ライフサイエンスコーパス: cyclization

1 1,5-diazahexa-1,3,5-triene, followed by 1,6-cyclization.

2 directed remote metalation (DReM)-initiated cyclization.

3 is faster than the respective 5-exo radical cyclization.

4 e of the triazole ring followed by oxidative cyclization.

5 e primary product of 1,4-diazahexatriene 1,5-cyclization.

6 n allied to an iridium-catalyzed dehydrative cyclization.

7 adening the scope of this asymmetric Nazarov cyclization.

8 non-like modes play an important role in DNA cyclization.

9 )-pyridines via acid promoted intramolecular cyclization.

10 tion, and THP formation via Pd(II)-catalyzed cyclization.

11 on and supporting rate-determining concerted cyclization.

12 lamino-ynol derivatives via a gold-catalyzed cyclization.

13 mino ynone generation followed by 6-endo-dig cyclization.

14 cid, via intramolectular [2+2]-photochemical cyclization.

15 reviously proposed mechanism of PT-catalyzed cyclization.

16 efin isomerization, 1,2-addition followed by cyclization.

17 rminal alkenes and intramolecular aza-Wacker cyclization.

18 n, oxo-vanadium oxidation, and atom-transfer cyclization.

19 alkylation and a diastereoselective pinacol cyclization.

20 lowed by Lewis acid catalyzed intramolecular cyclization.

21 es were employed to examine the scope of the cyclization.

22 ive moieties, particularly polyenes prone to cyclization.

23 tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization.

24 which undergoes an interrupted halo-Nazarov cyclization.

25 shed via condensation and two intramolecular cyclizations.

26 Through a tandem guanylation-cyclization, a series of 2-iminoimidazolin-4-ones could

27 e carbamate formation, lactone reduction and cyclization, afforded cyclopropyl pyran 1.

28 Cyclization also folds peptides into bioactive conformat

29 xa-2,4-dienones with ethyl acrylate, radical cyclization and 1,3-acyl shift in excited state are the

30 acid (chiral LBA) mediated cationic polyene cyclization and a titanocene-mediated radical cyclizatio

31 oxycyclopropyl)but-2-enoate (28) followed by cyclization and chiral separation to form 27c, the core

32 zed Ser65-Tyr66-Gly67 tripeptide, we modeled cyclization and dehydration reactions.

33 further probes the dimer-driven mechanism of cyclization and enables an efficient access to a wide ra

34 have been demonstrated to increase rates of cyclization and impose stereochemical constraints on the

35 ving alkynes and readily mediates both enyne cyclization and intramolecular hydroarylation reactions,

36 of which are productive for bi- (or larger) cyclization and lead to products.

37 dyl radicals and their use in hydroamination-cyclization and N-arylation reactions is reported.

38 Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence.

39 re shown to be superior reagents for protein cyclization and protein semisynthesis, with the latter i

40 lude pericyclic, cycloaromatization, radical cyclization and ring opening, and SN 2.

41 or lipoxin B4, likely by interfering with AA cyclization and shunting AA to the LOX pathway under phy

42 uggesting cationic charge buildup during the cyclization and supporting rate-determining concerted cy

43 occurs alongside, or instead of, borylative cyclization and the factors controlling the reaction out

44 The epimerized hexaketide failed to undergo cyclization and was exclusively hydrolyzed, confirming t

45 that enantioselective SmI2-mediated radical cyclizations and cascades that exploit a simple, recycla

46 Highly selective dearomatizing radical cyclizations and cyclization cascades, triggered by sing

47 non-ribosomal peptide ferribactin undergoes cyclizations and oxidations that result in the fluoropho

48 e stabilization of alkenyl anions in anionic cyclization) and nanomaterials chemistry (facile doping

49 ylofuranose precursor, [I(+)]-induced 6-endo cyclization, and 1,2-trans stereoselective glycosylation

50 mination of the photoredox-catalyzed radical cyclization, and a double 6-endo cyclization with cataly

51 on of methyllithium to the nitrile function, cyclization, and in situ acylation with di-tert-butyldic

52 rmation involves consecutive transamination, cyclization, and isomerization steps.

