ライフサイエンスコーパス: cyclophilin A

1 APDH and LDH) but not others (e.g. Hsp90 and cyclophilin A).

2 tion with the retinoblastoma protein but not cyclophilin A.

3 iciently in the presence of normal levels of cyclophilin A.

4 ncoding the prototypical cyclophilin protein cyclophilin A.

5 ied CD147 as the main signaling receptor for cyclophilin A.

6 l cis-trans isomerization catalyzed by human cyclophilin A.

7 disrupting the association of caveolin-1 and cyclophilin A.

8 ed for interaction with the cellular protein cyclophilin A.

9 f high PF74 concentrations was attenuated by cyclophilin A.

10 s: annexin II, cyclophilin 40, caveolin, and cyclophilin A.

11 59, were considered as candidate targets for cyclophilin A.

12 t not by cyclosporin A, a drug that binds to cyclophilin A.

13 ells, H9 cells express greater quantities of cyclophilin A.

14 on other isomerases such as Pin4, FKBP12, or cyclophilin A.

15 und crystal form and as a complex with human cyclophilin A.

16 apsid (residues 1-151) in complex with human cyclophilin A.

17 irions, gag encodes the functional target of cyclophilin A.

18 te of its primary cyclophilin enzyme ligand, cyclophilin A.

19 The binding site for cyclophilin A, a cellular rotamase that is packaged into

20 lpha-actin, a smooth muscle cell marker, and cyclophilin A, a control gene.

21 Cyclophilin A, a known ligand of BSG, competitively redu

22 inhibition of HIV infection by SUN2 involves cyclophilin A, a protein that binds the HIV capsid and d

23 Here, we characterize ECD in Cyclophilin A, a well-studied peptidyl-prolyl cis-trans

24 Surprisingly, a number of cyclophilin A active-site mutants previously assumed to

25 the finding that Gag mutants with decreased cyclophilin A affinity are dead in Jurkat cells but capa

26 The A224E Gag mutant has no effect on cyclophilin A affinity but renders HIV-1 replication cyc

27 oviruses encoding Gag mutants with decreased cyclophilin A affinity exhibit attenuated infectivity, a

28 ession in cis of a Gag mutant that decreases cyclophilin A-affinity.

29 EMENT We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-i

30 Cyclophilin A, also known as peptidylprolyl cis-/trans-i

31 ether, these data provide evidence that both cyclophilin A and B interact with CYDV-RPV, and these in

32 east mutants lacking the CsA target proteins cyclophilin A and calcineurin.

33 These results indicate that cyclophilin A and Ess1 function in parallel pathways and

34 tracellular binding proteins (i.e., CsA with cyclophilin A and FK506 with FKBP12) to form protein/dru

35 interact with the peptidyl-propyl isomerases cyclophilin A and FK506-binding protein (FKBP12), respec

36 neurin inhibitors, such as the cyclosporin A-cyclophilin A and FK506-FKBP12 complexes, regulate this

37 iae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting complexes inh

38 yclosporin A and tacrolimus binding proteins cyclophilin A and FKBP12 were also expressed by keratino

39 s of C2-C12 cells express similar amounts of cyclophilin A and FKBP12, immunophilins known to be intr

40 irus type 1 (HIV-1) Gag polyprotein binds to cyclophilin A and incorporates this cellular peptidyl pr

41 equired for proper interaction with the host cyclophilin A and influences its peptidyl-prolyl cis/tra

42 ive cyclosporin A analog SDZ NIM 811 bind to cyclophilin A and inhibit its incorporation into HIV-1 v

43 e cis-bound and trans-bound conformations of cyclophilin A and its substrate as the enzymatic reactio

44 domain cyclophilins, including the mammalian cyclophilin A and plant Roc1 and Roc2, which are ortholo

45 RIM5alpha is altered by interactions between cyclophilin A and the HIV-1 capsid.

46 cation of this putative factor-binding site, cyclophilin A and the restricting factor(s) cooperated t

47 ely inhibited both the virion association of cyclophilin A and the spread of the hybrid virus in infe

48 nsity collected from crystals of the enzymes cyclophilin A and trypsin.

49 ntified in this proof of principle work were cyclophilin A and UDP-glucose-4-epimerase, both of which

50 h a combination of the two being optimal for cyclophilins A and B.

