ライフサイエンスコーパス: cyclohexyl

1 decyl, n-tetradecyl, n-octadecyl, phenyl, or cyclohexyl).

2 PAu)(2)(2,7-naphthalenediyl) (3), where Cy = cyclohexyl.

3 after oxidative workup of the 3-octene and 1-cyclohexyl-1-butene hydroborations.

4 of alkenes such as 3-hexene, 3-octene, and 1-cyclohexyl-1-butene with the N-heterocyclic carbene (NHC

5 pproaching equilibrium, a secondary product, cyclohexyl-1-cyclohexene is formed.

6 liposome formulation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), an effective agent used

7 he chemotherapeutic drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in vitro.

8 ourea; BCNU], lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; CCNU], and streptozotocin, to

9 -cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-ind ole-2-carboxamide (SB269652) (1) adop

10 gen, as in 3-{[5-(adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carbonyl]amino }benzoic acid (

11 1848 (6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione).

12 ano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-1H- indole-2-carboxamide (SB269652), a compo

13 Integrating DMS-SHAPE data and including 1-cyclohexyl(2-morpholinoethyl) carbodiimide metho-p-tolue

14 N-cyclododecyl)4][Pt(CN)4] (1), [(phen)Pt(CN-cyclohexyl)2][Pt(CN)4] (2), and [Pt(CN-n-tetradecyl)4][P

15 5 nM were observed for 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyranone.

16 everal novel structural variants including 2-cyclohexyl, 2-naphthyl, and 6-carbomethoxy analogs also

17 selective adenosine A1 receptor agonist, N6-cyclohexyl-2'-O-methyladenosine (SDZ-WAG 994).

18 (S, S)-3-Cyclohexyl-2-[[5-(2, 4-difluorophenyl)-2-[(phosphonometh

19 ctrolyte (BGE) consisting of 10 mmol L(-1) N-cyclohexyl-2-aminoethanesulfonic acid (CHES) and 5 mmol

20 der ambient conditions in solvents such as N-cyclohexyl-2-pyrrolidone (CHP).

21 ors 1-ethyl-2-benzimidazolinone (1-EBIO) and cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methylpyrimi

22 Escherichia coli and Candida albicans with 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-to

23 The probes include 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-to

24 bination of dimethylsulfate, kethoxal, and 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metho-p-to

25 reagents, such as dimethyl sulfate (DMS), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

26 es, such as dimethylsulfate, kethoxal, and 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

27 cation interference with dimethyl sulfate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

28 hylisatoic anhydride, dimethyl sulfate and 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

29 This method utilizes 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide to derivati

30 We now show that the sEH inhibitor 1-cyclohexyl-3-dodecyl urea (CDU) inhibits human VSM cell

31 ministration of the specific SEH inhibitor 1-cyclohexyl-3-dodecylurea (CDU, 3 mg/d) for 10 d lowered

32 yrrolidines on reacting with cis-2-benzoyl-N-cyclohexyl-3-phenylaziridine, whereas with the other all

33 ogue [piperidyl-3,4-(3)H(N)]-N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([(3)H]TCP), [(3)H]ethidium,

34 -6-(cyclopropylmethoxy)-N-[(1R,2R)-2-hydroxy-cyclohexyl]-3-pyr idinecarboxamide] and its peripherally

35 ormation of the high-valent iron complex [Fe(cyclohexyl)4 ] from Fe(II) under reducing conditions is

36 ering compounds: picrotoxin, PF-670462 (4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimi

37 us work, where high-affinity sigma2 ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-

38 carbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit co

39 because the DpT analog, di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), does not

40 x of our lead compound, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), which is

41 rally related analogue, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC).

42 3-thiosemicarbazone and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone, which markedly

43 tastasis suppressor for di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone.

44 o-1, 2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarbo xamide (24, SB-277011).

45 no-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl] cyclohexyl]-4-quinolininecarboxamide (SB-277011-A) was a

46 (2-[(1S,2R,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phe nol) induced a pro

47 [2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phe nol], and HU-210 [

48 zotriazoles 2, 5, and 8 or 1-[1-(heterocycyl)cyclohexyl]-5-phenyltetrazole (12 and 14).

