ライフサイエンスコーパス: cyclic peptide

1 inhibition of SPSB2-iNOS interactions by the cyclic peptide.

2 chemical ligation to synthesize the grafted cyclic peptide.

3 erminal amine of ornithine to a nine residue cyclic peptide.

4 , varying the structure and ring size of the cyclic peptide.

5 over micro opioid receptors than the parent cyclic peptide.

6 hree opioid receptors compared to the parent cyclic peptide.

7 or the MVCB[8] complex, matching that of the cyclic peptide.

8 d the other one composed of an aptamer and a cyclic peptide.

9 based method for synthesizing disulfide-rich cyclic peptides.

10 easured by NMR to identify exposed amides in cyclic peptides.

11 ble biophysical properties of disulfide-rich cyclic peptides.

12 ses may be ideal catalysts for production of cyclic peptides.

13 late affinity for matriptase over trypsin in cyclic peptides.

14 view of nanotubes derived from this class of cyclic peptides.

15 rough conjugation of (macro)molecules to the cyclic peptides.

16 ates to generate a library of highly diverse cyclic peptides.

17 mising antiviral activity observed for these cyclic peptides.

18 onable yields (56-74%) of all of the desired cyclic peptides.

19 are all notable pharmacologically important cyclic peptides.

20 ization of tandem mass spectra obtained from cyclic peptides.

21 olding and oligomerization of this family of cyclic peptides.

22 del for the passive membrane permeability of cyclic peptides.

23 ids, and greatly simplified the synthesis of cyclic peptides.

24 ion to a new strategy for the preparation of cyclic peptides.

25 the library, resulting in linear rather than cyclic peptides.

26 yanobactins to include tryptophan-prenylated cyclic peptides.

27 A nonphosphorylated cyclic peptide 1 (known as G7-18NATE) inhibits Grb7 via

28 A novel cyclic peptide 1 (LXY1) with high binding specificity to

29 A novel cyclic peptide 2 (LXY3) with a high binding affinity (IC

30 y reported the discovery of a CXCL12-mimetic cyclic peptide (2) as a selective CXCR4 antagonist showi

31 , these experiments suggest a model in which cyclic peptide 3a oligomerizes to form a dimer of beta-s

32 terized nine non-natural triazole-containing cyclic peptides, a further ten molecules are also synthe

33 We have designed a cyclic peptide, Ac-c[CVDINNNC]-NH2, containing the key s

34 ength, and amino acid sequence, the tightest cyclic peptide achieved a Ki value of 2.9 muM against DE

35 The cyclic peptide AF17121 (VDECWRIIASHTWFCAEE) is a library

36 The cyclic peptide AF17121 is a library-derived antagonist f

37 e G protein-coupled receptor (GPCR), and its cyclic peptide agonist ligand, Tyr(1)-c(S-Et-S)[d-Cys(2)

38 y of different classes of peptide, including cyclic peptides, amyloid peptides and surfactant-like pe

39 kFL, here we report the synthesis of a novel cyclic peptide analogue cyclic WXEAAYQkFL.

40 This program facilitates cyclic peptide analysis, sequencing, and also acts as a

41 act on the product of OLP1, giving rise to a cyclic peptide and concomitant removal of a C-terminal f

42 phage library-derived colon cancer-specific cyclic peptide and fluorescent moieties.

43 have recently synthesized the corresponding cyclic peptide and found that it too has antitumor activ

44 Optimization of the cyclic peptide and mutagenesis experiments suggest that

45 sion of U2-OS cells, could be blocked with a cyclic peptide and with an antibody preventing binding o

46 gate the uncommon fragmentation phenomena of cyclic peptides and aids the characterization of newly d

47 in the inhibitory activity of this class of cyclic peptides and also present a binding model based u

48 ied macrocycles modeled on the structures of cyclic peptides and designed to be biologically stable.

49 eptide macrocyclization toward the design of cyclic peptides and peptidomimetics as calpain inhibitor

50 Cyclic peptides and peptoids were prepared using the thi

51 By screening a focused library of linear and cyclic peptides and performing structure-activity relati

52 to prepare a variety of peptide thioesters, cyclic peptides, and a fully functional Src homology 3 (

53 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bundles.