51 not CrkI, associates with the immunophilins, cyclophilin A, and 12-kDa FK506-binding protein, in rest

52 olin, heat-shock protein 56, cyclophilin 40, cyclophilin A, and cholesterol.

53 h caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary fo

54 clophilin A, compete with Gag for binding to cyclophilin A, and prevent incorporation of cyclophilin

55 ve expression of alpha-actin, alpha-tubulin, cyclophilin A, and proliferating cell nuclear antigen (P

56 SIVmac led to the efficient incorporation of cyclophilin A, and SDZ NIM 811 effectively inhibited bot

57 ive of these proteins as gp96, HSP70, HSP90, cyclophilin-A, and FKBP18.

58 Moreover, cyclophilin A, another cellular protein that binds to HI

59 es revealed that all cells labelled with the cyclophilin A antibody also showed staining for the neur

60 Since Nef and cyclophilin A appear to act in similar ways on postentry

61 he viral protein Nef and the cellular factor cyclophilin A are both required for full infectivity of

62 and its interaction with the human chaperone cyclophilin A are both targets for highly potent and pro

63 laboratory has shown that human recombinant cyclophilins A, B, and C have sequence homology with the

64 We report here that cyclophilin A becomes essential when Ess1 function is co

65 lt demonstrates that capsid dimerization and cyclophilin A binding are not thermodynamically coupled

66 infectivity of virions with mutations in the cyclophilin A binding loop of Gag.

67 he inner face of the viral matrix and at the Cyclophilin A binding loop of the capsid.

68 , including the N-terminal beta-hairpin, the cyclophilin A binding loop, the inter-domain linker, seg

69 n though these residues are distant from the cyclophilin A binding loop.

70 lso evolved amino acid changes in the capsid cyclophilin A binding loop.

71 lpha-helices 4 and 5 of CA, analogous to the cyclophilin A-binding loop of human immunodeficiency vir

72 A change in the cyclophilin A-binding loop of the HIV-1 capsid decreased

73 tants that were altered near the base of the cyclophilin A-binding loop of the N-terminal capsid doma

74 Neither mutation alters Gag's cyclophilin A-binding properties in vitro, and cyclophil

75 -1 replication in transformed cells requires cyclophilin A but is dependent on other interactions in

76 utant) resulted in a channel unresponsive to cyclophilin A but with pore properties similar to the wi

77 , in contrast to HCV, HAV does not depend on cyclophilin A, but rather on adenosine-triphosphate-bind

78 We found that mRNAs encoding for cyclophilin A, c-myc binding protein 1, the heat shock p

79 The structure suggests how cyclophilin A can act as a sequence-specific binding pro

80 That Gag's functional dependence on cyclophilin A can be differentiated genetically from its

81 n of cis-trans isomerization of the free and cyclophilin A-catalyzed process.

82 conformations, raising the possibility that cyclophilin A catalyzes interconversion of the cis- and

83 Among these proteins, annexin A4, cyclophilin A, cathepsin D, galectin-1, 14-3-3zeta, alph

84 One such cDNA shows homology to cyclophilins, a class of immunophilins with a peptidyl-p

85 cule-1, macrophage scavenger receptor-1, and cyclophilin A compared with controls 3 days after arteri

86 ppressive analogs bind with high affinity to cyclophilin A, compete with Gag for binding to cyclophil

87 The crystal structure of human recombinant cyclophilin A complexed with a substrate of succinyl-Ala

88 The structures of cyclophilin A complexed with dipeptides of Ser-Pro, His-

89 ing ratio is different from the structure of cyclophilin A complexed with the tetrapeptide N-acetyl-A

90 Reduced cyclophilin A content resulting in decreased binding of

91 ed a network of protein vibrations in enzyme cyclophilin A, coupled to its catalytic activity of pept

92 on of a non-G-protein substrate of TTS-ExoS, cyclophilin A (CpA), a peptidyl-prolyl isomerase (PPIase

93 The peptidyl-prolyl isomerase (PPIase) cyclophilin A (Cpr1p) is conserved from eubacteria to ma

94 Cyclophilin A (Cpr1p) was identified as a cytosolic prot

95 wo immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506.

