ライフサイエンスコーパス: cycloaddition

1 onents (covering Diels-Alder and 1,3-dipolar cycloadditions).

2 te in a second stage acylnitroso Diels-Alder cycloaddition.

3 nt to undergo a strain-promoted azide-alkyne cycloaddition.

4 nylation, hydrogenation and [2pi+2pi] alkene cycloaddition.

5 omethine ylide generation and intramolecular cycloaddition.

6 separation in the first step of the [2 + 2] cycloaddition.

7 hat are very effective catalysts for (4 + 2) cycloaddition.

8 ,3-dipoles, i.e., Munchnones, for subsequent cycloaddition.

9 which can be converted to poly(pyrroles) via cycloaddition.

10 phosphetane is formed by a concerted [2 + 2] cycloaddition.

11 assembled by means of a Co-catalyzed [6 + 2] cycloaddition.

12 otif that is inaccessible by the Diels-Alder cycloaddition.

13 me ligation and strain promoted alkyne-azide cycloaddition.

14 he time-resolved mechanism of this ambimodal cycloaddition.

15 alkyne-containing ligand via Cu(I)-catalyzed cycloaddition.

16 ronic and structural features of 1,3-dipolar cycloadditions.

17 ctions of this class of compounds, including cycloadditions.

18 le so far being strain-promoted alkyne-azide cycloadditions.

19 merizations, substitutions, and additions to cycloadditions.

20 electivity of the diazo group in 1,3-dipolar cycloadditions.

21 re performed to understand the mechanisms of cycloadditions.

22 es, obtained by enantiocatalyzed 1,3-dipolar cycloaddition (1,3-DC) of imino esters and nitroalkenes,

23 Optimization of the 1,3-dipolar cycloaddition (1,3-DC), original methods including elect

24 synthesize, engage in an unusual [4+2]-type cycloaddition/1,3-H shift/decyanation sequence to afford

25 In the case of 2 of the 16 possible cycloadditions, a pair of novel three-membered ring inte

26 Fe-catalyzed cycloaddition allowed for a straightforward synthesis of

27 nine to Uox and strain-promoted azide-alkyne cycloaddition allowed the conjugation of fatty acid (pal

28 Subsequent strain-promoted azide-alkyne cycloaddition allows conjugation of dyes and imaging of

29 A metal-free [2+2] cycloaddition and 1,4-addition sequence induced by S-cen

30 thin the active site to accelerate the [4+2] cycloaddition and impede the [6+4] cycloaddition through

31 ct products such as azepanimines via [2 + 2] cycloaddition and indolamines via protonation based on s

32 gher template-mediated rate constant for the cycloaddition and lower stability of the trans-T(p) temp

33 n shell through strain-promoted azide-alkyne cycloaddition and spontaneous concentration of the resul

34 of arenes has been achieved using arenophile cycloaddition and subsequent palladium-catalyzed substit

35 hesized using a cobalt-catalyzed [2 + 2 + 2] cycloaddition and subsequent template-directed cyclizati

36 free energy of activation (DeltaG()) for the cycloaddition and the cyclization steps, whereas we used

37 two-dimensional polymerization based on this cycloaddition and the third ever case for a scsc synthes

38 This four-step process involves three cycloadditions and electrocyclic ring opening of the str

39 Competing [4 + 2] cycloadditions and various sigmatropic shifts are also e

40 duced without a catalyst via thermal 2pi-2pi cycloaddition, and can form block structures, making the

41 tural enzymes catalyze even a formal [4 + 2] cycloaddition, and it remains uncertain if any of them p

42 se compounds undergo a variety of reduction, cycloaddition, and nucleophilic addition reactions to fo

43 mponent reactions, C-H activation processes, cycloadditions, and biomolecule-based chemical transform

44 y, including substitutions and eliminations, cycloadditions, and several types of organometallic reac

45 pe elimination; tropolone and furan, through cycloaddition; and alkaloids, through three-component fr

46 ative transformations include hydrogenation, cycloaddition, annulation, and diverse "breaking and men

47 [4 + 2]-Cycloadditions are increasingly being recognized in the

48 Both concerted and stepwise cycloadditions are predicted, depending on the nature of

49 Reaction barriers for the cycloaddition as well as a formaldehyde expulsion steps

50 ns their calculated higher reactivity toward cycloaddition, as compared to Rh analogues.