54 ),D-Nal(2')(7),Lys(10)]-NH2), a nonselective cyclic peptide antagonist at hMC3R and hMC4R and an agon

55 complex responsible for the synthesis of the cyclic peptide antibiotic Aureobasidin A (AbA) in Aureob

56 are functionalized with polymyxin B (PMB), a cyclic peptide antibiotic with high affinity for LPS.

57 and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to

58 ncluding peptide antitumor agents, hormones, cyclic peptide antibiotics, and model proteins.

59 matic approach to make carbohydrate-modified cyclic peptide antibiotics.

60 ynthetic reaction, which, for disulfide-rich cyclic peptides, appears to involve asparaginyl endopept

61 (Nod), a group of structurally related small cyclic peptides ( approximately 1000 Da) with more than

62 four contained new structures, including the cyclic peptides arbumycin and arbumelin, the diterpenoid

63 ids and peptide fragments into the homodetic cyclic peptide architecture.

64 Natural and non-natural cyclic peptides are a crucial component in drug discover

65 The resulting cyclic peptides are cell permeable and have improved pro

66 These five-residue cystine-linked cyclic peptides are flanked by a C-terminal methyl ester

67 bstrate requirements and demonstrate that KW cyclic peptides are more widespread than anticipated, no

68 Heterocycle-containing cyclic peptides are promising scaffolds for the pharmace

69 Our findings suggest that the use of cyclic peptides as structural backbones offers a promisi

70 can be applied to synthesize both linear and cyclic peptides, as well as peptides composed of natural

71 locked-open inhibition mechanism placing the cyclic peptide at the bi-domain interface.

72 blasts attached to substrates presenting the cyclic peptide at twice the rate they attached to substr

73 In this study, we explore the role of the cyclic peptide backbone and cystine ladder in the struct

74 he cyclic cystine ladder motif, comprising a cyclic peptide backbone and three parallel disulfide bon

75 ut additional amino acids can be used in the cyclic peptide backbone, varying the structure and ring

76 of an array of conformationally constrained cyclic peptides based on an epitope of the A-B loop with

77 A successful application of a cyclic peptide bearing a thioester handle in native chem

78 mposed of two self-complementary alpha,gamma-cyclic peptides bearing a Zn porphyrin cap that is used

79 We demonstrated that the cyclic peptide bound BIV TAR RNA with an affinity compar

80 e report the structure of the complex of the cyclic peptide bound to BIV TAR RNA determined using het

81 tandem mass spectrometry data obtained with cyclic peptides but also enables quantitative analysis o

82 portant roles in the passive permeability of cyclic peptides, but other structural features have been

83 lso successfully applied to the formation of cyclic peptides by macrocyclization.

84 e synthesis/semisynthesis of proteins and of cyclic peptides by native chemical ligation.

85 han residues reportedly involved in C5a- and cyclic peptide C5a antagonist-receptor interaction, sugg

86 ch a small biologically active synthetic exo-cyclic peptide can be engineered to enhance functional a

87 These cyclic peptides can be coupled to N-terminal cysteine-co

88 Large combinatorial libraries of cyclic peptides can now be routinely synthesized by the

89 tive targeting of rat PAH lesions by a novel cyclic peptide, CARSKNKDC (CAR).

90 We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the

91 n anti-immunocomplex phage clone bearing the cyclic peptide CFNGKDWLYC.

92 ogy and that most belong to the macrolide or cyclic peptide class.

93 A bridged cyclic peptide (CN2097), shown by nuclear magnetic reson

94 be achieved and/or controlled by varying the cyclic peptide components of similar SWCNT/SCPN hybrids.

95 aminoacylation and ribosomal translation of cyclic peptides comprised of unnatural amino acids that

96 AP301 [Cyclo(CGQRETPEGAEAKPWYC)], a cyclic peptide comprising the human tumor necrosis facto

97 Cyclotides are a family of plant-derived cyclic peptides comprising six conserved cysteine residu

98 d new mouse MAbs that were able to bind to a cyclic peptide containing E2 residues 412 to 422 (C-epit

99 Cyclic peptides containing a consensus motif (WXDDG) bou

100 The synthesis of cyclic peptides containing a thioester handle using a su

101 Microbubbles were conjugated to cyclic peptides containing either RRL (RRL-MB) or a glyc

102 Here we describe 125 cyclic peptides containing four to thirty-seven amino ac

103 ic method enables the efficient synthesis of cyclic peptides containing gamma-amino acids and is tole

104 Cyclic peptides containing the Arg-Gly-Asp (RGD) sequenc

105 Peptide 3a, as the representative of these cyclic peptides, contains a heptapeptide sequence (TSFTY

106 requiring the redesign and synthesis of the cyclic peptide core.

