ライフサイエンスコーパス: cyclophilin

1 the pregnane X receptor), and PPIA (encoding cyclophilin).

2 ER oxidative pathway that is modulated by ER cyclophilins.

3 hrin A inhibit the enzymatic activity of the cyclophilins.

4 describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-respo

5 Here we show that cyclophilin 40 (CyP40), a PPIase, dissolves tau amyloids

6 d in a pi-stacking interaction with Arg55 of cyclophilin A (Cyp A), and the m-Tyr residue was displac

7 or the first time that the chaperone protein cyclophilin A (CyPA) acts as a Ca(2+) modulator in plate

8 Extracellular cyclophilin A (CyPA) and CyPB have been well described a

9 Cyclophilin A (CyPA) and its peptidyl-prolyl isomerase (

10 ity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its c

11 tiprotein complex in which HCV NS5A and host cyclophilin A (CypA) have been shown to be present toget

12 PO3, addition of the CA-binding host protein cyclophilin A (CypA) inhibited HIV-1 uncoating and reduc

13 The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 c

14 Cyclophilin A (CypA) is required for viral replication,

15 Recent studies showed that cyclophilin A (CypA) promotes NF-kappaB/p65 nuclear tran

16 Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity t

17 Herein, we identify a novel Cyclophilin A (CypA) small molecule inhibitor (HL001) th

18 CA interactions with both CPSF6 and cyclophilin A (CypA) were essential for the unique dose-

19 tion was greatly reduced both by antibody to cyclophilin A (CyPA), a known mediator of inflammation i

20 e, using chemical inhibition or silencing of cyclophilin A (CypA), as well as CA mutant viruses, we i

21 on of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of re

22 rly part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation speci

23 ice lacking the essential cellular co-factor cyclophilin A (CypA), HCV RNA replication is markedly di

24 ding mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of AP

25 olecular dynamics simulations to study human cyclophilin A (CypA), in order to understand the role of

26 on specific factor 6 (CPSF6), as well as the cyclophilin A (CypA)-binding loop mutation P90A, all inc

27 5A, which encompasses residues implicated in cyclophilin A (CypA)-dependent HCV RNA replication.

28 ency virus type 1 (HIV-1) CA binding protein cyclophilin A (CypA).

29 ng Fv1NtD fused to the HIV-1 binding protein Cyclophilin A (CypA).

30 us (HCV) requires host cell factors, such as cyclophilin A (CypA).

31 red with wild-type controls through secreted cyclophilin A (CypA).

32 ted by the cellular peptidylprolyl isomerase cyclophilin A (CyPA).

33 that functions by targeting a host protein, cyclophilin A (CypA).

34 wn, including kallikrein-7 (KLK7; 2.2-fold), cyclophilin A (PPIA; 0.9-fold), and cofilin-1 (CFL1, 1.3

35 variants, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), are attractive candidates owing to

36 orthologs, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restricto

37 ether, these data provide evidence that both cyclophilin A and B interact with CYDV-RPV, and these in

38 equired for proper interaction with the host cyclophilin A and influences its peptidyl-prolyl cis/tra

39 e cis-bound and trans-bound conformations of cyclophilin A and its substrate as the enzymatic reactio

40 domain cyclophilins, including the mammalian cyclophilin A and plant Roc1 and Roc2, which are ortholo

41 nsity collected from crystals of the enzymes cyclophilin A and trypsin.

42 and its interaction with the human chaperone cyclophilin A are both targets for highly potent and pro

43 he inner face of the viral matrix and at the Cyclophilin A binding loop of the capsid.

44 , including the N-terminal beta-hairpin, the cyclophilin A binding loop, the inter-domain linker, seg

45 lso evolved amino acid changes in the capsid cyclophilin A binding loop.

46 -1 replication in transformed cells requires cyclophilin A but is dependent on other interactions in

47 We also found that purified cyclophilin A destabilizes in vitro-assembled HIV-1 CA-N

48 Our results suggest that TNPO3 and cyclophilin A facilitate HIV-1 infection by coordinating

49 protein processing, and the upregulation of cyclophilin A further support the notion that C. neoform

50 In this study, a human cyclophilin A homologue, TvCyclophilin 1 (TvCyP1), was i

51 fort, evidence of developmental functions of cyclophilin A in non-plant systems has remained obscure.