49 ceptor antagonist 2R,4R,5S-(2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid) (NPC 17742) or ci

50 thyl-2-(4-(trifluoromethyl)phenylsulfonyloxy)cyclohexyl acetate simultaneously improves the resolutio

51 .34 nM and also inhibits the effects of N(6)-cyclohexyl-adenosine and 2-chloro-N(6)-(3-iodobenzyl)-5'

52 ulations predicted that the positions of the cyclohexyl/Ala2 and Pro-NH2 moieties relative to < gluta

53 esized a pair of conformationally restricted cyclohexyl/Ala2-TRH analogues.

54 Unrestricted cyclohexyl/Ala2-TRH exhibited a 650-fold lower affinity

55 ydrazones [proline-phenylalanine or proline-(cyclohexyl)alanine], which reversibly combine through hy

56 With 3-[(2)H(11)-cyclohexyl]alanine as the substrate, the isotope effect

57 the hydroxylation of 3-[1,2,3,4,5,6-(2)H(6)-cyclohexyl]alanine.

58 methyl alpha-D-galactopyranoside, binding of cyclohexyl alpha-D-galactopyranoside to lactose permease

59 The N-cyclohexyl amide 14 represents a direct methine for nitr

60 lic alcohol, in similar amounts as the known cyclohexyl analogue 1.

61 2-(4-(Benzoylamino)cyclohexyl) analogues 23 and 24 were weak negative A(3)A

62 as diuretics, a series of 1,4-substituted 8-cyclohexyl and 8-bicyclo[2.2.2]octylxanthines were inves

63 The primary amines 6b and 7 bearing a cyclohexyl and a phenyl ring or two phenyl rings in posi

64 The binding affinities of a variety of cyclohexyl and bicyclo[2.2.2]octylxanthines for the rat

65 )(2)N(Bz)(2))(2)](BF(4))(2), 6b, (where Cy = cyclohexyl and Bz = benzyl) is a distorted square planar

66 (Cy)N(2)(Bz))(2)](BF(4))(2), 3b (where Cy is cyclohexyl and Bz is benzyl), the initial step is the re

67 Computational studies also suggest that cyclohexyl and cycloheptyl carbene systems are slightly

68 ted by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wher

69 y contrast, [Rh(CO)(PCy(3))Tp(Me2)] (3, Cy = cyclohexyl) and [Rh(PPh(3))(2)Tp(Me2)] (4) display elect

70 rs, i.e. Au28(S-c-C6H11)20 (where -c-C6H11 = cyclohexyl) and Au28(SPh-(t)Bu)20 (where -Ph-(t)Bu = 4-t

71 dditives was performed, and HCl.PCy(3) (Cy = cyclohexyl) and HCl.P-t-Bu(2)Et were in general found to

72 where R = methyl, isopropyl, tert-butyl, and cyclohexyl) and rhodium catalyst precursor compounds (in

73 isobutyl, pinacolyl (3,3-dimethyl-2-butyl), cyclohexyl, and 2-ethylhexyl).

74 ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, and cyclohexoxy substituents.

75 kifunensine analogues (including N-methyl, N-cyclohexyl, and N-bis(hydroxymethyl)methyl) and 2-desoxa

76 0 % (R=Ph) to greater than 90 % (R=n-C4 H9 , cyclohexyl, and PhCH2 CH2 ).

77 gent metabolites ethyl, isopropyl, isobutyl, cyclohexyl, and pinacolyl methylphosphonic acid has been

78 The cyclohexyl- and phenethyl-substituted esters, 8c and 8g,

79 l-, cyclopropylmethyl-, isopropyl-, benzyl-, cyclohexyl-, and 2-hydroxyethylamine gave N(6)-alkyl com

80 clohexyl-, diisobutyl-, diethyl-, diphenyl-, cyclohexyl-, and phenylphosphine.

81 nthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan).

82 ylmenthyl (Corey) and trans-2-(beta-naphthyl)cyclohexyl auxiliaries, using isobutyl iodide and benzyl

83 angman framework, the stereochemistry of the cyclohexyl backbone of the salen platform is revealed in

84 )-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]ben zeneacetamide methanesulfonate.