107 subunit of the NRPS to modify the daptomycin cyclic peptide core.

108 modular setup, were assembled by using these cyclic peptide cores to demonstrate large affinity gains

109 d is shown for synthesis of the irreversible cyclic peptide corresponding to the proposed depsipeptid

110 d upon overexpression of a LEDGF/p75-binding cyclic peptide CP65, originally developed to inhibit the

111 Caryophyllaceae-type cyclic peptides (CPs) of 5-12 proteinogenic amino acids

112 lical turns, beta-bulges, and alpha-turns in cyclic peptides cross-linked at i, i + 3 and i, i + 4 po

113 d to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution.

114 syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide syste

115 A conformationally constrained cyclic peptide (Cys527-Cys542) containing a high-affinit

116 e compared the avidity of a linear (911) and cyclic peptide (D002) reactive with concanavalin A prese

117 The reported cyclic peptide demonstrates the utility of our high-thro

118 r2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhum

119 we describe the inhibitory effect of a short cyclic peptide derived from the snake toxin metalloprote

120 In this study, cyclic peptides derived from MTII, Ac-Nle-cyclo(Asp-His6

121 ssive membrane diffusion in a related set of cyclic peptide diastereomers.

122 Interestingly, libraries of cyclic peptides displayed a steep drop-off in membrane p

123 Largamide H (8) is a unique cyclic peptide displaying a new 2,5-dihydroxylated beta-

124 These structurally related cyclic peptides each contain modified amino acid residue

125 ids the characterization of newly discovered cyclic peptides encountered in drug discovery programs.

126 cal structures of emerging TIs suggest these cyclic peptides evolved by internal gene amplification a

127 This cyclic peptide exemplifies potentially a new class of an

128 (2), which was a partial agonist, all of the cyclic peptides exhibited full agonist activity in the a

129 Pasireotide, a therapeutic cyclic peptide, exhibits poor collision-induced dissocia

130 ive and specific detection of disulfide-rich cyclic peptides extracted from plasma.

131 ve capacity to encode thousands of different cyclic peptides, few of which would display similar ring

132 egy was developed for preparing biotinylated cyclic peptides, first through an orthogonal end-to-end

133 spectrometry data of the lasso and branched-cyclic peptides for all charge states, including the hig

134 ts demonstrate the feasibility of developing cyclic peptides for the inhibition of intracellular prot

135 This study describes the use of cyclic peptides for use in the selection of single-chain

136 theta-Defensins are ribosomally synthesized cyclic peptides found in the leukocytes of some primate

137 nnotation program, it was observed that some cyclic peptides fragmented in unexpected ways resulting

138 e prenylated by CymD prior to release of the cyclic peptide from the CymA megasynthetase, whereas the

139 zation of the peptide chain, cleavage of the cyclic peptide from the resin under mild acidic conditio

140 ; and (ix). final acidolytic cleavage of the cyclic peptide from the resin.

141 imilar AEP-mediated processing of a class of cyclic peptides from unrelated precursor proteins in phy

142 Short peptides (iRGD is a 9-amino acid cyclic peptide) generally have a plasma half-life measur

143 tus constructed previously, dications of the cyclic peptide Gramicidin S (GS) and the photoactive org

144 zation phenomenon also was observed with the cyclic peptide gramicidin S, indicating the generality o

145 Physisorption of a cyclic peptide, Gramicidin S (GS), was studied for 8 h d

146 However, the cyclic peptide has a unique motional signature in the ap

147 Disulfide-rich cyclic peptides have exciting potential as leads or fram

148 Disulfide-rich cyclic peptides have generated great interest in the dev

149 Cyclic peptides have great potential as therapeutic agen

150 The resulting bioactive cyclic peptides have revealed new insights into structur

151 ed aggregation and fibril reversibility of a cyclic peptide hormone somatostatin (SST)-14 using vario

152 tide thioesters give easy, direct, access to cyclic peptides, illustrated by the synthesis of cyclora

153 Also, the orientation of the cyclic peptide in the antibody-combining site is rotated

154 This suggests that production of cyclic peptides in angiosperms has evolved in parallel u

155 ive and should greatly expand the utility of cyclic peptides in biomedical research.

