ライフサイエンスコーパス: cyclic nucleotide

1 d is controlled by intracellular pH, but not cyclic nucleotides.

2 a model system consisting of nucleotides and cyclic nucleotides.

3 o phosphodiesterases involved in cleavage of cyclic nucleotides.

4 (MSNs) with low micromolar affinity for both cyclic nucleotides.

5 lack of direct regulation of ERG channels by cyclic nucleotides.

6 f binding and regulation of KCNH channels by cyclic nucleotides.

7 e active conformation differed for the three cyclic nucleotides.

8 ulation of cell-signaling pathways involving cyclic nucleotides.

9 rs and open in response to direct binding of cyclic nucleotides.

10 Reduced levels of the myelin protein 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) are associa

11 esponse to energy depletion, and renal 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) metaboli

12 rotein, myelin proteolipid protein, and 2'3'-cyclic nucleotide 3'-phosphodiesterase compared with tho

13 vated form of Akt under control of the 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter, exhibit

14 HIV-1 virion production and found that 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP), a membrane

15 roRNAs (miRNAs) play in remyelination, 2',3'-cyclic-nucleotide 3'-phosphodiesterase-EGFP(+) mice were

16 Swiss 3T3 cells and assessed the ability of cyclic nucleotide analogs to modulate the activity of Ep

17 o the cAMP binding site in Crp but lacks the cyclic nucleotide-anchoring motif and has its entrance o

18 We conclude that cross-talk between cyclic nucleotide and RhoA signaling pathways dictates t

19 Activation of cyclic nucleotide and/or Ca(2+) signaling pathways in se

20 It has long been known that cyclic nucleotides and cyclic nucleotide-dependent signa

21 des, as well as several derivatives, namely, cyclic nucleotides and dinucleotides, dinucleoside 5',5'

22 iated with lower transport or sensitivity to cyclic nucleotides and increased expression of OATP2B1 a

23 Since C5a orthologs efflux cyclic nucleotides, and cAMP-dependent protein kinase (S

24 odulators of transcription factors, kinases, cyclic nucleotides, and G protein-coupled receptors.

25 The actions of cyclic nucleotides are generally mediated by binding of

26 Cyclic nucleotides are second messengers that regulate c

27 Cyclic nucleotides are vital in SMC proliferation and mi

28 ants apparently do not make extensive use of cyclic-nucleotide-based signalling.

29 Proteins with cyclic nucleotide binding and GAF domains can be identif

30 directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a

31 s of cAMP binding affinity to the N-terminal cyclic nucleotide binding domain and allosteric activati

32 -binding domain (CaMBD) overlapping with the cyclic nucleotide binding domain of plant CNGCs.

33 ing of cyclic adenosine monophosphate to the cyclic nucleotide binding domain of the bacterial potass

34 six transmembrane domains and a cytoplasmic cyclic nucleotide binding domain.

35 activated by the binding of cAMPs to the two cyclic nucleotide binding domains (CBDs), A and B, on ea

36 terminus contains a region with homology to cyclic nucleotide binding domains (cNBHD), which is dire

37 ain and a C-terminal domain with homology to cyclic nucleotide binding domains (referred to as the CN

38 of cAMP to conserved and well characterized cyclic nucleotide binding domains or structurally distin

39 ntrast to other cAMP-binding proteins, where cyclic nucleotide binding has been shown to involve intr

40 Although cyclic nucleotide binding has been shown to promote CNG

41 couples conformational changes triggered by cyclic nucleotide binding to the gate.

42 hysiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucle

43 membrane binding required the high-affinity cyclic nucleotide-binding (CNB) and Ras association doma

44 compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP senso

45 g voltages, and the binding of cAMP to their cyclic nucleotide-binding domain (CNBD) facilitates chan

46 cAMP binds to a conserved intracellular cyclic nucleotide-binding domain (CNBD) in the channel,

47 rized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD) that connects to

48 ic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connec

49 elements, including a C-linker region and a cyclic nucleotide-binding domain (CNBD).