51 rmediates generated via gold-catalyzed enyne cycloaddition been directly observed.

52 ructures using an intermolecular Diels-Alder cycloaddition between a pyrazinone and commercially avai

53 is short sequence is a [4 + 2]/retro-[4 + 2] cycloaddition between a pyrimidine and an ynamide, which

54 derived ammonium enolate and a formal [3+2] cycloaddition between an imidate and cyclopropenone.

55 A Rh(II) -catalyzed, formal [4+1]-cycloaddition between diazooxindoles as electrophilic C1

56 A recent asymmetric organocatalytic [2 + 2] cycloaddition between methylketene (MK) and methylphenyl

57 evant to catalysis, which requires transient cycloaddition between substrate and cofactor.

58 The "photoclick" cycloaddition between tetrazole-oligonucleotide conjugat

59 rocycle that is assembled via a formal [4+2] cycloaddition between two dehydroalanine (Dha) residues.

60 eoselective Pd-catalyzed dearomative [3 + 2] cycloaddition between vinylcyclopropane dicarboxylates a

61 arbene mediated Li-N insertions, and dipolar cycloadditions by controlling the reaction parameters.

62 cucurbit[6]uril (CB6) catalysed alkyne-azide cycloaddition (CB-AAC).

63 ombining the key features of the 1,3-dipolar cycloaddition chemistry of azides and cyclopropanes.

64 tion of pentafulvenes, their rich and varied cycloaddition chemistry, organometallic reactions, and t

65 sing copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition ("click chemistry").

66 r barrier for the kinetically favored second cycloaddition compared with the first one.

67 with reactivity and explore whether in situ cycloaddition could be accelerated in a concentrated, cr

68 The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has proven to be a pivota

69 hogonal sequential Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions is reported.

70 r ligation and copper catalyzed azide alkyne cycloaddition (CuAAC) reactions to synthesize heteromult

71 -DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of spin l

72 mechanism for copper-catalyzed azide-alkyne cycloaddition (CuAAC).

73 y step utilizes a novel intermolecular [4+2] cycloaddition-cyclization cascade between a vinyl p-quin

74 A Pd-catalyzed and ligand-free carbonylation/cycloaddition/decarboxylation cascade synthesis of sulfo

75 adiene, stereoselective intramolecular [4+2] cycloaddition, elimination, isomerization, and regio- an

76 +2] Diels-Alder reaction or a stepwise [6+4] cycloaddition followed by a Cope rearrangement.

77 tive were synthesized by using a Diels-Alder cycloaddition followed by an addition-elimination of bro

78 ytic asymmetric azomethine ylide 1,3-dipolar cycloaddition followed by an intramolecular Au(I)-cataly

79 Cycloaddition followed by aryl migration and reductive d

80 en achieved through copper-catalyzed [3 + 2]-cycloaddition followed by ketenimine formation and subse

81 ccessible A ring building block by a (4 + 2)-cycloaddition for annulation of the B ring.

82 ghlighting their applicability in asymmetric cycloadditions for the assembly of complex molecular arc

83 o- and stereospecific thermoreversible [2+2] cycloadditions from self-assembled hydrogen-bonded dimer

84 irects the reactants to regioselective [3+2]-cycloaddition generating cyclopenta[2,3]pyrrolo[2,1-b]ox

85 dine derivatives via organocatalyzed [3 + 2] cycloaddition has been achieved.

86 lcohol) and terminal alkynes through [4 + 2] cycloaddition has been developed.

87 sis of an intramolecular [Formula: see text]-cycloaddition has been experimentally verified as its on

88 CB6-promoted azide-alkyne cycloaddition has been previously used for the synthesis

89 cascade sequence involving dipole formation/cycloaddition in either an intra- or intermolecular sens

90 cycloaddition involves a different [6T + 4F] cycloaddition in which fulvene acts as the 4pi component

91 he mechanism of prFMN-associated 1,3-dipolar cycloadditions in related enzymes.