96 ith the CaN autoinhibitory peptide (CaP) and cyclophilin A/cyclosporin A (CyPA/CsA) using each peptid

97 Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are prese

98 Cyclophilin A (CyP A), a cellular chaperone with cis-tra

99 d in a pi-stacking interaction with Arg55 of cyclophilin A (Cyp A), and the m-Tyr residue was displac

100 Although cyclophilin A (CyP-A) is a relatively abundant small imm

101 or the first time that the chaperone protein cyclophilin A (CyPA) acts as a Ca(2+) modulator in plate

102 Extracellular cyclophilin A (CyPA) and CyPB have been well described a

103 Cyclophilin A (CyPA) and its peptidyl-prolyl isomerase (

104 eens on two model protein systems, including cyclophilin A (CypA) and the minor allele variant of hum

105 newly synthesized HIV-1 capsid with cellular cyclophilin A (CYPA) and the subsequent activation of th

106 Since Nef and cyclophilin A (CyPA) appear to act in similar ways on po

107 , as well as a nearby histidine (H87) in the cyclophilin A (CypA) binding loop.

108 ere, we demonstrate that substitution of the cyclophilin A (CyPA) binding region in the capsid of an

109 Cyclophilin A (CypA) binding to viral capsid protects HI

110 The peptidyl-prolyl isomerase cyclophilin A (CypA) binds a proline-rich loop on the su

111 The host cell protein cyclophilin A (CypA) binds to CA of human immunodeficien

112 ns of the cellular peptidyl-prolyl isomerase cyclophilin A (CyPA) by the Gag polyprotein.

113 Remarkably, in Owl monkeys (omk), a cyclophilin A (CypA) cDNA has been transposed into the T

114 rly restriction mediated by TRIMCyp, a TRIM5-cyclophilin A (CypA) chimera resulting from a CypA retro

115 e viral Nef protein and the cellular protein cyclophilin A (CyPA) during virus assembly.

116 The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich l

117 een CsA resistance and reduced dependency on cyclophilin A (CyPA) for replication was identified.

118 type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication.

119 ity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its c

120 More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated i

121 Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation

122 tiprotein complex in which HCV NS5A and host cyclophilin A (CypA) have been shown to be present toget

123 gp120 envelope protein and virion-associated cyclophilin A (CypA) have been shown to directly interac

124 e dynamics of the prolyl cis-trans isomerase cyclophilin A (CypA) in its substrate-free state and dur

125 ssion of small interfering RNA for targeting cyclophilin A (CypA) in p19 cells lose their potential f

126 nt study proposes a novel mode of action for cyclophilin A (CypA) in the HIV-1 life cycle.

127 The peptidyl-prolyl isomerase cyclophilin A (CypA) increases the kinetics by which hum

128 PO3, addition of the CA-binding host protein cyclophilin A (CypA) inhibited HIV-1 uncoating and reduc

129 The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 c

130 Packaging of cyclophilin A (CypA) into HIV-1 virions is essential for

131 lyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the f

132 Cyclophilin A (CyPA) is a 20-kDa chaperone protein secre

133 tudies conducted in cell lines indicate that cyclophilin A (CypA) is a component of HIV type 1 (HIV-1

134 Cyclophilin A (CypA) is a member of a family of cellular

135 Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that

136 Previously we demonstrated that cyclophilin A (CyPA) is a secreted oxidative stress-indu

137 We previously demonstrated that cyclophilin A (CyPA) is an essential cofactor for HCV in

138 Cyclophilin A (CypA) is an intracellular protein that is

139 HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness.

140 Cyclophilin A (CypA) is necessary for effective human im

141 Cyclophilin A (CypA) is required for viral replication,

142 Cyclophilin A (CyPA) is specifically incorporated into t

143 s of restriction mediated by owl monkey TRIM-cyclophilin A (CypA) or human TRIM5alpha.

144 residues Val86-Arg97 that contain the human cyclophilin A (CypA) packaging signal have (15)N heteron

145 Recent studies showed that cyclophilin A (CypA) promotes NF-kappaB/p65 nuclear tran

146 Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity t

147 for the binding of cyclosporin A (CsA) to a cyclophilin A (CypA) sample in which the protein was a c

148 Peptidyl prolyl cis/trans isomerase cyclophilin A (CypA) serves as a cellular receptor for t

149 Herein, we identify a novel Cyclophilin A (CypA) small molecule inhibitor (HL001) th

150 ng tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infectio

151 The binding of cyclophilin A (CypA) to the human immunodeficiency virus

152 enhanced by binding of the host cell protein cyclophilin A (CypA) to the viral capsid protein (CA).

