ライフサイエンスコーパス: cyclin-dependent protein kinase

1 ts with p34cdc2, the catalytic domain of the cyclin-dependent protein kinase.

2 drives cell-cycle transitions by activating cyclin-dependent protein kinases.

3 gulate the cell division cycle by activating cyclin-dependent protein kinases.

4 which functions as a universal inhibitor of cyclin-dependent protein kinases.

5 Cyclins are the regulatory subunits of cyclin-dependent protein kinases.

6 site has similarities with that of inactive cyclin-dependent protein kinases.

7 rtical release is disrupted in a hypomorphic cyclin-dependent protein kinase 1 (cdk-1) mutant and tha

8 Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme req

9 In eukaryotes, cyclin B-bound cyclin-dependent protein kinase 1 promotes mitotic entry

10 cell cycle is regulated by the action of the cyclin dependent protein kinase 2 (CDK2) in association

11 sterone receptors (PR) are phosphorylated by cyclin-dependent protein kinase 2 (CDK2) at multiple sit

12 Three other kinases [cyclin-dependent protein kinase 2 (CDK2), phosphorylase

13 ut not mutant) specifically disrupted an E2F-cyclin-dependent protein kinase 2-p107 DNA binding compl

14 ssion of proliferating cell nuclear antigen, cyclin-dependent protein kinase 4, cell division cycle 2

15 phorylation of phosphodiesterase-4 (PDE4) by cyclin-dependent protein kinase 5 (Cdk5) facilitated cAM

16 Cyclin-dependent protein kinase 5 (cdk5), a member of th

17 known Pgammas preserve a consensus motif for cyclin-dependent protein kinase 5 (Cdk5), a protein kina

18 ed levels of p25 and p35, both activators of cyclin-dependent protein kinase 5 (CDK5), enhanced calpa

19 Egr-1 silencing does not affect levels of cyclin-dependent protein kinase 5 (Cdk5), glycogen synth

20 ated with increased levels of tau oligomers, cyclin-dependent protein kinase 5 activators p35 and p25

21 ty of p35, a neuronal protein that activates cyclin-dependent protein kinase 5 through complex format

22 ylation by cAMP-dependent protein kinase and cyclin-dependent protein kinase-5.

23 K are related to Ime2p in budding yeast, and cyclin-dependent protein kinase-activating kinase Cak1p

24 arrested by mating pheromone show a loss of cyclin-dependent protein kinase activity caused by trans

25 f XlORC was affected by inhibitors of either cyclin-dependent protein kinase activity or DNA synthesi

26 T, a potential phosphorylation site for both cyclin-dependent protein kinase and mitogen-activated-pr

27 p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation.

28 bited by olomoucine, which potently inhibits cyclin-dependent protein kinases, and contained an appro

29 Cyclin-dependent protein kinases are among the key regul

30 The cyclin-dependent protein kinases are important targets i

31 entified BUR2, a cyclin for the Bur1/2 (BUR) cyclin-dependent protein kinase, as a specific regulator

32 The association of G(1) cyclins and Cdc28/cyclin-dependent protein kinase catalyzes the cell cycle

33 show that deletion of PHO85, which encodes a cyclin-dependent protein kinase, causes reduced transcri

34 In this article we consider the role of the cyclin-dependent protein kinase cdc2 in regulating progr

35 A specific amino acid substitution in the cyclin-dependent protein kinase Cdc28 was found to cause

36 Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.

37 horylation, most likely by the budding yeast cyclin-dependent protein kinase, Cdc28.

38 d with the increased levels of cyclin D3 and cyclin-dependent protein kinase (cdk) 6.

39 In Saccharomyces cerevisiae, PHO85 encodes a cyclin-dependent protein kinase (Cdk) catalytic subunit

40 roteins, including members of the cyclin and cyclin-dependent protein kinase (Cdk) families, and the

41 n about the posttranslational control of the cyclin-dependent protein kinase (CDK) inhibitor p21.

42 y oscillation of an engineered monomolecular cyclin-dependent protein kinase (CDK) module lacking muc

43 Ctk1 is a Saccharomyces cerevisiae cyclin-dependent protein kinase (CDK) that assembles wit

44 In Saccharomyces cerevisiae, PHO85 encodes a cyclin-dependent protein kinase (Cdk) with multiple role

45 species in vivo is dependent upon the Cdc28 cyclin-dependent protein kinase (CDK), which can directl

46 otic cell cycle requires the activation of a cyclin-dependent protein kinase (CDK).

47 e eukaryotic cell cycle are regulated by the cyclin-dependent protein kinases (CDK).

48 ase and requires phosphorylation by the G(1) cyclin-dependent protein kinase (cdk1).

49 e AMPA glutamate receptor subunit GluR2, the cyclin-dependent protein kinase Cdk5, and the transcript

50 activated protein kinases (MAPK) and by the cyclin-dependent protein kinase Cdk7.