92 ns can be explained by an asynchronous [4+2] cycloaddition; in the case of acetylenes, the obtained r

93 osed to proceed by the following steps:[2+2] cycloaddition, insertion of SO2 , 1,4-addition, diazotiz

94 a catalyst following a two-step 1,3-dipolar cycloaddition/intramolecular alkylation sequence.

95 oposed an alternative mechanism: the initial cycloaddition involves a different [6T + 4F] cycloadditi

96 tional theory calculations indicate that the cycloaddition involves concerted addition of the diene o

97 lts support a concerted asynchronous [3 + 2] cycloaddition involving an iminoisocyanate, which was ob

98 ction can be considered a normal 1,3-dipolar cycloaddition involving M horizontal lineC bonds.

99 Azide-alkyne cycloaddition is a powerful reaction for the formation o

100 Thermal 2pi-2pi cycloaddition is a rare reaction that begins in the sing

101 lly, we showed that Cu-catalyzed 1,3-dipolar cycloaddition is also chemically compatible with the BN

102 The scope of the chirality transfer [2+2] cycloaddition is also presented.

103 catalyzed by Cu(I) or strain promotion, this cycloaddition is considered to be a "click" reaction wit

104 The [2 + 2] cycloaddition is not observed because of the greater cha

105 uggest that a stepwise, cationic Diels-Alder cycloaddition is operative.

106 A novel bis-alkyne-dependent [2+2+2] cycloaddition is proposed as a mechanism for the color c

107 r based on photochemically triggered [2 + 2]-cycloaddition is reported.

108 followed by the Cu(I)-catalyzed azide-alkyne cycloaddition ligation and by biomimetic formation of a

109 The oxidized prFMN supports a 1,3-dipolar cycloaddition mechanism that underpins reversible decarb

110 d were in agreement with the polar concerted cycloaddition mechanism via the energetically favorable

111 atalysis of radical cation based Diels-Alder cycloadditions mediated by the first-row transition meta

112 ons of the diazo functional group; (2) [3+n]-cycloadditions (n = 1-5) by metallo-enolcarbenes formed

113 xtrusion from enoldiazo compounds; (3) [2+n]-cycloadditions (n = 3, 4) by donor-acceptor cyclopropene

114 heir versatility is exemplified by (1) [2+n]-cycloadditions (n = 3, 4) by the enol silyl ether units

115 ation, a cyclopropanation via formal [3 + 2] cycloaddition/nitrogen extrusion, and a remarkable olefi

116 zaspiro[3.3]heptanes are produced by [2 + 2] cycloaddition of 3-alkylidene-1,2-diazetidines with tetr

117 Oxidative dearomatization, pi(4)s + pi(2)s cycloaddition of 6,6-spiroepoxycyclohexa-2,4-dienones wi

118 esis of spinosyn A, catalyzes a formal [4+2] cycloaddition of a 22-membered macrolactone, which may p

119 lectivities through the first reported [3+3]-cycloaddition of a carbonyl ylide.

120 the formation of a PROTAC by Cu(I)-catalyzed cycloaddition of a thalidomide-derived azide to an alkyn

121 and alkenes, and [4 + 2] hetero-Diels-Alder cycloaddition of aldehydes with dienes.

122 nd application of a chirality transfer [2+2] cycloaddition of an allenic ketone and alkene.

123 r A-NK-amide then performed Cu(2+) catalyzed cycloaddition of azide-Alexa Fluor 488, which covalently

124 2 + 1] cycloisomerization of enynes, [3 + 2] cycloaddition of aziridines and alkenes, and [4 + 2] het

125 coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes

126 reactions, including the parent Diels-Alder cycloaddition of butadiene with ethylene, electrocyclic

127 Additionally, the [3+1]-cycloaddition of catalytically generated metallo-enolcar

128 The key steps involve the Diels-Alder cycloaddition of cyclopent-2-en-1-one to the acetonide d

129 A case study of the Diels-Alder cycloaddition of cyclopentadiene with ethylene serves, i

130 pentenones through the efficient [2 + 2 + 1] cycloaddition of dicobalt alkyne complexes with alkenes.