85 Dehydration of ortho-arylated N-cyclohexyl-benzamides by (CF3CO)2O results in efficient

86 )-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze neacetamide hydrochloride (200 nmol),

87 )-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benzene-acetamide methanesulfonate (U-50,488

88 )-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneac etamide [(-)U50,488H] caused desens

89 s-3, 4-dichloro-N-methyl-N-[2-(1-pyrolidinyl)cyclohexyl] benzeneaceamide methanesulfonate (U50,488H).

90 -3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetam ide methanesulfonate (1 microm)

91 s-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benzeneacetam ide methane sulfonate (U50,488

92 s-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetam ide] (0.3 mg/kg, i.p.) suppres

93 -3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methanesulfonate hydrate wa

94 /-)-3,4-dichloro-N-methyl-N-[2-(pyrrolidinyl)cyclohexyl] benzeneacetamide methanesulfonate), inhibite

95 )-3,4- dichloro-N-methyl-N-[2-(1-pyrrolidiny)cyclohexyl]benzeneacetamide (U50,488H) enhanced the asso

96 s-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide (U50488) and the KOR-depend

97 s-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benzeneacetamide methane sulfonate) signific

98 cloisomerization of acyclic dienyl esters to cyclohexyl beta-lactones.

99 tes (92-98% ee), with the exception of alpha-cyclohexyl-beta-phenylvinyl acetate which exhibited a lo

100 The cyclohexyl-BIQ-copper complex is an efficient catalyst f

101 tion of [Ni(P(Cy)(2)N(Bn)(2)H)(2)](2+) (Cy = cyclohexyl, Bn = benzyl) species formed during the oxida

102 provide the first spectroscopic evidence of cyclohexyl (C(6)H(11)) as a reactive surface intermediat

103 R(3)P)Ag[closo-1-H-CB(11)Me(11)] [R = Ph, 2; cyclohexyl (C(6)H(11)), 3; (3,5-Me(2)-C(6)H(3)), 4].

104 e Ni(0) complex (Cy3P)2Ni(eta(2)-C2H4) (Cy = cyclohexyl), C-P bond cleavage of the alkyne ligand resu

105 ropyl derivative of Bingel and a diisopropyl cyclohexyl C60 alcohol (4a) as synthesized by Ganapathi

106 te was significantly lower than that for the cyclohexyl carbamate derived from URB597.

107 -4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate (4).

108 arylcarbamate-based FAAH inhibitors, URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) and UR

109 nstrates that the reactive electrophile, the cyclohexyl carbenium ion, is directly formed in a proton

110 pared to the corresponding values for cyclic cyclohexyl carbonate and poly(cyclohexylene carbonate) p

111 er and only small quantities of trans-cyclic cyclohexyl carbonate, under similar conditions propylene

112 f antiviral activity, we discovered a set of cyclohexyl carboxylic acid analogues, highlighted by VX-

113 [(C(6)H(6))(PCy(3))(CO)RuH](+)BF(4)(-) (Cy, cyclohexyl) catalyzes the alkylation in solution within

114 {PCy2 (o-biphenyl)}Au(NCMe)](+) SbF6 (-) (Cy=cyclohexyl) catalyzes the intermolecular, anti-Markovnik

115 significant intermediate is the A/B-bicyclic cyclohexyl cation (III), from which two asynchronous con

116 y labeled products, thus suggesting that the cyclohexyl cation undergoes a 1,2-hydride shift competit

117 mers ("hyperconjomers") of delta-substituted cyclohexyl cations (b) and natural bond orbital (NBO) an

118 formational equilibrium of delta-substituted cyclohexyl cations.

119 netriaminepentaacetic acid (DTPA) derivative cyclohexyl-(CHX)-A", for 200 cGy TBI.

