ライフサイエンスコーパス: cyclize

1 r its derivatives (X = H, OH; X = H, OAc) to cyclize.

2 ed, but this species could not be induced to cyclize.

3 the 5'-activated 2'-amino nucleotides do not cyclize.

4 linear substrate so that the two ends can be cyclized.

5 known diazene precursors was synthesized and cyclized.

6 f which are heterochiral and/or N-C backbone-cyclized.

7 tion of a 2-(indol-1-yl)phenyl radical which cyclizes.

8 mino-4-hydroxybenzoic acid (3,4-AHBA), and a cyclized 5-aminolevulinic acid moiety, 2-amino-3-hydroxy

9 ducts in the absence of added ligand and the cyclized 7- and 8-substituted-imidazo[1,2-a]pyrrolo[2,3-

10 subsequent sequential oxidation reaction of cyclized 7-iodo-12-phenylindeno[2,1-alpha]phenalene (ipp

11 This study exemplifies a novel approach to cyclize a Type II beta-turn linear peptide and provides

12 e that sortase A can successfully be used to cyclize a variety of small disulfide-rich peptides, incl

13 te and act in a novel second transformation, cyclizing ALA-CoA to C(5)N.

14 nd, and finally protonation of the resulting cyclized alkyl complex by hydrazide to release the hydro

15 le of the (99m)Tc(CO)3-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone derivative

16 ring size of the radiolabeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone (alpha-MSH

17 perties of the (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptides.

18 design of a novel radiolabeled lactam bridge-cyclized alpha-MSH peptide for melanoma imaging and trea

19 A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg

20 cyclopentannulated examples either failed to cyclize altogether or underwent C2-C7 cyclization.

21 e form that predominates in the subsequently cyclized aminocoumarin scaffold.

22 Zn(II)] and their independently synthesized, cyclized analogs have been prepared to investigate their

23 ptide backbone methylation or preparation of cyclized analogues based on pyrrolidine were evaluated a

24 The manifold applications for cyclized analogues of the aromatic amino acids Phe, Tyr,

25 (OxyK and OxyN) are necessary to completely cyclize and aromatize the amidated tetracyclic aglycon.

26 de chain of an l-dopa precursor was shown to cyclize and form a proposed indole structure in C. neofo

27 A piperacillin-BSA adduct with cyclized and hydrolysed forms of the hapten bound to eig

28 tals in the presence of 1.5 mM Ca(2+) is not cyclized, and two calcium ions are observed in the 2.9 A

29 Nature oligomerizes, cyclizes, and then oxidizes gamma,gamma-dimethylallyl py

30 In situ hydrogenation of cyclized anhydrobase intermediates afforded 4-substitute

31 ized with side chains terminated in a doubly cyclized Arg-Gly-Asp motif KACDCRGDCFCG (RGD4C: active p

32 covalent networks (HDCNs), which can further cyclize at high temperatures, producing poly(hexahydrotr

33 orresponding 6-oxo analogue is well-known to cyclize at N7.

34 re planar complex that spontaneously Bergman cyclizes at ambient temperature to give the crystalline

35 Their end-to-end cyclized backbone that enhances molecular stability is a

36 Cyclized beta-lactamase was soluble even after heating a

37 p to a kDelta process involving formation of cyclized beta-silyl carbocation intermediates for electr

38 This isomerization suggests that the cyclized beta-silyl cation can isomerize and then reopen

39 B3LYP/6-31G* computational studies show only cyclized beta-silyl cations as energy minima.

40 rom the W4A9 sequence (Ac-ICVWQDWGAHRCT-NH2, cyclized between C2 and C12), based on structural, compu

41 The surface peptides were cyclized between their N-terminal amine and a carboxyl g

42 rate-analogue plasmin inhibitors, which were cyclized between their P3 and P2 side chains, provided a

43 k of coordination to purine, Y. pestis AC-IV cyclizes both ATP and GTP.