153 We found that cyclophilin A (CypA) was excluded from wild-type SIV par

154 Cyclophilin A (CypA) was recently reported to be overexp

155 CA interactions with both CPSF6 and cyclophilin A (CypA) were essential for the unique dose-

156 Also, virion incorporation of cyclophilin A (CypA), a cellular peptidyl-prolyl isomera

157 The host protein cyclophilin A (CypA), a cis-trans prolyl isomerase, in s

158 Cyclophilin A (CypA), a cytoplasmic, human immunodeficie

159 ivity to restriction factors is modulated by cyclophilin A (CypA), a host cell protein that binds the

160 tion was greatly reduced both by antibody to cyclophilin A (CyPA), a known mediator of inflammation i

161 Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin famil

162 Cyclophilin A (CyPA), a ubiquitously distributed intrace

163 ncluding ubiquitin, ribonuclease A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (

164 rised of ubiquitin, ribonuclease A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (

165 5 recognized a 20-kDa protein, identified as cyclophilin A (CypA), and CypA was present on the surfac

166 The cytoplasmic subtype of cyclophilin, cyclophilin A (CyPA), appears to be required for functio

167 e, using chemical inhibition or silencing of cyclophilin A (CypA), as well as CA mutant viruses, we i

168 riments showing that overexpressed wild-type cyclophilin A (CyPA), but not CyPA with a rotamase activ

169 on of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of re

170 rly part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation speci

171 ice lacking the essential cellular co-factor cyclophilin A (CypA), HCV RNA replication is markedly di

172 ding mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of AP

173 olecular dynamics simulations to study human cyclophilin A (CypA), in order to understand the role of

174 The founding member of the family, cyclophilin A (CyPA), is an abundant, ubiquitously expre

175 on with the human peptidyl prolyl isomerase, cyclophilin A (CypA), that results in packaging of CypA

176 cellular peptidyl-prolyl cis-trans isomerase cyclophilin A (CyPA), the cytosolic receptor for the imm

177 y incorporates the peptidyl prolyl isomerase cyclophilin A (CyPA), the cytosolic receptor for the imm

178 tigated the effects of the host cell protein cyclophilin A (CypA), which binds to HIV-1 CA, on HIV-1

179 ort that the peptidyl-prolyl isomerase (PPI) cyclophilin A (CypA), which is implicated in the regulat

180 t residues H(219), I(223), and M(228) in the cyclophilin A (CypA)-binding loop in B57(+) individuals

181 on specific factor 6 (CPSF6), as well as the cyclophilin A (CypA)-binding loop mutation P90A, all inc

182 5A, which encompasses residues implicated in cyclophilin A (CypA)-dependent HCV RNA replication.

183 ortant interaction with the cellular protein cyclophilin A (CypA).

184 ecessary and sufficient for CD147 binding to cyclophilin A (CypA).

185 that functions by targeting a host protein, cyclophilin A (CypA).

186 its CA is not bound to the cellular protein cyclophilin A (CypA).

187 to analyze the catalytic mechanism of human cyclophilin A (CypA).

188 by the peptidyl prolyl isomerase activity of cyclophilin A (CypA).

189 ency virus type 1 (HIV-1) CA binding protein cyclophilin A (CypA).

190 ng Fv1NtD fused to the HIV-1 binding protein Cyclophilin A (CypA).

191 us (HCV) requires host cell factors, such as cyclophilin A (CypA).

192 red with wild-type controls through secreted cyclophilin A (CypA).

193 ted by the cellular peptidylprolyl isomerase cyclophilin A (CyPA).

194 V-1 capsid (CA) interaction with target cell cyclophilin A (CypA).

195 ng substates of the human proline isomerase, cyclophilin A (CYPA, also known as PPIA).

196 Cyclophilin A (CypA, encoded by Ppia) is highly expresse

197 Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase

198 Cyclophilin A (CyPA; encoded by Ppia) is a ubiquitously

199 46 in TRIMCyp (or residues 66 and 143 in the cyclophilin A [CypA] domain) confer restriction specific

200 addition of cyclosporine A or infection of a cyclophilin A-deficient cell line.

201 V-2 or SIV Nef would have a direct effect on cyclophilin A dependence.

202 We also found that purified cyclophilin A destabilizes in vitro-assembled HIV-1 CA-N

203 ent conformational properties, rhodanese and cyclophilin A, during binding and encapsulation by GroEL

204 ss1 conditional and null mutations, and that cyclophilin A enzymatic activity is required for suppres

205 Further evidence that increased cyclophilin A expression in H9 cells is of functional re

206 and that infectivity is finely tuned by host cyclophilin A expression levels.

