ライフサイエンスコーパス: cyclic guanosine monophosphate

1 ed and stiff because of low nitric oxide and cyclic guanosine monophosphate.

2 ors increase intracellular concentrations of cyclic guanosine monophosphate.

3 denosine monophosphate [8br-cAMP] and 8bromo cyclic guanosine monophosphate [8br-cGMP]) in rat liver

4 n, 8-bromo-cyclic AMP (8BrcAMP), and 8-bromo-cyclic guanosine monophosphate (8BrcGMP) also inhibited

5 effect of sGCalpha1 is independent of NO and cyclic guanosine monophosphate, a major mediator of the

6 Urinary excretion of cyclic guanosine monophosphate, a marker for renal NO pr

7 Tissue 3',5'-cyclic guanosine monophosphate, a potent vasodilator, wa

8 oth basal and bradykinin-stimulated cellular cyclic guanosine monophosphate accumulation and L-citrul

9 e presence or absence of 7-nitroindazole and cyclic guanosine monophosphate accumulation was determin

10 o determined in vitro in cardiac fibroblasts cyclic guanosine monophosphate-activating and antiprolif

11 timulator of interferon genes (STING), 2'3'- cyclic guanosine monophosphate-adenosine monophosphate (

12 Here we show that M. tuberculosis activated cyclic guanosine monophosphate-adenosine monophosphate (

13 With the STING ligand cyclic guanosine monophosphate-adenosine monophosphate (

14 Here we show that HIV infection activates cyclic guanosine monophosphate-adenosine monophosphate (

15 ical approaches led to the identification of cyclic guanosine monophosphate-adenosine monophosphate (

16 nduces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (

17 hat mammalian cytosolic extracts synthesized cyclic guanosine monophosphate-adenosine monophosphate (

18 The DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (

19 A or HBV infection and mice lacking STING or cyclic guanosine monophosphate-adenosine monophosphate s

20 Cyclic guanosine monophosphate-adenosine monophosphate s

21 hrough a pathway dependent on the DNA sensor cyclic guanosine monophosphate-adenosine monophosphate s

22 poptosis, and these effects were mimicked by cyclic guanosine monophosphate analogs.

23 In addition, CD-NP in vitro activates cyclic guanosine monophosphate and inhibits cardiac fibr

24 lation of cyclic adenosine monophosphate and cyclic guanosine monophosphate and is highly expressed i

25 oxide synthase (NOS) activity and decreased cyclic guanosine monophosphate and nitrite production.

26 Venous admixture was calculated, and plasma cyclic guanosine monophosphate and sildenafil concentrat

27 s associated with elevation of intraplatelet cyclic guanosine monophosphate and was reversed by the n

28 itric oxide-dependent signaling (via sGC and cyclic guanosine monophosphate) and nitric oxide-indepen

29 levels of cyclic adenosine monophosphate and cyclic guanosine monophosphate, and, consequently, exhib

30 eases in vascular endothelial growth factor, cyclic guanosine monophosphate, angiogenesis, endogenous

31 nhardtii indicates that NO signaling through cyclic guanosine monophosphate arose before the origin o

32 aggregation in vitro by preventing platelet cyclic guanosine monophosphate catabolism.

33 n of hypotensive mediators, nitric oxide and cyclic guanosine monophosphate, cause these phenotypes.

34 In vitro 3',5'-cyclic guanosine monophosphate (cGMP) activation in resp

35 Sildenafil and an analog of cyclic guanosine monophosphate (cGMP) also induced capil

36 f IkappaBalpha accumulation; and b) a stable cyclic guanosine monophosphate (cGMP) analog (8-bromo-cG

37 sterase 3B (PDE3B), and a membrane-permeable cyclic guanosine monophosphate (cGMP) analog on KATP cha

38 Type V phosphodiesterase (PDE V) metabolizes cyclic guanosine monophosphate (cGMP) and is abundant in

39 In healthy control subjects, urinary cyclic guanosine monophosphate (cGMP) and natriuresis in

40 NP (ANP) and significantly smaller levels of cyclic guanosine monophosphate (cGMP) and peroxisome pro

41 sterase 5 (PDE5) catalytic-site affinity for cyclic guanosine monophosphate (cGMP) and potency of inh

42 iesterase type 5 (PDE5) acts specifically on cyclic guanosine monophosphate (cGMP) and terminates cGM

43 In this study we tested the hypothesis that cyclic guanosine monophosphate (cGMP) and the dependent

44 T-cyclic guanosine monophosphate (RpcGMP), a cyclic guanosine monophosphate (cGMP) antagonist, attenu

45 G protein-coupled receptors and cyclic guanosine monophosphate (cGMP) are implicated in

46 Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are now recognized

47 provided evidence that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) are signaling inte

48 production by using immunocytochemistry for cyclic guanosine monophosphate (cGMP) as an indicator.

