ライフサイエンスコーパス: cyclin-dependent kinase 5

1 nerated CAD cells results from activation of cyclin-dependent kinase 5.

2 EB enhanced the overactivation of cyclin-dependent kinase 5.

3 ing with the phosphatase PP2A and the kinase cyclin-dependent kinase 5.

4 tor erythroid 2-related factor 2, notch, and cyclin-dependent kinase 5.

5 lcineurin, and was opposed by the actions of cyclin-dependent kinase 5.

6 ndent on prior phosphorylation of Ser-778 by cyclin-dependent kinase 5.

7 The activity of cyclin-dependent kinase 5, a major kinase involved in bo

8 GRASP65, which is induced by Abeta-triggered cyclin-dependent kinase-5 activation.

9 a novel interaction between muskelin and the cyclin-dependent kinase 5 activator p39 and suggest that

10 ss is accompanied by generation of the Cdk5 (cyclin-dependent kinase 5)-activator p25, up-regulation

11 (n=12-14; P<0.05), and significantly higher cyclin-dependent kinase 5 activity (n=4; P<0.001).

12 r ratios of p25/p35, indicative of increased cyclin-dependent kinase 5 activity as compared with wild

13 using roscovitine and siRNA directed towards cyclin-dependent kinase 5) ameliorated the cilia phenoty

14 tion is enhanced by prior phosphorylation by cyclin-dependent kinase 5 and antagonized by Fyn phospho

15 ncreased phosphorylation of ezrin at T235 by cyclin-dependent kinase 5 and consequent dissociation of

16 mutations abolished Thr21 phosphorylation by cyclin-dependent kinase 5 and external signal regulated

17 lens library for proteins that interact with cyclin-dependent kinase 5 and its regulators, p35 and p3

18 Pharmacological inhibitors of cyclin-dependent kinase 5 and p38 mitogen-activated prot

19 Significantly, both inhibition of cyclin-dependent kinase-5 and expression of nonphosphory

20 including glycogen synthase kinase 3beta and cyclin-dependent kinase-5 and its activators p25 and p35

21 lycogen synthase kinase-3 beta (GSK-3 beta), cyclin-dependent kinase 5, and c-Jun NH(2)-terminal kina

22 ion of DeltaFosB, prodynorphin, dynorphin A, cyclin-dependent kinase 5, and increased phosphorylation

23 robust up-regulation of striatal DeltaFosB, cyclin-dependent kinase 5, and p35.

24 e homolog-1, glycogen synthase kinase 3beta, cyclin-dependent kinase 5, and tau protein phosphatase 2

25 he cytoplasmic serine/threonine kinase Cdk5 (cyclin-dependent kinase 5) are both required for normal

26 ave now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of

27 kinase, CaM kinase II, casein kinase II, or cyclin-dependent kinase 5, at concentrations 50 or more

28 s associated with a significant elevation in cyclin dependent kinase-5 but not other kinases that hav

29 ntrast, inhibiting protein tyrosine kinases, cyclin-dependent kinase 5, Ca(2+)/calmodulin-dependent k

30 The cyclin-dependent kinase 5 (CDK-5) activating protein, p3

31 Cyclin-dependent kinase 5 (CDK-5) and its activator CDKA

32 carboxy-terminal tail portion by the enzyme cyclin-dependent kinase 5 (CDK-5).

33 In addition, cyclin-dependent kinase-5 (CDK-5) facilitates new synaps

34 We previously showed that cyclin-dependent kinase-5 (CDK-5) positively regulates t

35 Cyclin dependent kinase 5 (Cdk5) contributes to neuronal

36 Here, we demonstrate that cyclin dependent kinase 5 (Cdk5), a protein known to fun

37 Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and pho

38 Cyclin-dependent kinase 5 (Cdk5) activity is significant

39 We have previously reported that cyclin-dependent kinase 5 (Cdk5) activity regulates noci

40 rn up-regulated p35 expression and increased cyclin-dependent kinase 5 (Cdk5) activity.