50 channels, TRIP8b also binds directly to the cyclic nucleotide-binding domain (CNBD).

51 cidate the conformational ensembles of PKA's cyclic nucleotide-binding domain A for the cAMP-free (ap

52 signal through key structural motifs in the cyclic nucleotide-binding domain and explore the role of

53 In this report, we found that the cyclic nucleotide-binding domain and the C terminus of t

54 Although the C-terminal cyclic nucleotide-binding domain B of PKG binds cGMP wit

55 apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

56 ealed that the conserved hinge region of the cyclic nucleotide-binding domain of Epac1 is a potential

57 Here using the conserved cyclic nucleotide-binding domain of protein kinase A's (

58 (TM) domain of a bacterial channel, and the cyclic nucleotide-binding domain of the mouse HCN2 chann

59 rrangements within the linker and N-terminal cyclic nucleotide-binding domain of the RIIbeta homodime

60 We show that TRIP8b binds the HCN cyclic nucleotide-binding domain through a 37-residue do

61 as disrupted by mutation within its putative cyclic nucleotide-binding domain within PDZ-GEF1.

62 inal nsSNVs located outside the KCNH2/Kv11.1 cyclic nucleotide-binding domain, the topology-specific

63 cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain.

64 le and requires the presence of a functional cyclic nucleotide-binding domain.

65 T) to directly observe binding at individual cyclic nucleotide-binding domains (CNBDs) from human pac

66 opening via a direct interaction between the cyclic nucleotide-binding domains and voltage sensors.

67 Upon cAMP binding, the cyclic nucleotide-binding domains move vertically toward

68 characterized potassium channel KcsA and the cyclic nucleotide-binding domains of the prokaryotic cyc

69 ial, and their gating regulated by cytosolic cyclic nucleotide-binding domains.

70 Sim (PAS) domains, as well as the C-terminal cyclic nucleotide-binding homology (cNBH) domain.

71 ereas the carboxy-terminal region contains a cyclic nucleotide-binding homology domain (CNBHD), which

72 ted gene (ERG) channels contain a C-terminal cyclic nucleotide-binding homology domain coupled to the

73 ere, we report the structure of the C-linker/cyclic nucleotide-binding homology domain of a mosquito

74 linker and two in the adjacent region of the cyclic nucleotide-binding homology domain, can fully acc

75 reveals that the region expected to form the cyclic nucleotide-binding pocket is negatively charged a

76 nker/CNBHD of ELK channels is similar to the cyclic-nucleotide-binding domain (CNBD) structure of the

77 arboxy-terminal linker connecting S6 and the cyclic-nucleotide-binding domain interacts directly with

78 at it is not just the absence or presence of cyclic nucleotides, but a highly coordinated balance bet

79 Synthesis of the cyclic nucleotide c-di-AMP has been reported for a numbe

80 Cyclic nucleotide cAMP is a ubiquitous secondary messeng

81 porter that regulates the cellular efflux of cyclic nucleotides (cAMP and cGMP) involved in various p

82 PGI2 and NO effects are mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kin

83 Here, we identify the pyrimidine cyclic nucleotide cCMP as another regulator of HCN chann

84 processes, here we investigated whether the cyclic nucleotide cGMP influences Abeta levels and funct

85 Cytosolic Ca(2+) elevations, cyclic nucleotide (cGMP)-activated Ca(2+) channels, and

86 egation, a novel hyperpolarization-activated cyclic nucleotide channel 4 (HCN4)-G482R mutation and a

87 s associated with impaired nitric oxide (NO)-cyclic nucleotide (CN)-coupled intracellular calcium (Ca

88 Here, we identify dysregulation of cyclic-nucleotide (CN)-linked neuronal Ca(2+) channel ac

89 Emerging evidence also suggests that cyclic nucleotide coupled phosphodiesterases (PDEs) play

90 n response to externally added cell-permeant cyclic nucleotides (cpt-cAMP and cpt-cGMP), MEF migratio

91 levels are tightly controlled by a family of cyclic nucleotide degrading enzymes, the PDEs.

