ライフサイエンスコーパス: cyclooctene

1 cycloaddition reactions faster than a trans-cyclooctene.

2 60 times more reactive than the parent trans-cyclooctene.

3 on Grubbs catalyst in the ethenolysis of cis-cyclooctene.

4 e and 3.1 kcal/mol lower for reaction with E-cyclooctene.

5 he ene reaction of singlet oxygen with trans-cyclooctene.

6 ty as hydrogenation catalysts for hexene and cyclooctene.

7 oss-metathesis of Z-1,2-dichloroethylene and cyclooctene.

8 addition of s-tetrazines with strained trans-cyclooctenes.

9 ctyne is 2.0 kcal/mol greater than that of E-cyclooctene (17.9 kcal/mol) but only 7.7 kcal/mol greate

10 equimolar mixture of cis-2-octene 20 and cis-cyclooctene 21 via promotion of the transformation in it

11 ering cis-cyclooctene (COE) and 3-methyl-cis-cyclooctene (3MCOE) as monomers and W(N-t-Bu)(CH-t-Bu)(O

12 The A:B monomer pairs copolymerized by 1 are cyclooctene (A):2,3-dicarbomethoxy-7-isopropylidenenorbo

13 enotypes in response to treatment with trans-cyclooctene, a potent receptor antagonist.

14 99% syndiotactic poly(DCMNBD), while ROMP of cyclooctene and 1,5-cyclooctadiene (300 equiv) with init

15 The rate of the ligation between trans-cyclooctene and 3,6-di-(2-pyridyl)-s-tetrazine is very r

16 27 times more reactive than the parent trans-cyclooctene and 4E-cyclooct-4-enol, respectively.

17 The strained dienophiles, trans-cyclooctene and cyclooctyne, are much more reactive than

18 via bioorthogonal "click" ligation of trans-cyclooctene and tetrazine.

19 o give first (PNP)ReH(2)(eta(2)-pyridyl) and cyclooctene and then, when not sterically blocked, (PNP)

20 markers of interest were modified with trans-cyclooctene and used as scaffolds to couple tetrazine-mo

21 actions of strained alkenes, including trans-cyclooctenes and norbornenes, with tetrazines, the BCN-t

22 mand Diels-Alder cycloaddition between trans-cyclooctenes and tetrazines is biocompatible and excepti

23 (300 equiv) with initiator 2a leads to poly(cyclooctene) and poly(cyclooctadiene) that have cis cont

24 efficient for ethenolysis of methyl oleate, cyclooctene, and cyclopentene.

25 dienophiles such as cyclopropenes and trans-cyclooctenes, and we demonstrate their application for l

26 }(C(8)H(14))(2)] precursors (C(8)H(14) = cis-cyclooctene), are air-sensitive, and can be electrochemi

27 ectively forming alpha,omega-diene using cis-cyclooctene as a prototypical substrate.

28 hydrogenations of ethylene, cyclohexene, and cyclooctene as model reactions were carried out over the

29 Addition of thioanisole or cyclooctene at -40 degrees C results in the formation of

30 ng state as [Ir(dtbpy)(COE)(Bpin)(3)] (COE = cyclooctene, Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborol

31 tathesis polymerization of 3-substituted cis-cyclooctenes by monoaryloxide pyrrolide imido alkylidene

32 ons occur with a catalyst generated from [Ir(cyclooctene)Cl]2, sterically hindered and electron-rich

33 Considering cis-cyclooctene (COE) and 3-methyl-cis-cyclooctene (3MCOE) a

34 genation of COA with TBE as acceptor to form cyclooctene (COE) and tert-butylethane (TBA).

35 s ferrocene was applied to a solution of cis-cyclooctene (COE) in dichloromethane/[NBu(4)][B(C(6)F(5)

36 ective (p-XPCP)IrH(2) complexes 4a-f and the cyclooctene (COE) olefin complexes (p-XPCP)Ir(COE) (6a-f

37 etathesis polymerization (ROMP) reactions of cyclooctene (COE), bulk-ROMP reactions of COE and norbor

38 y activated and covalently modified by trans-cyclooctene conjugates of small molecules, peptides, and

39 a BCN-containing amino acid, 1, and a trans-cyclooctene-containing amino acid 2 (which also reacts e

40 thod is based on two novel reagents: a trans-cyclooctene-containing ceramide lipid (Cer-TCO) and a hi

41 st and catalyst-free [4 + 2] tetrazine/trans-cyclooctene cycloaddition.

