ライフサイエンスコーパス: cyclin-dependent kinase 1

1 fingerprint analysis identified it as cdc2 (cyclin-dependent kinase 1).

2 mulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.

3 ed to uninfected cells, have lower levels of cyclin-dependent kinase 1.

4 he drug Roscovitine, a specific inhibitor of cyclin-dependent kinases 1, 2, 5, 7, and 9, we have show

5 Roscovitine, a potent inhibitor of cyclin-dependent kinases 1, 2, and 5, has recently been

6 bers, seven are pro-proliferation molecules: cyclin-dependent kinase-1, -2, -4, and -6 and cyclins A,

7 tein kinase kinase, ribosomal S6 kinase, and cyclin-dependent kinase 1/2 in combination with Bcl-XL i

8 phosphorylation and inhibition of cdc25B, a cyclin dependent kinase 1-activating phosphatase, and is

9 tus begins before M phase, is independent of cyclin-dependent kinase 1 activation, and requires MEK s

10 Cyclin-dependent kinase 1 activity also was found to reg

11 cle arrest in association with inhibition of cyclin-dependent kinase 1 activity and hyperphosphorylat

12 were competent for actin cable assembly, and cyclin-dependent kinase 1 activity was indispensible.

13 In contrast, cyclin-dependent kinase 1 activity, cyclin B1 protein, a

14 sistance that correlated with suppression of cyclin-dependent kinase-1 activity.

15 el sensitivity that correlated with enhanced cyclin-dependent kinase-1 activity.

16 G(2)/M transition due to the decreased CDK1 (cyclin-dependent kinase 1) activity and upregulated p21,

17 hase; reduced levels of cyclin B1, cyclin A, cyclin dependent kinases 1 and 2; and increased p21(Cip1

18 uration promoting factor (MPF), a complex of cyclin-dependent kinase 1 and cyclin B, drives oocyte ma

19 s G(2) arrest and represses the synthesis of cyclin-dependent kinase 1 and cyclin B1, two proteins re

20 inase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry.

21 cycle regulators and proliferation markers (cyclin-dependent kinase 1 and proliferating cell nuclear

22 F-L-Leu and celecoxib each reduced the cyclin-dependent kinase 1 and proliferating cell nuclear

23 d in all tissues by combined treatment where cyclin-dependent kinase 1 and proliferating cell nuclear

24 of retinoblastoma protein and activation of cyclin-dependent kinases 1 and 2 and promoted cell cycle

25 d) and ATR (ATM and Rad3-related) and by the cyclin-dependent kinases 1 and 2.

26 activity of several kinases, including CDK1 (cyclin-dependent kinase 1) and protein kinase C (PKC), h

27 and repression of G2/M regulators cyclin B1, cyclin-dependent kinase 1, and cyclin A indicated a G2/e

28 o on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, and dephosphorylated by the p

29 c regulatory proteins reveals that cyclin B, cyclin-dependent kinase 1, and the Ancdc14 phosphatase f

30 n a pool of inactive "pre-MPF" consisting of cyclin-dependent kinase 1 bound to B-type cyclins, of wh

31 netic stability, is governed by the cyclin B/Cyclin dependent kinase 1 (Cdc2) complex.

32 on of human CaP cells via an inactivation of cyclin-dependent kinase 1 (Cdc2)/cyclin B 1-mediated mit

33 ed with increased Tyr(15) phosphorylation of cyclin-dependent kinase 1 (Cdk 1) and inhibition of Cdk

34 Both drugs inhibit cyclin-dependent kinase 1 (cdk-1) and cdk-2 (required fo

35 inds to a phosphoepitope generated by either cyclin dependent kinase 1 (Cdk1) (non-self-priming) or P

36 mportant in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4

37 yclin A2, cyclin E, cyclin B1, cyclin F, and cyclin dependent kinase-1 (Cdk1) genes and diminished pr

38 We identify cyclin-dependent kinase 1 (cdk1 [cdc2]) and glycogen syn

39 SAMHD1 contains a target motif for cyclin-dependent kinase 1 (cdk1) ((592)TPQK(595)), and c

40 under physiological conditions, we show how cyclin-dependent kinase 1 (CDK1) activates the APC/C thr

41 ng interphase that corresponded with delayed cyclin-dependent kinase 1 (CDK1) activation.