207 Our results suggest that TNPO3 and cyclophilin A facilitate HIV-1 infection by coordinating

208 which confer the necessity to interact with cyclophilin A for efficient virus replication.

209 Nef are able to compensate for the need for cyclophilin A for full infectivity and that amino acids

210 mmunodeficiency viruses, only HIV-1 requires cyclophilin A for replication.

211 type 1 (HIV-1) Gag and the cellular protein cyclophilin A form an essential complex in the virion co

212 protein processing, and the upregulation of cyclophilin A further support the notion that C. neoform

213 ontained two- to threefold reduced ratios of cyclophilin A:Gag protein as compared with untreated vir

214 )) or by the product of the owl monkey TRIM5-cyclophilin A gene fusion (TRIMCyp).

215 roximately 61 % sequence identity with human cyclophilin A (hCyPA) and the structures are similar, co

216 r surface of recombinant human hexahistidine cyclophilin A (His-CypA) is described.

217 In this study, a human cyclophilin A homologue, TvCyclophilin 1 (TvCyP1), was i

218 Cyclophilin A immunoreactivity was undetectable in glial

219 hat only the trans cis form of AAPF binds to cyclophilin A implies that cyclophilin A predominantly c

220 only the cis form of the substrate bound to cyclophilin A in a stoichiometry of 1:1.

221 fort, evidence of developmental functions of cyclophilin A in non-plant systems has remained obscure.

222 ction between CD147 and another cyclophilin, cyclophilin A, in solution.

223 clophilin A-binding properties in vitro, and cyclophilin A incorporation into drug-resistant virions

224 virions; in parallel with the disruption of cyclophilin A incorporation into virions, there is a lin

225 Disruption of cyclophilin A incorporation, either by gag mutations or

226 In addition, cyclophilin A increased Crk SH3 domain-binding guanine-n

227 nnel had been opened by PKA phosphorylation, cyclophilin A increased the open probability of wild-typ

228 3-Rpd3 histone deacetylase complex, and that cyclophilin A increases and Ess1 decreases disruption of

229 us to identify a third cyclophilin protein, cyclophilin A, interacting directly or in complex with p

230 Disruption of the HIV-1 CA-cyclophilin A interaction caused a minimal increase in t

231 Disruption of the HIV-1 CA-cyclophilin A interaction inhibits Lv1 restriction in so

232 The observation that disruption of the Gag-cyclophilin A interaction rescues A224E mutant replicati

233 hat indirectly targets NS5A by blocking NS5A/cyclophilin A interaction.

234 ye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by

235 A-NS5A interactions but does not affect NS5A-cyclophilin A interactions.

236 Using assays for packaging of cyclophilin A into virions and for viral replication sen

237 unodeficiency virus (SIV) do not incorporate cyclophilin A into virions or need it for full infectivi

238 that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional t

239 cyclophilin A, and prevent incorporation of cyclophilin A into virions; in parallel with the disrupt

240 Cyclophilin A is a conserved peptidyl-prolyl cis-trans i

241 Cyclophilin A is a small, soluble protein which binds th

242 Cyclophilin A is a tractable model system to study using

243 or a simian lentivirus that does not recruit cyclophilin A is also stimulated by these drugs.

244 ntiated genetically from its ability to bind cyclophilin A is further demonstrated by the rescue of a

245 The cellular peptidyl-prolyl isomerase cyclophilin A is incorporated into human immunodeficienc

246 the more expanded and unstructured denatured cyclophilin A is not encapsulated but is expelled into s

247 f cyclophilin A with hensin, suggesting that cyclophilin A is the PPIase that mediates the polymeriza

248 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously

249 A sixth suppressor, cyclophilin A, is a member of a distinct family of PPIas

250 cyclosporin A (CsA), an inhibitory ligand of cyclophilin A, is a widely used immunosuppressive drug,

251 dentity with the central conserved region of cyclophilin A, is evolutionarily conserved by Southern b

252 Other notables include cyclophilin-A, keratin, GAPDH, and cytochrome c.

253 sponsible for the alteration of phenotype in cyclophilin A knockdown (CypA-KD) P19 cells, we observed

254 Roc2, which are orthologs of the yeast Cpr1p cyclophilin, a known inhibitor of TBSV replication in ye

255 ellular ligands for cyclosporine include the cyclophilins, a large family of phylogenetically conserv

256 particularly activation of a proinflammatory cyclophilin A-mediated pathway in brain vascular pericyt

257 r findings support a model in which Ess1 and cyclophilin A modulate the activity of the Sin3-Rpd3 com

258 Suppression by a panel of cyclophilin A mutants correlated with PPIase activity, c

259 the effect of the peptidyl-prolyl isomerase, cyclophilin A, on the CFTR channel.

