ライフサイエンスコーパス: cyclopentane

1 target HIV RNA compared with PNA without the cyclopentanes.

2 ffords a diverse range of beta-lactone fused cyclopentanes.

3 oped for the synthesis of highly substituted cyclopentanes.

4 yl}-N-methyl-N'-[4-(trifluor omethoxy)benzyl]cyclopentane-1,2-dicarboxamide (CDA54), a peripherally a

5 non-subtype selective mGluR agonist 1-amino-cyclopentane-1,3-dicarboxylic acid (tACPD).

6 mation, we synthesized analogues of 1 with a cyclopentane-1,3-diyl linker.

7 nd the fluorines at C1 and C3 in the singlet cyclopentane-1,3-diyl transition structure (TS) contribu

8 ven the catenation of two open-shell singlet cyclopentane-1,3-diyls is achieved.

9 n the peroxisome to 3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0), which subsequent

10 idene cyclopentanes 1b-9b and monoalkylidene cyclopentanes 10b-18b, respectively, in good to excellen

11 trans-1-(diphenylmethyl)-2-(1-methylethenyl)cyclopentane (11).

12 )4] (HEB = eta(6)-hexaethylbenzene; alkane = cyclopentane (16) or pentane (17-19); OR(f) = perfluoro-

13 carbocyclization to afford 1,2-dialkylidene cyclopentanes 1b-9b and monoalkylidene cyclopentanes 10b

14 The photoreactions in cyclopentane, 2-methyl-2-propanol, and the gas phase occ

15 ethoxy-3-methylene-4-(triethylsilylmethylene)cyclopentane (3) in 82% isolated yield with 26:1 Z:E sel

16 )(3)N)U(IV)}(2)(mu-eta(2):eta(2)-1,2-(CH)(2)-cyclopentane)] (3).

17 we synthesized a series of multisubstituted cyclopentane amide derivatives.

18 The anti cyclopentane analog 29b, was a low-micromolar inhibitor

19 KC inhibitor in the series, anti-substituted cyclopentane analog 29b.

20 ery, as well as accommodating guests such as cyclopentane and cyclohexane in its internal cavity (red

21 ctivities were observed for the C-H bonds of cyclopentane and cyclohexane, while the tertiary C-H bon

22 rd reaction consist of chiral derivatives of cyclopentane and cyclopentene and a chiral carbocyclic p

23 CH2CH2NH2, ribose ring replacement by chiral cyclopentane and cyclopentene derivatives, and phosphate

24 terio- and 1,1,1-trideuterio-2-iodooctane in cyclopentane and methanol was also studied.

25 ted through the synthesis of polysubstituted cyclopentane and piperidine derivatives.

26 rcaptosulfide functionality attached to both cyclopentane and pyrrolidine frameworks demonstrated tha

27 allowing for the synthesis of functionalized cyclopentanes and bicyclic cyclopentane-based structures

28 asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes is described.

29 odology uniquely provides beta-lactone-fused cyclopentanes and cyclohexanes readied for further trans

30 ized acyclic products or densely substituted cyclopentanes and pyrrolidines in high yields and regios

31 e dissociative chemisorption of cyclobutane, cyclopentane, and cyclohexane occurs via two different r

32 te esters containing chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with high to exce

33 Overall, this approach to cyclopentane annulation complements the related metal-ca

34 ese are the first examples of ring-expanding cyclopentane annulations that directly introduce a carbo

35 On the other hand, g(H) values in the R,R-cyclopentane are considerably larger than those in R,R-d

36 ilylation to form silylated 1,2-dialkylidene cyclopentanes as mixtures of regioisomers.

37 change at positions s120/s145, 6.4%), and d-cyclopentane-associated pol-gene mutations (2.4%).

38 niaquinoids bearing a carbon function on the cyclopentane B ring; it is also applicable to the synthe

39 of functionalized cyclopentanes and bicyclic cyclopentane-based structures in moderate to high yields

40 hod allows for the formation of exomethylene cyclopentanes bearing a quaternary center substituted by

41 is transformation generates tetrasubstituted cyclopentanes bearing three contiguous stereocenters in

42 ing (1R,2S)-cyclobutane (betaCbu) or (1R,2S)-cyclopentane (betaCpe) beta-amino acids, which display e

43 side chain or carbonyl functionality at the cyclopentane C2 position.