42 stigation of the transannular cyclization of cyclooctene, cyclodecene, and cycloundecene derivatives

43 The trans-cyclooctene derivative is selectively retained by the Ag

44 cid ligase site-specifically ligates a trans-cyclooctene derivative onto a protein of interest in the

45 Computation was used to design a trans-cyclooctene derivative that displays enhanced reactivity

46 bioorthogonal and mutually orthogonal: trans-cyclooctene derivatives greatly prefer to react with tet

47 for driving photochemical sytheses of trans-cyclooctene derivatives through metal complexation.

48 : the cycloaddition of s-tetrazine and trans-cyclooctene derivatives.

49 e thereby turning on reactivity toward trans-cyclooctene dienophiles.

50 The kinetics of cyclooctene epoxidation and hydrogen peroxide decomposit

51 n conducted of the mechanism and kinetics of cyclooctene epoxidation by hydrogen peroxide catalyzed b

52 re also capable of generating initiators for cyclooctene epoxidation.

53 e responses to the ethylene antagonist trans-cyclooctene, have mutations in the RAN1 copper-transport

54 nd cyclohexene hydrogenations but not in the cyclooctene hydrogenation.

55 change in mechanism arises because the trans-cyclooctene imposes a substantial strain in the transiti

56 ligated to a conformationally strained trans-cyclooctene in vitro and in vivo with reaction rates sig

57 usefully functionalized derivatives of trans-cyclooctene, including a derivative of 5-aza-trans-cyclo

58 For cis-cyclooctene, indene, methyl acrylate, methyl methacrylat

59 ular oxygen for the selective epoxidation of cyclooctene is fascinating.

60 l is strongly suggested by the conversion of cyclooctene monoxide to an aryl [3.3.0]bicyclooctanol.

61 )imidazol-2-carbene, py = pyridine, olefin = cyclooctene or ethylene) are highly active catalysts for

62 Cyclooctene oxidation rates are near first order in H(2)

63 Productivity in cis-cyclooctene oxidation to epoxide and cis-diol with 2-10

64 rmation of thioanisole oxide (100% yield) or cyclooctene oxide (30% yield), respectively; thus [Fe(IV

65 LiTMP-mediated alpha-lithiation of cis-cyclooctene oxide with subsequent oxacarbenoid formation

66 The formation of cyclooctene oxide, the only product, was determined by g

67 ons, including azide-alkyne, tetrazine-trans-cyclooctene, oxime, reductive amination, native chemical

68 ond was directly observed with [(PONOP)Ir(I)(cyclooctene)][PF(6)] at ambient temperature, resulting i

69 cyclopentene, cyclohexene, cycloheptene, and cyclooctene resulted in the formation of the seleniraniu

70 The cyclooctyne BCN and the trans-cyclooctene s-TCO are widely used in bioorthogonal chemi

71 to prepare functionalized macrocyclic oligo(cyclooctene)s (cOCOEs) in high purity and high yield by

72 library of functionalized macrocyclic oligo(cyclooctene)s.

73 complexes of conformationally strained trans-cyclooctenes should greatly expand their usefulness espe

74 ts selectively with cyclopropane-fused trans-cyclooctene (sTCO) with a bimolecular rate constant of 7

75 usly reported strained alkenes such as trans-cyclooctene (TCO) and 1,3-disubstituted cyclopropene, Sp

76 The drug of interest is modified with trans-cyclooctene (TCO) and incubated with live cells.

77 by a bioorthogonal interaction between trans-cyclooctene (TCO) and tetrazine would provide higher acc

78 bioorthogonal modification of CV with trans-cyclooctene (TCO) can be used to render gram-positive ba

79 n the bioorthogonal reaction between a trans-cyclooctene (TCO)-functionalized TAG72 targeting diabody

80 and capable of robust reactivity with trans-cyclooctene (TCO).

81 d tetrazine and an antibody-conjugated trans-cyclooctene (TCO).

82 mall molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active

83 in fluorochrome with the bioorthogonal trans-cyclooctene(TCO)-tetrazine chemistry platform.

84 The azide-dibenzocyclooctyne and trans-cyclooctene-tetrazine cycloadditions are both bioorthogo

85 ctene, including a derivative of 5-aza-trans-cyclooctene that underwent transannular cyclization upon

86 Ethenolysis of 30,000 equiv of cyclooctene to 1,9-decadiene could be carried out with a

87 result in nearly quantitative conversions of cyclooctene to epoxide within 1 min.

88 receptor binding of (19/18)F-tetrazine trans-cyclooctene (TTCO)-Cys(40)-exendin-4 was evaluated in vi

89 vity of films of 1 toward the epoxidation of cyclooctene using iodosylbenzene as the oxidant was comp

90 tions are responsible for the epoxidation of cyclooctene, whereas the iron(IV) oxo species are respon