120 decay occurs through energy transfer to the cyclohexyl co-product within the solvent cage, and slowe

121 The C(5)-cyclohexyl compound 2c (L-736,380) dose-dependently inhi

122 nversion of the cyclobutyl analogue 1 to its cyclohexyl constitutional isomer 5 via a vinyl cyclobuta

123 es displayed lower regioselectivity than the cyclohexyl counterparts presumably due to increased plan

124 Reactions between phosphines with small cyclohexyl- (Cy) or isopropyl- ((i)Pr) groups and the tr

125 al chelating reagent based on a preorganized cyclohexyl derivative of DTPA (CHX-A'') has been develop

126 Binding curves obtained with DTPA and a cyclohexyl derivative of DTPA in the presence and absenc

127 of a series of 1-Z-pentyl, 1-Z-propyl, and Z-cyclohexyl derivatives and of a series of N-alkylamides

128 With cyclohexyl derivatives, alpha-CH activation is only obse

129 lide (90)Y was coupled by the chelator trans-cyclohexyl-diethylene-triamine-pentaacetic acid (CHX-A''

130 B' and CHX-B") of 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaaceti c acid (CHX-DTPA

131 Di-substituted cyclohexyl (DSC) derivatives inhibit the voltage-gated p

132 , which is representative of a disubstituted cyclohexyl (DSC) template, displays a K(i) of ca. 300 nM

133 Y(III) complexes of a pair of diasteriomeric cyclohexyl-DTPA ligands.

134 hibitors [[1,1-biphenyl]-3-yl-carbamic acid, cyclohexyl ester (URB602) and MAFP (methylarachidonyl fl

135 5,6,7-tetrahydro-indazol -1-yl)-phenylamino]-cyclohexyl ester methanesulfonate (SNX-5422, 10) was ora

136 NCH(2)CH(2)N bridgehead, the phenyl and the cyclohexyl esters prefer the out conformation, whereas w

137 From these studies trans-2-[[4-(1H-3-indolyl)cyclohexyl]ethyl]-4- (2-pyridinyl)piperazine (30a) was s

138 hat are isomeric or nearly isomeric with the cyclohexyl example; each has four sp(3) carbons in the s

139 endent on exogenously supplied CHC for omega-cyclohexyl fatty acid production.

140 r production of significant amounts of omega-cyclohexyl fatty acids (as high as 49% of total fatty ac

141 y is also observed in trace amounts of omega-cyclohexyl fatty acids (typically less than 1% of total

142 se AsuC15 limits the cellular level of omega-cyclohexyl fatty acids and likely maintains homeostasis

143 he wild-type strain, could not produce omega-cyclohexyl fatty acids but was still able to grow effici

144 Content of cyclopropyl and omega-cyclohexyl fatty acids of microbial origin, respectively

145 hed tertiary phosphine sulfide, possessing a cyclohexyl fragment at the phosphorus.

146 ino)cyclohexanol (vesamicol, 1) in which the cyclohexyl fragment was replaced with an N-acyl or N-alk

147 a monoalkyl (methyl or t-butyl) substituted cyclohexyl fragment, have been synthesized and fully cha

148 ther protoadamantyl 4, homoadamantyl 5, or a cyclohexyl group 6, were synthesized and their thermal a

149 b (93:7) in which the large substituent is a cyclohexyl group and the medium substituent is a methyl

150 The chair conformation of the cyclohexyl group is clearly resolved.

151 The cyclohexyl group of Ches binds in the hydrophobic pocket

152 ak interactions between its phenyl group (or cyclohexyl group) and the carboxylate group.

153 1-enyl, 2-methylpropyl, (E)-prop-1-enyl, and cyclohexyl groups at the C-3' position are also prepared

154 The N-propyl and N-cyclohexyl groups generate deep cavity cavitands.

155 the following order: Me > n-Bu, Me > Ph, and cyclohexyl > Me.

156 mbident RNH[N(O)NO](-) ion (R = isopropyl or cyclohexyl) has been shown to occur at the terminal oxyg

157 2) the hydroxyl group of the ethanol and the cyclohexyl hydroxyl group of HHC, (3) the alkyl tail and

158 mposition and fragmentation pathways of four cyclohexyl hydroxylation metabolites and one ethylhydrox

159 se adduct of B(2)pin(2) and the NHC (1,3-bis(cyclohexyl)imidazol-2-ylidene), which was proposed to ac

160 site is 75-fold greater than that for the 5-cyclohexyl-indole derivative.