41 th a significant increase in activity of the cyclin-dependent kinase 5 (cdk5) and accumulation of its

42 ent time- and dose-dependent stimulations of cyclin-dependent kinase 5 (cdk5) and calcium/calmodulin-

43 g pharmacologic inhibitors of PI3K, Akt, and cyclin-dependent kinase 5 (cdk5) and constitutively acti

44 action content decreases after inhibition of cyclin-dependent kinase 5 (Cdk5) and ERK1/2.

45 Cyclin-dependent kinase 5 (cdk5) and glycogen synthase k

46 ivation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase k

47 es responsible for these phosphorylations as cyclin-dependent kinase 5 (CDK5) and glycogen synthase k

48 by sequential phosphorylation by the kinases cyclin-dependent kinase 5 (Cdk5) and glycogen synthase k

49 Neuronal migration is also regulated by cyclin-dependent kinase 5 (Cdk5) and its activating subu

50 In the CNS, cyclin-dependent kinase 5 (Cdk5) and its activator p35 a

51 Cyclin-dependent kinase 5 (Cdk5) and its activator p35 h

52 Cyclin-dependent kinase 5 (Cdk5) and its activator p35,

53 ients has been linked to overactivity of the cyclin-dependent kinase 5 (CDK5) and its activator p35.

54 Phosphorylated tau as well as cyclin-dependent kinase 5 (cdk5) and its coactivator, p2

55 Cyclin-dependent kinase 5 (cdk5) and its neuron-specific

56 Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific

57 Cyclin-dependent kinase 5 (Cdk5) and its regulatory subu

58 Furthermore, Cadm4, cyclin-dependent kinase 5 (Cdk5) and p39 mRNAs were sign

59 reover, A-705253 decreased the activation of cyclin-dependent kinase 5 (CDK5) and thereby diminished

60 Here we identify cyclin-dependent kinase 5 (Cdk5) as a downstream target

61 ied in soluble form and is phosphorylated by cyclin-dependent kinase 5 (CDK5) as well as by CaMKII.

62 EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by

63 as previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser67.

64 unction is inhibited upon phosphorylation by cyclin-dependent kinase 5 (Cdk5) at Thr345.

65 WAVE1 is phosphorylated at multiple sites by cyclin-dependent kinase 5 (Cdk5) both in vitro and in in

66 -type controls, resulting from activation of cyclin-dependent kinase 5 (CDK5) but not glycogen syntha

67 se in cyclin D1 attenuates the activation of cyclin-dependent kinase 5 (cdk5) by its neuronal activat

68 The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown t

69 ent requires tightly regulated activation of Cyclin-dependent kinase 5 (Cdk5) by two distinct cofacto

70 discovered that phosphorylation of Dixdc1 by cyclin-dependent kinase 5 (Cdk5) facilitates its interac

71 hatase calcineurin (CNAalpha) and the kinase cyclin-dependent kinase 5 (CDK5) has a dramatic influenc

72 Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been implicated in

73 While deregulation of cyclin-dependent kinase 5 (Cdk5) has been implicated in

74 Cyclin-dependent kinase 5 (cdk5) has been implicated in

75 Recently, cyclin-dependent kinase 5 (Cdk5) has been shown to funct

76 Cyclin-dependent kinase 5 (CDK5) has been shown to influ

77 ated receptor gamma (PPARgamma) at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimu

78 An essential role of cyclin-dependent kinase 5 (Cdk5) in brain development ha

79 t of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well a

80 Here, we demonstrate a novel role for p25/cyclin-dependent kinase 5 (Cdk5) in regulating APP proce

81 Recent studies implicate the cyclin-dependent kinase 5 (Cdk5) in regulating oligodend

82 We recently identified an essential role for cyclin-dependent kinase 5 (Cdk5) in T-cell activation an

83 Although tau is phosphorylated by cyclin-dependent kinase 5 (Cdk5) in vitro, its in vivo r

84 Cyclin-dependent kinase 5 (Cdk5) is a brain-specific mem

85 Cyclin-dependent kinase 5 (Cdk5) is a critical regulator

86 Cyclin-dependent kinase 5 (Cdk5) is a member of the fami

87 Cyclin-dependent kinase 5 (Cdk5) is a multi-faced kinase

88 Cyclin-dependent kinase 5 (Cdk5) is a multifunctional ne

89 Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk

90 Our laboratory has shown that cyclin-dependent kinase 5 (Cdk5) is a potent cell cycle

91 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed k

92 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

93 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

94 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed s

95 Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine k

96 Cyclin-dependent kinase 5 (cdk5) is a serine/threonine k

97 Cyclin-dependent kinase 5 (Cdk5) is a small serine/threo

98 Cyclin-dependent kinase 5 (Cdk5) is a ubiquitously expre

99 e with a targeted disruption in the gene for cyclin-dependent kinase 5 (cdk5) is abnormal in its stru

100 Here, we show that cyclin-dependent kinase 5 (Cdk5) is activated by ACh ago

101 Cyclin-dependent kinase 5 (Cdk5) is activated by the neu

102 Cyclin-dependent kinase 5 (Cdk5) is activated on binding

103 Cyclin-dependent kinase 5 (Cdk5) is an atypical but esse

104 Here, we show that cyclin-dependent kinase 5 (Cdk5) is an essential regulat

105 Here, we report for the first time that cyclin-dependent kinase 5 (Cdk5) is an essential regulat

106 Although cyclin-dependent kinase 5 (Cdk5) is closely related to o

107 It has been shown that cyclin-dependent kinase 5 (Cdk5) is crucial for neuronal

108 Cyclin-dependent kinase 5 (Cdk5) is essential for the pr

109 Cyclin-dependent kinase 5 (CDK5) is expressed at high le

110 Cyclin-dependent kinase 5 (cdk5) is found in an active f

111 Recent evidence indicates that cyclin-dependent kinase 5 (Cdk5) is inappropriately acti

112 pha(1)beta(1) integrin-induced activation of cyclin-dependent kinase 5 (cdk5) is involved in neurite

113 Cyclin-dependent kinase 5 (Cdk5) is much more than its n

114 Cyclin-dependent kinase 5 (Cdk5) is one of a subfamily o

115 Cyclin-dependent kinase 5 (Cdk5) is predominantly expres

116 Here we show that cyclin-dependent kinase 5 (Cdk5) is required for dbcAMP

117 Cyclin-dependent kinase 5 (Cdk5) is required for proper

118 Although cyclin-dependent kinase 5 (Cdk5) is widely expressed in

119 the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to reduced branchin

120 Cyclin-dependent kinase 5 (Cdk5) mediates neurotoxic eff

121 Cyclin-dependent kinase 5 (CDK5) negatively regulates po

122 Cyclin-dependent kinase 5 (Cdk5) null mice exhibit a uni

123 Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrat

124 Cyclin-dependent kinase 5 (CDK5) phosphorylated DRP1 to

125 Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptoj

126 Cyclin-dependent kinase 5 (Cdk5) phosphorylation of wild

127 Although cyclin-dependent kinase 5 (Cdk5) plays a critical role i

128 Cyclin-dependent kinase 5 (Cdk5) plays a key role in the

129 Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in

130 Growing evidence suggests that cyclin-dependent kinase 5 (cdk5) plays a role in tau pho

131 The proline-directed serine/threonine kinase cyclin-dependent kinase 5 (cdk5) plays an important role

132 Cyclin-dependent kinase 5 (Cdk5) plays key roles in norm

133 Cyclin-dependent kinase 5 (Cdk5) regulates dopamine neur

134 Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopa

135 Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopa

136 Cyclin-dependent kinase 5 (CDK5) regulatory subunit-asso

137 r-activated receptor gamma) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic

138 ites that were mediated by the activation of cyclin-dependent kinase 5 (cdk5) through increased forma

139 mechanism by which phosphorylation of GIV by cyclin-dependent kinase 5 (CDK5) triggers GIV's ability

140 Cyclin-dependent kinase 5 (CDK5) was identified as an SI

141 Cyclin-dependent kinase 5 (Cdk5) was originally isolated

142 neural-specific activating subunit, p35, of cyclin-dependent kinase 5 (Cdk5) was recently reported t

143 In our previous study, cyclin-dependent kinase 5 (cdk5) was shown to phosphoryl

144 Recently, cyclin-dependent kinase 5 (Cdk5) was shown to phosphoryl

145 CNS myelination, including the noncanonical cyclin-dependent kinase 5 (Cdk5) whose functions are reg

146 Cyclin-dependent kinase 5 (Cdk5), a complex of Cdk5 and

147 ry tangles (NFTs), it has been reported that cyclin-dependent kinase 5 (Cdk5), a critical neuronal ki

148 We show here that cyclin-dependent kinase 5 (CDK5), a known regulator of m

149 Cyclin-dependent kinase 5 (Cdk5), a member of the Cdc2 f

150 One candidate for such regulation is cyclin-dependent kinase 5 (Cdk5), a member of the Cdc2 f

151 Cyclin-dependent kinase 5 (CDK5), a neuronal kinase that

152 Here, we show that cyclin-dependent kinase 5 (CDK5), a Pro-directed Ser/Thr

153 ns three consensus phosphorylation sites for cyclin-dependent kinase 5 (cdk5), a proline-directed ser

154 Here, we show that cyclin-dependent kinase 5 (Cdk5), a serine-threonine kin

155 inction requires downregulation of Rac-1 and cyclin-dependent kinase 5 (Cdk5), and upregulation of p2

156 ycogen synthase kinase-3beta (GSK-3beta) and cyclin-dependent kinase 5 (Cdk5), as well as nonproline-

157 The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of i

158 glycogen synthase kinase-3beta (GSK-3beta), cyclin-dependent kinase 5 (Cdk5), cAMP-dependent protein

159 In this study, an identified cyclin-dependent kinase 5 (cdk5), isolated from nervous

160 ngly sensitised to PARP inhibitor, including cyclin-dependent kinase 5 (CDK5), MAPK12, PLK3, PNKP, ST

161 his pathway involves enzymatic activities of cyclin-dependent kinase 5 (CDK5), protein phosphatase 1

162 Hyperactivation of the cyclin-dependent kinase 5 (cdk5), triggered by proteolyt

163 Cyclin-dependent kinase 5 (CDK5), unlike other CDKs, is

164 Cyclin-dependent kinase 5 (Cdk5), which binds to and is

165 In HEK293 cells, high NaCl activates cyclin-dependent kinase 5 (CDK5), which directly phospho

166 p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated wi

167 factors, p35 and p39, independently activate Cyclin-dependent kinase 5 (Cdk5), which plays diverse ro

168 degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant dec

169 Mice deficient in p35--an activator of cyclin-dependent kinase 5 (Cdk5)--are characterized by a

170 sters that are not stabilized by agrin via a cyclin-dependent kinase 5 (Cdk5)-mediated mechanism, but

171 tubule affinity regulating kinase)/PAR1, and cyclin-dependent kinase 5 (CDK5).

172 One of the upregulated genes is cyclin-dependent kinase 5 (cdk5).

173 ed via activity-dependent phosphorylation by cyclin-dependent kinase 5 (Cdk5).

174 f PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5).

175 ated by RG108-estrogen receptor 1 (ESR1) and cyclin-dependent kinase 5 (CDK5).

176 hat serine 1116 of NR2B is phosphorylated by cyclin-dependent kinase 5 (Cdk5).