260 We show here that cyclophilin A, one of the most common PPIases, provides

261 Mutations in a tomato (Solanum lycopersicum) cyclophilin A ortholog, DIAGEOTROPICA (DGT), have been s

262 rated by the rescue of a mutation precluding cyclophilin A packaging by a mutation conferring cyclosp

263 We also report that cyclophilin A packaging is severely reduced in W23A and

264 We show that cyclophilin, a peptidyl-prolyl isomerase secreted from T

265 ses (tau(1), tau(2), tau(3)) to catalysis by cyclophilin, a peptidyl-prolyl isomerase.

266 inhibits virion infectivity, indicating that cyclophilin A plays an essential role in the HIV-1 life

267 phosphorylation during transcription of the cyclophilin A (PPIA), glyceraldehyde-3-phosphate dehydro

268 wn, including kallikrein-7 (KLK7; 2.2-fold), cyclophilin A (PPIA; 0.9-fold), and cofilin-1 (CFL1, 1.3

269 Employing the cyclophilin A PPIase together with its biologically rele

270 of AAPF binds to cyclophilin A implies that cyclophilin A predominantly catalyzes the trans to cis i

271 n binding interaction of Cyclosporine A with cyclophilin A protein in a yeast cell lysate is successf

272 ic effects of CsA are mediated by the 18-kDa cyclophilin A protein.

273 hat the Gly89-Pro90 dipeptide is the primary cyclophilin A recognition motif, with Pro85, Val86, His8

274 s macrophage migration inhibitory factor and cyclophilin A, respectively.

275 s were found and identified, namely enolase, cyclophilin-A, ribosomal protein L13 and actin-1.

276 The resulting larger quantity of cyclophilin A shown to be packaged into virions produced

277 Other host factors, such as cyclophilin A, stabilize the HIV-1 capsid and are requir

278 infectivity imposes narrow constraints upon cyclophilin A stoichiometry in virions and that infectiv

279 We also show that overexpression of cyclophilin A suppresses ess1 conditional and null mutat

280 variants, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), are attractive candidates owing to

281 orthologs, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restricto

282 o binds the human peptidyl prolyl isomerase, cyclophilin A, thereby packaging the enzyme into the vir

283 A content resulting in decreased binding of cyclophilin A to Gag could account, in part, for the obs

284 ant mutants do not require virion-associated cyclophilin A to initiate infection.

285 was promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclospo

286 as well as literature values for uncomplexed cyclophilin A, to theoretical predictions using a combin

287 The expression levels of alpha-actin and cyclophilin A varied little during the course of develop

288 UP153 depletion, as was wild-type HIV-1 when cyclophilin A was depleted simultaneously or when infect

289 teins was confirmed by Western blotting, and cyclophilin A was localized to the tumor cells by immuno

290 Cyclophilin A was produced and secreted into the media t

291 During catalytic action of the enzyme cyclophilin A, we detect conformational fluctuations of

292 lar to that of the peptidyl-prolyl isomerase cyclophilin A, we probed purified virions with antibodie

293 aturation, virus infectivity, and binding to cyclophilin A, whereas the subtype B portion of RT was l

294 nal domains on TRIM5alpha (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids.

295 ntiviral effect is mediated by inhibition of cyclophilin A, which is an essential host factor in the

296 at Pro-222 decreases virion incorporation of cyclophilin A, while mutation at Pro-231 abolishes infec

297 sing disparity is the weaker interactions of cyclophilin A with a transiently formed GroEL-GroES comp

298 onstant expression levels of alpha-actin and cyclophilin A with development, suggest that these are u

299 fied the direct CsA-sensitive interaction of cyclophilin A with hensin, suggesting that cyclophilin A

300 We have obtained HDX data for the complex of cyclophilin A with the immunosuppressant cyclosporin A.