49 de cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) as well as calcium

50 Production of cyclic guanosine monophosphate (cGMP) by guanylate cycla

51 coronary vasodilation through activation of cyclic guanosine monophosphate (cGMP) by way of particul

52 resistance may, in part, relate to increased cyclic guanosine monophosphate (cGMP) catabolism by PDE5

53 scular NO production, as estimated by aortic cyclic guanosine monophosphate (cGMP) concentration and

54 Atrial and serum nitrite/ nitrate and atrial cyclic guanosine monophosphate (cGMP) concentrations wer

55 Cyclic guanosine monophosphate (cGMP) content in the cha

56 y, nitric oxide synthase (NOS) activity, and cyclic guanosine monophosphate (cGMP) content were also

57 Moreover, relaxation was cyclic guanosine monophosphate (cGMP) dependent and was

58 , we hypothesized that nitric oxide promotes cyclic guanosine monophosphate (cGMP) formation, which,

59 , which stimulates production and release of cyclic guanosine monophosphate (cGMP) from intestinal ep

60 as associated with a significant decrease in cyclic guanosine monophosphate (cGMP) generation after S

61 production of NO, as estimated by measuring cyclic guanosine monophosphate (cGMP) in aortic tissue i

62 peptide (BNP) on cellular proliferation and cyclic guanosine monophosphate (cGMP) in human aortic va

63 (5-HT(2A)) receptors increase production of cyclic guanosine monophosphate (cGMP) in slices of rat f

64 tical slices obtained from endotoxemic mice, cyclic guanosine monophosphate (cGMP) increased signific

65 d by nitrite and nitrate accumulation and by cyclic guanosine monophosphate (cGMP) increases in rat r

66 3',5'-cyclic guanosine monophosphate (cGMP) is a common second

67 Cyclic guanosine monophosphate (cGMP) is a key secondary

68 Cyclic guanosine monophosphate (cGMP) is a second messen

69 Cyclic guanosine monophosphate (cGMP) is an important in

70 3',5'-Cyclic guanosine monophosphate (cGMP) is an important se

71 The intracellular nucleotide cyclic guanosine monophosphate (cGMP) is found in many h

72 Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increas

73 n = 5) and 28 days (n = 3) and evaluated for cyclic guanosine monophosphate (cGMP) levels (7 days), n

74 itor with a short half-life, increases brain cyclic guanosine monophosphate (cGMP) levels and improve

75 e messenger RNA (mRNA), protein, nitrite and cyclic guanosine monophosphate (cGMP) levels in Kupffer

76 sion/4-minute reperfusion cycles, myocardial cyclic guanosine monophosphate (cGMP) levels increased s

77 Vascular cyclic guanosine monophosphate (cGMP) levels were elevat

78 sulin with and without SNP did not affect EC cyclic guanosine monophosphate (cGMP) levels, and the cG

79 HO2 phosphorylation and activity as well as cyclic guanosine monophosphate (cGMP) levels, with all o

80 soluble guanylyl cyclase and, thus, enhances cyclic guanosine monophosphate (cGMP) levels.

81 Elevated intracellular levels of cyclic guanosine monophosphate (cGMP) may induce apoptos

82 partly attributable to hyporesponsiveness of cyclic guanosine monophosphate (cGMP) mediated vasorelax

83 In the vertebrate retina, cyclic guanosine monophosphate (cGMP) mediates photorece

84 ic cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) often mediate anta

85 enzyme producing the intracellular messenger cyclic guanosine monophosphate (cGMP) on activation with

86 activates the kinase independently of the NO-cyclic guanosine monophosphate (cGMP) pathway and is cou

87 mammals, the diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it func

88 rturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac

89 A key component of the nitric oxide-cyclic guanosine monophosphate (cGMP) pathway in smooth

90 O activates a soluble guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway in the beh

91 sodilator tone and platelet activity via the cyclic guanosine monophosphate (cGMP) pathway, but wheth

92 gulation of intracellular Ca2+ ([Ca2+]i) and cyclic guanosine monophosphate (cGMP) production (index

93 rrent study was to determine whether hepatic cyclic guanosine monophosphate (cGMP) reduces NHGU.