52 In addition, cyclophilin A increased Crk SH3 domain-binding guanine-n

53 hat indirectly targets NS5A by blocking NS5A/cyclophilin A interaction.

54 ye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by

55 A-NS5A interactions but does not affect NS5A-cyclophilin A interactions.

56 Cyclophilin A is a conserved peptidyl-prolyl cis-trans i

57 Cyclophilin A is a tractable model system to study using

58 the more expanded and unstructured denatured cyclophilin A is not encapsulated but is expelled into s

59 Mutations in a tomato (Solanum lycopersicum) cyclophilin A ortholog, DIAGEOTROPICA (DGT), have been s

60 n binding interaction of Cyclosporine A with cyclophilin A protein in a yeast cell lysate is successf

61 sing disparity is the weaker interactions of cyclophilin A with a transiently formed GroEL-GroES comp

62 We have obtained HDX data for the complex of cyclophilin A with the immunosuppressant cyclosporin A.

63 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously

64 nal domains on TRIM5alpha (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids.

65 APDH and LDH) but not others (e.g. Hsp90 and cyclophilin A).

66 Cyclophilin A, a known ligand of BSG, competitively redu

67 inhibition of HIV infection by SUN2 involves cyclophilin A, a protein that binds the HIV capsid and d

68 Here, we characterize ECD in Cyclophilin A, a well-studied peptidyl-prolyl cis-trans

69 EMENT We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-i

70 Cyclophilin A, also known as peptidylprolyl cis-/trans-i

71 not CrkI, associates with the immunophilins, cyclophilin A, and 12-kDa FK506-binding protein, in rest

72 , in contrast to HCV, HAV does not depend on cyclophilin A, but rather on adenosine-triphosphate-bind

73 ent conformational properties, rhodanese and cyclophilin A, during binding and encapsulation by GroEL

74 us to identify a third cyclophilin protein, cyclophilin A, interacting directly or in complex with p

75 We show here that cyclophilin A, one of the most common PPIases, provides

76 Other host factors, such as cyclophilin A, stabilize the HIV-1 capsid and are requir

77 as well as literature values for uncomplexed cyclophilin A, to theoretical predictions using a combin

78 ntiviral effect is mediated by inhibition of cyclophilin A, which is an essential host factor in the

79 particularly activation of a proinflammatory cyclophilin A-mediated pathway in brain vascular pericyt

80 f high PF74 concentrations was attenuated by cyclophilin A.

81 on other isomerases such as Pin4, FKBP12, or cyclophilin A.

82 Roc2, which are orthologs of the yeast Cpr1p cyclophilin, a known inhibitor of TBSV replication in ye

83 We show that cyclophilin, a peptidyl-prolyl isomerase secreted from T

84 s were found and identified, namely enolase, cyclophilin-A, ribosomal protein L13 and actin-1.

85 independent of cyclophilins, suggesting that cyclophilins act either in parallel to or downstream of

86 These discoveries imply that reduced cyclophilin activity contributes to the development of d

87 Leishmanial cyclophilin also mediates trialysin protection and metab

88 this study provides the structure of a plant cyclophilin and explains a possible mechanism for autoin

89 RNA replication was dependent on mouse cyclophilin and phosphatidylinositol-4 kinase III alpha

90 milar to the TPR-containing Cyp40-like Cpr7p cyclophilin and the Ttc4 oncogene-like Cns1 cochaperone,

91 ized urea-based small molecule inhibitors of cyclophilins and tested them against CypD using binding

92 l negative regulatory host proteins, such as cyclophilins and WW motif containing proteins, also bind

93 ree predicted pathogenicity genes, a MAPK, a cyclophilin, and a calcineurin regulatory subunit.

94 mprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins.

95 Cyclophilins are also chaperones.

96 Cyclophilins are host factors required for hepatitis C v

97 er, little is known about whether hepatocyte cyclophilins are involved in the hepatitis B virus (HBV)

98 Cyclophilins are ubiquitous proteins found in all domain

99 The cyclophilins are widely expressed enzymes that catalyze

100 Pol II) and inhibit the activity of CsCYP, a cyclophilin associated with the carboxyl-terminal domain

101 Here we provide evidence demonstrating that cyclophilin B (CypB) activity plays an important role in

102 (CRTAP), prolyl 3-hydroxylase 1 (P3H1), and cyclophilin B (CYPB) cause types VII-IX osteogenesis imp

103 Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the

104 omplex with cartilage-associated protein and cyclophilin B (CypB).