42 it, which is regulated by degradation of the cyclin-dependent kinase 1 (Cdk1) activator, cyclin B.

43 n mitotic cells was associated with the high cyclin-dependent kinase 1 (CDK1) activities.

44 725) demonstrate that the down-regulation of cyclin-dependent kinase 1 (Cdk1) activity triggers the o

45 effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage re

46 These changes are driven by cyclin-dependent kinase 1 (CDK1) activity, yet how cytop

47 ntially promote actin cable assembly through cyclin-dependent kinase 1 (Cdk1) activity.

48 We demonstrate that dCK interacts with cyclin-dependent kinase 1 (Cdk1) after IR and that the i

49 a physically and functionally interacts with cyclin-dependent kinase 1 (Cdk1) and Cdk2.

50 n of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs i

51 iven by the activities of two major kinases, cyclin-dependent kinase 1 (Cdk1) and mitogen-activated p

52 rodimer undergoes mitotic phosphorylation by cyclin-dependent kinase 1 (Cdk1) at a single site, p27 T

53 Cyclin B activates cyclin-dependent kinase 1 (CDK1) at mitosis, but conflic

54 ba is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) at Ser(119) and Ser(175

55 Ezh2 is phosphorylated by cyclin-dependent kinase 1 (CDK1) at threonine residues 3

56 Phosphorylation by Cyclin-dependent kinase 1 (CDK1) at two conserved sites

57 sister chromatid disjunction and inactivates cyclin-dependent kinase 1 (Cdk1) causing mitotic exit.

58 Mitotic entry is controlled by the cyclin B-cyclin-dependent kinase 1 (Cdk1) complex, and the inhibi

59 Cyclin-dependent kinase 1 (Cdk1) controls cell prolifera

60 e show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interaction

61 l4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug

62 Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cy

63 Activation of cyclin-dependent kinase 1 (Cdk1) has been linked to cell

64 t study sheds light on two distinct roles of cyclin-dependent kinase 1 (CDK1) in promoting polarized

65 Here we report that cyclin-dependent kinase 1 (Cdk1) inhibition can induce b

66 nd the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(5

67 Cyclin-dependent kinase 1 (CDK1) inhibitory phosphorylat

68 tase promotes entry into mitosis by removing cyclin-dependent kinase 1 (Cdk1) inhibitory phosphorylat

69 Cyclin-dependent kinase 1 (Cdk1) initiates mitosis and l

70 Cyclin-dependent kinase 1 (Cdk1) is an archetypical kina

71 Cyclin-dependent kinase 1 (Cdk1) is required for initiat

72 Cyclin-dependent kinase 1 (Cdk1) is the primary upstream

73 Cyclin-dependent kinase 1 (Cdk1) is thought to trigger c

74 Cyclin-dependent kinase 1 (Cdk1) kinase dephosphorylatio

75 Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphoryla

76 promote checkpoint recovery independently of cyclin-dependent kinase 1 (Cdk1) or Plx1 (Xenopus polo-l

77 Here, we discovered that the cyclin-dependent kinase 1 (CDK1) pathway is also affecte

78 Cyclin-dependent kinase 1 (Cdk1) phosphorylates BRCA1, a

79 Here, we demonstrate that cyclin-dependent kinase 1 (Cdk1) phosphorylates septin 9

80 failure to remove inhibitory phosphate from cyclin-dependent kinase 1 (Cdk1) prevents entry into mit

81 Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phen

82 Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphoryl

83 During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR an

84 Furthermore, decreased levels of Cyclin-dependent kinase 1 (Cdk1), a kinase partner of Cy

85 osphorylated at T341 most likely by Cyclin B/Cyclin-dependent kinase 1 (Cdk1), and then dephosphoryla

86 The activity of the cyclin-dependent kinase 1 (Cdk1), Cdc28, inhibits the tr

87 (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and

88 s involved in mitotic progression, including cyclin-dependent kinase 1 (Cdk1), cyclin B2, and their t

