ライフサイエンスコーパス: cyclopropane

1 rgy (1.8 kcal/mol) of a cyclobutane versus a cyclopropane.

2 hich upon reductive elimination releases the cyclopropane.

3 he usually inert sites of the donor-acceptor cyclopropane.

4 approach for the synthesis of functionalized cyclopropanes.

5 alogous to that observed with donor-acceptor cyclopropanes.

6 opening cyclizations of donor-acceptor (D-A) cyclopropanes.

7 nd to be stereospecific as in the case of DA cyclopropanes.

8 and enamides to afford 1,2,3-trisubstituted cyclopropanes.

9 catalyzed enantioselective C-H activation of cyclopropanes.

10 olds affords multifunctional, donor-acceptor cyclopropanes.

11 bromide delivered the corresponding alkenyl cyclopropanes.

12 rofuran derivatives from enantioenriched D-A cyclopropanes.

13 electrophiles to generate highly substituted cyclopropanes.

14 in the same fashion with trans-2-methyl-1-X-cyclopropanes.

15 ng generates a range of substituted bicyclic cyclopropanes.

16 ipolar cycloaddition chemistry of azides and cyclopropanes.

17 ts together three acetophenones to construct cyclopropanes.

18 ither diastereomer of di- and trisubstituted cyclopropanes.

19 a highly regioselective aminofluorination of cyclopropanes.

20 access to synthetically useful hydroxymethyl cyclopropanes.

21 cloisomerization of enynes to trisubstituted cyclopropanes.

22 cycloaddition of nitrones to donor-acceptor cyclopropanes.

23 ross-couplings, affording highly substituted cyclopropanes.

24 ve small-size rings such as cyclobutanes and cyclopropanes.

25 cles, we have also demonstrated that racemic cyclopropane 1,1-diesters can undergo dynamic kinetic as

26 The ring-opening of cyclopropane-1,1-dicarboxylates with vicinal donor aryl

27 trans-2-Aryl-3-nitro-cyclopropane-1,1-dicarboxylates, upon treatment with BF3

28 ctron (NIPE) spectra of the radical anion of cyclopropane-1,2,3-trione, (CO)3(*-), have been obtained

29 by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones reported herein.

30 by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones, e.g., 3.

31 through a nucleophilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the azide ion.

32 rboxylate relative to methyl 1-azidocarbonyl cyclopropane-1-carboxylate was attributed to a weaker bo

33 ene-1-carboxylate and methyl 1-azidocarbonyl cyclopropane-1-carboxylate were studied by (1)H NMR spec

34 2 and ACS6, two type I ACS isozymes (1-amino-cyclopropane-1-carboxylic acid synthase).

35 l)amino)isoxazol-5 -yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid) in rhesus monkeys to ima

36 a mixture of products including debrominated cyclopropanes 12.

37 carbene derived from ethyl diazoacetate gave cyclopropane 15 as the major product.

38 roach for the dimerization of donor-acceptor cyclopropanes (2-arylcyclopropane-1,1-dicarboxylates) un

39 The synthetic sequence starts with the cyclopropane 3 and involves intramolecular Heck alkenyla

40 inane 34 or mixtures of cyclobutanone 36 and cyclopropane 38, respectively.

41 -1 to trans,trans-1,2,3-tri(2-(5-phenylfuryl)cyclopropane (4) occurred as a byproduct of treatment wi

42 lkene moiety, subsequent ring-opening of the cyclopropane affords either cyclopentane or cyclohexane

43 This synthesis features a diastereoselective cyclopropane/aldehyde [3+2] cycloaddition to install the

44 irgatusin have been achieved; both rely upon cyclopropane/aldehyde annulation for construction of the

45 n demonstrated for the synthesis of a chiral cyclopropane aldol and a gamma-lactone in a >95:5 diaste

46 f one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.