44 Furthermore, the obtained chiral cyclopentanes can be readily functionalized to provide v

45 yl)-2-azabicyclo[3.3.1]non -7-yl-(1-phenyl-1-cyclopentane)carboxamide [(+)-KF4, (+)-4], showed a K(e)

46 yl)-2-azabicyclo[3.3.1]non -7-yl-(1-phenyl-1-cyclopentane)carboxamide [(+)-KF4, (+)-5] as a novel che

47 d; (Cpc1)4OT in which Pro1 was replaced with cyclopentane carboxylate; a derivative [Met(O)45]4OT in

48 the gamma-amino acid (1R,2R)-2-aminomethyl-1-cyclopentane carboxylic acid (AMCP) and an evaluation of

49 lkylation of enals leading to functionalized cyclopentanes catalyzed by O-trimethylsilyldiphenylproli

50 A trisubstituted cyclopentane chiron has been prepared by dynamic kinetic

51 as been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramol

52 Functionalized cyclopentanes containing a quaternary carbon center are

53 th (E)-1,3-disubstituted 2-butenols generate cyclopentanes, containing four new stereogenic centres w

54 lytic hydrogenation, were transformed to new cyclopentane-containing pyrazolopyrimidines 24 and 28, a

55 products are known, more often than not, the cyclopentane core is assembled in a stepwise manner beca

56 zarov cyclization to construct the congested cyclopentane core revealed an unanticipated electronic b

57 es the three contiguous stereocenters of the cyclopentane core.

58 g furanose-fused oxepane, thiepane, azepane, cyclopentane, cycloheptane, tetrahydrofuran, and pyranos

59 h mechanisms predicted similar lifetimes for cyclopentane, cyclohexane, and, to a lesser extent, cycl

60 ings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus

61 yclopentadienyl), with samples of [CpRe(CO)2(cyclopentane)] decaying significantly more rapidly than

62 potent and selective (>50,000-fold vs CatK) cyclopentane derivative 22 by exploiting specific ligand

63 e the proline ester based auxiliary from the cyclopentane derivatives by gamma-lactone formation unde

64 merically pure, tetra- and penta-substituted cyclopentane derivatives in which all of the substituent

65 ring an internal alkyne furnished the chiral cyclopentane derivatives with excellent enantiomeric exc

66 oach to a diverse range of saturated bridged cyclopentane derivatives.

67 o appropriately situated side chains to form cyclopentane derivatives.

68 Silylated cyclopentanes derived from HSiMe(2)OSiMe(3) were oxidize

69 Silylated cyclopentanes derived from HSiMe(2)OSiPh(2)t-Bu were oxi

70 ious molecules: S,S-cyclopentane diacid, R,R-cyclopentane diacid, and succinic acid.

71 ptides were linked to various molecules: S,S-cyclopentane diacid, R,R-cyclopentane diacid, and succin

72 that were oxidatively ring-opened to afford cyclopentane dialdehydes.

73 PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several

74 acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases bindi

75 he general mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were closely corre

76 d-spectrum mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid [(1S,3R)-ACPD], group I/I

77 latter event may provide a driving force for cyclopentane formation.

78 leading to the enantioselective synthesis of cyclopentane-fused beta-lactones is presented.

79 n cyclization-pinacol reactions that provide cyclopentane-fused cycloalkanone products are described.

80 For the surface PNA probe, four cyclopentane groups were incorporated to promote stronge

81 Replacing the S,S-dioxolane by an S,S-cyclopentane had no effects on the g(H)-[H(+)] relations

82 f cyclopentanes, including gem-disubstituted cyclopentanes having substitution on three contiguous ca

83 ired cycloisomerization pathway to methylene cyclopentanes; however, double bond isomerization, elimi

84 The replacement of the furanose ring by a cyclopentane in nucleosides generates a group of analogu

85 (3))(2)] to form the corresponding silylated cyclopentanes in good yield with high diastereoselectivi

86 -protected norbornylamine and to substituted cyclopentanes in nearly enantiopure form.

87 The overall scheme gave a diverse array of cyclopentanes, including gem-disubstituted cyclopentanes

88 e synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-hetero

89 the methylpyrroline ring of pyrrolysine with cyclopentane indicated that solely hydrophobic interacti

90 carbon cyclize to give 1,2-trans-substituted cyclopentanes is experimentally disproved by study of th

91 ethylene group bound to the metal within the cyclopentane ligand in 16 was observed at 212 K, with th

92 tingly, g(H)-[H(+)] relationships in the R,R-cyclopentane-linked gA channel are quite similar to thos

93 dicinal chemistry effort to develop novel P2 cyclopentane macrocyclic inhibitors guided by HCV NS3 pr

94 ic and resolved 2-iodooctane was examined in cyclopentane, methanol, and 2-methyl-2-propanol, media w

95 nd PGD(2) direct their opposite faces of the cyclopentane moieties toward the nicotinamide ring of th

96 ts the QueG active site places the substrate cyclopentane moiety in close proximity of the cobalt.

