ライフサイエンスコーパス: cyclic-di-GMP

1 c phosphodiesterases, while CgsB displayed a cyclic-di-GMP synthase phenotype.

2 more, DRaCALA can detect the expression of a cyclic-di-GMP (cdiGMP)-binding protein in whole-cell lys

3 yticus strain previously shown to accumulate cyclic-di-GMP and in vitro using phosphodiesterase activ

4 dA encodes a cyclic bis(3',5')guanylic acid (cyclic di-GMP)-forming enzyme with an unusual GGDEF moti

5 as a cue for surface adhesion and activates cyclic-di-GMP signaling.

6 on the presence of the allosteric activator cyclic-di-GMP, but is independent of lipid-linked reacta

7 bound domains from riboswitches for adenine, cyclic di-GMP, and glycine.

8 Cyclic di-AMP (c-di-AMP) and cyclic di-GMP (c-di-GMP) are signaling molecules that pl

9 olysaccharide (biofilm matrix component) and cyclic di-GMP (biofilm-regulatory molecule) were detecte

10 effector that directly links cyclic GMP and cyclic di-GMP signalling.

11 esent a model for the roles of magnesium and cyclic di-GMP in the control of motility of V. fischeri.

12 , AMP, phosphoadenylyl adenosine (pApA), and cyclic di-GMP (c-di-GMP).

13 ental conditions are quorum sensing (QS) and cyclic di-GMP (c-di-GMP) signaling, respectively.

14 by quorum sensing, two-component systems and cyclic di-GMP signalling.

15 this recent work: tRNA(Phe), the adenine and cyclic-di-GMP riboswitches, and 5S rRNA.

16 ut not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA,

17 indicating that the impact of magnesium and cyclic-di-GMP primarily acts following transcription.

18 sults reveal an important connection between cyclic-di-GMP, B. burgdorferi motility and Lyme disease

19 This protein was found to bind cyclic-di-GMP (c-di-GMP) and regulate type 3 fimbrial ex

20 olysaccharides, as well as its activation by cyclic-di-GMP.

21 and its synthesis is likewise stimulated by cyclic-di-GMP.

22 re demonstrated: OpaR increases the cellular cyclic di-GMP (c-di-GMP) level, positively controls chit

23 une activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses.

24 ll three loss-of-function mutations enhanced cyclic-di-GMP-mediated bacterial biofilm formation in th

25 esigned RNA-based fluorescent biosensors for cyclic di-GMP and cyclic AMP-GMP by fusing the Spinach a

26 dition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of

27 cyclases, suggesting an inhibitory role for cyclic di-GMP.

28 swimming pattern, indicating a function for cyclic-di-GMP in regulating B. burgdorferi motility.

29 se (PTS(Ntr)) system, as being important for cyclic-di-GMP production and for biofilm formation.

30 resolves unexpected tertiary proximities for cyclic-di-GMP, glycine, and adenosylcobalamin riboswitch

31 pecies, the results are broadly relevant for cyclic-di-GMP- and HAMP domain-regulated transmembrane s

32 in mice, demonstrating an important role for cyclic-di-GMP in B. burgdorferi infection.

33 results reveal a previously unknown role for cyclic-di-GMP in type 3 fimbrial production.

34 ism involved in Y. pestis biofilm formation, cyclic-di-GMP signaling, is also widespread in bacteria;

35 0.054 microM, confirming it is a functional cyclic-di-GMP phosphodiesterase.

36 Bacterial bis-(3'-5') cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger a

37 However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake

38 BB0363 specifically hydrolyzed cyclic-di-GMP with a K(m) of 0.054 microM, confirming it

39 EAL domain protein that binds and hydrolyzes cyclic di-GMP (c-di-GMP).

40 The activity of XC_0249 in cyclic di-GMP synthesis was enhanced by addition of cycl

41 omologous to EAL domain proteins involved in cyclic-di-GMP regulation, appears to act at a step after

42 carrying genes known to alter intracellular cyclic-di-GMP pools in Vibrio parahaemolyticus revealed

43 result of the accumulation of intracellular cyclic-di-GMP.

44 regulation of CsrB/C decay does not involve cyclic di-GMP metabolism.

45 g proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting

46 is regulated by the inner membrane-localized cyclic-di-GMP receptor LapD via direct protein-protein i

47 nts for the feedback between mechanosensors, cyclic-di-GMP signaling, and production of adhesive poly

48 The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and

49 The second messenger cyclic di-GMP (c-di-GMP) controls the transition between

50 The bacterial second messenger cyclic di-GMP (c-di-GMP) has emerged as a prominent medi

51 The second messenger cyclic di-GMP (c-di-GMP) is a nearly ubiquitous intracel

52 Signaling through the second messenger cyclic di-GMP (c-di-GMP) is central to the life cycle of

53 many bacterial species, the second messenger cyclic di-GMP (c-di-GMP) negatively regulates flagellar

54 In Vibrio cholerae, the second messenger cyclic di-GMP (c-di-GMP) positively regulates biofilm fo

55 eria employ the prokaryotic second messenger cyclic di-GMP (c-di-GMP) to coordinate responses to shif

56 p1 is the production of the second messenger cyclic di-GMP (c-di-GMP), which is indispensable for B.

57 -styles is regulated by the second messenger cyclic di-GMP (c-di-GMP).