47 Cyclopropane, an anesthetic that acts with unusually low

48 (1), and a less active but extremely stable cyclopropane analog 2, which is currently undergoing pre

49 und: a straightforward decoordination of the cyclopropane and a cationic rearrangement of the three-m

50 The shielding pattern arising from the cyclopropane and cyclobutane CC framework response to a

51 -catalyzed annulation between donor-acceptor cyclopropane and N-tosylaziridinedicarboxylate to access

52 biochemically to determine the mechanisms of cyclopropane and vinyl chloride formation.

53 d enoyl reductase, leads to the formation of cyclopropane and vinyl chloride moieties.

54 sformation (DyKAT) of racemic donor-acceptor cyclopropanes and (E)-aldimines.

55 loaddition of activated donor-acceptor (D-A) cyclopropanes and aldehydes catalyzed by ((t)Bu-pybox)Mg

56 tituted tetrahydrofurans from donor-acceptor cyclopropanes and aldehydes has been developed.

57 + 2] cycloadditions of donor-acceptor (D-A) cyclopropanes and aldehydes is described.

58 eving the synthesis of tetrahydrofurans from cyclopropanes and C horizontal lineO pi bonds.

59 orides to give a variety of substituted aryl cyclopropanes and cyclobutanes.

60 d styrenes under Rh2(OAc)4 catalysis to give cyclopropanes and dihydrofurans in a highly regioselecti

61 We describe the synthesis of a variety of cyclopropanes and epoxides by combining a readily access

62 reported and is amenable to a variety of D-A cyclopropanes and primary amines.

63 age of different spiro-4-hydroxychroman-3,1'-cyclopropanes and similar thiochroman analogues.

64 n efficient and general entry to unsaturated cyclopropane- and lactone-containing oxylipins of marine

65 Characterization of immune responses to the cyclopropane- and MAMT-deficient strains indicated that

66 The imine, unsaturated lactam, and cyclopropane are essential for efficient DNA alkylation.

67 Trifluoromethyl-substituted cyclopropanes are an attractive family of building block

68 Stereochemically defined cyclopropanes are employed as mechanistic probes to prov

69 yclization reactions of donor-acceptor (D-A) cyclopropanes are recognized as versatile methods for co

70 Furthermore, the role of D-A acceptor cyclopropanes as reactive subunits in natural product sy

71 for the synthesis of highly enantioenriched cyclopropanes as single diastereoisomers.

72 ique cyclopropane natural products or use of cyclopropanes as versatile strategic intermediates.

73 Comparisons to alkenes, cyclopropanes, aziridines, thiiranes, and phosphiranes a

74 Most crucially, the use of a validated cyclopropane-based radical-clock substrate has demonstra

75 For cyclopropanes bearing a trisubstituted alkenyl group eit

76 ss-coupling to form diverse tetrasubstituted cyclopropanes bearing all-carbon quaternary stereocenter

77 resence of a catalytic amount of Sn(OTf)(2), cyclopropanes bearing an aryl or conjugated donor substi

78 Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thiophenyl, and (N-me

79 This strengthens the idea that cyclopropane behaves as a quasi-double bond.

80 It is suggested that the cyclopropane bond fragmentation dissipates the triplet e

81 t energy dissipation by fragmentation of the cyclopropane bond is also proposed.

82 t, which subsequently fragments the strained cyclopropane bond to give a lower energy and unreactive

83 atom bends 31 degrees toward the endo-fused cyclopropane bond, elongating it to r = 1.69 A.

84 triplet state, which fragments the strained cyclopropane bond.

85 d double bond in 1 interacts with the distal cyclopropane bonds in a manner that eventually leads to

86 an be used to produce a product that lacks a cyclopropane but retains a quaternary stereogenic center

87 > n-BuI > n-BuBr approximately (bromomethyl)cyclopropane (but t-Bu2C horizontal lineO < ClSiMe3 in T

88 strain energies exceeding those of saturated cyclopropanes by >10 kcal/mol.

89 ric synthesis of trifluoromethyl-substituted cyclopropanes by means of myoglobin-catalyzed olefin cyc

90 bles highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetim

91 ariety of monocyclic and bicyclic vinylidene cyclopropanes can be prepared.