156 ylate C-3 of Trp residues in both linear and cyclic peptides in vitro.

157 egy was developed for the synthesis of these cyclic peptides in which the final peptides could be cle

158 strated for a range of biologically relevant cyclic peptides, including somatostatin, proteins, and a

159 Cyanobacteria produce a wide variety of cyclic peptides, including the widespread hepatotoxins m

160 In addition, many cyclic peptides incorporate gamma-amino acids and other

161 e show that even a pulse treatment with this cyclic peptide induced parasite death due to proteasome

162 These cell-permeable cyclic peptides inhibit Ras signaling by binding to Ras-

163 e in the apparent affinity for verapamil and cyclic peptide inhibitor QZ59-SSS was observed in deterg

164 and treatment of embryos with stereoisomeric cyclic peptide inhibitors (QZ59 compounds).

165 Two additional P-gp structures with cyclic peptide inhibitors demonstrate distinct drug-bind

166 For ribonucleotide reductase, we identified cyclic peptide inhibitors from genetically encoded libra

167 Here we report cyclic peptide inhibitors of the KDM4A-C with selectivit

168 We have developed cyclic peptide inhibitors that target UHM domains.

169 In this study, we designed a series of cyclic peptides interacting with both sides of the activ

170 ed intramolecular transpeptidation through a cyclic peptide intermediate.

171 LAG) connected tumor-homing and -penetrating cyclic peptide iRGD to HPMA copolymer.

172 A hexameric oligomer of the cyclic peptide is found in both crystal forms and indica

173 of para-substituted phenylalanine containing cyclic peptides is described.

174 This new family of mostly backbone-cyclic peptides is structurally diverse, but the proteas

175 Two of three cyclic peptides isolated after two rounds of selection c

176 ine arginine (pLR) belongs to a new class of cyclic peptides isolated from frog skin.

177 Cyclotides are bioactive cyclic peptides isolated from plants that are characteri

178 es and filoviruses, and that the PE-specific cyclic peptide lantibiotic agent Duramycin efficiently i

179 es, termed largamides A-G (1-7), and one new cyclic peptide, largamide H (8), have been isolated from

180 we describe a method for the biosynthesis of cyclic peptide libraries of up to 10(8) members in Esche

181 relationship (SAR) study, two highly focused cyclic peptide libraries were further designed, synthesi

182 at are amenable to the in-cell production of cyclic peptide libraries.

183 After screening of the cyclic peptide library against a macromolecular target,

184 The cyclic peptide library can potentially be of any size an

185 put method for the sequence determination of cyclic peptide library members has been developed.

186 In this work, a cyclic peptide library was synthesized and screened agai

187 The cyclic peptide ligand was synthesized on a poly(methacry

188 ategy is presented for the identification of cyclic peptide ligands from combinatorial libraries of r

189 formationally constrained side chain-bridged cyclic peptide ligands were also designed, prepared, eva

190 ch a delivery system based on a 9-amino acid cyclic peptide, LyP-1.

191 This engineered cyclic peptide maintained the overall fold of the natura

192 have discovered conformationally-constrained cyclic peptide mimetics of Tat that are specific nM inhi

193 An HDAC inhibitor based on a cyclic peptide mimic of known structure, linked by an al

194 However, the new cyclic peptide mimic of Tat represents a new class of li

195 We previously reported the discovery of a cyclic peptide mimic of the RNA-binding domain of BIV Ta

196 Cyclic peptides mimicking the extracellular loops of CCR

197 We explored the potential of cyclic peptides mimicking this structure to elicit anti-

198 esent time it is still difficult to annotate cyclic peptides MS/MS spectra.

199 s and resulted in the discovery of three new cyclic peptides, namely microcystin-MhtyR (6), which com

200 n nanotubes (SWCNTs) and the self-assembling cyclic peptide nanotubes (SCPNs).