131 s previously studied the [2sigma+2sigma+2pi] cycloaddition of diethyl azodicarboxylate (DEAD) and qua

132 cis-gamma-lactones through a formal [3 + 2] cycloaddition of enediolates with alpha,beta-unsaturated

133 has revealed concerted pathways for [2 + 2] cycloaddition of ethylene to all 10 of the cumulenes wit

134 As simple model reactions, cycloaddition of ethylene to formaldehyde, thioformaldeh

135 An efficient cycloaddition of heterocyclic alkenes with nitrile oxide

136 ion proceeds via a tandem hetero-Diels-Alder cycloaddition of N,N'-bis(benzenesulfonyl)sulfur diimide

137 nown bioorthogonal reaction, the 1,3-dipolar cycloaddition of nitrileimines and electron-poor olefins

138 A green and efficient 1,3-dipolar cycloaddition of nitrones with different styrenes and ci

139 The intramolecular 1,3-dipolar cycloaddition of ortho-substituted 1,1,1-trifluoromethyl

140 [4 + 3] cycloaddition of phthalazinium dicyanomethanides with in

141 ential, a general catalytic asymmetric [4+2]-cycloaddition of simple and electronically unbiased dien

142 Oxidative dearomatization, cycloaddition of spiroepoxycyclohexa-2,4-dienone, radica

143 ctive intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been a

144 on Co(acac)2 has been developed for [6 + 2] cycloaddition of terminal alkynes to 1,3,5,7-cyclooctate

145 ssembly modification (PAM) via a Diels-Alder cycloaddition of the anthracene panels of the cage with

146 azide on pyrilium intermediate over [3 + 2] cycloaddition of the azide on the alkyne.

147 The stereoselectivity of the [2 + 2]cycloaddition of the carbene to the quinoid substrate is

148 Using the cycloaddition of the epoxides and CO2 as a model reactio

149 the gold mesoionic carbene mediated [2+2+2] cycloaddition of these enynes with benzaldehyde are repo

150 (of the possible six) isomers upon oxidative cycloaddition of TrFE: the cis and trans head-tail isome

151 in the monomer via the stereospecific [2+2] cycloaddition of trichloroacetyl isocyanate with a d-gly

152 peri-, regio-, and stereoselective [6F + 4T] cycloaddition of tropone [4pi] to dimethylfulvene [6pi],

153 drogen shift, and, finally, a second [6 + 4] cycloaddition of tropone [6pi] to the cyclopentadiene mo

154 s and an activation energy for the gas-phase cycloaddition of two hexafluoropropene molecules of 36.9

155 idine dialdimine (PDAI) ligands catalyze the cycloaddition of two terminal alkynes and one cyanamide.

156 een discovered that promote the unique [2+2] cycloaddition of unactivated terminal alkenes.

157 gh regio- and stereoselectivity by the [3+2] cycloaddition of unstabilized azomethine ylides generate

158 uthenium(0) catalyzed transfer hydrogenative cycloadditions of 1,2-diols with cyclohexadiene or norbo

159 addition, catalytic, enantioselective [4+2] cycloadditions of 2'-hydroxychalcones have been accompli

160 er substituents were prepared by Diels-Alder cycloadditions of cyclopentadiene with dimethyl fumarate

161 Herein, we present the intramolecular [2+2] cycloadditions of dienones promoted through sensitizatio

162 We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes.

163 The mechanisms and selectivities of the cycloadditions of tropone to dimethylfulvene have been i

164 eviously, and normal electron-demand [4 + 2] cycloadditions of unactivated dialkylhydrazones are unpr

165 equently undergo either a formal Diels-Alder cycloaddition or a competitive Michael addition/reductio

166 s (by cyclic voltammetry), suggesting that a cycloaddition pathway involving mixed-valence dicopper s

167 haracterization determined that this primary cycloaddition photoproduct undergoes photohydration.

168 d chain-growth copper-catalyzed azide-alkyne cycloaddition polymerization, two structural parameters

169 omputations now demonstrate that the initial cycloaddition proceeds via an ambimodal transition state

170 ependent on the distortion effect during the cycloaddition process.

171 he treatment of DIPEA, and the corresponding cycloaddition products were obtained in excellent yields

172 ylene and phenyl acetylene to give the [2+2] cycloaddition products.