161 dent SFG experiments that dehydrogenation of cyclohexyl is a rate-limiting step in the cyclohexane ca

162 h the catecholate dianion in the presence of cyclohexyl isocyanide results in the formation of [(o-(P

163 ium dimer [(H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce various novel nitrogen

164 tion and detection of 1,6-dichlorohexane and cyclohexyl isothiocyanate as part of the diesel fuel ana

165 h an IC50 = 0.54 mm and PAC, a disubstituted cyclohexyl Kv channel inhibitor, inhibited with an IC50

166 sublethal nitrosourea ([1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea]; CCNU) concentrations.

167 h is driven by dispersive forces between the cyclohexyl ligands and the formation of short and strong

168 y by replacing the phenyl linker of 1 with a cyclohexyl linker and by replacing the 4-benzylpiperidin

169 ron length of venule (16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S- methyl-LXA4-Me, respecti

170 (LXA4) analogs (i.e., 16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S-methyl-LXA4-Me) were stud

171 n in this series, two analogues ([N(epsilon)-cyclohexyl-Lys(8)]degarelix, IC(50) = 1.50 nM) (23) and

172 4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229), from the c

173 cetone, t-butyl methyl ketone, acetophenone, cyclohexyl methyl ketone, and cyclohexyl phenyl ketone.

174 yl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl) cyclohexyl]methyl]-1H-indole-3-propanamide] and PD176252

175 d PD176252 [(S)-N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-a-methyl-a-[[-(4-nitrophenyl )amino]c

176 4,264 (N-[(1R)-2-[[[(1S*,3R*)-3-(aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylm ethyl)-2-oxoe

177 N-alkyl side chain and the 2-position of the cyclohexyl moiety afford a 60,000-fold range of rates.

178 final reduction step in the formation of the cyclohexyl moiety of ansatrienin from shikimic acid.

179 appending an (S)-carboxyl group beta to the cyclohexyl moiety provided the less potent tripeptide in

180 spartate was subsequently labeled with the N-cyclohexyl-N'-(4-(dimethylamino)naphthyl)carbodiimide (N

181 he structure of the human sEH complex with N-cyclohexyl-N'-(iodophenyl)urea (CIU) has been determined

182 cadmium doping into the [Au23(SR)16](-) (R = cyclohexyl) nanocluster, in which two neighboring surfac

183 Two bifunctional alpha-phenyl-N-cyclohexyl nitrones were synthesized with the expectatio

184 In addition, particular benzyl and cyclohexyl odorants evoked activity in dorsal modules pr

185 R)N](3-) were prepared by addition of either cyclohexyl or isobutyronitrile to the base free dihafnoc

186 Four different P(R)2N(R')2 ligands with cyclohexyl or phenyl substituents on phosphorus and benz

187 n the present study, galactopyranosides with cyclohexyl or phenyl substitutions, both in alpha and be

188 eptor affinity; in particular, the choice of cyclohexyl- or arylureas led to substantial improvements

189 to hydrolyze the RP-enantiomer of O-methyl O-cyclohexyl p-nitrophenyl thiophosphate with net inversio

190 ethylheptyl)-2-(5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)phenol (CP55,940) robustly internalized CB(2)

191 g shows that intramolecular rearrangement of cyclohexyl phenyl ether does not significantly contribut

192 acetophenone, cyclohexyl methyl ketone, and cyclohexyl phenyl ketone.

193 f large hydrophobic substituents (isopropyl, cyclohexyl, phenyl, o- or p-nitrophenyl) in beta anomeri

194 R-CF=CF-CF3 (2a, R = cyclopentyl and 2b, R = cyclohexyl), prepared in high yield in two steps from he

195 stly to cycloalkane-derived structures, with cyclohexyl proving to be particularly promising.

196 A series of [4-[2(4-arylpiperazin-1-yl)alkyl]cyclohexyl]pyrimidin-2-ylamine s was prepared and found

197 luminescence of HBC for both a good solvent, cyclohexyl pyrrolidone (CHP), and a poor solvent, tetrah

198 ns of individual molecules in four solvents: cyclohexyl pyrrolidone, 1-chloronaphthalene, 1-bromonaph

199 A substituent on the 3-position of the cyclohexyl radical enables ring-cleavage of the cyclohex

200 ilizing substituent on the 2-position of the cyclohexyl radical stabilizes the final cyclopentylmethy

201 The rearrangement of a substituted cyclohexyl radical to a cyclopentylmethyl radical on the

202 lohexyl radical enables ring-cleavage of the cyclohexyl radical, while a radical stabilizing substitu

203 are present at the 2- and 3-positions of the cyclohexyl radical.

