ライフサイエンスコーパス: cyclin-dependent kinase inhibitor p27

1 alignancies; and KIP1, the gene encoding the cyclin-dependent kinase inhibitor p27.

2 ar localization relies on its binding to the cyclin-dependent kinase inhibitor p27.

3 IRES) in the 5'-UTR of the mRNA encoding the cyclin-dependent kinase inhibitor p27.

4 n D protein levels while down-regulating the cyclin-dependent kinase inhibitor p27.

5 to target certain substrates, including the Cyclin-dependent kinase inhibitor p27.

6 g II)-induced Rac1-mediated, upregulation of cyclin-dependent kinase inhibitor p27.

7 st partially through the upregulation of the cyclin-dependent kinase inhibitor p27.

8 activator, is involved in degradation of the cyclin-dependent kinase inhibitor p27.

9 ls arrest in G1 with increased levels of the cyclin-dependent kinase inhibitor p27.

10 Cyclin-dependent kinase inhibitor p27, a critical determ

11 The cyclin-dependent kinase inhibitor, p27, accumulates upon

12 of TGFbeta, plus reduction in levels of the cyclin-dependent kinase inhibitor p27, allows transducti

13 Down-regulation of the cyclin-dependent kinase inhibitor p27 alone significantl

14 C/C(Cdh1)), resulting in accumulation of the cyclin-dependent kinase inhibitor p27 and a concomitant

15 LMP1 decreases expression of the cyclin-dependent kinase inhibitor p27 and increases the

16 of cell cycle regulation: suppression of the cyclin-dependent kinase inhibitor p27 and induction of t

17 kdown results in the nuclear localization of cyclin-dependent kinase inhibitor p27 and prevents the p

18 expression, in particular cyclin D1 and the cyclin-dependent kinase inhibitors p27 and p21.

19 dicted to target the cell growth suppressive cyclin-dependent kinase inhibitors p27 and p57.

20 d by a growth arrest and the upregulation of cyclin-dependent kinase inhibitors, p27 and p57, as well

21 toma protein levels, a rapid increase in the cyclin-dependent kinase inhibitor p27, and accelerated G

22 on of D-type cyclins, down-regulation of the cyclin-dependent kinase inhibitor p27, and, therefore, i

23 a reduced binding of cytoplasmic RhoA to the cyclin-dependent kinase inhibitor p27 both contributed t

24 Therefore, we conclude that the cyclin-dependent kinase inhibitor p27, but not p21, is r

25 ng the receptors EGFR, ERBB3 (HER3), and the cyclin-dependent kinase inhibitor p27 (CDKN1B) was found

26 1 and E1 while suppressing the expression of cyclin-dependent kinase inhibitor p27 (CDKN1B), each con

27 ted in a dose-dependent up-regulation of the cyclin-dependent kinase inhibitor p27, down-regulation o

28 , a calcium-activated protease, degrades the cyclin-dependent kinase inhibitor, p27, during the mitot

29 The cyclin-dependent kinase inhibitor p27 is a key regulator

30 The cyclin-dependent kinase inhibitor p27 is a negative regu

31 The cyclin-dependent kinase inhibitor p27 is a negative regu

32 The cyclin-dependent kinase inhibitor p27 is a negative regu

33 In addition, we found that the cyclin-dependent kinase inhibitor p27 is induced by hypo

34 , cyclin D3, and cyclin E and an increase in cyclin-dependent kinase inhibitor p27 (Kip).

35 The cyclin-dependent kinase inhibitor p27(kip) regulates the

36 d with rapamycin produced an increase in the cyclin-dependent kinase inhibitor p27(Kip), through a de

37 enterocytes display increased levels of the cyclin-dependent kinase inhibitor p27(Kip).

38 ndent manner and increased the expression of cyclin-dependent kinase inhibitor p27(Kip-1) (p27).

39 occurs, associated with a suppression of the cyclin-dependent kinase inhibitor p27(kip-1).

40 ll cycle and increased the expression of the cyclin-dependent kinase inhibitor, p27(kip-1).

