ライフサイエンスコーパス: cyclic nucleotide-gated channel

1 of cyclic AMP and subsequent activation of a cyclic nucleotide-gated channel.

2 ar to the voltage-gated Ca2+ channel and the cyclic nucleotide-gated channel.

3 proteins coupled to cGMP binding domains or cyclic nucleotide gated channels.

4 activation of a nonselective current through cyclic nucleotide-gated channels.

5 and is controlled by cAMP, possibly through cyclic nucleotide-gated channels.

6 M Ca(2+), Mg(2+), or Sr(2+), the blockers of cyclic nucleotide-gated channels.

7 nce (G(IRK)) or hyperpolarization-activated, cyclic nucleotide-gated channels.

8 n-activated cyclic nucleotide-modulated, and cyclic nucleotide-gated channels.

9 nism to modulate hyperpolarization-activated cyclic nucleotide-gated channels.

10 hate (cGMP)-dependent influx of Ca2+ through cyclic nucleotide-gated channels.

11 emonstrated that AtCNGC1 and NtCBP4 are also cyclic nucleotide-gated channels.

12 II activation, cAMP increase, and opening of cyclic nucleotide-gated channels.

13 l transduction is unlikely to be mediated by cyclic-nucleotide-gated channels.

14 mma (Prkcc), and hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1)) that were cons

15 The gene, hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1), regulates neur

16 ingle QTG, Hcn1 (hyperpolarization-activated cyclic nucleotide-gated channel 1), which has been impli

17 Here, we report that CYCLIC NUCLEOTIDE-GATED CHANNEL 14 (CNGC14) is essential

18 ion of the HCN2 (hyperpolarization-activated cyclic nucleotide-gated channel 2) subunit of the Ih cha

19 n channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the correspondin

20 noreactivity for hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and the transcr

21 cell marker hyperpolarization-activated and cyclic nucleotide-gated channel 4 (HCN4) in Vsx1-null mi

22 oreactivity for hyperpolarization activated, cyclic nucleotide-gated channel 4, were located in the b

23 ctivity of the cyclase in the dark increased cyclic nucleotide-gated channel activity and elevated th

24 cAMP opens cyclic nucleotide-gated channels allowing a Ca(2+) influ

25 We expressed the rat olfactory cyclic nucleotide-gated channel alpha subunit in Xenopus

26 localization and trafficking process of rod cyclic nucleotide-gated channel alpha-subunit (CNGA1), a

27 omparison to the highly homologous olfactory cyclic nucleotide-gated channel alpha-subunit, which doe

28 onstrate that mice lacking functional CNGA2 (cyclic nucleotide-gated channel alpha2), which is requir

29 ut mice have been produced: a knockout for a cyclic nucleotide-gated channel and a G(olf) knockout.

30 e NaK selectivity filter resembles that of a cyclic nucleotide-gated channel and its structure may re

31 Slow gating kinetics of the cyclic nucleotide-gated channel and the detection of sin

32 suggest that in tissues where they co-exist, cyclic nucleotide-gated channels and Ca2+-sensitive aden

33 are responsible for the direct activation of cyclic nucleotide-gated channels and for modulation of t

34 to stimulation, Ca(2+) enters the cilia via cyclic nucleotide-gated channels and is extruded by Na(+

35 portant role for hyperpolarization-activated cyclic nucleotide-gated channels and the cAMP/protein ki

36 polypeptide, BCNG-1, is distantly related to cyclic nucleotide-gated channels and the voltage-gated c

37 es more potent than cyclic GMP in activating cyclic-nucleotide-gated channels and cGMP-dependent prot

38 ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide m

39 e, raising cyclic GMP concentration, opening cyclic nucleotide-gated channels, and increasing circula

40 hannels, CLC chloride transporters/channels, cyclic nucleotide-gated channels, and ionotropic glutama

41 Thus, we propose that native rod cyclic nucleotide-gated channels are arranged with like

42 Retinal rod cyclic nucleotide-gated channels are composed of alpha a

43 Cyclic nucleotide-gated channels are important in visual

44 Cyclic nucleotide-gated channels are key molecular eleme

45 These cyclic nucleotide-gated channels are located at the nucl

46 Cyclic nucleotide-gated channels are nonselective cation

47 Cyclic nucleotide-gated channels are tetramers and, in t

48 ings, we now show that retinal and olfactory cyclic-nucleotide-gated channels are activated by a cycl