105 tric analysis to identify the M9-5 target as cyclophilin B (CypB).

106 of the collagen triple helix is catalyzed by cyclophilin B (CypB).

107 at is facilitated by the host cell chaperone cyclophilin B (CyPB).

108 ges in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2)

109 Cyclophilin B and FKBP13 exhibited much lower activity t

110 n the rER, and so far, two of these enzymes, cyclophilin B and FKBP65, have been shown to be involved

111 avage of the minor capsid protein L2 by host cyclophilin B and furin.

112 ational changes, leading to isomerization by cyclophilin B and proprotein convertase-mediated L2 mino

113 The G6R mutation in cyclophilin B found in the American Quarter Horse leads

114 tive presenilin 1 were observed in brains of cyclophilin B knockout mice.

115 In contrast to cyclophilin B null mice, where little 3-hydroxylation wa

116 The absence of either cyclophilin B or FKBP65 leads to a recessive form of ost

117 Two cyclophilin B proteins, S28 and S29, were identified pre

118 The mutation disrupts the interaction of cyclophilin B with the P-domain of calreticulin, with ly

119 doplasmic reticulum (ER)-resident chaperone, cyclophilin B, from assisting presenilin 1 to fold prope

120 leavage of the minor capsid protein, L2, and cyclophilin B-mediated separation of L2 and the viral ge

121 during infection at a step downstream of the cyclophilin B-mediated unfolding of L2.

122 ic reticulum (ER) cyclophilin in addition to cyclophilin B.

123 ent that triggered efficient ER depletion of cyclophilins B and C by inducing their secretion to the

124 a cells, we found that combined knockdown of cyclophilins B and C delayed transferrin secretion but s

125 philin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis, and sugges

126 Drosophila NinaA and its mammalian homolog, cyclophilin-B, impair opsin biogenesis and cause osteoge

127 n N-terminal helical bundle and a C-terminal cyclophilin beta-barrel, connected by an acidic loop.

128 l beta-strands become part of the C-terminal cyclophilin beta-barrel, thereby making a previously und

129 n hydrophobicity of the P4 residue preserves cyclophilin binding and antiviral potency while decreasi

130 o studies revealed that CypA, Roc1, and Roc2 cyclophilins bound to the viral replication proteins, an

131 isomerases to protein folding and identified cyclophilin C as an endoplasmic reticulum (ER) cyclophil

132 These findings establish cyclophilin C as an ER cyclophilin, demonstrate the nove

133 Because cyclophilins can regulate nuclear gene expression, we ex

134 The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomeri

135 Cyclophilin catalyzes the ubiquitous process "peptidyl-p

136 tion of the unfolding of yeast mitochondrial cyclophilin (CPR3) induced by urea.

137 The citrus (Citrus sinensis) cyclophilin CsCyp is a target of the Xanthomonas citri t

138 Cyclophilin (Cyp) allergens are considered pan-allergens

139 tion of binders to different isoforms of the cyclophilin (Cyp) protein family.

140 luated by small interfering RNA knockdown of cyclophilin (CYP)A, CYPC, or CYPD in HepG2215 cells, or

141 Regulated necrosis (RN) may result from cyclophilin (Cyp)D-mediated mitochondrial permeability t

142 rix may activate the mitochondrial chaperone cyclophilin D (CypD) and trigger permeability transition

143 ER-000444793 neither affected cyclophilin D (CypD) enzymatic activity, nor displaced o

144 Cyclophilin D (CypD) is a mitochondrial matrix peptidyl-

145 The mitochondrial matrix protein cyclophilin D (CypD) is an essential component of the mi

146 production, while within ATP synthase is the cyclophilin D (CypD) regulated mitochondrial permeabilit

147 Cells deficient in cyclophilin D (CypD), a component of the MPTP, are resis

148 inhibition of the mitochondrial MAM protein, cyclophilin D (CypD), altered insulin signaling in mouse

149 mitochondrial permeability transition pore, cyclophilin D (CypD), influenced endothelial metabolism

150 The PTP is regulated by matrix cyclophilin D (CyPD), which also binds the lateral stalk

151 mitochondrial single-channel patch clamp and cyclophilin D (CypD)-deficient mice (Ppif (-/-)) with st

152 Here, we report an unexplored role of cyclophilin D (CypD)-dependent mitochondrial permeabilit

153 ant platelets, is impaired in the absence of cyclophilin D (CypD).

