role for FHOD1 in cyclic GMP-dependent inhibition of VSMC stress fiber for

119 es, namely channel noise and fluctuations in cyclic GMP.

120 em of Manduca sexta undergoes an increase in cyclic GMP (cGMP) when exposed to the insect peptide ecl

121 wo PKGI isozymes, PKGIalpha and PKGIbeta, in cyclic GMP-mediated inhibition of [Ca2+]i in VSMCs are u

122 GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)-regulated cyclic nucleotide phosphodie

123 o downstream signaling components, including cyclic GMP.

124 onsible for ETEC-induced diarrhea, including cyclic GMP (cGMP) produced by GUCY2C, activation of cGMP

125 posed to activate the ISD pathway, including cyclic GMP-AMP synthase (cGAS).

126 noic acid and docosahexaenoic acid increased cyclic GMP levels and blocked cardiac fibroblast transfo

127 n and vasodilation, which acts by increasing cyclic GMP (cGMP) levels in VSMC, thereby activating cGM

128 These results show that increasing cyclic GMP in tumor microvessels can increase permeabili

129 lary collecting duct linking two independent cyclic GMP-generating signal transduction systems involv

130 ed derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhi

131 ith the concomitant decline in intracellular cyclic GMP levels appears to account for a significant p

132 se C (GCC) and accumulation of intracellular cyclic GMP ([cGMP]i), which opens the cystic fibrosis tr

133 increased their expression of intracellular cyclic GMP (cGMP) when treated with ST and their express

134 Elevation of intracellular cyclic GMP either by inhibition of cyclic GMP phosphodie

135 Real-time analysis of intracellular cyclic GMP using the Cygnet2 biosensor revealed p38 to a

136 NO-ASA had no effect on intracellular cyclic GMP concentrations.

137 Agents which increase the intracellular cyclic GMP (cGMP) concentration and cGMP analogs inhibit

138 g induces apoptosis by a mechanism involving cyclic GMP (cGMP) phosphodiesterase inhibition, sustaine

139 share a phototransduction pathway involving cyclic GMP.

140 tment with DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP).

141 on with a novel effector that directly links cyclic GMP and cyclic di-GMP signalling.

142 In addition, the mitogens also lower cyclic GMP concentrations (50% decrease) in cells not tr

143 Thus FGF signaling lowers cyclic GMP production in the growth plate, which counter

144 thase (cNOS) mRNA and protein levels, and LV cyclic GMP levels as compared with age-matched controls.

145 mals with LVH) and a 1.7-fold increase in LV cyclic GMP levels (p < 0.05 vs untreated animals with LV

146 eloping an in vivo imaging system to measure cyclic GMP production in intact tibia, we show that FGF-

147 The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like be

148 O signal into the classical second messenger cyclic GMP (cGMP).

149 (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).

150 into the production of the second messenger cyclic GMP.

151 cell-specific generation of second-messenger cyclic GMP in the retinal neurons.

152 h the involvement of the secondary messenger cyclic GMP and a cyclic GMP-activated Ca(2+)-conducting

153 s the concentration of the second messenger, cyclic GMP (cGMP), causing closure of cGMP-sensitive cha

154 signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of in

155 in to generate the odorant second messenger, cyclic GMP.

156 levels of the nitric oxide second messenger, cyclic GMP.

157 ng in the synthesis of the second messenger, cyclic GMP.

158 elerates production of the second messenger, cyclic GMP.

159 s stimulated at least fivefold by 1.0 microM cyclic GMP, but was not stimulated by cAMP or by 8-pCPT-

160 Cyclic guanosine 3',5'-monophosphate (cyclic GMP) is a second messenger whose role in bacteria

161 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP) in vitro from adenosine tripho

162 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates

163 ion of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in buffered media.

164 els of guanosine 3',5'-cyclic monophosphate (cyclic GMP) were measured by radioimmunoassay technique.

165 myocytes, which constitutively produced more cyclic GMP, detected with a new transgenic FRET sensor.

166 t be dephosphorylated and thus produces more cyclic GMP.

167 The findings provide evidence for a new cyclic GMP transduction system in synaptic layers and th

168 verexpression had increased S-nitrosylation, cyclic GMP, NO formation, and were protected from postin

169 sphoinositide 3-kinase-Akt-nitric oxide (NO)-cyclic GMP pathway and also provide an explanation why L

170 ry neurons that requires a nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway.

171 A nitric oxide (NO)/cyclic GMP (cGMP) signaling pathway is thought to play a

172 ced acute antinociception might involve a NO-cyclic GMP-protein kinase G-ATP-sensitive potassium (K(A

173 ciception might be due to activation of a NO-cyclic GMP-protein kinase G-K(ATP) channel pathway.

174 However, long-term stimulation of NO-cyclic GMP signaling depressed in vivo LV systolic funct

175 Moreover, METH induced the accumulation of cyclic GMP and activated caspase-3 in approximately 18%

176 second messenger induces the accumulation of cyclic GMP and activated caspase-3 in some striatal neur

177 ypoxia triggers NO-dependent accumulation of cyclic GMP and translocation of cytoplasmic GFP-Relish (

178 f cells with LPS resulted in accumulation of cyclic GMP.