44 P450 (P450) enzymes that are responsible for cyclizing bound peptides.

45 nverted to regiospecific vinyl triflates and cyclized by a palladium-catalyzed intramolecular arene-v

46 ynylphenyl propargyl ethers were efficiently cyclized by potassium tert-butoxide to the corresponding

47 se potent Dyn A analogues are the first ones cyclized by RCM.

48 The ligand strands can be cyclized by ring-closing olefin metathesis to form a mol

49 -(Cbz-aminoacyl)thiosemicarbazides 3a-c were cyclized by treatment with sulfuric acid to give 1,3,4-t

50 The pyroglutamyl-tRNA is most likely a cyclized by-product derived from gamma-phosphoryl-Glu-tR

51 tones, and "reducing" ARO/CYCs, which act on cyclized C9 reduced poly-beta-ketones.

52 esents the first example of a fluorescent N1-cyclized cADPR analogue and is a new pharmacological too

53 ll0254 in Synechocystis sp. strain PCC 6803, cyclized carotenoids were replaced by linear, relatively

54 pondingly reduced or increased production of cyclized carotenoids, which would be expected if CruP wa

55 t Sll0254 catalyzes formation of oxygenated, cyclized carotenoids.

56 acrocyclization-based strategies to complex, cyclized cembranoids.

57 l. report on their successful synthesis of a cyclized competitor peptide that blocks the binding of F

58 The findings permitted development of a cyclized competitor peptide that demonstrated strong inh

59 mproved the ligand efficiency/potency of the cyclized compound relative to its acyclic analogue.

60 Our data show that cyclized Crp4 can be biosynthesized by using this approa

61 We present here the biosynthesis of backbone-cyclized Crp4 using a modified protein splicing unit or

62 We show that cyclized CRRETAWAC fully displaced MSC adhesion to FN, w

63 results indicate the potential for backbone-cyclized defensins in the development of novel peptide-b

64 inobutyryl to the Cl-ACC product but did not cyclize delta- or epsilon-chloroaminoacyl-S-CmaD substra

65 This highly methylated cyclized depsipeptide exhibited an unprecedented selecti

66 as UV irradiation generated the two expected cyclized diastereomers.

67 Cyclized dihydrofolate reductase was similarly resilient

68 ear-quantitatively generates the cis-Bergman-cyclized, diiodo product 3 ((31)P: delta = 41 ppm, J(Pt-

69 ted CH(2)=CHCH(2)CH(OR)(2) acetals, and they cyclize divinyl ethers to analogous cyclic acetals.

70 resilience even at 100 degrees C, where the cyclizing domains themselves were unfolded.

71 properties of (111)In-labeled lactam bridge-cyclized DOTA-[X]-CycMSH(hex) {1,4,7,10-tetraazacyclodod

72 -Arylthioketones and 2-arylaminoketones also cyclize effectively under these conditions.

73 precursors ranging from 3 to 15 amino acids cyclize effectively under this photoredox method.

74 -aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to the corresponding cyclohexanones.

75 The derived alpha-aryl-alpha-diazo ketones cyclize efficiently with Rh catalysis to give the corres

76 Chemically activated short oligonucleotides cyclize efficiently, which severely impairs polymer grow

77 The derived alpha-azido ketone 16 cyclized efficiently to the heptacyclic pyrazine core of

78 a a delocalized 2-aza-pentadienyl anion that cyclizes either by a suprafacial electrocyclic mechanism

79 lience, we established the SpyRing approach, cyclizing enzymes by sandwiching between SpyTag and SpyC

80 sed in Escherichia coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as

81 e in CD38, Thr-221, is shown to disfavor the cyclizing folding of the substrate, resulting in NADase

82 a role for molecular oxygen in trapping the cyclized form of GFP.

83 to 1134, and 1128 to 1150) that in linear or cyclized form were recognized by pooled intestinal IgA a

84 CmaC will not cyclize free gamma-chloro amino acids or their S-N-acety

85 yclotides but are biosynthetically unable to cyclize from their precursors.