92 exciting a single molecular conformation of cyclopropane carboxaldehyde above the barrier to C-C sin

93 nd selectively react with olefins, providing cyclopropane carboxaldehydes and 2,3-dihydropyrroles in

94 Additionally, employing cyclopropane carboxaldehydes led to ring-opened products

95 act with Michael acceptors to give esters of cyclopropane carboxylic acids substituted with p-nitroar

96 The borylation of cyclopropanes catalyzed by the combination of (eta(6)-me

97 The subsequent beta-hydride elimination and cyclopropane cleavage are competitive, determining the e

98 In trans-VCP, the cyclopropane cleavage is intrinsically favored and leads

99 acyclopentene intermediate, in contrast to a cyclopropane cleavage pathway in the reaction with Rh(I)

100 The cyclopropane containing betaine, rac-dysibetaine CPa, wa

101 acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse

102 ard previously to explain the origin of C 20 cyclopropane-containing algal products.

103 designed and synthesized a series of chiral cyclopropane-containing alpha4beta2-specific ligands tha

104 heterogeneous catalyst for the formation of cyclopropane-containing products.

105 from Capitella teleta (Ct) in complex with a cyclopropane-containing selective alpha4beta2-nicotinic

106 A 3-pyridyl ether scaffold bearing a cyclopropane-containing side chain was recently identifi

107 nabled the multigram synthesis of the chiral cyclopropane core of four drugs (Tranylcypromine, Tasime

108 ppears that commonly cited bond energies for cyclopropane, cyclobutane, and cyclohexane are 3 to 4 kc

109 queous or organic solvent, where ring-opened cyclopropanes, cyclobutanes, and homoallyl products are

110 in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes

111 ess for (4 + 2)-annulation of donor-acceptor cyclopropanes (DACs) with unsaturated compounds in the p

112 losis would be viable and what the effect of cyclopropane deficiency on virulence would be.

113 Purified TDM isolated from a cyclopropane-deficient pcaA mutant was hypoinflammatory

114 However, it is unknown whether a cyclopropane-deficient strain of M. tuberculosis would b

115 ize the peculiar (1)H NMR chemical shifts of cyclopropane (delta 0.22) and cyclobutane (delta 1.98) w

116 In this work, ring-opening reactions of cyclopropane derivatives under hydrogen catalyzed by met

117 to a number of densely functionalized chiral cyclopropane derivatives, including alpha-cyclopropyl-be

118 n the cyclohexyl system, a small amount of a cyclopropane derived from 1,3-hydrogen migration occurs,

119 Succinate- and cyclopropane-derived phosphotyrosine (pY) replacements w

120 he substituents on both the carbinol and the cyclopropane determine both chemo- and stereoselective o

121 With SnCl4, the cyclopropane dicarboxylates afforded cyclopentene deriva

122 tic asymmetric transformation of racemic 1,1-cyclopropane diesters to prepare enantioenriched tetrahy

123 luoromethyl groups to olefins and access 1,1-cyclopropane diesters.

124 e styrene, we synthesized non-natural phenyl cyclopropanes directly from D-glucose in single-vessel f

125 The reaction proceeds with inversion at the cyclopropane donor site and allows absolute stereochemic

126 ereospecific, with inversion observed at the cyclopropane donor site.

127 The cyclopropane donor substituents determine the overall re

128 roducts are observed with highly stabilizing cyclopropane donor substituents.

129 transport calculations, which show that the cyclopropane dumbbell gives a higher calculated single-m

130 of spectroscopic techniques reveals that the cyclopropane dumbbell possesses better electronic commun

131 gold(I) carbene reacts with alkenes to form cyclopropanes either intra- or intermolecularly.