92 alters both the cell surface expression and cyclic nucleotide dependence of these channels.

93 s a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels.

94 phorylation of the GluA1 subunit of AMPAR by cyclic nucleotide-dependent kinases, making cyclic nucle

95 t Ser(696)-Thr(697) and Ser(854)-Thr(855) by cyclic nucleotide-dependent protein kinases had no effec

96 long been known that cyclic nucleotides and cyclic nucleotide-dependent signaling molecules control

97 ive pathogens including S. pyogenes use this cyclic nucleotide derivative as a second messenger inste

98 Small cyclic nucleotide derivatives are employed as second mes

99 Of four cyclic nucleotides, dibuturyl-cAMP induced the largest s

100 monstrated to be effective, each immobilized cyclic nucleotide did not discriminate in the enrichment

101 e can travel across many layers of cells via cyclic nucleotide diffusion through gap junctions could

102 These observations reveal that cyclic nucleotide efflux controlling transporter-MRP4 pl

103 cells, fluid shear stress or the addition of cyclic nucleotides enhanced AQP1 surface expression and

104 my perceived role in discoveries made in the cyclic nucleotide field that culminated in the advent of

105 phosphorylation of its target, the beta-type cyclic nucleotide gated (CNG) channel subunit, TAX-2, wa

106 aliana ortholog CNGC2, encode a component of cyclic nucleotide gated Ca(2+) channels that act as the

107 Here, we found that the cyclic nucleotide gated calcium channel (CNGC) CNGCb gen

108 n channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the correspondin

109 xpression of the hyperpolarization-activated cyclic-nucleotide gated ion channel 4 (Hcn4).

110 Cyclic nucleotide-gated (CNG) and hyperpolarization-acti

111 Exposure to daylight closes cyclic nucleotide-gated (CNG) and voltage-operated Ca(2+

112 ia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a d

113 In contrast, the cyclic nucleotide-gated (CNG) channel inhibitor l-cis-di

114 proteins, adenylate cyclase III (ACIII), and cyclic nucleotide-gated (CNG) channel, as well as disrup

115 ular OSNs, odorants elicit activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2+ g

116 We found that cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induc

117 Cyclic nucleotide-gated (CNG) channels are expressed in

118 Photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal ro

119 Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal ro

120 Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca(2+) i

121 ncoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channels undergoes alterna

122 ivated cyclic nucleotide-modulated (HCN) and cyclic nucleotide-gated (CNG) channels, MloK1 lacks a C-

123 icantly disrupts the localization of the rod cyclic nucleotide-gated (Cng) channels, which accumulate

124 l transduction, a previously uncharacterized cyclic nucleotide-gated (CNG) ion channel, encoded by th

125 Cyclic nucleotide-gated (CNG) ion channels are nonselect

126 Cyclic nucleotide-gated (CNG) ion channels, despite a si

127 sensory neurons arises from the activity of cyclic nucleotide-gated (CNG) ion channels.

128 cturally related hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassiu

129 he open state of hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels, which are

130 ation of the hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel subunits HCN1, HCN

131 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are subthreshold

132 was dependent on hyperpolarization activated cyclic nucleotide-gated (HCN) channels as blockade with

133 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the sup

134 Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels contribute to cat

135 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAM

136 plasma membrane hyperpolarization-activated cyclic nucleotide-gated (HCN) channels enhanced presynap

137 distribution of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in human SAN has

138 mine whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in ICCs-DM were r

139 Activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated in

140 tor (NMDAR) and hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels play in this noci

141 t Ih mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels plays an importan

142 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate excitabi

143 mory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the

144 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the cont

145 rmeation through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and contributes

146 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, particularly tha

147 presence of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, the STA characte

148 sked whether the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are activa

149 hanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

150 rmeation through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

151 c attenuation of hyperpolarization-activated cyclic nucleotide-gated (HCN) current as the cause for i

152 cium (CaV), and hyperpolarization-activated, cyclic nucleotide-gated (HCN) currents, and can generate

153 s and with their hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel current charac