86 enones is a peri-fused tricyclic ring system cyclized from a linear polyketide precursor via an unres

87 In vivo, systemic delivery of cyclized GACRETAWACGA linked to (DSS)6 to allow delivery

88 CmaC could cyclize gamma,gamma-dichloroaminobutyryl to the Cl-ACC p

89 ptor binding, we have engineered peptides by cyclizing gamma-MSH using a thioether bridge.

90 on of the resulting adducts 3 to provide the cyclized gem-difluoromethylenated diquinanes 4 as a mixt

91 ay, an isomerocyclase that can rearrange and cyclize geranylated indolenine (2) to a previously unkno

92 Post-growth excitation of fully cyclized GNRs induces cleavage of sacrificial carbonyl g

93 that monolayer protection is accomplished by cyclized gold(I)-thiolate tetramers on the gold core sur

94 s are best representatives of this family: a cyclized heptapeptide (called CyRP-71) and a linear octa

95 because of the generation of a redox-labile cyclized hydroquinone, further demonstrating the lack of

96 properties of (99m)Tc-labeled lactam bridge-cyclized HYNIC-linker-Nle-CycMSHhex (hydrazinonicotinami

97 CCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IG

98 Styryl-substituted sulfilimines cyclize in a stereospecific manner and produce a 3:2-mix

99 allylanilines and 4-pentenylarylsulfonamides cyclize in high yield and with good enantioselectivity,

100 3S-epoxy-9Z,15Z-octadecadienoic acid did not cyclize in the presence of PpAOC1; however, when bound t

101 ne precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dependent reaction catalyzed by th

102 steps to iodoacetamide ketone 10, which was cyclized in good yield to the key bridged keto lactam 11

103 ng terminal as well as internal alkynes were cyclized in high to excellent yields within 2-24 h under

104 Several 4-aryl pentenoic acids were cyclized in the presence of 0.1 equiv of (DHQD)(2)PHAL,

105 Aminoalkenes are catalytically cyclized in the presence of cyclopentadienylbis(oxazolin

106 afforded a chalcone that was deprotected and cyclized in the presence of sodium acetate in refluxing

107 do-Mannich products were found to be readily cyclized in the presence of triethylamine to afford the

108 minal element involved in a potential genome cyclizing interaction (3'CSI) exhibited the greatest pot

109 beta to the protonated -CN group to form the cyclized intermediate 12, which tautomerizes to its most

110 to correct the ring topology of incorrectly cyclized intermediates and products, suggesting that the

111 In the last step, they were conveniently cyclized into spirooxaphospholenes with one equivalent o

112 e enamines generated in this reaction can be cyclized into substituted indoles employing copper catal

113 Substrates, bearing axial chirality, can cyclize intra- or inter-molecularly with concomitant tra

114 ions, H(2)C=C(OH)CON(+)(R)=C(R')CH(3) 5a-c, cyclize intramolecularly to 3b or undergo intermolecular

115 imminium ions H2C=C(OH)CON+(R)=C(R')CH3 9a,b cyclize intramolecularly to give 7a,b.

116 r that is responsible for the synthesis of a cyclized isocyano derivative of tyrosine.

117 n to synthesize the heptaketide backbone and cyclize it into the angular, hemiketal-containing naphth

118 Although the potential of such cyclized/knot polymer architectures is far from being fu

119 ing how RDRP has led to the formation of new cyclized/knotted polymer structures.

120 erol synthase ((S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7).

121 Paenicidin A is a highly cyclized lantibiotic, containing six lanthionine and met

122 y for the rapid production and evaluation of cyclized loops.

123 Remarkably, the cyclized lysine branch of the peptide moiety lies in the

124 e polyketide precursor and the corresponding cyclized macrolactone, were also synthesized.