132 expected to find utility in the synthesis of cyclopropanes, epoxides and their derivatives, as well a

133 The in vivo studies presented here show that cyclopropane fatty acid synthase transcription induced b

134 er sigmaS control encoding, for example, the cyclopropane fatty acid synthase, Cfa, the glycogen synt

135 Cyclopropane fatty acids (CPAs) are desirable as renewab

136 limidazolium chloride include an increase in cyclopropane fatty acids in the cell membrane, scavengin

137 5) higher total percentages of saturated and cyclopropane fatty acids than did control cells.

138 of unsaturated fatty acids and low levels of cyclopropane fatty acids, (iii) increased membrane fluid

139 sis surface protein, and (v) M. tuberculosis cyclopropane fatty acyl-phopholipid synthase.

140 synthesis of cis-configured trifluoromethyl cyclopropanes for a broad range of substrates with excel

141 amolecular transformations of donor-acceptor cyclopropanes for cycloisomerizations, formal cycloaddit

142 ough the catalytic oxidative ring-opening of cyclopropanes for the synthesis of 1,3-fluoroacetoxylate

143 The cyclopropane-forming catalyst is CmaC, catalyzing an int

144 ation at the Ti-C bond, respectively, in the cyclopropane-forming step.

145 t is proposed that the complexes result from cyclopropane fragmentation subsequent to alkene insertio

146 ctive synthesis of novel multifunctionalized cyclopropanes from gamma,delta-epoxy malonates and amine

147 tes over alpha-mycolates and devoid of trans-cyclopropane functions.

148 bonyl compounds furnishes the donor-acceptor cyclopropane-fused benzoxa[3.2.1]octane scaffold with ex

149 fforded medicinally relevant benzoindolines, cyclopropane-fused indenopyridines, pyrroloquinolines, o

150 Cyclopropane-fused pyrrolidines and azepines are obtaine

151 n situ from enoldiazo compounds that produce cyclopropane-fused ring systems.

152 containing Tet-v2.0 reacts selectively with cyclopropane-fused trans-cyclooctene (sTCO) with a bimol

153 ated cyclocarbonylation of a derived alkenyl cyclopropane gave a bicyclic enone that then was hydroge

154 he interactions of the Walsh orbitals of the cyclopropane group with the breaking C-N bonds in N2 los

155 t a dimethyl group at C4 as well as a C9,C19 cyclopropane group, as found in oryzanol, negatively aff

156 The cis-cyclopropanes had 20- to 30-fold less affinity than the

157 The SE of cyclopropane has been increased to 28.6 kcal/mol after c

158 As the cyclopropane has been shown to be essential for genotoxi

159 ituted C-C bond of the cis-1,2-disubstituted cyclopropane has steric repulsions from the substituent,

160 Donor-acceptor cyclopropanes have been evaluated as substrates for reac

161 led acid-catalyzed cleavage of the resulting cyclopropane (HCl), further improvements in a unique int

162 Cyclopropane hemimalonates, when treated with sodium azi

163 ClbS or an active site residue mutant reveal cyclopropane hydrolase activity that converts the electr

164 a molecular-level view of the first reported cyclopropane hydrolase and support for a specific mechan

165 from Lyngbya majuscula form a beta-branched cyclopropane in the curacin A pathway (Cur), and a vinyl

166 a variety of alkenes, providing cis-dominant cyclopropanes in excellent yields and moderate enantiose

167 ystems, vicinal quaternary centers, and even cyclopropanes in good yield.

168 of synthetically and biologically important cyclopropanes in high levels of enantio- and diastereose

169 ange of alkenes, affording the corresponding cyclopropanes in high yields with effective control of b

170 ted transfer hydrogenation of donor-acceptor cyclopropanes in the presence of aldehydes.

171 straightforward access to highly substituted cyclopropanes in two steps from commercially available a

172 wn that the reactivity of the donor-acceptor cyclopropane increases with the increase of the electron

173 a design in which a reactive donor-acceptor cyclopropane intermediate is generated by in situ conden

174 cin C, involving a novel electrophilic spiro-cyclopropane intermediate is hypothesized.