49 Cyclic-nucleotide-gated channels are essential for visio

50 ir 3.x) channels, like the distantly related cyclic nucleotide-gated channels, are tetramers and exhi

51 ells, we used the patch-cramming method with cyclic nucleotide-gated channels as real-time biosensors

52 Cone density in cone cyclic nucleotide-gated channel B subunit-deficient and

53 Further, cone cyclic nucleotide-gated channel B subunit-deficient mice

54 Mutations in cyclic nucleotide-gated channel beta 1 (CNGB1) cause app

55 The canine homolog of the cyclic nucleotide-gated channel beta-subunit gene (CNGB3

56 cs analysis revealed the z13 receptor as the cyclic nucleotide-gated channel beta3, a sorting pathway

57 with guanidinium, an ion which permeates the cyclic nucleotide-gated channel but does not support Na(

58 t calcium concentration ([Ca2+]i) by closing cyclic nucleotide-gated channels but can also increase [

59 via Ca(2+)-dependent GCAP proteins, and (3) cyclic nucleotide-gated channels by binding of Ca(2+)-ca

60 underlie previously reported potentiation of cyclic nucleotide-gated channels by sulfhydryl-reactive

61 s, sodium transporters, calcium antiporters, cyclic nucleotide-gated channels, cation diffusion facil

62 In cyclic nucleotide-gated channels (CNG), direct binding o

63 eptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests d

64 A mutation in a cyclic nucleotide-gated channel (CNGA1) is associated wi

65 locking adenylyl cyclase or knocking out the cyclic nucleotide-gated channel CNGA2 eliminates the odo

66 e indicates that pollen tube growth requires cyclic nucleotide-gated channel (CNGC) 18.

67 Cyclic nucleotide-gated channel (CNGC) family members me

68 lecules for CPK32 led to identification of a cyclic nucleotide-gated channel, CNGC18, as an interacti

69 Cyclic nucleotide-gated channels (CNGCs) are nonspecific

70 Cyclic nucleotide-gated channels (CNGCs) have been impli

71 Cyclic nucleotide-gated channels (CNGCs) on the dendriti

72 Cyclic nucleotide-gated channels (CNGCs) transduce exter

73 ith structural similarities to cloned animal cyclic nucleotide-gated channels (CNGCs).

74 ence that native hyperpolarization-activated cyclic nucleotide-gated channel complexes (HCN1-4) also

75 ponse relations for a large number of single cyclic nucleotide-gated channels composed of the bovine

76 deactivation of hyperpolarization-activated cyclic nucleotide-gated channels conducting the hyperpol

77 Cyclic nucleotide-gated channels contain four ligand-bin

78 Cyclic nucleotide-gated channels contain four subunits,

79 n vertebrate visual and olfactory systems, a cyclic nucleotide-gated channel couples receptor activat

80 coding intraflagellar transport proteins and cyclic nucleotide gated channels, demonstrating that C.

81 y adaptation within neurons that require the cyclic nucleotide-gated channel for olfaction; in these

82 permeable to Ca(2+) We demonstrate that the cyclic nucleotide-gated channels form a complex with the

83 ere, we study ligand binding of a tetrameric cyclic nucleotide-gated channel from Mesorhizobium loti

84 icle electron cryo-microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis eleg

85 emaker gene, the hyperpolarization-activated cyclic nucleotide-gated channel gene (HCN2), was studied

86 PSKR1 is coexpressed with the CYCLIC NUCLEOTIDE-GATED CHANNEL gene CNGC17.

87 Hyperpolarization-activated cyclic nucleotide-gated channel (HCN) 4 is a major subun

88 ockade of septal hyperpolarization-activated cyclic nucleotide-gated channels (HCN) impairs hippocamp

89 abolished by the hyperpolarization-activated cyclic-nucleotide-gated channel (HCN)-specific antagonis

90 kedly depends on hyperpolarization-activated cyclic nucleotide-gated channel (HCNC) activation.

91 y understood how hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) function.

92 augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (Ih or HCN channels).