154 physical interaction with the PTP regulator cyclophilin D (CypD).

155 by which p53 activates the key mPT regulator cyclophilin D (CypD).

156 ochondria inner pore permeability regulator, Cyclophilin D (CypD).

157 that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial

158 r mitochondrial Ca(2+) retention, similar to cyclophilin D (CypD, PPIF) knockdown with sustained Delt

159 The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of t

160 revents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mit

161 +) retention in brain mitochondria, and that cyclophilin D ablation abolished this effect.

162 Surprisingly, cyclophilin D ablation completely abolished the phenotyp

163 As anticipated, we found that cyclophilin D ablation markedly increased Ca(2+) retenti

164 unique mechanism involving the regulation of cyclophilin D activity, a component of the mitochondrial

165 Combined genetic blockade of cyclophilin D and acid sphingomyelinase renders the high

166 Both pathways were mediated by cyclophilin D and led to mitochondrial depolarization an

167 rial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS.

168 with megakaryocyte-directed deletion of the cyclophilin D gene.

169 by Mg(2+)/ADP; (ii) that expression of human cyclophilin D in mitochondria of Drosophila S2R(+) cells

170 peripheral stalk, provides the site at which cyclophilin D interacts.

171 Cyclophilin D is a mitochondrial protein that promotes m

172 An X-ray structure of 33 bound to rat cyclophilin D is reported.

173 hibitor cyclosporine A, sanglifehrin, and in cyclophilin D knockout mice.

174 examined the effects of genetic ablation of cyclophilin D on gender differences in mice expressing G

175 Targeted deletion of the cyclophilin D subunit of the mPT complex abrogated the e

176 ndrial buffering of Ca(2+) in the absence of cyclophilin D was maintained throughout disease course a

177 he pathway involving enhanced interaction of cyclophilin D with ATP synthase mediates L-arginine-indu

178 m(s) by eliminating ubiquitous expression of cyclophilin D, a critical regulator of Ca(2+)-mediated o

179 Triple knockout mice lacking Bax/Bak and cyclophilin D, a key regulator of necrosis, fail to show

180 Double-knockout mice lacking MCL-1 and cyclophilin D, an essential regulator of the mPTP, exhib

181 nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation

182 nthase complex promoted its interaction with cyclophilin D, and sensitized the opening of mitochondri

183 are formed via regulated necrosis involving cyclophilin D, and that they may be targeted independent

184 PR formation is shear-dependent and requires cyclophilin D, calpain, and Rac1 activation.

185 ice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administration of L-a

186 gh two pathways: modulation of mitochondrial cyclophilin D, implicated in mitochondrial permeability

187 rs including reactive oxygen species, matrix cyclophilin D, Pi (inorganic phosphate), and matrix pH.

188 reported sirtuin substrate proteins such as cyclophilin D, superoxide dismutase, and PEPCK1 were not

189 and mitochondrial damage are prevented in a cyclophilin D-dependent manner.

190 Similarly, the cyclophilin D-inhibiting drug alisporivir and the acid s

191 These pathologic responses were abrogated in cyclophilin D-knockout mice.

192 er may involve the peptidyl prolyl isomerase cyclophilin D.

193 n be inhibited by cyclosporin A mediated via cyclophilin D.

194 ndrial permeability transition by binding to cyclophilin D.

195 t the protection was lost in neurons lacking cyclophilin D.

196 oes not provide the site of interaction with cyclophilin D.

197 arges the c-subunit ring and unhooks it from cyclophilin D/cyclosporine A binding sites in the ATP sy

198 avage of integrin-associated proteins and by cyclophilin D/TMEM16F-dependent phospholipid scrambling.