41 s shown to regulate the transcription of the cyclin-dependent kinase inhibitor p27 Kip1 gene directly

42 that its oncogenic signals down-regulate the cyclin-dependent kinase inhibitor p27 Kip1, which is def

43 Expression of the cyclin dependent kinase inhibitor p27(KIP1) is intimatel

44 o changes in the ability to downregulate the cyclin-dependent kinase inhibitor p27(Kip1) (also known

45 s generated an adenovirus that expresses the cyclin-dependent kinase inhibitor p27(Kip1) (p27) and be

46 Cyclin-dependent kinase inhibitor p27(kip1) (p27) has re

47 In addition, we show that the levels of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) rise f

48 l endothelial cells (rCECs) by degrading the cyclin-dependent kinase inhibitor p27(Kip1) (p27) throug

49 rein results in lack of up-regulation of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) to arr

50 used an adenoviral (Ad) vector that encodes cyclin-dependent kinase inhibitor p27(Kip1) (p27) with t

51 which is cytoplasmic mislocalization of the cyclin-dependent kinase inhibitor p27(Kip1) (p27).

52 nd cyclin B1, with reduced protein levels of cyclin-dependent kinase inhibitor p27(Kip1) (p27).

53 ession by their effects on the levels of the cyclin-dependent kinase inhibitor p27(Kip1) [1,2].

54 associated with increased expression of the cyclin-dependent kinase inhibitor p27(Kip1) and a reduce

55 tating translation of mRNAs encoding for the cyclin-dependent kinase inhibitor p27(Kip1) and antiapop

56 ls is preceded by elevated expression of the cyclin-dependent kinase inhibitor p27(Kip1) and cell cyc

57 was associated with the up-regulation of the cyclin-dependent kinase inhibitor p27(Kip1) and down-reg

58 ciated with a selective up-regulation of the cyclin-dependent kinase inhibitor P27(KIP1) and inductio

59 ated protein kinase, increases the levels of cyclin-dependent kinase inhibitor p27(kip1) and reduces

60 ors of cell proliferation and migration, the cyclin-dependent kinase inhibitor p27(Kip1) and the micr

61 EFs leads to an increase in the level of the cyclin-dependent kinase inhibitor p27(Kip1) and to rapid

62 The cyclin-dependent kinase inhibitor p27(Kip1) arrests cell

63 Here, we have identified the cyclin-dependent kinase inhibitor p27(Kip1) as a critica

64 Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor

65 Expression of the cyclin-dependent kinase inhibitor p27(Kip1) defines a po

66 targeted inactivation of both alleles of the cyclin-dependent kinase inhibitor p27(kip1) developed bo

67 ion and hyperproliferation by downregulating cyclin-dependent kinase inhibitor p27(kip1) in a proteas

68 cyclin E displayed an increase in the cyclin/cyclin-dependent kinase inhibitor p27(Kip1) in both asyn

69 f c-Myc and cyclin E and upregulation of the cyclin-dependent kinase inhibitor p27(Kip1) in both the

70 atment with NaBT increased expression of the cyclin-dependent kinase inhibitor p27(kip1) in HT29 cell

71 hibits ubiquitination and degradation of the cyclin-dependent kinase inhibitor p27(kip1) in vitro.

72 The cyclin-dependent kinase inhibitor p27(Kip1) is a critica

73 The cyclin-dependent kinase inhibitor p27(Kip1) is a powerfu

74 The mammalian cyclin-dependent kinase inhibitor p27(Kip1) is required

75 The cyclin-dependent kinase inhibitor p27(Kip1) is transcrip

76 colleagues (3121-3134) demonstrate that the cyclin-dependent kinase inhibitor p27(Kip1) is ubiquityl

77 Loss of the cyclin-dependent kinase inhibitor p27(Kip1) leads to an

78 The cyclin-dependent kinase inhibitor p27(Kip1) plays a crit

79 Low or absent expression of the cyclin-dependent kinase inhibitor p27(Kip1) serves as an

80 es a posttranscriptional accumulation of the cyclin-dependent kinase inhibitor p27(KIP1) that is acco

81 that HINT1 regulates cellular levels of the cyclin-dependent kinase inhibitor p27(KIP1) through mult

82 t is not clear whether 14-3-3sigma regulates cyclin-dependent kinase inhibitor p27(Kip1) to negativel

83 The cyclin-dependent kinase inhibitor p27(kip1) was decrease

84 Expression of the cyclin-dependent kinase inhibitor p27(Kip1) was decrease

85 g for the proliferation marker Ki-67 and the cyclin-dependent kinase inhibitor p27(Kip1) were perform

86 orroborated in this study by coexpression of cyclin-dependent kinase inhibitor p27(Kip1)), we hypothe

87 ein Skp2 as well as by downregulation of the cyclin-dependent kinase inhibitor p27(Kip1), a principal