173 virtue of their ability to display multiple cycloaddition profiles.

174 Overall, this metal-free formal [2 + 2 + 2] cycloaddition provides access to polycyclic pyridine der

175 d alpha-keto esters could participate in the cycloaddition, providing novel 5-hydroxy-2-isoxazolines

176 We describe an unusual net [2+2] cycloaddition reaction between boron alkylidenes and una

177 e of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and tetraphenylcy

178 perimental and computational studies for the cycloaddition reaction between N-(3-pyridyl)aldimines an

179 An enantioselective [3 + 2] cycloaddition reaction between nitrile oxides and transi

180 the photo- and cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction between the corresponding naphthy

181 cular, we show that the azide-alkyne Huisgen cycloaddition reaction catalyzed by copper(I) is fully c

182 reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethylaluminum chl

183 several constrained agonists generated by a cycloaddition reaction displayed high selectivity (223-

184 metal-free highly diastereoselctive [3 + 2] cycloaddition reaction has been developed between N-phen

185 supplement to the Cu-catalyzed azide-alkyne cycloaddition reaction in "click" chemistry.

186 plets (ca. 5 mum diameter) and find that the cycloaddition reaction is accelerated even further (by a

187 The [4+2] cycloaddition reaction is an enabling transformation in

188 We find that the precursor of this [2 + 2] cycloaddition reaction is the singlet doubly pi(2)pi*(2)

189 The key step is an intramolecular [3 + 2]-cycloaddition reaction of an in situ generated azomethin

190 A 1,3-dipolar cycloaddition reaction of nonstabilized azomethine ylide

191 We report a formal [4+2] cycloaddition reaction of styrenes under visible-light c

192 lectivity was observed in the intramolecular cycloaddition reaction producing 5 to 7-membered rings.

193 s and 1,4,2-dioxazolidines revealed that the cycloaddition reaction takes place through a concerted m

194 , the result is a sequential [5 + 2]/[4 + 2] cycloaddition reaction that provides sp(3)-rich products

195 The alkene undergoes the cycloaddition reaction via a 1D coordination polymer to

196 isoxazoline complex as the catalyst, a [3+3]-cycloaddition reaction was achieved with excellent yield

197 cially available amide base and trapped in a cycloaddition reaction with furan in moderate to good yi

198 polarophiles in a 1,3-dipolar intramolecular cycloaddition reaction, leading to the corresponding iso

199 BO-NOTA) via copper-free Huisgen-1,3-dipolar cycloaddition reaction.

200 her understand the mechanism of this [3 + 2]-cycloaddition reaction.

201 enantioselective triple cascade 1,3-dipolar cycloaddition reaction.

202 bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction.

203 A single pot dipolar cycloaddition reaction/Cope elimination sequence was dev

204 Cycloaddition reactions are among the most important too

205 itution and the participation of corroles in cycloaddition reactions as 2pi or 4pi components (coveri

206 th 1 and 2 are effective catalysts for [3+2] cycloaddition reactions between alkynes and azides (i.e.

207 It is found that the [4 + 2]-cycloaddition reactions between these cyclophanes and te

208 e first general method for catalysis of such cycloaddition reactions by using solvent hydrogen bondin

209 These cycloaddition reactions create replicators trans-T(p) an

210 tions, other intermolecular and transannular cycloaddition reactions included intermolecular Pauson-K

211 dines has been developed via the 1,3-dipolar cycloaddition reactions of arynes with N-oxides.

212 r the realization of switchable catalysis in cycloaddition reactions of CO2 with epoxides.

213 ino esters are formed catalytically by [3+2] cycloaddition reactions of enecarbamates with electrophi

214 Highly selective divergent cycloaddition reactions of enoldiazo compounds and alpha

215 This comprehensive review on cycloaddition reactions of enoldiazo compounds, with emp

216 vealed a formally forbidden pathway in [2+2] cycloaddition reactions of maleimide moieties.

217 le core through highly regioselective alkyne cycloaddition reactions of sydnones.