97 tein or the bound NADPH, indicating that the cyclopentane moiety is movable in the active site.

98 n H-bonding with protein residues, while the cyclopentane moiety is surrounded by water molecules and

99 Although a number of biologically relevant cyclopentane natural products are known, more often than

100 Stereoselective synthesis of a cyclopentane nucleus by convergent annulation constitute

101 (001) surface, dissociative chemisorption of cyclopentane occurs via initial C-C bond cleavage over t

102 g-opening of the cyclopropane affords either cyclopentane or cyclohexane derivatives in which the C6F

103 or N(2) gives 2-methyl-1-silylmethylidene-2-cyclopentane or its heteroatom congener in excellent yie

104 sponding 2-formylmethyl-1-silylmethylidene-2-cyclopentane or its heteroatom congener with excellent s

105 ates with alkynes were utilized to construct cyclopentanes or dehydro-delta-lactams.

106 Moreover, the cyclopentane portion of the fluorophore structure provid

107 itional fusion of a cyclopropane ring to the cyclopentane produces a bicyclo[3.1.0]hexane system that

108 acid alkylidenes to give highly substituted cyclopentane products.

109 nder silylene-mediated conditions to provide cyclopentane products.

110 ives in which all of the substituents on the cyclopentane ring are syn to one another.

111 eocenters at the other four positions of the cyclopentane ring can also be introduced with good stere

112 c acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction

113 the nucleobase is able to lock the embedded cyclopentane ring into conformations that mimic the typi

114 ssified into two types: methods in which the cyclopentane ring is formed by ring closing reactions (C

115 The cyclopentane ring of PGD(2) and the phenyl ring of rutin

116 ential neuraminidase inhibitors in which the cyclopentane ring served as a scaffold for substituents

117 The racemic cyclohexane-for-cyclopentane ring substitution analogue of the potent pr

118 roxides with the two alkyl chains syn on the cyclopentane ring were formed preferentially to those wi

119 f an alpha-diazo-beta-ketoester to build the cyclopentane ring, followed by reduction of the enol tri

120 ipulation of individual positions around the cyclopentane ring, namely highly diastereoselective inst

121 iguration of the substituents in the forming cyclopentane ring.

122 well as a flexible analogue (7) built with a cyclopentane ring.

123 he dibiphytanyl chain due to the presence of cyclopentane rings and branched methyl groups and due to

124 are most likely dominated by cyclohexane and cyclopentane rings and not larger cycloalkanes.

125 unsaturated acylpyrroles, giving the product cyclopentane rings bearing three stereocenters in high e

126 c compounds possessing highly functionalized cyclopentane rings has been developed employing soft ket

127 attributed to the decrease in the number of cyclopentane rings in PLFE at the lower growth temperatu

128 Incorporation of cyclopentane rings into the tetraether lipids did not af

129 rol tetraethers containing one, two or three cyclopentane rings were enriched at the base of the SMTZ

130 Changing the central cyclopentane scaffold to the analogous pyrrolidine deriv

131 led to the discovery of a 1,3-disubstituted cyclopentane scaffold with enhanced hCCR2 receptor bindi

132 One of these molecules has an unusual cyclopentane structure similar to those recently reporte

133 ntrolled construction of densely substituted cyclopentane structures not synthetically accessible usi

134 Because of the frequent occurrence of cyclopentane subunits in bioactive compounds, the develo

135 1,3-diaxial conformers are more favored for cyclopentane than for cyclohexane rings.

136 With meso-2,2'-bis(difluoromethylene)cyclopentane, this destabilization is sufficient to favo

137 ovides efficient and direct access to chiral cyclopentanes through the generation of two stereocenter

138 2-methylpropane, 2-butyne, acetone, pentane, cyclopentane, trifluoroethane, fluoromethane, dimethyl e

139 polymer contains the expected methylene-1,3-cyclopentane units as well as the unexpected 3-vinyl tet

140 w simple method to access highly substituted cyclopentanes via Lewis acid-initiated formal [3 + 2]-cy

141 trast, no thermal reaction between ozone and cyclopentane was observed.