125 C(beta) bond in the Tyr-67 side chain in the cyclized Met-66-Tyr-67-Gly-68 tripeptide.

126 , the p-methoxyphenyl-substituted radical 3f cyclized much faster than expected from the Hammett anal

127 e catalytic differences and the mechanism of cyclizing NAD, the crystal structure of a stable complex

128 s of directly reduced, cyclized/reduced, and cyclized/non-reduced products depend not only on the rea

129 1) the ratio of cyclized/reduced products to cyclized/non-reduced products depends on the ability of

130 /reduced products and iodides giving largely cyclized/non-reduced products.

131 bolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadien

132 ty relationships of a series of rhenium (Re)-cyclized octreotide derivatives are described.

133 me to diffuse out of the solvent cage and to cyclize onto a pendant olefin.

134 However, iminyl radicals did cyclize onto indoles, enabling indolopyridines to be pre

135 wing to the ease with which the C(15)-(S)-OH cyclized onto the epoxide of intermediate 50.

136 The alcohol then cyclizes onto an aldehyde, resulting in the elimination

137 ion of a copper carbenoid intermediate which cyclizes onto the adjacent carbonyl group to give a reac

138 The favored gamma-H abstraction pathway can cyclize or cleave to 1-pentene and hydroxyethene, which

139 ring closure, the oxazolidinone ring and the cyclizing pentadienyl cation are distorted from coplanar

140 in a rodent model of cast nephropathy, this cyclized peptide construct served as an effective inhibi

141 In animal studies, this cyclized peptide was capable of reducing cast formation

142 The N- to C-terminus amide cyclized peptide with one d-amino acid (k) displayed hig

143 As this procedure generates side chain-cyclized peptides bearing a bis-triazole linkage, it is

144 tion of libraries of disulfide-rich backbone-cyclized peptides to quickly perform structure-activity

145 Thus, 17 cyclized peptides were synthesized by solid phase click

146 e of 2F5 than sera elicited with flexible or cyclized peptides, a resemblance heightened by heterolog

147 lent linkage of the N and C termini, and the cyclized pilin integrates into the inner membrane (IM) a

148 articles with sulfur-doped graphene and with cyclized polyacrylonitrile to provide a robust nanoarchi

149 corporation of 1D silicon nanowires into the cyclized-polyacrylonitrile-based electrode-architecture

150 r metabolism and 6-deoxyerythronolide B (the cyclized polyketide precursor to erythromycin) productio

151 t the design and synthesis of new 3D "Single Cyclized" polymeric gene vectors with well-defined compo

152 Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthes

153 The fully cyclized primary products then are converted to various

154 by I(-) is on the reaction trajectory to the cyclized product 5.

155 egioselective 6-endo cyclization to afford O-cyclized product in the presence of Au(I)/AgNO3 and N-cy

156 product in the presence of Au(I)/AgNO3 and N-cyclized product in the presence of Au(I)/AgOTf under a

157 support the mechanistic conclusion that the cyclized product is formed via an intramolecular [3,3]-s

158 The six-membered cyclized product is generated through two reaction pathw

159 bability, deduced from the relative yield of cyclized product, can be used in conjunction with statis

160 bon resulting in the formation of 6-endo-dig cyclized product.

161 , which leads to the formation of 6-endo-dig cyclized product.

162 ing good regio- and stereospecificity in the cyclized product.

163 was smoothly scaled up to produce >400 kg of cyclized product.

164 ilic nitrogen atom and a decreased amount of cyclized product.

165 The first method (A) yields the cyclized products after only 20 min of microwave (MW) he

166 The ability of the iodides to provide cyclized products can be largely restored by adding base

167 sponding acrylate esters 1 and the yields of cyclized products compared to the calculated rate consta

168 )-Hexp (C), it has been shown to provide the cyclized products exclusively.

169 The aromatic 1,6 eneyne (8) gave cyclized products in 78% yield under catalytic condition

170 The electrochemical conversion of COE to cyclized products is complete in a few minutes, in contr

171 in the former, facilitating the formation of cyclized products not observed for Rh.