53 steps of amidation, alcohol activation, and cyclization are all mediated by one reagent (TBD) in a s

54 a C6F5-substituted formazan undergoes facile cyclization as a result of intermolecular nucleophilic s

55 Here we used backbone cyclization as a strategy to improve the folding yield a

56 The reaction provided an unusual mode for cyclization as sodium sulfide, a soft nucleophile, prefe

57 iethynylquinoxaline showed C(1)-C(6) Bergman cyclization as the favored thermodynamic reaction pathwa

58 A plausible mechanism is proposed for this cyclization based on the results of a control experiment

59 these reactions, exemplified by the Bergman cyclization (BC), two bonds are sacrificed to form a sin

60 However, competitive 5-exo-dig cyclization, beta-elimination of the ynone, and dimeriza

61 catalysis of rhodium(II) octanoate, [3 + 2]-cyclization between enoldiazoacetamides and nitrosoarene

62 een developed by employing Michael-Dieckmann cyclization between enone 3 and a fully built and protec

63 a one-pot sequential N-acylation/dehydrative cyclization between ethyl carbazate and N-acylbenzotriaz

64 e (B(C6F5)3), an activating agent capable of cyclization but not dealkylation, resulted in the isolat

65 oach to azetidine synthesis than traditional cyclization by nucleophilic displacement and provide nov

66 rug cleavage unless 3-exo-tet intramolecular cyclization can occur, suggesting that enzymatic hydroly

67 s a novel intermolecular [4+2] cycloaddition-cyclization cascade between a vinyl p-quinone methide an

68 face-catalysed cross-coupling and sequential cyclization cascade of 1,2-bis(2-ethynyl phenyl)ethyne o

69 te a highly stereoselective C-C bond-forming cyclization cascade reaction using (2-halo)aryl ethers a

70 precedented NaBH4-promoted one-pot reductive cyclization cascade that efficiently yielded a hydroxyl

71 ein engineering can be used to reprogram the cyclization cascade to generate alternative and commerci

72 ed polycyclization, and (2) an isomerization-cyclization cascade to generate the remaining bicyclo[3.

73 A reductive radical cyclization cascade was utilized to build the B ring, an

74 carbocation intermediates that propagate the cyclization cascade, and the chemical strategies that te

75 es of substrate activation that initiate the cyclization cascade, the management and manipulation of

76 d the chemical strategies that terminate the cyclization cascade.

77 diastereoselective aldol/Brook rearrangement/cyclization cascade.

78 Enantioselective radical cyclization cascades have the potential to deliver compl

79 ctive dearomatizing radical cyclizations and cyclization cascades, triggered by single electron trans

80 ct product groups resulting from alternative cyclization cascades.

81 Subsequent cyclization catalyzed either enzymatically by a norcocla

82 d to be unreactive or rearranged under these cyclization conditions.

83 ade itself, incorporating an ensemble of pre-cyclization conformations of the platinum-alkene reactan

84 an alkynophilic Lewis acid in electrophilic cyclization/dealkylation reactions.

85 All reaction steps including cyclization, dehydration, and oxidation are characterize

86 The highest computed energy barriers at the cyclization-dehydration (17 kcal/mol) and oxidation (21

87 trong support to the mechanism involving the cyclization-dehydration-oxidation sequence of the chromo

88 The radical cyclizations deliver new polycyclic hemiaminals or enami

89 C-H activation chemistry and subsequent Heck cyclization delivers the aglycone framework in an overal

90 o ClBcat, failed to mediate the complete the cyclization/demethylation reaction sequence by itself.

91 (de, ee up to >99%) via domino ring opening cyclization (DROC) of activated aziridines with 2-vinyli

92 nvolves a cascade Michael addition-Dieckmann cyclization-elimination sequence, offers rapid and conve

93 erizable E,Z dienyl motif followed by Pinner cyclization enabled the construction of the tetrahydrofu

94 followed by an iron-mediated decarboxylative cyclization event.

95 ombination with a highly efficient "one-pot" cyclization-folding approach, we obtained an RTD-1-based

96 n reaction proceeds via a nucleophilic amino cyclization followed by an intermolecular C-N bond forma

97 em catalysis involving atom-transfer radical cyclization followed by catalytic dehydrohalogenation.

98 mately implemented a sequence of carbazolyne cyclization followed by Rh-catalysed fragmentation to in

99 Control experiments reveal that the cyclization, followed by 1,3-allylic amino dehydroxylati

100 activation that triggered a Vilsmeier-Haack cyclization, followed by an azomethine ylide generation

101 yclization and a titanocene-mediated radical cyclization for the asymmetric assembly of the "AB" ring

102 unsaturated methyl ketone, and (v) a radical cyclization for the cyclobutane ring formation to provid

103 ons with a TMSOTf-catalyzed oxonium-mediated cyclization gave general access to pyrrolo[2,1-a]isoquin

104 ng effect of a remote substituent on radical cyclization has also been presented.