154 Hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels attenuate exc

155 Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels control neuro

156 Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an impor

157 sphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels regulates the

158 ssory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels, alters both

159 Hz generated by hyperpolarization-activated cyclic nucleotide-gated (HCN) pacemaker channels and tha

160 hypothesis that hyperpolarization-activated cyclic nucleotide-gated (HCN)-based biological pacing mi

161 The hyperpolarization-activated cyclic nucleotide-gated (HCN1) channels are predominantl

162 Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are critic

163 eptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests d

164 Cyclic nucleotide-gated channel (CNGC) family members me

165 kedly depends on hyperpolarization-activated cyclic nucleotide-gated channel (HCNC) activation.

166 mma (Prkcc), and hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1)) that were cons

167 The gene, hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1), regulates neur

168 ingle QTG, Hcn1 (hyperpolarization-activated cyclic nucleotide-gated channel 1), which has been impli

169 Here, we report that CYCLIC NUCLEOTIDE-GATED CHANNEL 14 (CNGC14) is essential

170 noreactivity for hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and the transcr

171 oreactivity for hyperpolarization activated, cyclic nucleotide-gated channel 4, were located in the b

172 localization and trafficking process of rod cyclic nucleotide-gated channel alpha-subunit (CNGA1), a

173 Cone density in cone cyclic nucleotide-gated channel B subunit-deficient and

174 Further, cone cyclic nucleotide-gated channel B subunit-deficient mice

175 Mutations in cyclic nucleotide-gated channel beta 1 (CNGB1) cause app

176 cs analysis revealed the z13 receptor as the cyclic nucleotide-gated channel beta3, a sorting pathway

177 ence that native hyperpolarization-activated cyclic nucleotide-gated channel complexes (HCN1-4) also

178 ere, we study ligand binding of a tetrameric cyclic nucleotide-gated channel from Mesorhizobium loti

179 PSKR1 is coexpressed with the CYCLIC NUCLEOTIDE-GATED CHANNEL gene CNGC17.

180 mpartmentalization allows the confinement of cyclic nucleotide-gated channel in the PM, while prevent

181 interacted with hyperpolarization-activated cyclic nucleotide-gated channel proteins (HCN proteins)

182 s the photoreceptors LITE and GUR-3, and the cyclic nucleotide-gated channel subunit TAX-2.

183 lecules for CPK32 led to identification of a cyclic nucleotide-gated channel, CNGC18, as an interacti

184 ger of Gata6 induces loss of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

185 node with some retention of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

186 Cyclic nucleotide-gated channels (CNGCs) are nonspecific

187 Cyclic nucleotide-gated channels (CNGCs) have been impli

188 augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (Ih or HCN channels).

189 cAMP opens cyclic nucleotide-gated channels allowing a Ca(2+) influ

190 portant role for hyperpolarization-activated cyclic nucleotide-gated channels and the cAMP/protein ki

191 These cyclic nucleotide-gated channels are located at the nucl

192 permeable to Ca(2+) We demonstrate that the cyclic nucleotide-gated channels form a complex with the

193 We show that three cyclic nucleotide-gated channels in Medicago truncatula

194 odulation in hyperpolarization-activated and cyclic nucleotide-gated channels that display voltage-de

195 nce (G(IRK)) or hyperpolarization-activated, cyclic nucleotide-gated channels.

196 n-activated cyclic nucleotide-modulated, and cyclic nucleotide-gated channels.

197 II activation, cAMP increase, and opening of cyclic nucleotide-gated channels.

198 n and vertical migrations required the TAX-4 cyclic nucleotide-gated ion channel in the AFD sensory n

199 rexpression of a hyperpolarization-activated cyclic nucleotide-gated ion channel rescues the muscle p

200 ed by the gcy genes, and two presently known cyclic nucleotide-gated ion channel subunits, encoded by

201 Arabidopsis (Arabidopsis thaliana) cyclic nucleotide-gated ion channels (CNGCs) form a larg

202 the structure-function relationship of plant cyclic nucleotide-gated ion channels (CNGCs), we identif

203 ttention will be given to the involvement of cyclic nucleotide-gated ion channels and Ca(2+) sensors.