175 ific conversion of enantiomerically enriched cyclopropanes into nonracemic heterocycles, we have also

176 rising from an aromatic-like ring current in cyclopropane, involving six electrons in the three C-C b

177 opropane substrate, the substituent from the cyclopropane is away from the reaction center in both pa

178 her the more or less substituted C-C bond of cyclopropane is cleaved.

179 iles at the donor position of donor-acceptor cyclopropanes is described, representing an inversion of

180 n between cyclopropenones and donor-acceptor cyclopropanes is described.

181 A novel organocatalytic activation mode of cyclopropanes is presented.

182 lorotetrahydropyrans to afford disubstituted cyclopropanes is reported.

183 intermolecular reactivity of donor-acceptor cyclopropanes is widely reported, reviews that center on

184 -carbon analogue of these species (methylene cyclopropane) is only briefly discussed.

185 s are reported for methane, ethane, propane, cyclopropane, isobutane, neopentane, tetramethylbutane,

186 gaseous constituents butane, carbon dioxide, cyclopropane, isobutylene, and methane.

187 ion of a ring-expanded fused cyclobutane (vs cyclopropane), its chemical and structural characterizat

188 These highly potent cyclopropane ligands possess superior subtype selectivit

189 The racemic cyclopropane-linked compounds showed PLK4 affinity and a

190 Optimization of this new cyclopropane-linked series was based on a computational

191 al control of host immune activation through cyclopropane modification of TDM as a critical pathogeni

192 Here we show that cyclopropane modification of the Mtb cell envelope glyco

193 ne such alteration in lipid structure is cis-cyclopropane modification of the mycolic acids on trehal

194 ch is governed by rapid isomerization of the cyclopropane moieties at ~1.2 nN, from the force-rate co

195 rization of 1,6-diynes bearing an alkylidene cyclopropane moiety has been developed.

196 s a large preference for N2 loss anti to the cyclopropane moiety rather than syn from adducts formed

197 tegic considerations for introduction of the cyclopropane motif in a collection of recent total synth

198 emistry by characterizing an M. tuberculosis cyclopropane-mycolic acid synthase 2 (cmaA2) null mutant

199 ed to enable the synthesis of various unique cyclopropane natural products or use of cyclopropanes as

200 also carried out, and a revised C-H BDE for cyclopropane of 108.9 +/- 1.0 kcal mol(-1) is recommende

201 ase activity that converts the electrophilic cyclopropane of the colibactins into an innocuous hydrol

202 vergent fragment coupling via a nucleophilic cyclopropane opening, a highly diastereoselective formal

203 ules have been synthesized containing either cyclopropane or pyrrolidine rings connecting two fullere

204 a wide variety of products by attack at the cyclopropane or the carbene carbons.

205 , resulting in the formation of a variety of cyclopropanes or C-H insertion products with high stereo

206 esence of MgI2 as Lewis acid, donor-acceptor cyclopropanes or corresponding cyclobutanes were treated

207 The role of protonated cyclopropane (PCP(+)) structures in carbocation rearrang

208 Complex molecular architectures containing cyclopropanes present significant challenges for any syn

209 We describe the formation of a bis-cyclopropane product, a tricyclic[4.1.0.0(2,4)]heptane,

210 under mild conditions, affording the desired cyclopropane products in high yields with both high dias

211 e same ligand [Fe(1)Cl] afforded the desired cyclopropane products in low yields and poor enantiosele

212 literature, many examples of these polarized cyclopropanes' reactivity with nucleophiles, electrophil

213 ing step involves a difluorocarbene addition/cyclopropane rearrangement sequence.

214 Theoretical investigation of cyclopropane-to-cyclopropane rearrangements of sterols indicates a role

215 In vitro assays of the synthesized cyclopropanes revealed that the K(i) of one of the enant

216 rrangement, resulting in the cleavage of the cyclopropane ring and the formation of energetically sta

217 sigma-interaction between the C-C bond of a cyclopropane ring and the Hf.