172 mogeneous reaction (C') between oxidized and cyclized products of DA and NE and drops below that of D

173 the acid counterion is incorporated into the cyclized products providing an overall aminotrifluoroace

174 ylic alcohols as initiators gave the desired cyclized products, and in neat HFIP, a tricyclization re

175 alcogenide species affected the formation of cyclized products, whereas diorganyl diselenides gave hi

176 , resulting in the regioselective 6-endo-dig-cyclized products.

177 ing and leads to the formation of 5-endo-dig cyclized products.

178 tion was completely eliminated to yield 100% cyclized products.

179 ive angularly versus linearly fused azaacene cyclized products.

180 oups can all react to give the corresponding cyclized products.

181 biological synthesis of circular or backbone-cyclized proteins and peptides.

182 the cell lysate, to drive aggregation of non-cyclized proteins.

183 ollowed by hydrolysis delivered benzylically cyclized pyridines in good yield.

184 ated hydrazide and a Pt-alkyl complex of the cyclized pyrrolidinone (20 for N-phthalimido).

185 For epinephrine, the quinone cyclizes quickly and adrenochrome formation dominates, b

186 monstrate that oxidation products, including cyclized quinones derived from dopamine and related comp

187 re analyzed, and the nature of the resulting cyclized radical cation intermediates was characterized.

188 Transfer of an H* back to the metal from the cyclized radical results in a cycloisomerization.

189 ramolecularly to a double bond, generating a cyclized radical.

190 he method utilizes split-intein chemistry to cyclize randomized peptide sequences.

191 The Glu cyclized readily to pyroGlu.

192 ry precursors, with chlorides giving largely cyclized/reduced products and iodides giving largely cyc

193 into two different effects: (1) the ratio of cyclized/reduced products to cyclized/non-reduced produc

194 The ratios of directly reduced, cyclized/reduced, and cyclized/non-reduced products depe

195 these linear carotenoids were converted into cyclized, relatively hydrophilic pigments, with masses c

196 ylation of the carbonyl oxygen preceding the cyclized residue.

197 interfering RNA silencing or treatment with cyclized Retro-2 strongly decreases AAV2 transduction an

198 obes show integrin mechanical preference for cyclized RGD over linear RGD peptides.

199 ion dominates, but for dopamine, the quinone cyclizes slowly and the back reaction prevails.

200 ini of recombinant monoclonal antibodies can cyclize spontaneously to pyroglutamate (pE) in vitro.

201 squalene-hopene cyclase protein (Shc), which cyclizes squalene to the basic hopene structure, resulte

202 lyst productivity in RCM, even for a readily cyclized substrate.

203 eld and 99% ee of epoxy alcohols rather than cyclized tetrahydrofuran compounds could be obtained in

204 ramolecular Heck coupling has been chosen to cyclize the 14-membered macrocycle.

205 r-domain NRPS that also putatively serves to cyclize the chain after amino acid insertion.

206 Our attempts to cyclize the isolated and purified butenoatediazeniumdiol

207 cular assembly (1) is shown to catalytically cyclize the monoterpene citronellal and two homologues.

208 n that swings between T1 and T2a/T2b with C3 cyclizing the chain when it reaches the full length.

209 ed that VrtK is the sole enzyme required for cyclizing the geranyl moiety.

210 ort peptides out of a precursor protein, and cyclizes these peptides in vivo and in vitro.

211 the hexa-peptide beta-hairpin loop from AGRP cyclized through a DPro-Pro motif.