204 irectly activated by cAMP (EPAC), as well as cyclic nucleotide-gated ion channels in certain tissues.

205 In sea urchin sperm, a cyclic nucleotide-gated K(+) channel (CNGK) mediates a c

206 animal HCN (for Hyperpolarization-activated, cyclic nucleotide-gated K(+)) channels as structure temp

207 and function of hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channe

208 gnaling cascade that leads to the opening of cyclic-nucleotide-gated (CNG), nonselective cation chann

209 ically expressed hyperpolarization-activated cyclic-nucleotide-gated (HCN) and transient potassium ch

210 l neurons to show that hyperpolarization and cyclic-nucleotide-gated (HCN) channels are expressed in

211 Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are tetramers tha

212 ssed the role of hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels in altering hippo

213 helial Na(+) channel (ENaC) and nonselective cyclic-nucleotide-gated cation channels creates the majo

214 icle electron cryo-microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis eleg

215 ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide m

216 Cyclic-nucleotide-gated channels are essential for visio

217 ning mediated by hyperpolarization-activated cyclic-nucleotide-gated nonspecific-cation channels.

218 lator of HCN channels and indicate that this cyclic nucleotide has to be considered in HCN channel-re

219 liary subunit of hyperpolarization-activated cyclic nucleotide (HCN)-gated channels.

220 Binding of cyclic nucleotides increases the rate and extent of chan

221 r activities are controlled by intracellular cyclic nucleotides instead of transmembrane voltage.

222 rting the novel concept that balance between cyclic nucleotides is critical for cell migration.

223 rom Mrp4(-/-) mice have higher intracellular cyclic nucleotide levels and migrate faster compared wit

224 To maintain homeostasis, cyclic nucleotide levels are regulated by phosphodiester

225 ges in membrane potential, intracellular pH, cyclic nucleotide levels, and intracellular Ca2+ concent

226 ys a role in the regulation of intracellular cyclic nucleotide levels.

227 ereas exchange protein activated directly by cyclic nucleotide/MAPK kinase, another cAMP downstream e

228 st they are likely to have distinct roles in cyclic nucleotide-mediated signaling in human myocardium

229 also identified changes in genes related to cyclic nucleotide metabolism, chromatin structure, and t

230 Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform v

231 unlike eukaryote hyperpolarization-activated cyclic nucleotide-modulated (HCN) and cyclic nucleotide-

232 The hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are pacemaker

233 Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetrameri

234 The hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels control r

235 ucleotide-binding domains of the prokaryotic cyclic nucleotide-modulated channel MloK1.

236 go-like K(+) and hyperpolarization-activated cyclic nucleotide-modulated channels, suggesting that th

237 The hyperpolarization-activated and cyclic nucleotide-modulated ion channel (HCN) drives the

238 binding thermodynamics of cAMP to an intact cyclic nucleotide-modulated ion channel using isothermal

239 understanding of the evolutionary origin of cyclic nucleotide-modulated ion channels and pave the wa

240 Cyclic nucleotide-modulated ion channels are important f

241 Cyclic nucleotide-modulated ion channels are molecular p

242 Cyclic nucleotide-modulated ion channels play crucial ro

243 nformational changes in full-length MloK1, a cyclic nucleotide-modulated potassium channel from the b

244 mic in the KCNH, hyperpolarization-activated cyclic nucleotide-modulated, and cyclic nucleotide-gated

245 e of the related hyperpolarization-activated cyclic-nucleotide-modulated (HCN) channels, there are ma

246 athy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of related channels.

247 modulation of HCN4 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels.

248 er amino acids, fatty acids, prostaglandins, cyclic nucleotides, odorants, polyamines, and vitamins.

249 gesting that the physiological effect of the cyclic nucleotide on LTP and memory is dependent upon Ab

250 To study effects of cyclic nucleotides on energy homeostatic mechanisms, mic

251 probed the allosteric mechanism of different cyclic nucleotides on the CNBD and on channel gating.