218 Conjugation between the cyclopropane ring and the pi bond of the etheno bridge i

219 Important features of the cyclopropane ring are, the (1) coplanarity of the three

220 ne scaffold (I), the relocation of the fused cyclopropane ring bond and the shifting of the oxygen at

221 The methylene carbon of the cyclopropane ring derives from the activated methyl grou

222 catalyzes a cryptic chlorination leading to cyclopropane ring formation in the synthesis of the natu

223 One example involved cyclopropane ring formation, and the other carbon-carbon

224 oxin coronatine involves construction of the cyclopropane ring from a gamma-chloro-L-allo-Ile interme

225 Efforts to substitute the cyclopropane ring in a series of aryl cyclopropylnitrile

226 pendent enzyme catalyzing the opening of the cyclopropane ring of ACC to give alpha-ketobutyric acid

227 rotonyl-ACP, the postulated precursor of the cyclopropane ring of curacin A.

228 form unsaturated imines that alkylate DNA by cyclopropane ring opening (2 --> 3).

229 Deprotonation of 22 resulted in cyclopropane ring opening to afford the benzoindolizidin

230 electively at the methylene C-H bonds of the cyclopropane ring over methine or methyl C-H bonds.

231 A 13C label on the fused cyclopropane ring permitted the rapid identification of

232 philic and electrophilic attack on the fused cyclopropane ring results in pyrido[1,2-a]indole and aze

233 The cyclopropane ring takes part in pi-acceptor hydrogen bon

234 20% bicyclogermacrene, a hydrocarbon with a cyclopropane ring that underlines the dual 1,10-/1,11-cy

235 The additional fusion of a cyclopropane ring to the cyclopentane produces a bicyclo

236 dition of the distal carbon-carbon bond of a cyclopropane ring to the palladium(0) catalyst and the r

237 ctionalized bicyclic sugar unit to which the cyclopropane ring was introduced via carbene addition.

238 Oxidative cyclopropane ring-opening of 5-substituted 3-azabicyclo[

239 at solvent may play an important role in the cyclopropane ring-opening step.

240 addition of Ade to AF followed by hydrolytic cyclopropane ring-opening, indicating the potential for

241 reochemistry or ring opening of the adjacent cyclopropane ring.

242 poxides with the alkene double bond to yield cyclopropane rings are presented.

243 insight into the importance of mycolic acid cyclopropane rings in the PMB and provide the first evid

244 The cyclopropane rings of both agents displace a single wate

245 Finally, purified TDM lacking trans-cyclopropane rings was 5-fold more potent in stimulating

246 that an M. tuberculosis mutant lacking trans-cyclopropane rings was hypervirulent in mice.

247 rium tuberculosis cell wall, are modified by cyclopropane rings, methyl branches, and oxygenation thr

248 n branched fatty acids that are decorated by cyclopropane rings.

249 ine, and arginine) from a unique fluorinated cyclopropane scaffold is described.

250 catalyst, the organocatalytically activated cyclopropanes show an unexpected and highly stereoselect

251 X-ray structure analysis of the resultant cyclopropanes showed that formal migration to the distal

252 In addition, cyclopropane stereochemistries on mycolic acids interact

253 nd immunomodulatory function of mycolic acid cyclopropane stereochemistry by characterizing an M. tub

254 e high affinity for hSERT, and the preferred cyclopropane stereochemistry was determined to be (1S,2S

255 In the trans-1,2-disubstitued cyclopropane substrate, the substituent from the cyclopr

256 plied to effect methylene C-H olefination of cyclopropane substrates.

257 ents and can engage a variety of substituted cyclopropane substrates.

258 In this reaction, cyclobutanones serve as cyclopropane surrogates, reacting in a formal (4+2-1) tr

259 ulating crop, we expressed nine higher plant cyclopropane synthase (CPS) enzymes in the seeds of fad2

260 activities usually associated with the trans-cyclopropane synthase CmaA2.

261 f which can function as both a cis and trans cyclopropane synthase for the oxygenated mycolates.