51 Phosphorylation of CTD is mediated by the cyclin-dependent protein kinases Cdk7 and Cdk9, whereas

52 cently been shown to associate with a unique cyclin dependent protein kinase (cdk8) and it has been p

53 Cyclin dependent protein kinases (CDKs) have become attr

54 of proteins whose functions are regulated by cyclin dependent protein kinases (Cdks).

55 karyotes is governed by a complex network of cyclin-dependent protein kinases (CDKs) and auxiliary pr

56 Cyclin E is a regulator of cyclin-dependent protein kinases (Cdks) and is involved

57 Cyclin-dependent protein kinases (Cdks) are key regulato

58 The activation of cyclin-dependent protein kinases (Cdks) is dependent upo

59 Activating phosphorylation of cyclin-dependent protein kinases (CDKs) is necessary for

60 The activity of cyclin-dependent protein kinases (cdks) is physiological

61 Cyclin-dependent protein kinases (Cdks) play a key role

62 Complete activation of most cyclin-dependent protein kinases (CDKs) requires phospho

63 l division cycle is regulated by a family of cyclin-dependent protein kinases (CDKs) that are functio

64 n mRNA and protein expression of cyclins and cyclin-dependent protein kinases (cdks), activity of cdk

65 sion through the cell cycle is controlled by cyclin-dependent protein kinases (Cdks), but the mechani

66 In addition, the inhibitor of cyclin-dependent protein kinases (CDKs), p16INK4a, whose

67 aryotes emphasize the periodic activation of cyclin-dependent protein kinases (CDKs), recent experime

68 itogen-activated protein kinases (MAPKs) and cyclin-dependent protein kinases (CDKs), respectively.

69 ere the first identified binding partners of cyclin-dependent protein kinases (cdks), their cell cycl

70 hoice between repair pathways is governed by cyclin-dependent protein kinases (CDKs), with a major si

71 tively regulates cell division by activating cyclin-dependent protein kinases (CDKs).

72 tions in eukaryotes through association with cyclin-dependent protein kinases (CDKs).

73 The Drosophila melanogaster cyclin-dependent protein kinase complex CycD/Cdk4 stimul

74 The Drosophila cyclin-dependent protein kinase complex Cyclin D/Cdk4 in

75 e the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essentia

76 ne H3 (H3K4), which included components of a cyclin-dependent protein kinase (Ctk complex) that phosp

77 RB is phosphorylated by cyclin-dependent protein kinase during cell cycle progre

78 tation group B (XPB) and D (XPD) genes and a cyclin-dependent protein kinase encoded by the CDK7 gene

79 in-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase family, which has been f

80 ase was not GSK3 but instead a member of the cyclin-dependent protein kinase family.

81 phosphorylation of Cdh1 by Cdc28, the major cyclin-dependent protein kinase in budding yeast.

82 n and is accompanied by up-regulation of the cyclin-dependent protein kinase inhibitor p21(CIP1).

83 by an increase in protein expression of the cyclin-dependent protein kinase inhibitor p21(WAF1/Cip1)

84 on, which alters the conserved sequence, the cyclin-dependent protein kinase inhibitor Sic1, an SCF(C

85 ion of the Ace2 transcription factor and the cyclin-dependent protein kinase inhibitor Sic1.

86 orylation of T320 of PP-1 was reduced by the cyclin-dependent protein kinase inhibitor, olomoucine, a

87 Phosphorylation of RB, which is catalyzed by cyclin-dependent protein kinases, inhibits all three pro

88 iation is prompted during G(1) phase by Cln3/cyclin-dependent protein kinase-mediated transcriptional

89 nds to the consensus target sequence for the cyclin-dependent protein kinase p34(cdc2).

90 (state III), whereas phosphorylation by the cyclin-dependent protein kinase Pcl10p/Pho85p decreased

91 The cyclin-dependent protein kinase Pho85 is a known negativ

92 The cyclin-dependent protein kinase, Pho85, in conjunction w

93 ressed Cdc6 protein that is dependent on the cyclin-dependent protein kinase phosphorylation sites on

94 dent kinase G (CDKG) gene defines a clade of cyclin-dependent protein kinases related to CDK10 and CD

95 e loss of Bur2, a component of the Bur1/Bur2 cyclin-dependent protein kinase, results in a decrease i

96 protein kinase systems, the S-phase-specific cyclin-dependent protein kinases (S-CDKs) and the Dbf4-C

97 Pho85p is a cyclin-dependent protein kinase that antagonizes SNF1 co

98 of proteins, are the regulatory subunits of cyclin-dependent protein kinase that are essential activ

99 otein kinase (Cak1) is itself a Cdc2-related cyclin-dependent protein kinase that associates with cyc

100 These results reveal that the same cyclin-dependent protein kinase that initiates mitosis i

101 ic and regulatory subunits, respectively, of cyclin-dependent protein kinases that control progressio

102 Cks proteins are essential components of the cyclin-dependent protein kinases that regulate mitosis i