177 he N-type calcium channel is a substrate for cyclin-dependent kinase 5 (Cdk5).

178 Cyclin-dependent kinase 5 (cdk5)/p35 kinase activity is

179 highly conserved phosphorylation site and by cyclin-dependent kinase-5 (Cdk5) at a newly described si

180 Cyclin-dependent kinase-5 (Cdk5) is a serine/threonine k

181 The activity of cyclin-dependent kinase-5 (Cdk5) is tightly regulated by

182 In this study, we reported that cyclin-dependent kinase-5 (Cdk5) regulates Akt activity

183 Cyclin-dependent kinase-5 (Cdk5) was reported to downsca

184 lycogen synthase kinase-3beta (GSK3beta) and cyclin-dependent kinase-5 (CDK5), are involved in the ne

185 uding glycogen synthase kinase 3 (GSK-3) and cyclin-dependent kinase-5 (Cdk5), to phosphorylate sever

186 Cyclin-dependent kinase 5(CDK5) in complex with its acti

187 Cyclin-dependent kinase 5(cdk5) is highly homologous to

188 Cyclin-dependent kinase 5, coupled with its activator p3

189 as phosphorylation sinks where they mitigate cyclin-dependent kinase 5 dysregulation induced by mutan

190 We also found that cyclin-dependent kinase-5 expression is upregulated duri

191 These include the modelling of Cdk5 (cyclin-dependent kinase 5) from Cdk2, thymidine phosphor

192 Previous studies implicate cyclin-dependent kinase 5 in cell adhesion and migration

193 purmorphamine treatment was shown to reduce cyclin-dependent kinase 5 in patient cells, suggesting a

194 phenomenon associated with the activation of cyclin-dependent kinase 5 in several neurodegenerative d

195 67) of inhibitor-1 serves as a substrate for cyclin-dependent kinase 5 in the brain.

196 t feeding activates the protein kinase Cdk5 (cyclin-dependent kinase 5) in adipose tissues.

197 Cyclin-dependent kinase 5 is activated by small subunits

198 nd that c-Jun NH2-terminal kinase (JNK), not cyclin-dependent kinase 5, is required for APP phosphory

199 of histone modifications at the murine Cdk5 (cyclin-dependent kinase 5) locus, given growing evidence

200 trations in which olomoucine is specific for cyclin-dependent kinases (5 microM), it reduced only ant

201 ddition, levels of the activation subunit of cyclin-dependent kinase 5, p25, are elevated significant

202 The neuronal-specific activator of cyclin-dependent kinase 5, p35, has been recognized as a

203 , extracellular signal-regulated kinase, and cyclin-dependent kinase-5 pathways.

204 inase C phosphorylation site, and Thr-574, a cyclin-dependent kinase 5 phosphorylation site, regulate

205 We show here that CDK5 (cyclin-dependent kinase 5) plays a role.

206 that p35, the neuronal-specific activator of cyclin-dependent kinase 5, plays a key role in proper ne

207 Cyclin-dependent kinase 5 regulates numerous neuronal fu

208 Previously identified risk variants in cyclin-dependent kinase 5 regulatory subunit associated

209 PP1), and phosphorylation at Thr-75 by Cdk5 (cyclin-dependent kinase 5) results in inhibition of prot

210 The functions of cyclin-dependent kinase 5 signalling in cognition and co

211 er-137, and decreases phosphorylation at the cyclin-dependent kinase 5 site, Thr-75.

212 r34 (protein kinase A site, Thr34A), Thr75, (cyclin-dependent kinase 5 site, Thr75A), Ser97 (kinase C

213 phosphorylation state at Thr75-DARPP-32, the cyclin-dependent kinase 5 site.

214 f Drp1 (dynamin-related protein 1) and Cdk5 (cyclin-dependent kinase 5), targets known to contribute

215 In contrast, Ser(67) phosphorylation by cyclin-dependent kinase 5 was unaffected by phospho-Ser(