58 The universal second messenger cyclic di-GMP (cdG) is involved in the regulation of a d

59 two-component systems, the second messenger cyclic di-GMP and direct interactions of photoreceptors

60 DNA, RNA, and the bacterial second messenger cyclic-di-GMP (c-di-GMP).

61 asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulat

62 d by the Lap system and the second messenger cyclic-di-GMP.

63 r production of the intracellular messenger, cyclic-di-GMP.

64 work suggests that the secondary messenger, cyclic-di-GMP, promotes biofilm formation.

65 ferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is

66 he site of cyclic GMP binding that modulates cyclic di-GMP synthesis.

67 The second-messenger molecule cyclic di-GMP (c-di-GMP) and quorum sensing (QS) are imp

68 The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile

69 vels of the intracellular signaling molecule cyclic di-GMP (c-di-GMP) due to loss of BifA, a c-di-GMP

70 vels of the intracellular signaling molecule cyclic di-GMP (c-di-GMP).

71 d synthesis of the second messenger molecule cyclic-di-GMP.

72 The intracellular signaling molecule cyclic-di-GMP (c-di-GMP) has been shown to influence sur

73 modulating levels of the signaling molecule cyclic-di-GMP, coregulate swarming motility and biofilm

74 The intracellular signaling molecule, cyclic-di-GMP (c-di-GMP), has been shown to influence ba

75 d in cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) metabolism.

76 ff state, acquisition requires activation of cyclic di-GMP (c-di-GMP) synthesis by the Hk1/Rrp1 TCS;

77 at this process coincides with alteration of cyclic di-GMP (c-di-GMP) levels.

78 rp mutant, showing the connection between of cyclic di-GMP and cAMP signaling in V. cholerae.

79 at modulate the synthesis and degradation of cyclic di-GMP (cdGMP).

80 erties and increased intracellular levels of cyclic di-GMP (c-di-GMP).

81 s aeruginosa is known to require a number of cyclic di-GMP (c-di-GMP)-degrading phosphodiesterases (P

82 We assayed for the production of cyclic di-GMP using two-dimensional thin-layer chromatog

83 esses genes responsible for the synthesis of cyclic di-GMP, an activator of PGA production.

84 te that HmsT is involved in the synthesis of cyclic di-GMP.

85 A variety of cyclic di-GMP regulons are revealed, including some ribo

86 and thereby the corresponding activation of cyclic-di-GMP signaling, can be adjusted both by varying

87 High cytoplasmic levels of cyclic-di-GMP activate the transmembrane receptor LapD t

88 llular signaling by modulating the levels of cyclic-di-GMP, and the virulence factors tolC and pglA r

89 to monitor apparent alteration in levels of cyclic-di-GMP, both BpdA and BpdB displayed a phenotype

90 To investigate the role of cyclic-di-GMP in B. melitensis, all 11 predicted cyclic-

91 Valentini and Filloux focus on cyclic di-GMP, while Kavanaugh and Horswill discuss the

92 cyclic diguanosine 3',5'-(cyclic)phosphate (cyclic di-GMP) and mediated by the action of several GGD

93 ic-di-GMP in B. melitensis, all 11 predicted cyclic-di-GMP-metabolizing proteins were separately dele

94 hown to be diguanylate cyclases that produce cyclic di-GMP (cdiG), a second messenger that modulates

95 sponds to growth on agar surfaces to produce cyclic-di-GMP, which stimulates biofilm formation.

96 nosa Wsp signal transduction system produces cyclic-di-GMP (c-di-GMP), an intracellular messenger tha

97 xtent to which bb0419 or any of the putative cyclic-di-GMP metabolizing genes impact B. burgdorferi m

98 response regulators, HnoB and HnoD, regulate cyclic-di-GMP levels and influence biofilm formation.

99 sis and degradation of the nucleotide signal cyclic di-GMP (c-di-GMP) in many bacteria.

100 nown that intracellular levels of the signal cyclic-di-GMP increase upon surface adhesion and that th

101 terically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological c

102 We found that cyclic di-GMP in many bacterial species is sensed by a r

103 Paul et al. in Molecular Cell, now show that cyclic di-GMP also regulates flagellar motor speed throu

104 We have previously shown that cyclic di-GMP (c-di-GMP [c-diguanylate]) is a novel smal

105 The cyclic di-GMP (c-di-GMP) second messenger represents a s

106 motor speed through interactions between the cyclic di-GMP binding protein YcgR and the motor protein

107 The RetS/LadS/Gac/Rsm network and the cyclic-di-GMP (c-di-GMP) signaling pathways are both cen

108 he other end inserted at a GTGTC site of the cyclic-di-GMP phosphodiesterase A (PDEA) gene (BMEII1009

109 Three of these cyclic-di-GMP-metabolizing proteins were found to alter

110 turn stimulates cellulose production through cyclic di-GMP (c-di-GMP).

111 scent biosensors that respond selectively to cyclic di-GMP, an intracellular bacterial second messeng

112 We established that WarA binds to cyclic-di-GMP, which potentiates its methyltransferase a

113 The universal cyclic-di-GMP second messenger is instrumental in the sw

114 As was employed to assess binding of the Vc2 cyclic-di-GMP riboswitch to its ligand.

115 ation of flagella in Brucella melitensis via cyclic-di-GMP.

116 tside-in signal that is reinforced only when cyclic-di-GMP levels increase.

117 However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a

118 A mechanism by which cyclic-di-GMP influences motility and infection is propo

119 migrated with an R(f) value consistent with cyclic di-GMP that was not produced by strains carrying

120 d BpdB displayed a phenotype consistent with cyclic-di-GMP-specific phosphodiesterases, while CgsB di