ライフサイエンスコーパス: cyclohexanone

1 smoke irritants (acrolein, acetic acid, and cyclohexanone).

2 with inexpensive and commercially available cyclohexanone.

3 t mechanism for the enzymatic oxygenation of cyclohexanone.

4 intermediate could oxygenate the substrate, cyclohexanone.

5 the enzymes responsible for the oxidation of cyclohexanone.

6 -H = 6.91 Hz is nearly double those found in cyclohexanone.

7 r, in 27% (7 steps) for the (R)-isomer, from cyclohexanone.

8 epine starting from 2-((1H-indol-3-yl)methyl)cyclohexanone.

9 ing its precursor, epsilon-caprolactam, from cyclohexanone.

10 tion was more complex for 3-akyl-substituted cyclohexanones.

11 ze of the substituents at C-2 and C-4 of the cyclohexanones.

12 ss of the substituents at C-2 and C-4 of the cyclohexanones.

13 ed to oxidize 15 different alkyl-substituted cyclohexanones.

14 uctural variety of fused cyclopentanones and cyclohexanones.

15 reocontrol in ring expansions of symmetrical cyclohexanones.

16 C-C bonds in simple cyclopentanones and some cyclohexanones.

17 sis cyclize efficiently to the corresponding cyclohexanones.

18 cyclopentanone, 2,6-bis(4-amidinobenzylidene)cyclohexanone, 2,7-bis(4-amidinobenzylidene)cycloheptano

19 tic approach starting from readily available cyclohexanone 3.

20 ic alcohol 35, while 19 provided ring-opened cyclohexanone 41 (39%) along with the tricyclic epoxide

21 ed from unraveling of the tetracyclic system cyclohexanone 46.

22 The carbonyl deprotection in 22 yielded cyclohexanone 5 that was subjected to Julia coupling wit

23 The known cyclohexanone 5 was converted in five steps to the alpha

24 dol addition of a silyloxyfuran to a complex cyclohexanone 83 appended the butenolide, and a few addi

25 selective detection of cyclic ketones, e.g. cyclohexanone, a component of plasticized explosives.

26 d sensitive gas sensor to selectively detect cyclohexanone, a target analyte for explosive detection.

27 ovides functionalized alpha-(hetero)arylated cyclohexanones, a scaffold present in many natural produ

28 a ring-expansion reaction of a 4-substituted cyclohexanone accomplished with a chiral 1,3-azidopropan

29 ilic substitution reactions of 4-substituted cyclohexanone acetals display different selectivities de

30 The reactions of cyclohexanone acetals substituted with thiophenyl groups

31 The dehydrogenation of cyclohexanones affords cyclohexenones or phenols via rem

32 ted irritation responses to acetic acid, and cyclohexanone, an agonist of the capsaicin receptor, TRP

33 Novel 2,6-bis benzylidine cyclohexanone analogues of curcumin were synthesized, an

34 series of cycloalkanone rings, 4-substituted cyclohexanone analogues, and modified amidine derivative

35 a highly efficient host for the inclusion of cyclohexanone and 2-, 3-, and 4-methylcyclohexanone, all

36 ble responses in less than 30 s to 10 ppm of cyclohexanone and displayed an average theoretical limit

37 ric Schmidt reaction between 4-disubstituted-cyclohexanone and hydroxyalkylazides, 1H-azepine-2-oxo-5

38 trolling TS for the Michael reaction between cyclohexanone and nitrostyrene is proposed.

39 14 times more active in the condensation of cyclohexanone and phenol to bisphenol Z.

40 iacetal, which then undergoes elimination to cyclohexanone and phenol/alkanol products.

41 nally biased imines derived from substituted cyclohexanones and benzylamine or diphenylmethylamine, r

42 investigation of aerobic dehydrogenation of cyclohexanones and cyclohexenones to phenols with a Pd(T

43 as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the correspon

44 The cyclohexanones and the title compounds showed a strong t

45 carbon dioxide, isoprene, acetone, benzene, cyclohexanone, and 4 thioethers.

46 Reactions of 1a with cyclopentanone, cyclohexanone, and cyclooctanone enolates afforded new t

47 ze lithium enolates derived from 1-indanone, cyclohexanone, and cyclopentanone in solution.

48 henyl-4-[3-(methoxyphenyl)-3-oxo-2-azapropyl]cyclohexanone, and our own compound Psora-4 inhibit the

49 chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-

50 Additions to cyclohexanone are relatively slow but form a single isom

51 Functionalized cyclohexanones are formed in excellent yield and diaster

52 Using 2,2-dimethyl cyclohexanone as the starting compound, (+)-antrocin and

53 cess to highly substituted alpha-spirocyclic cyclohexanones as well as cyclopentanones.