204 Trapping of cyclohexyl radicals by quinoxaline is inefficient except

205 Pd(PCy(3))(2) (Cy = cyclohexyl) reacts with As(7)(3-) in en/tol solvent mixt

206 f the phenolic ring (A ring) relative to the cyclohexyl ring (C ring), and the orientation of the hyd

207 hed by replacement of the 2-aryl ring with a cyclohexyl ring and subsequent elaboration of the 4-posi

208 esting that the stabilization comes from the cyclohexyl ring and/or the electronic effect of the carb

209 It was determined that the presence of the cyclohexyl ring did not affect either the reduction or o

210 ctures, displaying alkyl groups bound to the cyclohexyl ring in equatorial position, and other quite

211 e ring as well as methyl substitution on the cyclohexyl ring significantly improved metabolic stabili

212 revealed that attaching alkyl groups to the cyclohexyl ring significantly improved Mtb activity but

213 this ligand was systematically replaced by a cyclohexyl ring system, which more closely resembles the

214 re synthesized with the expectation that the cyclohexyl ring will impart lipophilicity to the molecul

215 sequent elaboration of the 4-position of the cyclohexyl ring with a variety of hydrophilic functional

216 logues incorporating fluorine atoms onto the cyclohexyl ring(s) provided a range of different fluorop

217 nts of TSA.1 are almost perpendicular to the cyclohexyl ring, leading to decreased orbital overlap an

218 Ph-OH pointing toward the alpha-face of the cyclohexyl ring, while for 4, there is an increased pref

219 iated by a Michael reaction to introduce the cyclohexyl ring.

220 h the aromatic ring and points away from the cyclohexyl ring; ii) the dimethylheptyl chain adopts one

221 yl (DMH) side chain, the conformation of the cyclohexyl rings, the orientation of the phenolic ring (

222 s, each with a nonpolar domain formed by six cyclohexyl side chains arranged along one side of the 14

223 hydrophobic interaction generated by the six cyclohexyl side chains.

224 ydroxymethyl, phenyl, carboxyl, pyridyl, and cyclohexyl substituent groups alpha to the nitrogen atom

225 wo electron-rich ortho-biphenyl groups and a cyclohexyl substituent.

226 alized with p-nitrobenzyl, methyl, and trans-cyclohexyl substituents were studied.

227 erant to the stereochemistry of the attached cyclohexyl substituents.

228 We tested cyclohexyl-substituted isochroman, carbocyclic, and chro

229 ly fails to react (too bulky), that with R = cyclohexyl suffers a (controllable) tendency to abstract

230 In the cyclohexyl system, a small amount of a cyclopropane deri

231 mpregnated with bis-nitroxide biradical (bis-cyclohexyl-TEMPO-bisketal, bCTbK) solutions of organic s

232 The formation of a spiro-cyclohexyl-thiadiazoline system (sCT) offered the rare o

233 ether with the observation that a simplified cyclohexyl thioglycoside mycothiol analogue is a good su

234 The content of omega-cyclohexyl tridecanoic acid varied from 0.0% to 0.15% of

235 xanol forms initially but then esterifies to cyclohexyl trifluoroacetate.

236 Pd(PCy(3))(2) (4) (1-Ad = 1-adamantyl, Cy = cyclohexyl) was studied to determine the effect of steri

237 larger, branched beta-alkyl esters, such as cyclohexyl, were less potent.

238 Alkyl Grignard reagents (Et, (n)Bu, (i)Pr, cyclohexyl), with the exception of (t)BuMgCl, undergo ex

239 Alpha-ethyl and alpha-cyclohexyl (Z)-trisubstituted allylic alcohols can now b

240 [eta5-C5H2((S)-CHMeCMe3)]]ZrCl2, (S)-7 (Cy = cyclohexyl), zirconocene dichlorides that have an enanti