105 A tandem olefin metathesis/oxidative cyclization has been developed to synthesize 2,5-disubst

106 d Bi(OTf)3-catalyzed intramolecular olefinic cyclization has been developed.

107 ably fabricated indoles via C-N bond forming cyclization in 28-82% yield.

108 utions at 3- and other positions followed by cyclization in a domino fashion has been developed.

109 ziridine followed by a concomitant 5-exo-dig cyclization in a domino fashion to furnish the 2-iminoth

110 this study highlights the value of backbone cyclization in directing folding, improving yields, and

111 ryl isothiocynates undergo efficient cascade cyclization in the presence of Ag2CO3 to form indoloquin

112 lating to the mechanism of Garratt-Braverman cyclization in two systems, namely bis-propargyl sulfone

113 ein we describe a novel strategy for peptide cyclization in which intramolecular iminoboronate format

114 ylquinoxaline undergoes irreversible Bergman cyclization indicative of a large retro-Bergman ring ope

115 Additionally, the cyclization intermediate 3 was isolated, allowing us to

116 The cyclizations involve the formation of betaines (imidazol

117 The first dearomatizing radical cyclizations involving radicals derived from amide carbo

118 r benzannelation effectively renders Bergman cyclization irreversible due to favorable aromatic stabi

119 Photo-mediated 6pi cyclization is a valuable method for the formation of fu

120 The tail-to-head terpene cyclization is arguably one of the most complex reaction

121 The cyclization is diverted from those catalyzed by the char

122 rate, enantio- and site-selectivity for the cyclization is investigated.

123 are competent traps in the bromonium-induced cyclizations, leading to the formation of enantioenriche

124 Optimization of a reductive diene cyclization led to the development of an intermolecular

125 phine sulfide followed by haloalkylation and cyclization led to the enantiomerically enriched tertiar

126 By optimizing the cyclization linker, length, and amino acid sequence, the

127 lytic cycles involve a concerted or stepwise cyclization mechanism has not been addressed experimenta

128 cally relevant for their exquisite enzymatic cyclization mechanism.

129 Cyclization minimizes degradation in the gut, blood, and

130 ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air

131 The cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles v

132 Free radical cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles w

133 Fe(acac)3 mediates the deiodinative cyclization of (2-halo)aryloxy furfuranyl ethers, follow

134 dines has been developed using a 6-endo-trig cyclization of (E)-enones.

135 A Bi(OTf)3-catalyzed ring-opening cyclization of (hetero)aryl cyclopropyl carbinols to for

136 The selectivity of the cyclization of (omega-haloalkyl)alkylarylphosphine deriv

137 a cobalt-catalyzed asymmetric hydroboration/cyclization of 1,6-enynes with catalysts generated from

138 ugh the molecular iodine-catalyzed oxidative cyclization of 2-aminopyridine/amidine and isothiocyanat

139 An acid- and oxidant-promoted intramolecular cyclization of a tetrahydro-beta-carboline-based dipepti

140 ation orientation on C(1)-C(5) and C(1)-C(6) cyclization of acyclic quinoxalenediynes.

141 in) via in situ formation and intramolecular cyclization of alkyl 2-[(2-alkoxybuta-2,3-dienimidoyl)su

142 ydroindolizin-3(5H)-ones from a condensation cyclization of alpha-oxoesters with five- and six-member

143 tion, the study indicates that 6-exo radical cyclization of an alkyl radical to a phenyl ring is fast

144 ective synthesis of this type of compound by cyclization of an aryl bicyclosesquiterpene.