88 s are actively cycling, but some express the cyclin-dependent kinase inhibitor p27(Kip1), and are pre

89 s T-cell proliferation by the destruction of cyclin-dependent kinase inhibitor p27(kip1), and deletio

90 One of these, miR-221, a regulator of the cyclin-dependent kinase inhibitor p27(kip1), displayed r

91 ivation, and cytoplasmic localization of the cyclin-dependent kinase inhibitor p27(Kip1), which has b

92 Decreased abundance of cyclin-dependent kinase inhibitor p27(kip1), which requi

93 T lymphocyte growth is regulated by the cyclin-dependent kinase inhibitor p27(Kip1).

94 1) arrest and express elevated levels of the cyclin-dependent kinase inhibitor p27(Kip1).

95 endogenous expression of the E2F1-regulated cyclin-dependent kinase inhibitor p27(Kip1).

96 d IIC9 cells expressed high levels of the G1 cyclin-dependent kinase inhibitor p27(KIP1).

97 ical target of this signaling process is the cyclin-dependent kinase inhibitor p27(KIP1).

98 possess significantly reduced levels of the cyclin-dependent kinase inhibitor p27(kip1).

99 ion in part through the up-regulation of the cyclin-dependent kinase inhibitor p27(kip1).

100 t ultimately involves destabilization of the cyclin-dependent kinase inhibitor p27(Kip1).

101 promote G(0)/G(1) arrest by stabilizing the cyclin-dependent kinase inhibitor p27(Kip1).

102 phase associated with elevated levels of the cyclin-dependent kinase inhibitor p27(KIP1).

103 progression, and increased expression of the cyclin-dependent kinase inhibitor p27(KIP1).

104 cell cycle, the MYC antagonist MAD1 and the cyclin-dependent kinase inhibitor p27(KIP1).

105 ation is associated with upregulation of the cyclin-dependent kinase inhibitor p27(Kip1).

106 te oligodeoxynucleotide (S-ON) targeting the cyclin-dependent kinase inhibitor, p27(kip1), enhanced a

107 a candidate to regulate the abundance of the cyclin-dependent kinase inhibitor, p27(KIP1), in human l

108 The cyclin-dependent kinase inhibitor, p27(Kip1), which regu

109 rrelate with modulation of the expression of cyclin-dependent kinase inhibitors (p27(Kip1) and p21(Wa

110 polarization also caused accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP

111 jugating E3 ligase Skp2 and up-regulation of cyclin-dependent kinase inhibitors p27(Kip1) and p21(Cip

112 and (3) an increase in the expression of the cyclin-dependent kinase inhibitors p27(kip1) and p21(cip

113 r agonist kainate caused accumulation of the cyclin-dependent kinase inhibitors p27(Kip1)and p21(CIP1

114 e complex, and promotes the stability of the cyclin-dependent kinase-inhibitor p27(Kip1) through an u

115 regulation of c-Myc and stabilization of the cyclin-dependent kinase inhibitor p27/KIP1.

116 lls were proliferative, most coexpressed the cyclin-dependent kinase inhibitor p27/Kip1.

117 osol, which causes hyper-accumulation of the cyclin-dependent kinase inhibitor p27, leading to mitoti

118 Proteolysis of cyclin-dependent kinase inhibitor p27 occurs predominant

119 rapamycin, mTOR) and altered activity of the cyclin-dependent kinase inhibitor p27 (p27(kip1)) and ex

120 differentiation by modulating expression of cyclin-dependent kinase inhibitor p27/p57 and E3 ubiquit

121 The cyclin-dependent kinase inhibitor p27 regulates cell cyc

122 mmunocytochemical analysis of the cell cycle cyclin-dependent kinase inhibitor p27 showed that treatm

123 Tamoxifen activates the cyclin-dependent kinase inhibitor, p27 to mediate G(1) a

124 The cyclin-dependent kinase inhibitor p27 was elevated durin

125 , and cyclin D3, and decreased levels of the cyclin-dependent kinase inhibitor p27 were intact.

126 We have investigated the role of the cyclin-dependent kinase inhibitor p27(Xic1) in the co-or

127 n G(1) phase by increasing expression of the cyclin-dependent kinase inhibitor p27(Xic1).

128 This data demonstrates that a single cyclin-dependent kinase inhibitor, p27(Xic1), controls i

129 We have investigated the role of the cyclin-dependent kinase inhibitor, p27(Xic1), in the coo