218 ficient and stereoselective Pt(IV)-catalyzed cycloaddition reactions of the corresponding quinone met

219 catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of the synthesized spiro-cyclopr

220 des have proven to be versatile reagents for cycloaddition reactions that allow highly efficient cons

221 ites-that react pairwise through 1,3-dipolar cycloaddition reactions to create a network of four leng

222 prepared in situ, is exemplified by dipolar cycloaddition reactions with nitrones to give highly sub

223 ognition site can participate in 1,3-dipolar cycloaddition reactions with two maleimides that differ

224 dition reactions, intermolecular [2 + 2 + 2] cycloaddition reactions, and intermolecular [2 + 2 + 1 +

225 Baylis-Hillman, imino-ene, Mannich-type, and cycloaddition reactions, as well as hydrogenation and re

226 les are found to proceed through retro-(3+2)-cycloaddition reactions, generating the experimentally r

227 Pauson-Khand reactions, transannular [4 + 2] cycloaddition reactions, intermolecular [2 + 2 + 2] cycl

228 products of synthetic and biosynthetic [4+2] cycloaddition reactions.

229 ving as electron-rich dienophiles in [4 + 2] cycloaddition reactions.

230 for subsequent copper-catalyzed azide-alkyne cycloaddition reactions.

231 t of its reactivity in Michael, radical, and cycloaddition reactions.

232 reactivity of pentafulvenes in a plethora of cycloaddition reactions.

233 eactions, and intermolecular [2 + 2 + 1 + 1] cycloaddition reactions.

234 Within each dipole type, the predicted cycloaddition reactivities correlate with the reaction e

235 The geometries, stabilities, and 1,3-dipolar cycloaddition reactivities of 24 mesoionic azomethine yl

236 n addition to initial studies describing the cycloaddition reactivity of these new heterocyclic inter

237 via an intramolecular amidofuran Diels-Alder cycloaddition/rearrangement followed by an iminium ion/c

238 emperature in a common solvent, sequences of cycloadditions result in the rapid generation of complex

239 be prepared in moderate yields via classical cycloaddition-retrocycloaddition strategies from 4-[N-(2

240 oss-coupling reaction and subsequent [2 + 2] cycloaddition-retroelectrocyclization reaction with tetr

241 y, an intramolecular alkylation/desilylation/cycloaddition sequence provides convenient and rapid ent

242 r, an intramolecular alkylation/desilylation/cycloaddition sequence with the N-trimethylsilylmethyl-1

243 enabled a semiquantitative treatment of the cycloaddition site- and regioselectivity.

244 ia solid-phase copper-catalysed azide-alkyne cycloaddition (SP-CuAAC) click reactions.

245 In this study, we focus on the [4 + 2] cycloaddition step in the biosynthesis of spinosyn A, a

246 Metal-free, formal [2 + 2 + 2] cycloaddition strategies for the synthesis of polycyclic

247 efficient [3 + 2]/[4 + 2] or double [4 + 2] cycloaddition strategy has been established for the synt

248 C resulted in the topochemical azide-alkyne cycloaddition (TAAC) polymerization to 1,4-triazole-link

249 , an amine-aldehyde-dienophile (AAD) [4 + 2] cycloaddition takes place by formation of an intermediat

250 prepared by a ruthenium-catalyzed [2+2+1+1] cycloaddition that has not been used previously in natur

251 chemists' access to classes of photochemical cycloadditions that have not previously been feasible in

252 promoted inverse electron-demand Diels-Alder cycloaddition, that is, tetrazine ligation, is reported.

253 trast to previous examples of straight [2+2] cycloadditions, these efficient crossed additions were a

254 the [4+2] cycloaddition and impede the [6+4] cycloaddition through interactions with active-site resi

255 Cycloaddition to 5 converts an azide moiety into a photo

256 including the first enantioselective (4 + 2) cycloaddition to alpha,beta-unsaturated acid chlorides.