54 cus sp. HI-31 in complex with its substrate, cyclohexanone, as well as NADP(+) and FAD, to 2.4 A reso

55 A new procedure for the synthesis of cyclohexanone-based inhibitors of serine proteases is re

56 Compounds 1, 3, and 5 were cyclohexanone-based inhibitors, whereas compounds 2, 4,

57 th 2,6-Bis-(3-methoxy-4-propoxy-benzylidene)-cyclohexanone (BM2) was 17 times more toxic than curcumi

58 ho methoxyphenol was rapidly bioreduced to a cyclohexanone cis-diol.

59 d to inhibitors that are based upon a simple cyclohexanone core.

60 achieved in the oxidation of cyclohexane to cyclohexanone/cyclohexanol (100 degrees C, conversion: 1

61 -fluorophenolate and the lithium enolates of cyclohexanone, cyclopentanone and 4-fluoroacetophenone h

62 The SEs of cyclohexanone, delta-valerolactone, and delta-valerolact

63 ia coupling of sulfones 39a and 39b with the cyclohexanone derivative 23.

64 ved in this process takes place with several cyclohexanone derivatives and 2-aminoaromatic aldehydes,

65 substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quate

66 y for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quate

67 either by peroxidation of the corresponding cyclohexanone derivatives in H(2)SO(4)/CH(3)CN or by ozo

68 ilable via the peroxidation of corresponding cyclohexanone derivatives in H2SO4/CH3CN.

69 e with an aldehyde provides pentasubstituted cyclohexanone derivatives in which the annulation reacti

70 y amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an alpha,beta-unsat

71 In this study, we explored benzylidine cyclohexanone derivatives with non-polar groups, to see

72 of tetralone, indanone, cyclopentanone, and cyclohexanone derivatives.

73 Cyclohexanone-derived Knoevenagel adducts (cyclohexylide

74 ed axial attack of the carbonyl oxide on the cyclohexanone dipolarophiles.

75 gh the cyclization of a suitably substituted cyclohexanone enol ether or enol silane with malonyl dic

76 is was also true for the 2-alkyl-substituted cyclohexanones examined.

77 talyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis

78 Cyclohexanones give products arising from equatorial att

79 s of tertiary alpha-aryl cyclopentanones and cyclohexanones has been accomplished via a Pd-catalyzed

80 amic kinetic resolution of alpha-substituted cyclohexanones has been performed and yields versatile i

81 tabolic genes involved in the degradation of cyclohexanone in a new halotolerant Brevibacterium envir

82 al standard in a mixture of ethylbenzene and cyclohexanone in hexane with analyte quantities of < 3 n

83 low reactivity of alicyclic ketones such as cyclohexanone in reactions with triflic anhydride and al

84 provide a range of alpha,beta-disubstituted cyclohexanones in high yield although the products are p

85 The role of twist-boat conformers of cyclohexanones in hydride reductions was explored.

86 -diacetal protection to produce a key chiral cyclohexanone intermediate, from which all five carbasug

87 oxidation of cyclohexane to cyclohexanol and cyclohexanone is used as a model reaction to investigate

88 f the Ruppert-Prakash reagent to substituted cyclohexanones is presented.

89 trolled approach to alpha-alkyl beta-alkynyl cyclohexanones is reported through a Lewis acid mediated

90 Instead, the substrate, cyclohexanone, is found at this location, in an appropri

91 The N-isopropylimine of cyclohexanone lithiates via an ensemble of monomer-based

92 H(3)CN or by ozonolysis of the corresponding cyclohexanone methyl oximes.

93 ing an embedded tetrahydrofuran in which the cyclohexanone moiety was converted to a triisopropylsily

94 eport the first crystal structure of a BVMO, cyclohexanone monooxygenase (CHMO) from Rhodococcus sp.

95 Cyclohexanone monooxygenase (CHMO), a bacterial flavoenz

96 ymatic Baeyer-Villiger reaction catalyzed by cyclohexanone monooxygenase (CHMO).

97 , which is different from the specificity of cyclohexanone monooxygenase favoring short-chain cyclic

98 ich each newly cloned enzyme, as well as the cyclohexanone monooxygenase from Acinetobacter sp. NCIB

99 Whereas one ORF showed high homology to cyclohexanone monooxygenase from Acinetobacter sp. strai

100 ssing either cyclopentanone monooxygenase or cyclohexanone monooxygenase was immobilised in the form

101 s, including phenylacetone monooxygenase and cyclohexanone monooxygenase.

102 identification of the genes of two distinct cyclohexanone monooxygenases, the enzymes responsible fo

103 nd the structure and reactivity of lithiated cyclohexanone N-cyclohexylimine.