179 erferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

180 tone by elevation of cGMP and activation of cyclic GMP-dependent protein kinase (PKG).

181 di-GMP synthesis was enhanced by addition of cyclic GMP.

182 he application of a cell permeable analog of cyclic GMP (8-bromo-cGMP; 0.01-1000 microM) is without e

183 tion of SGC alpha-subunit (SGCalpha), and of cyclic GMP (cGMP) after exposure to an NO donor.

184 s active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces c

185 Here, we report the discovery of a class of cyclic GMP-AMP synthase inhibitors identified by a high-

186 ere we demonstrate that marked elevations of cyclic GMP induced by C-type natriuretic peptide (CNP),

187 ibition) disrupt CNP-dependent elevations of cyclic GMP.

188 sepsis), mechanisms other than formation of cyclic GMP may be activated.

189 uanylate cyclase and subsequent formation of cyclic GMP.

190 guanylate cyclase activation, generation of cyclic GMP (cGMP), and activation of cGMP-dependent prot

191 dulated Ca(2+) signal into the generation of cyclic GMP, in vivo, exists as a homodimer, the two subu

192 mical analyses showed enhanced generation of cyclic GMP-AMP, STING aggregation, and TANK-binding kina

193 n, suggesting that mechanisms independent of cyclic GMP production may mediate relaxing effect of hig

194 activate potassium channels independently of cyclic GMP.

195 acellular cyclic GMP either by inhibition of cyclic GMP phosphodiesterase or by addition of 8-bromocy

196 (Mr 103,000), with or without inhibition of cyclic GMP-specific phosphodiesterase or soluble guanyla

197 KT5823, an inhibitor of cyclic GMP-dependent protein kinase (PKG) reversed the R

198 vation of a fibroblast is an interruption of cyclic GMP production from this receptor.

199 iosensor revealed p38 to act at the level of cyclic GMP, upstream of the mobilization of intracellula

200 Cellular levels of cyclic GMP and bilirubin were not significantly altered

201 ginine treatment increased cardiac levels of cyclic GMP, but it did not modify cardiac mass in rats w

202 Measurements of cyclic GMP levels in cerebral arterial wall demonstrated

203 oxide (NO) signaling involves modulation of cyclic GMP (cGMP) levels through activation of the solub

204 n was examined in the absence or presence of cyclic GMP in human coronary VSMC cells (Co403).

205 tration (3 x 10(-6) M) of ODQ, production of cyclic GMP in response to 10(-6) M of DEA-NONOate was ab

206 0 function, the ANP-stimulated production of cyclic GMP was inhibited.

207 ular relaxation by stimulating production of cyclic GMP, which activates type I cGMP-dependent protei

208 anylate cyclase and subsequent production of cyclic GMP.

209 uanylyl cyclase domain for the production of cyclic GMP.

210 ior work has established the central role of cyclic GMP (cGMP) from the granulosa cells in maintainin

211 This study sought to determine the role of cyclic GMP in increased permeability across the blood-tu

212 These findings indicate a key role of cyclic GMP-AMP synthase for the initiation of self-DNA-i

213 Here we investigate the role of cyclic GMP-dependent protein kinase (PKG) in the contrac

214 toward understanding the biological roles of cyclic GMP-AMP synthase and can serve as a molecular sca

215 f the holo-complex, demonstrated the site of cyclic GMP binding that modulates cyclic di-GMP synthesi

216 onships and we present crystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibi

217 EAM-mediated delivery of the beta subunit of cyclic GMP phosphodiesterase (PDE) cDNA to mice affected

218 C1 and GC2) are responsible for synthesis of cyclic GMP in rods and cones, but their individual contr

219 in degradation of the intracellular pool of cyclic-GMP (cGMP).

220 The production of cyclic-GMP and cAMP, and the activation of the MAP kinas

221 t catalytic domain of suPDE5 hydrolyzes only cyclic GMP (cGMP) and the activity is pH-dependent.

222 GMP activates either cyclic AMP-dependent or cyclic GMP-dependent protein kinase, respectively, outsi

223 Nitric oxide cyclic GMP signaling is postulated to depress vascular g

224 we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length

225 ition of VSMC activation by the nitric oxide/cyclic GMP pathway.

226 herapeutic agents targeting the nitric oxide/cyclic GMP signaling pathway have successfully treated p

227 stem with nitroprusside or membrane-permeant cyclic GMP analogs mimicked the proexocytotic effect of

228 , the second messenger of phototransduction, cyclic GMP, is rapidly degraded and must be replenished

229 let-rich plasma for two min and the platelet cyclic GMP level was measured.

230 tabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were s

231 lase (R-GC) signaling molecules that produce cyclic GMP (cGMP) and stimulate the cystic fibrosis tran

232 c oxide inhibitors and mimicked by prolonged cyclic GMP elevation.