199 Cyclophilin-D (Cyp-D) is a mitochondrial matrix peptidyl

200 Accordingly, cyclophilin-D and mPTP were increased in heterozygous he

201 HAX-1 were mediated through interference of cyclophilin-D binding to heat shock protein-90 (Hsp90) i

202 Suppression of cyclophilin-D expression or enforced detachment of hexok

203 heterozygous hearts, but genetic ablation of cyclophilin-D in these hearts significantly alleviated t

204 Mechanistically, alterations in cyclophilin-D levels by HAX-1 were contributed by the ub

205 re attributed to specific down-regulation of cyclophilin-D levels leading to reduction in mPTP activa

206 dings reveal the role of HAX-1 in regulating cyclophilin-D levels via an Hsp90-dependent mechanism, r

207 AX-1 overexpressing cardiomyocytes increased cyclophilin-D levels, as well as mPTP activation upon ox

208 ion, whereas proteosomal inhibition restored cyclophilin-D levels.

209 HAX-1 overexpression enhanced cyclophilin-D ubiquitination, whereas proteosomal inhibi

210 sirtuin-3 activity led to the activation of cyclophilin-D, which mediated an increased binding of he

211 oassays revealed decreased virulence for two cyclophilins (DeltaBbCypE and DeltaBbCyp6) and the simul

212 se findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclop

213 Previous studies showed that the tomato cyclophilin DIAGEOTROPICA (DGT) promotes auxin response,

214 packed together with the putative C-terminal cyclophilin domain and establishes a strong intramolecul

215 action, thereby preventing the access of the cyclophilin domain to other proteins.

216 h the E-loop of CP47 is mediated through its cyclophilin domain.

217 pA was found to be the most highly expressed cyclophilin during growth and purified recombinant BbCyp

218 Extracellular cyclophilins (eCyps) have been identified as a novel cla

219 papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of most of the major

220 rthermore, isomerization is regulated by the cyclophilin family of peptidyl-prolyl isomerases, highli

221 The structure revealed a typical cyclophilin fold consisting of a compact beta-barrel mad

222 eof, suggesting an overlapping dependency on cyclophilins for replication.

223 lin38 (CYP38) is one of the highly divergent cyclophilins from Arabidopsis thaliana.

224 logical idiosyncrasy stemming from potential cyclophilin functions, we generated mice lacking endogen

225 enic fungus, Beauveria bassiana, contains 11 cyclophilin genes whose roles were probed via individual

226 estingly, Cns1p and the TPR-containing Cpr7p cyclophilin have similar inhibitory functions during TBS

227 survival or silencing of other genes (e.g., cyclophilin, Hsp90, translin).

228 clophilin C as an endoplasmic reticulum (ER) cyclophilin in addition to cyclophilin B.

229 results revealed common and unique roles for cyclophilins in B. bassiana and validate a method for ex

230 The roles of individual cyclophilins in drug response was evaluated by small int

231 Alisporivir inhibition of cyclophilins in hepatocyte cell lines reduces replicatio

232 le for the cytosolic single-domain Cpr1-like cyclophilins in RNA virus replication.

233 lds has produced many analogues that inhibit cyclophilins in vitro but have reduced immunosuppressive

234 treatment with small molecule inhibitors of cyclophilins, including the approved drug cyclosporine,

235 eport, we further characterize single-domain cyclophilins, including the mammalian cyclophilin A and

236 atly upregulated inflammatory proteins (e.g. cyclophilin, inducible nitric oxide synthase, annexins,

237 Cyclophilin inhibition has been a target for the treatme

238 d be duplicated by incubating cells with the cyclophilin inhibitor cyclosporine A, a treatment that t

239 residue in trialysin and is inhibited by the cyclophilin inhibitor cyclosporine A.

240 lisporivir, a host-targeting antiviral, is a cyclophilin inhibitor that indirectly targets NS5A by bl

241 Alisporivir (ALV) is a cyclophilin inhibitor with pan-genotypic activity agains

242 We investigated the effects of 2 cyclophilin inhibitors (alisporivir and NIM811) on HBV r

243 Three nonimmunosuppressive cyclophilin inhibitors (alisporivir, SCY-635, and NIM811

244 regulate CyPA dependence and sensitivity to cyclophilin inhibitors (CPIs) have been defined to date.

245 Cyclophilin inhibitors (CPIs), including cyclosporine (C

246 B polymerase inhibitors, NS5A inhibitors and cyclophilin inhibitors currently in development.

247 Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for th

248 Recent publications suggest that cyclophilin inhibitors may have utility for the treatmen

249 Cyclophilin inhibitors such as alisporivir have shown st

250 In this study, a set of macrocyclic cyclophilin inhibitors was synthesized based on the core

251 Cyclophilin inhibitors, cyclosporine A, and alisporivir

252 inhibitors include, but are not limited to, cyclophilin inhibitors, miR122 antagonists, and statins.