94 ape and provide evidence for a novel role of cyclic guanosine monophosphate (cGMP) signaling in the r

95 adenosine monophosphate (cAMP) and augmented cyclic guanosine monophosphate (cGMP) signaling is chara

96 The cyclic guanosine monophosphate (cGMP) specific phosphodi

97 Cyclic guanosine monophosphate (cGMP) stimulated human p

98 ic measurement of [Ca (2+)] i in response to cyclic guanosine monophosphate (cGMP) stimulation.

99 ependent on and independent of modulation of cyclic guanosine monophosphate (cGMP) subsequent to acti

100 Assays of cyclic guanosine monophosphate (cGMP) synthesis from gua

101 cAMP) was increased 11-fold and the K(i) for cyclic guanosine monophosphate (cGMP) was 27-fold higher

102 Cyclic guanosine monophosphate (cGMP) was measured by en

103 y investigated whether nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were involved in m

104 itric oxide (NO), catalyzes the formation of cyclic guanosine monophosphate (cGMP), an intracellular

105 thase expression and levels of nitric oxide, cyclic guanosine monophosphate (cGMP), and nitrotyrosine

106 chemical methods to study the effects of NO, cyclic guanosine monophosphate (cGMP), and peroxynitrite

107 ften functions through its second messenger, cyclic guanosine monophosphate (cGMP), and protein kinas

108 tivates soluble guanosine cyclase to produce cyclic guanosine monophosphate (cGMP), and we observed t

109 f the nitric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP), has been implicat

110 Cyclic guanosine monophosphate (cGMP), however, has been

111 The second messenger, cyclic guanosine monophosphate (cGMP), mediates the acti

112 NO-mediated events, such as the induction of cyclic guanosine monophosphate (cGMP), NADPH diaphorase

113 yocyte diameter, and its upstream control by cyclic guanosine monophosphate (cGMP), nitrosative/oxida

114 Inhibitors and activators of sGC, 3',5'-cyclic guanosine monophosphate (cGMP), protein kinase G

115 yclase in follicular somatic cells, produces cyclic guanosine monophosphate (cGMP), which maintains m

116 t report, VWF did not promote an increase in cyclic guanosine monophosphate (cGMP), while agents that

117 is a downstream target of sildenafil in the cyclic guanosine monophosphate (cGMP)-activated protein

118 d channel from Caenorhabditis elegans in the cyclic guanosine monophosphate (cGMP)-bound open state.

119 y depends on NOS2 activity and the canonical cyclic guanosine monophosphate (cGMP)-cGMP-dependent pro

120 Cyclic guanosine monophosphate (cGMP)-dependent protein

121 filaments are phosphorylated transiently by cyclic guanosine monophosphate (cGMP)-dependent protein

122 pecies is the foraging gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein

123 s as a signalling paradigm, we show that the cyclic guanosine monophosphate (cGMP)-dependent protein

124 The gene Prkg2, encoding cyclic guanosine monophosphate (cGMP)-dependent protein

125 ns, whereas the response to ascr#3 relies on cyclic guanosine monophosphate (cGMP)-gated channels and

126 Mutations in genes encoding subunits of a cyclic guanosine monophosphate (cGMP)-gated ion channel

127 both endothelium-dependent and -independent cyclic guanosine monophosphate (cGMP)-mediated vasodilat

128 voking a depolarizing conductance carried by cyclic guanosine monophosphate (cGMP)-sensitive cyclic n

129 shed leukocyte Mac-1-integrin activation and cyclic guanosine monophosphate (cGMP)-signaling, leading

130 d decreasing intracellular concentrations of cyclic guanosine monophosphate (cGMP).

131 neurons label positively with an antibody to cyclic guanosine monophosphate (cGMP).

132 of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).

133 ate nitric oxide (NO) and increase levels of cyclic guanosine monophosphate (cGMP).

134 n by increasing pulmonary vascular levels of cyclic guanosine monophosphate (cGMP).

135 nhibition of calcium influx into the cell by cyclic guanosine monophosphate (cGMP).

136 f the muscle to the relaxant effects of 8-Br-cyclic guanosine monophosphate (cGMP).

137 resulted in markedly increased production of cyclic guanosine monophosphate (cGMP).

138 n that converts guanosine-5'-triphosphate to cyclic guanosine monophosphate (cGMP).

139 r-guanylyl-cyclase, GCY-8, which synthesizes cyclic guanosine monophosphate (cGMP).

140 e proliferative effect is mediated via an NO/cyclic guanosine monophosphate (cGMP)/cGMP-dependent pro

141 he major PDE activity in platelets is PDE3A (cyclic guanosine monophosphate [cGMP]-inhibited PDE).