104 N-(isopropanesulfinyl)ketimines derived from cyclohexanone, N-Boc-piperidin-4-one, and tetrahydropyra

105 The inhibitors are based upon a cyclohexanone nucleus and are designed to probe binding

106 Ethylbenzene and cyclohexanone of a single D enrichment are analyzed as u

107 potency of inhibitors that are based upon a cyclohexanone or a tetrahydro-4H-thiopyran-4-one 1,1-dio

108 Bis-cyclohexanone oxalyldihydrazone (cuprizone) was administ

109 a strategy based only on the knowledge that cyclohexanone oxidation was inducible in this strain, th

110 arginally similar to the analogous genes for cyclohexanone oxidation.

111 Oxidation of cyclohexanone oxime with lead tetraacetate yields 1-nitr

112 -4-[3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl]cyclohexanone (PAC), which is representative of a disubs

113 s starting with a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole f

114 re reduced to isotetralin (74%) and 3-methyl cyclohexanone (quantitative) with 5 and 2.2 Li/mol of st

115 alpha-lithiation of the N-isopropylimine of cyclohexanone reveal monomer-based transition structures

116 ithiations of N-alkyl ketimines derived from cyclohexanones reveal that simple substitutions on the N

117 ethyl 2-adamantanone oxime and 4-substituted cyclohexanones reveals that the major tetrasubstituted o

118 ring an additional alpha-substitution on the cyclohexanone ring was then epimerized into its thermody

119 ss of the substituents at C-2 and C-4 of the cyclohexanone ring.

120 dicted stereoselectivity of the reduction of cyclohexanone strongly favors axial approach of hydrogen

121 74% ee were achieved for cyclopentanone and cyclohexanone substrates, respectively.

122 lations on the starting electrophile 2-aroyl-cyclohexanone support a correlation between the energy o

123 For all 4-alkyl-substituted cyclohexanones tested, enzymes were discovered that affo

124 e the QM region consisting of the substrate (cyclohexanone), the isoalloxazine ring of C4a-peroxyflav

125 talyst mediates the first dehydrogenation of cyclohexanone to cyclohexenone, after which it evolves i

126 ate of Pd(TFA)2-catalyzed dehydrogenation of cyclohexanone to cyclohexenone, while it strongly inhibi

127 idic and redox sites, which smoothly convert cyclohexanone to epsilon-caprolactam with selectivities

128 carries out an oxygen insertion reaction on cyclohexanone to form a seven-membered cyclic product, e

129 ion of NADPH and a two-electron oxidation of cyclohexanone to form epsilon-caprolactone.

130 In the course of these studies, the Kd for cyclohexanone to the C4a-peroxyflavin form of CHMO was d

131 ing reaction of various brominated PAHs with cyclohexanone to yield alpha-arylated ketones, which are

132 high chemoselectivity for the conversion of cyclohexanones to cyclohexenones, without promoting subs

133 asymmetric fluorination of alpha-substituted cyclohexanones to generate quaternary fluorine-containin

134 ne ligand, for the conversion of substituted cyclohexanones to the corresponding phenols.

135 Rate studies of addition to cyclohexanone trace the lack of aggregation-dependent se

136 ors with the general structure Cbz-X(aa)-Trp-cyclohexanone-Trp-Y(aa)-OH has been constructed.

137 ith cofacial pi-pi interactions, it binds to cyclohexanone via hydrogen bond (mechanistic studies wer

138 ain, the mRNA population of cells exposed to cyclohexanone was compared to that of control cells usin

139 responding to axial and equatorial attack at cyclohexanone were located.

140 thium aluminum hydride with formaldehyde and cyclohexanone were obtained using ab initio and density

141 Calculations of geometries of the guest cyclohexanones were determined at the MP2/6-311++G(2df,2

142 d enantiomerically enriched 2-methyl 3-allyl cyclohexanone, which engaged in acid-catalyzed Robinson

143 sis, yielded the corresponding 4-(arylmethyl)cyclohexanones, which were then condensed with cyanoguan

144 The mechanism of the oxidation of cyclohexanone with an aqueous solution of hydrogen perox

145 x reactions involving the aldol reactions of cyclohexanone with benzaldehyde or with isobutyraldehyde

146 on of prochiral ketones of type 4-alkylidene cyclohexanone with formation of the corresponding axiall

147 Aldol additions to isobutyraldehyde and cyclohexanone with lithium enolates derived from acylate

148 The reaction of 2-aroyl-cyclohexanones with 2-cyanoacetamide and base in ethanol

149 le to promote the direct reaction of various cyclohexanones with dibenzoyl peroxide, thus affording t

150 stems that effect aerobic dehydrogenation of cyclohexanones with different product selectivities.

151 This process delivers functionalized cyclohexanones with good to excellent levels of diastere

152 catalytic desymmetrization of 4-substituted cyclohexanones with O-arylhydroxylamines and is catalyze

153 examethylene triperoxide diamine (HMTD), and cyclohexanone, with detection limits in the parts-per-tr

154 A series of 2-aroyl-cyclohexanones, with para-substituents ranging from elec