ライフサイエンスコーパス: cyclophilin B

1 ic reticulum (ER) cyclophilin in addition to cyclophilin B.

2 of the peptidyl-prolyl isomerase activity of cyclophilin B.

3 ed with GRP94, ERp72, BiP, calreticulin, and cyclophilin B.

4 ith a value of 6.3x10(6)M(-1)s(-1) for human cyclophilin B.

5 parable to the value of 84nM found for human cyclophilin B.

6 eat shock protein 90-alpha (HSP90-alpha) and cyclophilin B.

7 actin has been demonstrated to interact with cyclophilin B, a member of the immunophilin family of pr

8 Cyclophilin B and FKBP13 exhibited much lower activity t

9 n the rER, and so far, two of these enzymes, cyclophilin B and FKBP65, have been shown to be involved

10 avage of the minor capsid protein L2 by host cyclophilin B and furin.

11 CRTAP forms a complex with cyclophilin B and prolyl 3-hydroxylase 1, which is encod

12 ational changes, leading to isomerization by cyclophilin B and proprotein convertase-mediated L2 mino

13 ent that triggered efficient ER depletion of cyclophilins B and C by inducing their secretion to the

14 a cells, we found that combined knockdown of cyclophilins B and C delayed transferrin secretion but s

15 philin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis, and sugges

16 into the media to a much greater extent than cyclophilins B and C.

17 sly been shown to form a stable complex with cyclophilin B, and P3H1 was shown to catalyze the 3-hydr

18 g, the endoplasmic reticulum luminal protein cyclophilin B, and the long cytoplasmic tail of gp41.

19 The CAMLG gene encodes a novel cyclophilin B-binding protein called calcium-modulating

20 ligand (CAML) was originally described as a cyclophilin B-binding protein whose overexpression in T

21 ngs indicate that the intranuclear prolactin/cyclophilin B complex acts as a transcriptional inducer

22 Here we provide evidence demonstrating that cyclophilin B (CypB) activity plays an important role in

23 ), cartilage-associated protein (CRTAP), and cyclophilin B (CypB) can be isolated from chick embryos

24 (CRTAP), prolyl 3-hydroxylase 1 (P3H1), and cyclophilin B (CYPB) cause types VII-IX osteogenesis imp

25 CRTAP and P3H1 form a complex with cyclophilin B (CyPB) in the endoplasmic reticulum (ER) w

26 ls a role for the host cell prolyl isomerase cyclophilin B (CyPB) in the replication of the hepatitis

27 Cyclophilin B (CypB) is a 21-kDa protein with peptidyl-p

28 Cyclophilin B (CypB) is an endoplasmic reticulum (ER)-re

29 Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the

30 CRTAP can form a complex with P3H1 and cyclophilin B (CYPB), and Crtap-/- bone and cartilage co

31 disrupts its interaction with its cofactor, cyclophilin B (CypB), even though the I432V mutation is

32 eptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient repl

33 se B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex

34 omplex with cartilage-associated protein and cyclophilin B (CypB).

35 tric analysis to identify the M9-5 target as cyclophilin B (CypB).

36 of the collagen triple helix is catalyzed by cyclophilin B (CypB).

37 at is facilitated by the host cell chaperone cyclophilin B (CyPB).

38 oposed model of regulation of RNA binding by cyclophilin B (CyPB).

39 -hydroxylase 1 (P3H1; encoded by LEPRE1) and cyclophilin B (CYPB; encoded by PPIB), which reside in t

40 ges in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2)

41 a recently identified ER Hsp40 cochaperone; cyclophilin B; ERp72; GRP170; UDP-glucosyltransferase; a

42 The G6R mutation in cyclophilin B found in the American Quarter Horse leads

43 doplasmic reticulum (ER)-resident chaperone, cyclophilin B, from assisting presenilin 1 to fold prope

44 nd granzyme B and a constitutively expressed cyclophilin B gene were measured with the use of a compe

45 Drosophila NinaA and its mammalian homolog, cyclophilin-B, impair opsin biogenesis and cause osteoge

46 Here we show that cyclophilin B in the complex shows peptidyl-prolyl cis-t

47 Cyclophilin B interaction with prolactin potentiated pro

48 The spatial expression patterns of the cyclophilin B isoforms were examined using transgenic an

49 tive presenilin 1 were observed in brains of cyclophilin B knockout mice.

50 leavage of the minor capsid protein, L2, and cyclophilin B-mediated separation of L2 and the viral ge

51 during infection at a step downstream of the cyclophilin B-mediated unfolding of L2.

52 In contrast to cyclophilin B null mice, where little 3-hydroxylation wa

53 The absence of either cyclophilin B or FKBP65 leads to a recessive form of ost

54 We report a mutation in cyclophilin B (PPIB) as a novel, causal candidate gene f

55 Two cyclophilin B proteins, S28 and S29, were identified pre

56 found to code for a presumptive periplasmic cyclophilin B-type peptidyl prolyl cis-trans isomerase (

57 tidyl-prolyl cis-trans isomerase activity of cyclophilin B was shown previously to catalyze the rate

58 d the central 64-amino-acid section of human cyclophilin B, which contained its peptidyl-prolyl isome

59 st strongly resembles the structure of human cyclophilin B with conserved changes in loop structure a

60 The mutation disrupts the interaction of cyclophilin B with the P-domain of calreticulin, with ly