142 gh soluble guanylyl cyclase (which generates cyclic guanosine monophosphate, cGMP) was the first iden

143 By using immunohistochemistry against cyclic guanosine monophosphate, cochlear sGC activity wa

144 ity by inorganic nitrate-nitrite, myocardial cyclic guanosine monophosphate content by neprilysin or

145 mation reduces nitric oxide bioavailability, cyclic guanosine monophosphate content, and protein kina

146 cGMP (B-cGMP) and N(2),2'-o-dibutyryl 3', 5'-cyclic guanosine monophosphate (dB-cGMP), and of the sel

147 by its endogenous peptide ligands initiates cyclic guanosine monophosphate-dependent (cGMP) salt and

148 f cell cycle progression, which include both cyclic guanosine monophosphate-dependent and -independen

149 ing proteins involved in the mating process, cyclic guanosine monophosphate-dependent kinase, and the

150 PT1 in vessels from endotoxemic animals in a cyclic guanosine monophosphate-dependent manner, suggest

151 ion of either guanylyl cyclase A receptor or cyclic guanosine monophosphate-dependent protein kinase

152 racellular signal-related kinase pathway via cyclic guanosine monophosphate-dependent protein kinase

153 The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase

154 atriuresis associated with increased urinary cyclic guanosine monophosphate excretion (UcGMPV), glome

155 gh glucose media was paralleled by decreased cyclic guanosine monophosphate generation; however, ther

156 s that catalyze the breakdown of cAMP and/or cyclic guanosine monophosphate (GMP) to their inactive f

157 ally increased in parallel with a decline in cyclic guanosine monophosphate (GMP).

158 Most cyclic guanosine monophosphate hydrolysis (about 80%) in

159 Sildenafil is a potent inhibitor of cyclic guanosine monophosphate hydrolysis [corrected] in

160 sterase Type 5 is the main factor regulating cyclic guanosine monophosphate hydrolysis and downstream

161 d to exogenous NO also was examined by using cyclic guanosine monophosphate immunocytochemistry.

162 l-specificity cyclic adenosine monophosphate/cyclic guanosine monophosphate-inhibiting enzyme.

163 induced a greater elevation of intracellular cyclic guanosine monophosphate levels compared with nitr

164 n, ventricles from Cav-3 OE mice had greater cyclic guanosine monophosphate levels, less nuclear fact

165 Neither cyclic guanosine monophosphate nor guanylate cyclase wer

166 creased NO-stimulated platelet generation of cyclic guanosine monophosphate (p < 0.02) but not with c

167 as was the ability to activate plasma 3',5'-cyclic guanosine monophosphate (p < 0.05 vs. placebo).

168 normalized ex vivo by augmentation of the NO-cyclic guanosine monophosphate pathway without normaliza

169 Mechanisms of action of nitric oxide/cyclic guanosine monophosphate/PDE5 pathway in the treat

170 utant allele of the gamma subunit of retinal cyclic guanosine monophosphate phosphodiesterase (PDE ga

171 ctive toward the effector of transducin, the cyclic guanosine monophosphate phosphodiesterase.

172 splice site mutation in intron 2 of the rod cyclic guanosine monophosphate-phosphodiesterase (cGMP)

173 photoreceptor-specific expression of the rod cyclic guanosine monophosphate-phosphodiesterase beta-su

174 ted extracellular matrix remodeling via PDE5/cyclic guanosine monophosphate-PKG regulatory pathways.

175 alogue RO-25-6760, increased NPR-A-dependent cyclic guanosine monophosphate production and NPR-A gene

176 variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with

177 ly available BNP assays and cell activity by cyclic guanosine monophosphate production in vascular ce

178 nd nitric oxide synthase 1 blockade inhibits cyclic guanosine monophosphate production; 3) pharmacolo

179 complex pathways that involve nitric oxide, cyclic guanosine monophosphate, protein kinase G, extrac

180 Plasma BNP and 3',5'-cyclic guanosine monophosphate rapidly increased and pea

181 itric oxide synthase inhibitor, and Rp-8 CPT-cyclic guanosine monophosphate (RpcGMP), a cyclic guanos

182 l, gene-targeted regulation of cardiomyocyte cyclic guanosine monophosphate-selective phosphodiestera

183 Sildenafil (SIL) inhibits cyclic guanosine monophosphate-specific PDE5A and can bl

184 guanylate cyclase and a higher production of cyclic guanosine monophosphate that together may help ex

185 ular guanylate cyclase domains that mobilize cyclic guanosine monophosphate upon binding of peptide.

186 The levels of nitric oxide and cyclic guanosine monophosphate were also significantly r

187 ic peptide-dependent excretion of sodium and cyclic guanosine monophosphate without affecting mean ar