89 In eukaryotic cells, cyclin-dependent kinase 1 (CDK1), in combination with ei

90 The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry

91 Phosphorylation of Thr92 by cyclin-dependent kinase 1 (CDK1)-cyclin B1 initiates deg

92 Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylati

93 Here we demonstrate that the cyclin-dependent kinase 1 (Cdk1)-dependent phosphorylati

94 Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylatio

95 s inhibited during prophase and metaphase by cyclin-dependent kinase 1 (CDK1)-mediated phosphorylatio

96 -box domain (PBD) of Plk1 and is enhanced by cyclin-dependent kinase 1 (Cdk1)-mediated phosphorylatio

97 mitosis by phosphorylating and inactivating cyclin-dependent kinase 1 (Cdk1).

98 posttranslational stabilization of the G2/M cyclin-dependent kinase 1 (CDK1).

99 transition because of impaired activation of cyclin-dependent kinase 1 (Cdk1).

100 on at serine 81 is stimulated by the mitotic cyclin-dependent kinase 1 (CDK1).

101 ynthesis of cyclins, which bind and activate cyclin-dependent kinase 1 (Cdk1).

102 to mitosis by phosphorylating and inhibiting cyclin-dependent kinase 1 (Cdk1).

103 Wild-type Cdc6 but not Cdc6-TV binds cyclin-dependent kinase 1 (Cdk1).

104 olymerase alpha (polalpha) and controlled by cyclin-dependent kinase 1 (CDK1).

105 tosis in eukaryotes requires the activity of cyclin-dependent kinase 1 (Cdk1).

106 eolysis of cyclin B, a regulatory subunit of cyclin-dependent kinase 1 (Cdk1).

107 CDC25C activity and, consequentially, higher cyclin-dependent kinase 1 (CDK1)/cyclin B activity, and

108 In this report, evidence is presented that cyclin-dependent kinase 1 (CDK1)/cyclin B catalyzes mito

109 orylated at Ser 29 (S29) specifically by the cyclin-dependent kinase 1 (cdk1)/cyclinB complex, primar

110 osphorylation of hundreds of proteins by the cyclin-dependent kinase 1 (Cdk1):cyclin B (CycB) complex

111 that Ser1232 in eIF4G1 is phosphorylated by cyclin-dependent kinase 1 (Cdk1):cyclin B during mitosis

112 Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using pall

113 ondria, in which it binds to, and activates, cyclin-dependent kinase-1 (Cdk1).

114 Resumption of meiosis requires activation of cyclin-dependent kinase-1 (CDK1, p34cdc2), one component

115 Rad53, was required to both maintain active cyclin-dependent kinase 1, Cdk1(Cdc28), and prevent anap

116 urchin zygotes arrested in S phase, whether cyclin-dependent kinase 1-cyclin B (Cdk1-B) activity rem

117 We have shown previously that the cyclin-dependent kinase 1/cyclin B (cdk1/CyB or cdc2/CyB

118 Phospho-mimetic mutation of known cyclin-dependent kinase 1/cyclin B sites, all of which a

119 This activates cyclin-dependent kinase 1/cyclin B1 (CDK1/CYCB1) to dire

120 in the G(2)/M phase, and there was increased cyclin-dependent kinase 1/cyclin B1 activity.

121 an cells by signaling that is independent of cyclin-dependent kinase 1/cyclin B1 down-regulation.

122 osphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin

123 Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte gro

124 ,3 -b] pyridine), which were shown to act as cyclin-dependent kinase 1 inhibitors, consistently reduc

125 to down-regulation of cyclin B1, cdc25c, and cyclin-dependent kinase 1 levels.

126 NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and ki

127 In vitro assays showed that cyclin-dependent kinase 1 phosphorylates hamartin at thr

128 Hamartin with alanine mutations in the three cyclin-dependent kinase 1 phosphorylation sites increase

129 SNP rs2456778, which maps to CDK1 ('cyclin-dependent kinase 1'), was associated with cocaine