145 as synthesized from dimethoxytetralone 8 via cyclization of an intermediate benzylic radical, generat

146 on the quantitative intramolecular reductive cyclization of an oligo(diyne) with a low-valent zircono

147 BCl3 -induced borylative cyclization of aryl-alkynes possessing ortho-EMe (E=S, O

148 In this paper, we report an intramolecular cyclization of benzylic-substituted propargyl alcohols p

149 Metal catalyzed post-Ugi cyclization of bis-amides is reported in this study.

150 CHI activity, which catalyze stereospecific cyclization of both 6'-hydroxychalcone and 6'-deoxychalc

151 -catalyzed intramolecular and stereospecific cyclization of chalcones is a committed step in the prod

152 s are formed, respectively, via 1,5- and 1,6-cyclization of common (5Z)-1,4-diazahexa-1,3,5-triene in

153 tional framework can be used to describe the cyclization of DNA sequences that contain a base pair mi

154 For the cyclization of geranyl acetate, it was found that the cl

155 Due to a fast occurring cyclization of l-glutamine to pyroglutamic acid, the typ

156 A regioselective base-mediated cyclization of mono-N-acylpropargylguanidines is reporte

157 through a palladium-catalyzed carbonylative cyclization of N-(2-iodoaryl)enaminones, proved to inhib

158 The intramolecular cyclization of N-benzylfumaramide [2]rotaxanes is descri

159 e formation of indazolones by Friedel-Crafts cyclization of N-isocyanates using blocked (masked) N-is

160 Intramolecular cyclization of nitrogen tethered alkenols catalyzed by p

161 to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presen

162 zido-iodo-pyranoquinolines via electrophilic cyclization of o-alkynylaldehydes in the presence of sod

163 elective 5-exo-trig intramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN

164 possess a critical pharmacophore (HFRW), and cyclization of peptide agonists often enhances potency.

165 The catalytic, enantioselective, cyclization of phenols with electrophilic sulfenophthali

166 The method is based on the cyclization of readily available substrates and proceede

167 Specifically, cyclization of ribbon GeXIVA with a two-residue linker m

168 Liberation and cyclization of SFTI-1, however, was inefficient, suggest

169 SiH2OO, i.e., the calculated barrier for the cyclization of SiH2OO is only 4.4 kcal/mol, which is nea

170 iodothiophenes, nucleophilic azidation, and cyclization of tetrazolopyrimidines, followed by glycosy

171 Cyclization of the amidine-tethered anthranilate then af

172 bacteriochlorin macrocycle, and (ii) Nazarov cyclization of the beta-(propenoyl)-substituted ring C f

173 ine intermediate before the rate-determining cyclization of the hydrazone onto the alkyne group.

174 The key step of synthetic sequence was the cyclization of the latter under Heck reaction conditions

175 Sesterterpene synthase (STS)-mediated cyclization of the linear C25 isoprenoid precursor geran

176 products 2-7 have been prepared by reductive cyclization of the relevant 2-arylcyclohex-2-en-1-one (e

177 diones 2 followed by stereoselective radical cyclization of the resulting adducts 3 to provide the cy

178 arylboronic acid to the alkyne, followed by cyclization of the resulting alkenylnickel species onto

179 ionalization of two ketide units followed by cyclization of the resulting octaketide into tylactone.

180 r both the nonenzymatic and enzyme-catalyzed cyclization of the SpnF substrate.

181 re formed during roasting by dehydration and cyclization of their precursors, the chlorogenic acids (

182 nditions for the subsequent deprotection and cyclization of these intermediates allowed access to pyr

183 Nickel-catalyzed reductive cyclization of this alkynylaldehyde, to construct the ei

184 ation of the transition state by Ox promotes cyclization of traditionally resistant substrates, broad

185 The oxidative cyclization of various aldoximes with 1-propene-1,3-sult

186 ase catalyst and selectively accelerates the cyclizations of 4-allen-1-ols into one prochiral allene

187 3 enabled the first catalytic intramolecular cyclizations of carboxylic acid substrates using this Le

188 rtant classes of heterocycles via controlled cyclizations of easily accessible common precursors.

189 In addition, intramolecular cyclizations of esters enable C-C bond formation as cata

190 s) are responsible for controlling the aldol cyclizations of poly-beta-ketone intermediates assembled

191 Enantioselective nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosph

192 lished via palladium(II)-catalyzed oxidative cyclizations of terminal bis(vinylboronate esters).

193 ids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered

194 crystallography to understand the effect of cyclization on the electronic properties and structure.

195 hylaluminum chloride followed by a 5-exo-dig cyclization/oxidation reaction catalyzed by copper(II) c

196 nd tetracyclic sesterterpenes, revealing the cyclization path for the pentacyclic sesterterpene (-)-r

197 suggest that these STSs catalyze an unusual cyclization path involving reprotonation, intramolecular

198 the substrate/catalyst interaction along the cyclization path.