93 mpartmentalization allows the confinement of cyclic nucleotide-gated channel in the PM, while prevent

94 We show that three cyclic nucleotide-gated channels in Medicago truncatula

95 CNGB3 encodes the beta-subunits of cyclic nucleotide-gated channels in the photoreceptor pl

96 We find no evidence for cyclic nucleotide-gated channels in VNO neurons under a

97 t structural and functional understanding of cyclic nucleotide-gated channels, in this study we exper

98 lts in increased cAMP production, opening of cyclic nucleotide-gated channels, influx of Ca2+ and Na+

99 -br-cGMP were reversed by L-cis-diltiazem, a cyclic nucleotide-gated channel inhibitor, as well as by

100 dour stimulates the influx of Ca(2+) through cyclic nucleotide-gated channels into the small volume w

101 The activation of a cyclic nucleotide-gated channel is the final step in sen

102 Activation of cyclic nucleotide-gated channels is thought to involve t

103 e suggests that a subset of this family, the cyclic nucleotide-gated channels, may deviate from this

104 Although cyclic nucleotide-gated channels mediate sensory transdu

105 Caenorhabditis elegans cyclic nucleotide-gated channel mutants respond normally

106 that it was produced by ion flux through the cyclic nucleotide-gated channels of the outer segment; h

107 to diffuse into the cilium and activate the cyclic nucleotide-gated channels on the plasma membrane.

108 cGMP is the natural activator of the cyclic nucleotide-gated channel originally isolated from

109 el and its structure may represent that of a cyclic nucleotide-gated channel pore.

110 hannels, which include the K+, Ca2+, Na+ and cyclic nucleotide-gated channels, probably share a simil

111 interacted with hyperpolarization-activated cyclic nucleotide-gated channel proteins (HCN proteins)

112 ession of three CBPs including an isoform of cyclic nucleotide-gated channels (PvCNGC-A) and two hypo

113 tein kinase, which limits the conductance of cyclic nucleotide-gated channels, reducing the influx of

114 ndent protein kinase I (CaMKI) and the TAX-4 cyclic nucleotide-gated channel regulate gene expression

115 zed and evaluated for potency of blockade of cyclic nucleotide-gated channels relative to a multiply

116 noassay and membrane-delineated flow through cyclic nucleotide-gated channels, respectively.

117 In the present study we have employed a cyclic nucleotide-gated channel sensor to report acute c

118 sequence alignments between AQP1 and sensory cyclic-nucleotide-gated channels showed similarities bet

119 ger of Gata6 induces loss of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

120 node with some retention of hyperpolarizing cyclic nucleotide-gated channel, subtype 4 staining in t

121 diesterase 2a, cGMP-dependent kinase II, and cyclic nucleotide gated channel subunit A3 coupled to a

122 The olfactory cyclic nucleotide-gated channel subunit 1 (OCNC1) is req

123 ene encoding the hyperpolarization-activated cyclic nucleotide-gated channel subunit 2 (HCN2), an ion

124 channel M5 (TRPM5), is coexpressed with the cyclic nucleotide-gated channel subunit A2 in a subset o

125 sing the receptor guanylyl cyclase GC-D, the cyclic nucleotide-gated channel subunit CNGA3, and the c

126 sensory neurons by targeted mutagenesis of a cyclic nucleotide-gated channel subunit gene, OCNC1.

127 s the photoreceptors LITE and GUR-3, and the cyclic nucleotide-gated channel subunit TAX-2.

128 ha(olf), adenylyl cyclase III, the olfactory cyclic nucleotide-gated channel subunits, and olfactory

129 that tax-2 encodes a predicted subunit of a cyclic nucleotide-gated channel that is expressed in olf

130 genes of C. elegans encode two subunits of a cyclic nucleotide-gated channel that is required for che

131 odulation in hyperpolarization-activated and cyclic nucleotide-gated channels that display voltage-de

132 studied two inheritable cysteine mutants of cyclic nucleotide-gated channels that produce achromatop

133 on the sequence differences between CRP and cyclic nucleotide gated channel, three mutants of CRP we

134 response of ligand-binding proteins, such as cyclic-nucleotide-gated channels, to different biologica

135 sts of candidate channel subtypes including: cyclic nucleotide-gated channels, transient receptor pot

136 ng movements of the intracellular domains of cyclic nucleotide-gated channels using simultaneous site

137 The cDNA coding for the rat olfactory cyclic nucleotide-gated channel was inserted into an ade

138 egion of the alpha subunit of the bovine rod cyclic nucleotide-gated channel was probed using cystein

139 channel appears to differ from the olfactory cyclic nucleotide-gated channel, which is also modulated

140 ion of homomeric and heteromeric retinal rod cyclic nucleotide-gated channels with the four ligand-bi