212 The resultant products can be further cyclized through nucleophilic displacement of suitable l

213 methyl acetals of (E)-2-alkylcinnamaldehydes cyclize to 1-methoxy-2-alkyl-1H-indenes in good-to-high

214 2+4] cycloadducts and borane adducts, and to cyclize to 1H-diazirenes of the type 24 in mildly exothe

215 ence of a carbodiimide-functionalized resin, cyclize to benzazoles with the safe removal of one equiv

216 lpha-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitri

217 paration over a series of 10 constructs that cyclize to form 862-bp minicircles yielded positive and

218 shown that 2-lithiotetrahydropyran reagents cyclize to form spirocycles with the alkene cis to the p

219 The catecholamine quinone may cyclize to form the absorbing product, or it may be redu

220 ing large substituents on the radical carbon cyclize to give 1,2-trans-substituted cyclopentanes is e

221 ular 6-exo or 7-endo attack to a double bond cyclize to give aliphatic radicals, which react along th

222 and tosylamide pronucleophiles were found to cyclize to give either five- or six-membered ring nitrog

223 eading to benzylpalladium intermediates that cyclize to give indenylsilanes through carbopalladation

224 of acyclic intermediates, which subsequently cyclize to give tetrahydroindolizines (stepwise 1,3-dipo

225 lu, and pGlu, we found that free Gln and Glu cyclize to pGlu in the electrospray ionization source, r

226 n proteins or peptides have been reported to cyclize to pyroglutamic acid (pGlu) during liquid chroma

227 defined 3-aminopropyl mesylates, which were cyclized to 1,2,3,4-tetrasubstituted 3-chloroazetidines

228 halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to hig

229 The alpha-(N-carbamoyl) allenes can be cyclized to 2-oxazolidinones or deprotected to afford th

230 Compound 1 is first cyclized to a tricyclene core ring structure analogous t

231 was the first intermediate detected, and it cyclized to a tricyclic adduct and its conjugate acid.

232 chlorides can be ionized, stereospecifically cyclized to an array of complex bromocyclic scaffolds, o

233 upling yields alpha-aryl ketones that can be cyclized to benzofurans, and it enables access to eupoma

234 ected to afford the free amines which can be cyclized to Delta(3)-pyrrolines with either AgNO(3) or R

235 ed analogues of 1 and 3 were synthesized and cyclized to discern what structural features are require

236 Seven model substrates were synthesized and cyclized to examine the structural features responsible

237 Three rotator-forming linkers were cyclized to form a rigid cyclotriveratrylene (CTV) stato

238 s introduced at the N terminus, which can be cyclized to form pyroglutamate in mammalian cells, the I

239 Ketoester 1 is cyclized to give pyran-3,5-dione 2 in 78% yield using a

240 olyl alpha-diazocarbonyls can be selectively cyclized to give six distinct products through the caref

241 his precursor is furthermore chlorinated and cyclized to merochlorin A and isomeric merochlorin B by

242 ce a side chain that is further modified and cyclized to produce the benz[f]indene ring system.

243 The linear homochiral dimers cyclized to produce the same cyclic homochiral diastereo

244 The resultant N-terminal glutamine was cyclized to pyroglutamate (pyrGln(23)), and several C-te

245 The ratio of cyclized to solvolysis products decreases with the incre

246 Free NH 3,3-diarylacrylamides are cyclized to substituted 2-quinolones in the presence of

247 n 1,6-diene functionalities that are readily cyclized to substituted cyclopentenes.

248 ions, the reaction outcome can be tuned from cyclized to sulfur oxidation products.

249 ted, and carbon-based substrates are readily cyclized to the corresponding hetero- and carbocycles wi

250 a stereodefined allene, which could then be cyclized to the corresponding stereodefined spiro produc

251 s via Suzuki cross-coupling and subsequently cyclized to the corresponding triphenylenes utilizing th

252 gamma-chloroisoleucyl intermediate which is cyclized to the final product by KtzA without redox part

253 noline-3-carboxylamide (Tic) moiety could be cyclized to the P3 capping group.

254 to form acyloximes which can be oxidatively cyclized to yield ioxazoles.

255 ord a beta-diketone intermediate that can be cyclized to zapotin in good overall yield, thus avoiding

256 n to o-biphenylylcarbene (o-BPC), which then cyclizes to FL.