199 This stereoisomer induced a novel cyclization pathway leading to sesquiterpenes based on h

200 o understand how the substituent affects the cyclization pathway.

201 radicals can undergo reduction or reductive cyclization pathways, providing a powerful method for (i

202 iosynthetic intermediates toward alternative cyclization pathways.

203 clic urea fused derivatives through a double cyclization process from readily available aminophenyl p

204 d adduct to the aflatoxin system via the Nef-cyclization process was achieved by the assistant of ZnB

205 In a cyclization process, Cys residues then attack the dehydr

206 arylation step followed by an intramolecular cyclization process.

207 observed during a reductive radical cascade cyclization process.

208 revealing the general exo-preference for the cyclization processes.

209 a side reaction that afforded an alternative cyclization product, are discussed.

210 enabling access to the otherwise suppressed cyclization product.

211 In addition, further modifications of the cyclization products enabled stereochemistry-function st

212 ly, in the presence of K2CO3, tandem C-C/C-N cyclization products were obtained for a couple of subst

213 iminocarbenes, 1H-azirines, ketenimines, and cyclization products, and 1,2,4-triazoles are precursors

214 ine, via butenylation and diastereoselective cyclization promoted by N,N-dimethyl-4-aminopyridine.

215 A cross-coupling/reductive cyclization protocol has been employed in a unified appr

216 The developed cyclizations provide a concise, atom-economical route to

217 generation of iminyl radicals and subsequent cyclization/radical trapping, which allows the effective

218 ecarboxylative pyrimidine/pyridine migratory cyclization (rather than deprotection of pyrimidine/pyri

219 An intramolecular cyclization reaction leading to the loss of the C-X chai

220 The cyclization reaction mechanism and the enantiomeric comp

221 A tandem deprotection-cyclization reaction of 1,1-diacylcyclopropanes is descr

222 The halogen-mediated cyclization reaction of aryldiynes to produce halogenate

223 eropyrenes were formed after a 4-fold alkyne cyclization reaction promoted by triflic acid.

224 This work showcases a new catalytic cyclization reaction using a highly Lewis acidic borane

225 An unexpected diastereoselective cyclization reaction was observed, leading preferentiall

226 iterpenoid oxidation activities, including a cyclization reaction, leading to a triterpenoid lactone.

227 bridization during a single enzyme-catalyzed cyclization reaction.

228 MeHg(+) and hCy7 through a mercury-promoted cyclization reaction.

229 zo[b][1,6]naphthyridones via a base-mediated cyclization reaction.

230 a sequential Suzuki-Miyaura coupling/Petasis cyclization reaction.

231 )-Ynamides are converted to oxazolones via a cyclization reaction.

232 The DFT calculation of the iodine-mediated cyclization reactions for molecules containing methoxy,

233 ts efficient and stereoselective dehydrative cyclization reactions from monoallylic diols, with stere

234 Several formal heteroborylative cyclization reactions have been recently reported, but l

235 Novel molecular iodine catalyzed cyclization reactions of 2-amino anilines with aryl alky

236 re is generated by periplasmic oxidation and cyclization reactions of d-tyrosine and l-diaminobutyric

237 The first cyclization reactions of enoldiazo compounds with nitros

238 This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from

239 oach is exploited for multifold C-C coupling cyclization reactions with C-C cleavage using symmetrica

240 iates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the constr

241 yl shift proposed as part of the carbocation cyclization/rearrangement leading to ledol, viridiflorol

242 ent Pictet-Spengler and Bischler-Napieralski cyclization/reduction cascades furnish the cis- and tran

243 Repeated addition of 1 to 4 followed by cyclization resulted in the stereoselective synthesis of

244 lowed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo

245 An alternative fragmentation-radical cyclization sequence of related substrates allows access

246 lic iridoid scaffold in a two-step reduction-cyclization sequence.

247 vage/rotation around the N-C single bond/1,6-cyclization" sequence.

248 , stop, and cysteine-encoding (for disulfide cyclization) sequences.

249 This highly versatile strategy for peptide cyclization should find applications in many areas of ch

250 nial is clearly enzymatically catalyzed, the cyclization step appears to be subject to less stringent

251 To ensure that the cyclization step is rapid, our design capitalizes on two

252 AmISY is clear, in both AmISY and CrISY, the cyclization step produces a diastereomeric mixture.

253 ne and the indole nucleophile in the initial cyclization step through an intermolecular hydrogen bond

254 The intramolecular cyclization step was completed in a short time (1-2 h) a

255 tation around C3-C4 and a subsequent thermal cyclization step.