257 Nitrile oxide 1,3-dipolar cycloaddition to arylsulfonyl- and dialkylaminoallenes h

258 lyzed furan formation and furan-allene [4+3] cycloaddition to build the 5,7-fused ring system with an

259 he complete selectivity of the nitrile oxide cycloaddition to dialkylaminoallenes according to previo

260 ides via the domino Mannich reaction-dipolar cycloaddition to form 3,3-disubstituted pyrrolidines, in

261 (III)-mediated asynchronous, concerted [2+2]-cycloaddition to form an intermediate oxetane as the tur

262 onjunction with strain-promoted azide-alkyne cycloaddition to generate distinct bioconjugates in prot

263 ils mediates diazoalkane formation and [3+2] cycloaddition to generate more than 30 azoles in a teles

264 age intramolecular Diels-Alder furan (IMDAF) cycloaddition to install the indole.

265 N-alkyl imines readily undergo formal [4+2] cycloaddition to provide lactams with high levels of ena

266 under kinetic control, and with MeCCPh [2+2] cycloaddition to Sc horizontal lineNimide takes place.

267 with O2, CO2, and ethylene via formal [4+2] cycloaddition to the central diborabutadiene core.

268 es, cyclization to nitrones, and 1,3-dipolar cycloaddition to tricyclic isoxazolidines as single ster

269 vel stereo- and regiospecific intramolecular cycloadditions, under tight functional group control, th

270 azidolysis and copper-catalyzed azide-alkyne cycloaddition using water as the solvent for the synthes

271 t light-controlled, cobalt-catalyzed [2+2+2] cycloaddition via a dual cobalt and photoredox catalyst

272 tep, a chiral auxiliary-mediated Diels-Alder cycloaddition was developed, introducing the three stere

273 one by oxidative dearomatization/Diels-Alder cycloaddition was investigated.

274 The first asymmetric [3+1]-cycloaddition was successfully achieved by copper(I) tri

275 mol.cm(-2), and copper-mediated azide-alkyne cycloaddition was used to attach a small molecule dye an

276 ssignment, and copper-catalyzed azide-alkyne cycloaddition, we can overcome these challenges for targ

277 To elucidate the mechanism of cycloaddition, we have determined atomic resolution stru

278 All the studied cycloadditions were found to be concerted involving smal

279 HDDA cyclization reactions and the simple DA cycloadditions were measured.

280 d alkenes leads to cyclobutenes by a [2 + 2] cycloaddition, which takes place stepwise, first by form

281 The product derived from cycloaddition with 2-nitroacrylate required an additiona

282 nstabilized ylides that successfully undergo cycloaddition with a range of symmetrical and unsymmetri

283 from sulfonyl azides, followed by a [2 + 2] cycloaddition with amides and subsequent decarboxylation

284 a difluorinated cyclooctyne in a 1,3-dipolar cycloaddition with benzylazide.

285 ves undergo microwave-induced formal [3 + 2] cycloaddition with cis-N-benzyl-2-benzoyl-3-phenylazirid

286 Aromatics are formed via Diels-Alder cycloaddition with ethylene, which is produced in situ f

287 The transient species are trapped by cycloaddition with N-ethylmaleimide, and the reactions a

288 A new catalytic asymmetric Tamura cycloaddition with nitroolefins was developed.

289 artially intermolecular [2+2+n] (n = 1 or 2) cycloaddition with substrates containing three diyne uni

290 Diazomethylpyridine 1D undergoes 1,3-dipolar cycloaddition with tetracyanoethylene (TCNE) at 20-90 de

291 serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aroma

292 s exocyclic unstabilized ylides that undergo cycloaddition with unsymmetrical alkynes to give indoliz

293 tetrahydroindolizines (stepwise 1,3-dipolar cycloadditions with 3) and cyclopropanes (with 4 and 5),

294 tabilized ylides that undergo intermolecular cycloadditions with carbonyl compounds to give bicyclic

295 and the mechanism by which HFIP accelerates cycloadditions with enamines are characterized.

296 hides", which engage in intermolecular [4+2] cycloadditions with isatins 2a-2f to form 2-oxindole spi

297 lder reaction partner and engages in [4 + 2] cycloadditions with normally unreactive azadienophiles i

298 d indolines and hydroindolines through [4+2] cycloadditions with substitution patterns difficult to a

299 emonstrated by copper-catalyzed azide-alkyne cycloaddition, with 1,3,5-triethynylbenzene, forming two

300 2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne and azide rea