262 halose dimycolate (TDM) mediated by proximal cyclopropane synthase of alpha mycolates (pcaA), a proin

263 In addition, TDM modification by the cyclopropane synthase pcaA was both necessary and suffic

264 Here, we demonstrated that mycolic acid cyclopropane synthase PcaA, but not MmaA2, was phosphory

265 Also demonstrated is an asymmetric cyclopropane synthesis that combines enantioselective ep

266 at pH 1) relative to N-Boc-CBI containing a cyclopropane (t(1/2) = 133 h at pH 3) may be attributed

267 (4.0 equiv), the spontaneous ring-opening of cyclopropanes takes place to lead to stereoselective (E)

268 ing the synthesis, we isolated an unexpected cyclopropane that presumably stems from a carbonium ion

269 o- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to prov

270 In the case of cyclopropane, the CC framework shielding pattern implies

271 least substituted carbon-carbon bond of the cyclopropane to form a platinacyclobutane intermediate.

272 vided by their dimerization/combination with cyclopropane to form a six-membered ring reference compo

273 at the CBS-Q level by their combination with cyclopropane to produce a six-member ring reference comp

274 rmal [3 + 2]-cycloaddition of donor-acceptor cyclopropanes to 1,3-dienes.

275 pecifically, upon exposure of donor-acceptor cyclopropanes to alcohols in the presence of a cyclometa

276 c C-C-bond activation of electron-poor vinyl cyclopropanes to generate synthetically useful a1,a3,d5-

277 he presence of Fe(CO)5 converted the alkenyl cyclopropanes to the 2-substituted cyclohexenones.

278 Theoretical investigation of cyclopropane-to-cyclopropane rearrangements of sterols i

279 ic Rh(I)-catalyst systems, amino-substituted cyclopropanes undergo carbonylative cycloaddition with t

280 The choice of N-substituent on the cyclopropane unit controls the oxidation level of the pr

281 ene (1) by the single bond in the endo-fused cyclopropane unit of carbene 3 led to similar outcomes.

282 a general strategy for the 1,3-oxidation of cyclopropanes using aryl iodine(I-III) catalysis, with e

283 eta-unsaturated imines or alpha-(iminomethyl)cyclopropanes via a Ti(II)/Ti(IV) redox cycle.

284 ocol toward amino-substituted donor-acceptor cyclopropanes via the formal nucleophilic displacement i

285 organocatalyst-promoted ring opening of the cyclopropanes, whereas such reactions have been intensiv

286 y selective construction of poly-substituted cyclopropanes which can be transformed into acyclic deri

287 generation catalyst) gives the corresponding cyclopropane with an enantiomeric ratio of 70/30 and, th

288 exclusively obtained in yield of 51-99% when cyclopropanes with a 2-substituted alkenyl group as a do

289 for the [4 + 2] annulation of donor-acceptor cyclopropanes with acetylenes under the effect of anhydr

290 nulations of malonate-derived donor-acceptor cyclopropanes with aldehydes are unusually broad in scop

291 ranones, based on reaction of donor-acceptor cyclopropanes with dienes, has been developed.

292 arbenes, which react with olefins to produce cyclopropanes with excellent diastereo- and enantioselec

293 able of providing access to 1-carboxy-2-aryl-cyclopropanes with high trans-(1R,2R) selectivity and ca

294 romide ion, and halogenation of intermediate cyclopropanes with N-bromo- or N-iodosuccinimide.

295 opane-1,1-diesters as well as donor-acceptor cyclopropanes with other types of electron-withdrawing a

296 egioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH reductive system was deve

297 pwise 1,3-dipolar cycloadditions with 3) and cyclopropanes (with 4 and 5), respectively.

298 drocarbons (including methane, isobutene and cyclopropane) with Ph(2)SiH(2) via sigma-bond metathesis

299 ubstrate spiro[bicyclo[2.2.1]hept-2-ene-7,1'-cyclopropane] with Pt(II) catalysts such as (Me2bpy)PtPh

300 related N chelates afford comparatively low cyclopropane yields (</=20 %).