253 pounds in the search for orally bioavailable cyclophilin inhibitors.

254 itors, and host-directed antivirals, such as cyclophilin inhibitors.

255 type of a new class of non-immunosuppressive cyclophilin inhibitors.

256 w type of allosteric regulation in divergent cyclophilins, involving disulfide bond formation and a l

257 Calcium-modulating cyclophilin ligand (CAML) is a ubiquitously expressed pr

258 Calcium-modulating cyclophilin ligand (CAML) is an endoplasmic reticulum re

259 membrane activator and calcium-modulator and cyclophilin ligand (TACI).

260 ansmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) are found in 8% to

261 ansmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) controls differenti

262 membrane activator and calcium modulator and cyclophilin ligand interactor (TACI) mutations in the pa

263 membrane activator and calcium modulator and cyclophilin ligand interactor (TACI) often display dysfu

264 membrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) was severely reduce

265 membrane activator and calcium modulator and cyclophilin ligand interactor (TACI), contribute to comm

266 membrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), is a key molecule

267 ransmembrane activator calcium modulator and cyclophilin ligand interactor (TACI).

268 membrane activator and calcium modulator and cyclophilin ligand interactor) on GC B cells, thus limit

269 ansmembrane activator and calcium-modulating cyclophilin ligand interactor.

270 in combination with CAML (calcium-modulating cyclophilin ligand), which is not homologous to Get2.

271 erentiation factor 88 and calcium-modulating cyclophilin ligand.

272 UMO-1 and S1-binding mutations in the Ranbp2 cyclophilin-like domain.

273 The structure reveals that the CTD adopts a cyclophilin-like fold with a non-canonical active-site c

274 n by T. cruzi, indicating that extracellular cyclophilin may be critical to adaptation in other insec

275 Taken together, our findings indicate that cyclophilin-mediated activity is an important factor aff

276 Specific cyclophilin mutants showed impaired hyphal growth and di

277 ion specificity factor subunit 6 (CPSF6) and cyclophilins (Nup358 and CypA), respectively, cannot rep

278 M811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity

279 no selectivity between the tightly conserved cyclophilin paralogs and exhibit significant off-target

280 proteostatic impairment of two novel Ranbp2 cyclophilin partners, the cytokine-responsive effectors,

281 We further show that host cell cyclophilins play an important role in regulating these

282 se and chaperone activities reflect distinct cyclophilin properties.

283 This analysis enabled us to identify a third cyclophilin protein, cyclophilin A, interacting directly

284 teins rDau c IFR 1, rDau c IFR 2; the carrot cyclophilin rDau c Cyc) were analyzed by ImmunoCAP.

285 e physiological roles and substrates of most cyclophilins remain unknown.

286 eted gene knockouts or overexpression of any cyclophilin resulted in temperature sensitivity (TS).

287 nt models, experiments on the involvement of cyclophilins revealed little, if any, role for these cel

288 This work demonstrates that cyclophilin serves as molecular sensor leading to the ev

289 in tomato, translocation of a phloem-mobile cyclophilin, SlCyp1, from a wild-type scion into a mutan

290 report, we examined the contributions of the cyclophilin subset of peptidyl-prolyl isomerases to prot

291 ound that cleavage is largely independent of cyclophilins, suggesting that cyclophilins act either in

292 main of RNA polymerase II and is a divergent cyclophilin that carries the additional loop KSGKPLH, in

293 lude that HIV-1 has evolved to use CPSF6 and cyclophilins to cloak its replication, allowing evasion

294 en PPIase and chaperone activities of Ranbp2 cyclophilin toward proteostasis of selective substrates

295 In addition, cyclophilin-trialysin complexes enhance the production o

296 Parasites exposed to cyclophilin-trialysin have enhanced binding and invasion

297 Calcineurin phosphatase activity of cyclophilin-trialysin-treated parasites was higher than

298 Cyclophilins, which are a large family of cellular proly

299 (tetratricopeptide repeat) domain-containing cyclophilins, which are members of the large family of h

300 Noncatalytic mutations affecting the only cyclophilins with known but distinct physiological subst