233 lso show expression of the antiviral protein cyclic GMP-AMP synthase (cGAS) in neuronal SH-SY5Y cells

234 act independently of the classic NO radical/cyclic GMP pathway to increase CFTR expression and matur

235 ration, activating guanylyl cyclase, raising cyclic GMP concentration, opening cyclic nucleotide-gate

236 ndent of the cytosolic nucleic acid receptor cyclic GMP-AMP (cGAMP) synthase (cGAS), but cGAS neverth

237 infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the secon

238 ository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS).

239 One of several upstream receptors, cyclic GMP-AMP synthase, binds to cytosolic DNA and gene

240 cteristics by mutagenesis of PDE5, a related cyclic GMP-specific, cGMP-binding PDE.

241 ginine (1 mM) increased the nitrite release, cyclic GMP production and the Isc in control ileum, but

242 pase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta

243 t (Galphat) synergizes activation of retinal cyclic GMP phosphodiesterase (PDE) by activated Galphat.

244 acilitate the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme.

245 n the gene encoding the alpha subunit of rod cyclic GMP phosphodiesterase (PDE6A), and a null mutatio

246 The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) mediated sensing

247 n of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) produces the se

248 S2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation

249 The DNA sensor cyclic GMP-AMP synthase (cGAS) has been shown to bind cy

250 tigated the roles of the putative DNA sensor cyclic GMP-AMP synthase (cGas), as well as the downstrea

251 ustering highlights the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) as

252 rom activation of the cytoplasmic DNA sensor cyclic GMP-AMP synthase by a nucleic acid substrate of T

253 demonstrate that knocking out the DNA sensor cyclic GMP-AMP synthase completely abrogates spontaneous

254 upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP synthase (cGAS), the innate immune adapto

255 s a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS), which catalyzes

256 recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in pro

257 data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-indu

258 We report that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activati

259 racellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon ga

260 y, we report that the cytosolic DNA sensors, cyclic GMP-AMP synthase (cGAS) and Ifi204, are both requ

261 e immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interfer

262 t response can be corrected by supplementing cyclic GMP.

263 re guanylate cyclase (GC), which synthesizes cyclic GMP, and cyclic GMP-dependent protein kinase (PKG

264 Recently, targeting cyclic-GMP specific phosphodiesterase-5 (PDE5) has attra

265 are up to a thousand times more potent than cyclic GMP in activating cyclic-nucleotide-gated channel

266 These data demonstrate that cyclic GMP-AMP produced in infected cGAS(+)STING(-) cell

267 It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an importan

268 protein and substrate in VSMCs and show that cyclic GMP negatively regulates the FHOD1-PKGI interacti

269 The cyclic GMP analogue 8-bromo-cGMP rescues a sensory defec

270 The cyclic GMP-dependent kinase (PKG) is an important mediat

271 The cyclic GMP-dependent kinase activator 8-bromo-cyclic GMP

272 The cyclic GMP-gated cationic channels of vertebrate photore

273 ieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious p

274 h its specific cellular target/effector, the cyclic GMP phosphodiesterase (PDE).

275 unological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.

276 f multiple signaling cascades, including the cyclic GMP-dependent PKG pathway.

277 mutant produces insufficient amounts of the cyclic GMP needed to drive the machinery of phototransdu

278 Activation of the cyclic GMP phosphodiesterase (PDE6) by transducin is the

279 e is a central transduction component of the cyclic GMP signaling pathway.

280 caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-T

281 xO1a directly activates transcription of the cyclic GMP-dependent protein kinase I (cGKI) gene and wh

282 lear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblas

283 mine NONOate or sodium nitroprusside) or the cyclic GMP analog, 8-bromo-cyclic GMP.

284 epigenetic silencing of either STING or the cyclic GMP-AMP synthase, which generates STING-activatin

285 tide receptors, NPR-A and NPR-B, raising the cyclic GMP (cGMP) levels.

286 ual signal terminating transition state, the cyclic GMP phosphodiesterase (PDE6) inhibitory gamma-sub

287 *) linker mutants were able to stimulate the cyclic GMP phosphodiesterase.

288 ntle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of int

289 investigate this possibility, we applied the cyclic-GMP analogue 8-Bromo-cyclic-GMP (8-Br-cGMP) onto

290 cleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of do

291 ion and exerting signaling primarily through cyclic GMP production, offer a new perspective on the pa

292 e, we report that the ratio of cyclic AMP to cyclic GMP activities sets the polarity of netrin-1-indu

293 acid-inducible gene I (RIG-I) in response to cyclic GMP-AMP, a second messenger produced by cyclic GM

294 In contrast to the transducin-cyclic GMP phosphodiesterase pathway found in vertebrate

295 polymer-linked ligand dimers containing two cyclic GMP moieties are up to a thousand times more pote

296 sponses to human CMV that are dependent upon cyclic GMP-AMP synthase (cGAS), STING, and interferon re

297 important role antagonizing the vasodilatory cyclic GMP system.

298 ere triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon re

299 dings describe a regulatory pathway in which cyclic GMP regulates virulence and biofilm formation thr

300 The non-canonical Wnt/cyclic GMP/Ca(2+)/NF-AT pathway operates via Frizzled-2,