256 emic tropanes were synthesized using Mannich cyclization strategies (Robinson-Schopf and by way of a

257 Mechanistic studies of the reductive cyclization suggest a hydride insertion pathway, explain

258 The key operation is a Pd-catalyzed tandem cyclization that directly establishes the requisite 1,3-

259 switched to an unprecedented formal [5 + 1]-cyclization that provided multifunctionalized 1,3-oxazin

260 that was engaged in MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processe

261 xygen mediated gamma-CH oxidation, a Stetter cyclization to access the pendant cyclopentenone, and a

262 and N-tosyl homoallylamine undergo aza-Prins cyclization to afford (1R,5S,7S)-7-[(benzyloxy)methyl]-2

263 roducts undergo an acid-mediated dehydrative cyclization to arrive at these targets.

264 tro-Bergman ring opening, allowing C(1)-C(5) cyclization to become a competitive reaction channel.

265 Coupled with a late-stage radical cyclization to construct the [3.2.2]-bridged bicycle, th

266 include a Mn(III)-mediated oxidative radical cyclization to construct the trans-decalin ring, and a 6

267 olecule of nitrile followed by electrophilic cyclization to deliver the desired product.

268 4-Pentenylalcohols also undergo oxidative cyclization to form gamma-lactones predominantly.

269 Cyclization to form pyrrolidines, piperidines, or morpho

270 ered alkyl/aryl halides that undergo radical cyclization to generate C(sp(3))-Cu complexes in situ, w

271 mote cascade, tandem condensation to oximes, cyclization to nitrones, and 1,3-dipolar cycloaddition t

272 eric C12-fragment (R)-30 underwent reductive cyclization to provide the desired product in 60% yield.

273 atalyst to a Echavarren's gold(I) turned off cyclization to seven member ring and turned on 6-exo-dig

274 om proton-coupled electron-transfer-mediated cyclizations to C-C bond constructions, dehalogenations,

275 sation, cyclopropyl ring opening followed by cyclization took place in a single-pot operation.

276 ynthetic methodologies commonly used for the cyclization toward medium-sized heterocycles cannot be a

277 ased affinity of Au-catalysts to the Bergman cyclization transition state as one of the key component

278 nctionality and a dehydrative intramolecular cyclization under mild conditions to form the oxadiazine

279 mation from readily available precursors and cyclization under mild reaction conditions.

280 r iminoboronate formation allows spontaneous cyclization under physiologic conditions to yield monocy

281 mides could undergo intramolecular oxidative cyclization under the optimized conditions to give isoin

282 on, tandem hydrogenation/hydrogenolysis, and cyclization upon reaction with 4-bromobutanal to give th

283 e, and methane-toward Garratt-Braverman (GB) cyclization using density functional theory calculations

284 undergoes decarboxylative pyridine migratory cyclization using MeOTf/NaOMe in toluene providing 6-met

285 catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed.

286 Cyclization via a thiolactone bond is essential for AIP

287 matic ring at the activated triple bond, and cyclization via an exclusive 6-endo-dig process.

288 Bergman cyclization via thermal activation of these constructs y

289 cloaddition and subsequent template-directed cyclization via Yamamoto coupling.

290 d reduction of amides and reductive umpolung cyclizations via aminoketyl radicals as a key step.

291 derivatives through ring opening followed by cyclization (vinylcyclopropane-cyclopentene rearrangemen

292 A three-component cascade cyclization was developed to synthesize 2,3-diarylisoind

293 The base-mediated intramolecular cyclization was found to be general for both alkyl- and

294 gement in diastereoselective Pictet-Spengler cyclization were the key steps.

295 he final step involved a highly unusual Heck cyclization whereby ligand control enabled efficient for

296 zed radical cyclization, and a double 6-endo cyclization with catalyst loadings as low as 0.01 mol%.

297 yl vinyl ketones that undergo facile Nazarov cyclization with excellent chemo-, regio-, and stereocon

298 ctive pseudo-four-component tandem oxidative cyclization with fragmentation from a 1,3-dicarbonyl com

299 atic reaction suggest a similar mechanism of cyclization within the enzyme active site; however, ther

300 tory studies on photoredox-catalyzed radical cyclizations yielded interesting results, including the