201 Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has been ac

202 Cyclic peptide natural products contain a variety of con

203 Cyclic peptide natural products have evolved to exploit

204 ividually incorporated into the nine-residue cyclic peptide of chlorofusin (4 steps each) providing a

205 theta-Defensins, the only cyclic peptides of animal origin, have been isolated fro

206 It has been proposed that the cyclic peptides of the patellamide class found in didemn

207 beta-Sheet forming self assembling cyclic peptides offer a versatile scaffold for the const

208 se fungi have a broad capacity to synthesize cyclic peptides on ribosomes.

209 de (JASP), an actin polymerization-promoting cyclic peptide, or sphingosine-1-phosphate (S1P), a foll

210 ibitors I-Pc and Cl-Pc were derived from the cyclic peptide Pc, a mimetic of the C-terminal CK2alpha-

211 In summary, the data presented suggest that cyclic peptide Pep42 might be a powerful tool in the con

212 ching is an effective, yet untapped, tool in cyclic peptide permeability optimization.

213 Here we describe the screening of a pool of cyclic peptide phage display libraries using whole-cell

214 We report here the use of a naive cyclic peptide phage display library to identify peptide

215 The cyclic peptide phalloidin binds and stabilizes actin fil

216 te MscL to introduce the cell-impermeable bi-cyclic peptide phalloidin, a specific marker for actin f

217 ytoplasm, including peptide nucleic acids, a cyclic peptide (phalloidin), and organic compounds.

218 ion and self-assembly of a new generation of cyclic peptide-polymer conjugates into well-defined phos

219 The thermoresponsive character of the cyclic peptide-polymer conjugates lays the foundation fo

220 By varying the structural parameters of the cyclic peptide-polymer conjugates through the ligation o

221 ip (SAR) analysis, we discovered a family of cyclic peptides possessing both Ras-binding and cell-pen

222 pic breast MDA-MB-231 tumors showed that the cyclic peptide preferentially accumulates in tumor (2 h

223 -mining, we discovered that anabaenopeptins, cyclic peptides produced by cyanobacteria, were potent i

224 s are a rapidly growing family of linear and cyclic peptides produced by cyanobacteria.

225 g from 35 to 70 amino acids, are the largest cyclic peptides produced by lactic acid bacteria to supp

226 icity requirements at the excision sites for cyclic peptide production.

227 Cyclic peptides provide attractive lead compounds for dr

228 We have utilized reversible cyclic peptides (RCPs)-peptides containing alternating l

229 Base hydrolysis of the ester linkage in the cyclic peptides regenerated linear peptides that contain

230 The cyclic peptides reported here as DENV protease inhibitor

231 An 8-aa cyclic peptide retains most of the activity of the full-

232 rationale for functional nanotubes based on cyclic peptide ring size and chemical functionality is d

233 eplacing the noncritical residues within the cyclic peptide ring with arginine residues and shown to

234 gens, Tn and STn, were assembled on a single cyclic peptide scaffold in a highly convergent manner.

235 hese peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic po

236 three copies of Man(9)GlcNAc(2) coupled to a cyclic peptide scaffold.

237 of geometrically diverse, membrane permeable cyclic peptide scaffolds based on the synthesis and perm

238 one diversity and improve ADME properties in cyclic peptide scaffolds.

239 results demonstrate that the new method for cyclic peptide sequence determination is reliable, opera

240 en and CB[8] (MVCB[8]) within a vast pool of cyclic peptide sequences.

241 y asparaginyl endopeptidases (AEPs) into the cyclic peptide SFTI-1 (sunflower trypsin inhibitor-1) an

242 Correlation analysis of the reduced cyclic peptide shows that two of the three disulfide dis

243 the fragment are fused into a macrocycle (= cyclic peptide) structure, thus "losing" the memory of t

244 hyl-lysine or methylated arginine results in cyclic peptide substrates, indicating that KDM4s may act

245 uct in the biosynthesis of several bioactive cyclic peptides such as lantibiotics, thiopeptides, and

246 lly annotated the sequence of representative cyclic peptides, such as seglitide, tyrothricin, desmeth

247 The plant-derived cyclic peptide, sunflower trypsin inhibitor-1 (SFTI-1),

248 roves both the convergence and divergence of cyclic peptide synthesis.

249 atile intermediates for peptide ligation and cyclic peptide synthesis.