252 e in the distribution and/or availability of cyclic nucleotides or ADP may interfere with platelet re

253 s increasing intracellular levels of cAMP by cyclic nucleotide PDE inhibition both suppresses the imm

254 the successful identification of novel 3',5'-cyclic nucleotide phosphodiesterase (PDE) inhibitors, co

255 Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have ino

256 apped direct interactions between a specific cyclic nucleotide phosphodiesterase (PDE8A) and a PKA re

257 The cyclic nucleotide phosphodiesterase 10A (PDE10) has been

258 Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates

259 e were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, whi

260 f hepatocytes with 991 increases the Vmax of cyclic nucleotide phosphodiesterase 4B (PDE4B) without a

261 te modulation of the rate of inactivation of cyclic nucleotide phosphodiesterase 6 (PDE6).

262 Peptidyl arginine deiminase-2 and cyclic nucleotide phosphodiesterase are novel LRP1 ligan

263 Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and Tb

264 In recent years, cyclic nucleotide phosphodiesterase type 4 (PDE4) has ar

265 urally distinct cGMP-specific and -regulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, a

266 Here, we provide evidence that type 4 cyclic nucleotide phosphodiesterases (PDE4s) are critica

267 The 11 families of the Class I cyclic nucleotide phosphodiesterases (PDEs) are critical

268 Cyclic nucleotide phosphodiesterases (PDEs) catalyze the

269 Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet

270 nction, and regulation of cAMP hydrolysis by cyclic nucleotide phosphodiesterases (PDEs) is a critica

271 cyclic nucleotide-dependent kinases, making cyclic nucleotide phosphodiesterases (PDEs) potential re

272 The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play

273 ration and migration, which are regulated by cyclic nucleotide phosphodiesterases (PDEs).

274 composed of a GAF domain (commonly found in cyclic nucleotide receptors) and a GGDEF domain (found i

275 nnel called the hyperpolarization-activated, cyclic nucleotide-regulated (HCN) channel is activated b

276 -gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) ion channels play cruc

277 part of the gating conformational change in cyclic nucleotide-regulated channels.

278 Cyclic nucleotide-regulated ion channels bind second mes

279 to be mediated by protein kinase A (PKA) and cyclic nucleotide-regulated ion channels.

280 iated, and it requires a specific method for cyclic nucleotide regulation.

281 namics of multiple distinct steps underlying cyclic nucleotide regulation: a slow initial binding ste

282 ase/PDE enzyme pair to dynamically control a cyclic nucleotide second messenger (i.e., cAMP) for the

283 s response pathway in pollen that connects a cyclic nucleotide signal, a Ca(2+)-permeable ion channel

284 importance in cross-talk between calcium and cyclic nucleotide signaling (PDE1), control of cell prol

285 whether PDE2 inhibition modulates pulmonary cyclic nucleotide signaling and ameliorates experimental

286 n and nitric oxide, which trigger inhibitory cyclic nucleotide signaling involving cyclic AMP-depende

287 Cyclic nucleotide signaling is impaired in HD models, an

288 cyte proliferation mediated through distinct cyclic nucleotide signaling pathways.

289 an optogenetics tool for the manipulation of cyclic nucleotide signaling pathways.

290 channel in TVs, links transmitter-initiated cyclic nucleotide signaling with Ca(2+)-dependent TV exo

291 latelets and was suggested to be a target of cyclic nucleotide signaling.

292 roles of different PDEs in the regulation of cyclic nucleotide signaling.

293 erases (PDEs) are critical for regulation of cyclic nucleotide signaling.

294 ey times during the cell cycle, often using (cyclic) nucleotide signals.

295 effect on the C-linker and render all three cyclic nucleotides similarly potent activators of the ch

296 wledge, this is the first observation of non-cyclic-nucleotide small molecules with agonist propertie

297 e end organ, and is coupled to impairment of cyclic nucleotide targeted pathways linked to abnormal i

298 Instead of cyclic nucleotide, the binding pocket is occupied by a s

299 They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic

300 ach using competitive concentrations of free cyclic nucleotides to isolate each kinase and its second