257 ylamine (DPA) attached to an aldehyde moiety cyclizes to form a pyridinium-fused heterocycle.

258 4,5-dihydroxy-2,3-pentanedione (DPD), which cyclizes to form AI-2.

259 lism of S-ribosylhomocysteine, spontaneously cyclizes to form autoinducer 2 (AI-2).

260 ce of trapping agents, diphenylnitrenium ion cyclizes to form carbazole.

261 ch case, the more nucleophilic pendant amine cyclizes to give a benzofused saturated heterocyclic 5-

262 of a tethered electrophile the alkyllithium cyclizes to produce a spiro compound, again with inversi

263 The resulting ketenimmonium cation then cyclizes to produce naphthyl cation, which rapidly react

264 an open-chain intermediate that subsequently cyclizes to produce the tetrazole nucleus.

265 The enzymatic product subsequently cyclizes to quinolinate, an intermediate in the biosynth

266 ommon N-hydroxysulfenamide intermediate that cyclizes to release a masked fluorophore leading to fluo

267 ition 4 in 5, zwitterion 17 is formed, which cyclizes to stable naphthofuran photoproducts 9-12.

268 The resulting pi-allyl intermediate cyclizes to the products by an intramolecular allylic al

269 were ineffective due to chemical instability cyclizing to form a unique diazo-imine.

270 Cyclized Trp-cage is remarkably stable and afforded two

271 This system was also used to cyclize two terminal alkynes and a cyanamide to afford a

272 t, Z,E- and Z,Z-macrocyclic lactones did not cyclize under similar reaction conditions.

273 the analogous bis-ene substrate could not be cyclized under any reasonable conditions.

274 mann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-t

275 The resulting N-aminoimidazoles were cyclized under different conditions to the corresponding

276 uted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence

277 "Stapled Peptides" are cyclized using an all-hydrocarbon cross-linking strategy

278 nes whereby simple prenyl-derived chains are cyclized using radical, rather than cationic, reaction p

279 s was observed for either native Crp4 or its cyclized variants.

280 eptide with the Trp-cage fold, we prepared a cyclized version of this motif.

281 ochiral twisted tetrachloroperylene monomers cyclized via a cooperative reaction, forming the homochi

282 These new linear peptides are cyclized via a cystine moiety and have their C-terminus

283 minimal PKSs produced nonfungal polyketides cyclized via different regioselectivity, whereas the fun

284 peptide sequence, Ac-C(FKFE)(2)CG-NH(2), was cyclized via disulfide bonding of the flanking cysteine

285 to 2,3,4,5-tetra-O-alkyl-dialdoses that were cyclized via the benzoin reaction promoted by a triazoli

286 ly of the vir-T4SS composed of processed and cyclized VirB2 (major subunit) and VirB5 (minor subunit)

287 )) help rationalize why the lactone does not cyclize whereas the ether does.

288 yclizations, syn diastereomers were prone to cyclize, while anti isomers were not.

289 ide in THF-H2O led to bromohydrins that were cyclized with Amberlite IRA 400 HO(-) to yield the serie

290 es were encoded by phage display, chemically cyclized with an azobenzene linker, exposed to UV light

291 Several Ueno-Stork-type precursors cyclized with excellent diastereocontrol in good yields.

292 nitrite, and the resultant bromo nitrile is cyclized with guanidine.

293 llenyl sulfinimines can be stereoselectively cyclized with hexamethylditin under palladium catalysis

294 with Pd/C, H2 to reduce the nitro groups and cyclized with nitrous acid, and the corresponding 4-posi

295 was found that homoallylic amine 40 could be cyclized with PhSCl in the presence of silica gel to gen

296 veral peptides bound with high affinity when cyclized with the azobenzene linker, and their affinity

297 s verified that the backbone of 4 was indeed cyclized with the expected regioselectivity.

298 anslocation even when UbcH10 is artificially cyclized without a free terminus.

299 a-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization pa

300 The partially cyclized ZDI is also separated as a minor product.