250 cholestane linked to a disulfide-constrained cyclic peptide, termed FcIII, known to exhibit high affi

251 -soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Me

252 discovery of a novel proteolytically stable cyclic peptide that can be used for targeted drug delive

253 sing this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide

254 Compstatin is a 13-residue cyclic peptide that inhibits complement activation by bi

255 peptide mimic of the Tat basic domain and a cyclic peptide that potently inhibits Tat-dependent acti

256 Meditopes are cyclic peptides that bind in a specific pocket in the an

257 n and characterization of two such unnatural cyclic peptides that bind the protease thrombin with low

258 theoretical diversity of 160 000) identified cyclic peptides that bind to streptavidin.

259 y of >10(13) different sequences and isolate cyclic peptides that bind with high affinity and specifi

260 port a bacterial system for the evolution of cyclic peptides that makes use of an expanded set of ami

261 nthesis, and characterization of a family of cyclic peptides that mimic protein quaternary structure

262 se inhibitors, resulting in the discovery of cyclic peptides that operate in an unprecedented manner,

263 The goal was to develop smaller partially cyclic peptides that retain the antiviral activity of re

264 atalytic site of PPM1D and inhibition by the cyclic peptides that will be useful both for the subsequ

265 ables the emergence of extensively different cyclic peptides through short mutational paths based on

266 eported methods for producing disulfide-rich cyclic peptides, thus offering great potential to facili

267 synthesized by conjugation of a known short cyclic peptide to a cross-bridged chelator (CB-TE2A), fo

268 peptide topologies, indicating the branched-cyclic peptide to be folded in the gas phase into a conf

269 lum and reveal the first functional Agr-type cyclic peptide to be produced by a thermophilic member o

270 tion at D-Lys(2)-Xxx(3) is crucial for these cyclic peptides to maintain high affinity, selectivity,

271 d MOR agonist/DOR antagonist behavior in the cyclic peptides to the tetrahydroquinoline scaffold and

272 Furthermore, a self-sorting of the cyclic peptides toward semiconducting rather than metall

273 Cyclic peptide triazoles (cPTs) retained the gp120 inhib

274 +) occur in some functional contexts: in the cyclic peptides valinomycin and antamanide; in several e

275 In the case of longer, linear or cyclic peptides, vice versa results are obtained.

276 The cyclic peptides violated to different degrees all of the

277 bilized on gold microcantilever surface, the cyclic peptide was able to capture breast cancer cells s

278 To address this gap, a genetically encoded cyclic peptide was designed based on the sonic hedgehog

279 s outside the FXIIa active site, a synthetic cyclic peptide was tested.

280 the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammat

281 the discovery of cyclotides and related non-cyclic peptides we called "acyclotides" from petunia of

282 Both ends of the cyclic peptide were shown to interact with the top of tr

283 ally segregated into outer and inner layers; cyclic peptides were displayed on the bead surface, wher

284 d its carbamate-protected form in linear and cyclic peptides were investigated using NMR and alpha-ch

285 The passive membrane permeabilities of 11 cyclic peptides were obtained experimentally using a par

286 These cyclic peptides were then conjugated to 21 azido sugars

287 Eudistomides A (1) and B (2), two new cyclic peptides, were isolated from a Fijian ascidian Eu

288 listatins is one of the families of Pro-rich cyclic peptides whose synthetic counterparts have reveal

289 In a control experiment, a protonated cyclic peptide with 6 amino acid residues, cyclo(Gln-Trp

290 s matured into SFTI-1, a protease-inhibiting cyclic peptide with a motif homologous to unrelated inhi

291 MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity a

292 apsule based on a beta-sheet self-assembling cyclic peptide with the ability to recognize and release

293 -activity relationship analysis, we designed cyclic peptides with 4-fold improved binding affinity fo

294 Fusion of cyclic peptides with a cyclic cell-penetrating peptide p

295 of membrane-permeable scaffolds to identify cyclic peptides with good to excellent passive cell perm

296 Inspired by a series of cyclic peptides with partially elucidated structures, we

297 peptide cyclo(d-Ala-Ala5 ); 2) selection of cyclic peptides with the highest intestinal permeability

298 tly increased the inhibitory activity of the cyclic peptide, with the optimized molecule having a K(i

299 d trans isomers were obtained for all of the cyclic peptides, with the ratio of cis to trans isomers

300 tegy for engineering conformationally rigid, cyclic peptides without the need for disulfide-bond rein