ライフサイエンスコーパス: cyclopropene

1 an in situ generated azomethine ylide onto a cyclopropene.

2 ers containing both an alkyl diazirine and a cyclopropene.

3 und to dirhodium to produce a donor-acceptor cyclopropene.

4 substituted isatins, alpha-amino acids, and cyclopropenes.

5 e aromaticities and antiaromaticities of the cyclopropenes.

6 syn from adducts formed from reactions with cyclopropenes.

7 ion of nitrile imines with 3,3-disubstituted cyclopropenes.

8 ed from two Pauson-Khand reactions of chiral cyclopropenes.

9 oxaldehydes from readily available prochiral cyclopropenes.

10 egioselectivity in Pauson-Khand reactions of cyclopropenes.

11 azoacetate and terminal acetylenes to chiral cyclopropenes.

12 opropenone or 2,3-bis(2,3,4-trimethoxyphenyl)cyclopropene-1-thione with oxalyl bromide results in the

13 cloaddition between two unstable components, cyclopropene 10 and cyclopentadiene 11.

14 The high strain energy of cyclopropene (54.1 kcal/ mol) is attributed largely to a

15 n both the gas phase and acetonitrile, :CCl2-cyclopropene addition follows an asymmetric, non-least-m

16 a vinylcarbene (in addition to the expected cyclopropene), additional calculations and preliminary e

17 /6-31G*) to yield the expected corresponding cyclopropene adducts.

18 Subsequent hydrolysis of selected cyclopropenes afforded the corresponding cyclopropenones

19 We just click: Genetic incorporation of a cyclopropene amino acid CpK (see scheme) site-specifical

20 ence of both the trimethylsilyl group on the cyclopropene and the platinum catalyst are crucial for t

21 1,3]-electrocyclizations to produce reactive cyclopropenes and furans, and these are capable of furth

22 The cycloadditions of tetrazines with cyclopropenes and other strained alkenes have become amo

23 -fold) when reacted with dienophiles such as cyclopropenes and trans-cyclooctenes, and we demonstrate

24 -substituted cyclopentadienes, 3-substituted cyclopropenes, and 7-substituted cycloheptatrienes have

25 es and for 6 halogen-substituted butadienes, cyclopropenes, and a cyclobutene.

26 eaction of tetrazines with 1,3-disubstituted cyclopropenes, and the 1,3-dipolar cycloaddition of nitr

27 [1,3] hydrogen shifts in cyclopropenes are very difficult, passing through transi

28 to measure the acidity of 3-(4-methylphenyl)cyclopropene at the allylic position (delta H(o)acid = 3

29 )][BF(4)] (5) and eta(2)-1-metalla(methylene)cyclopropene complex [C(5)Me(5)(CO)(2)Re(eta(2)-PhC-C=CH

30 (3)-propargyl and eta(2)-1-metalla(methylene)cyclopropene complexes is very rapid and results in coal

31 tically encoded incorporation of alkyne- and cyclopropene-containing amino acids at distinct sites in

32 nly slightly higher for the strained alkenes cyclopropene (DeltaE++ = 14.5 kcal/mol) and cyclobutene

33 Although the cyclopropene derivatives are unusually stable, they are

34 e synthesized from enantiomerically enriched cyclopropene derivatives with >99% stereotransfer and go

35 talyzed addition of diorganozinc reagents to cyclopropene derivatives.

36 pi-donor ability of the substituents on the cyclopropene double bond (C1 and C2).

37 stabilization of the transition state by the cyclopropene double bond.

38 The substituents on cyclopropenes effectively inhibited homoaddition and pre

39 Cyclopropene exhibited fast reaction kinetics in the pho

40 ts CPA-FAs are usually minor components with cyclopropene fatty acids (CPE-FAs) more abundant.

41 y [3+2]-cycloaddition between donor-acceptor cyclopropenes generated from enoldiazoacetamides and car

42 -cycloadditions (n = 3, 4) by donor-acceptor cyclopropenes generated in situ from enoldiazo compounds

43 ng quenched fluorophore-tetrazine and methyl-cyclopropene groups that rapidly react by bioorthogonal

44 bimetallic species (ditins and silyltins) to cyclopropenes has been developed.

45 A key mechanistic intermediate, a ring-fused cyclopropene, has been isolated and characterized.

46 ring-opening regioselectivity of substituted cyclopropenes in the presence of gold(I) catalysts.

47 30(+/-8)% methylacetylene, and less than 10% cyclopropene, in agreement with previous RRKM results.

48 well as the involvement of an in situ formed cyclopropene intermediate in gold catalysis.

49 ase-assisted dehydrohalogenation producing a cyclopropene intermediate, which subsequently undergoes

50 elling evidence against mechanisms involving cyclopropene intermediates.

51 that the addition across the double bond of cyclopropene is generally controlled by steric factors a

52 The donor-acceptor cyclopropene is in equilibrium with the dirhodium-bound

53 that the addition across the double bond of cyclopropenes is generally controlled by steric factors

54 mation of the SEs of a series of substituted cyclopropenes is provided by their dimerization/combinat

55 protein) via a rapid, copper-free, tetrazine-cyclopropene ligation reaction (k2 > 5 M(-1) s(-1)).

56 y, yielding the transient unsaturated eta(2)-cyclopropene/metallabicyclobutane intermediate [Tp(Me2)N

57 nation reflects thermodynamically controlled cyclopropene-methylenecyclopropene rearrangement.

58 lso for double and triple labeling using the cyclopropene-modified 2'-deoxyuridine triphosphate.

59 triphosphates with tetrazines and one with a cyclopropene moiety were designed for Diels-Alder reacti

60 henols, and thioacids with 3,3-disubstituted cyclopropenes occur in a regioselective and chemoselecti

61 The cyclopropene-oligonucleotide conjugate could be successf

62 lar cyclopropenation reaction to produce the cyclopropene product (3), and undergoes intersystem cros

63 ne (B3LYP/6-31G*) shows the formation of the cyclopropene product and also possible formation of a vi

64 l, the vinylcarbene easily rearranges to the cyclopropene product, or to an exocyclic vinyl bicyclo[3

65 ective copper-catalyzed carbomagnesiation of cyclopropenes, reaction with acylsilanes, and addition o

66 g a useful predictive model for gold-induced cyclopropene ring-opening.

67 Spirocyclic xanthene-cyclopropene scaffolds were obtained.

68 A variety of substituted cyclopropene scaffolds were synthesized and found to be

69 rans-cyclooctene (TCO) and 1,3-disubstituted cyclopropene, Sph exhibits balanced reactivity and stabi

70 The effect of cyclopropene substituents on the rate of conversion is e

71 l stages with diverse chemistries, including cyclopropene-tetrazine inverse electron demand Diels-Ald

72 Unlike other cyclopropenes that bear a single substitutent at C-3, th

73 erics, we developed a class of disubstituted cyclopropenes that selectively underwent single monomer

74 We describe here a new chemical reporter-cyclopropene-that can be used to target biomolecules in

75 aryne precursor led to ring cleavage of the cyclopropene to afford an unprecedented xanthylium salt.

76 the ring size of cycloalkenes increases from cyclopropene to cyclohexene, resulting in an increase in

77 es of cycloalkenes, from the highly strained cyclopropene to the unstrained cyclohexene, have been st

78 eo- and enantioselective desymmetrization of cyclopropenes to afford nonracemic cyclopropylboronates

79 lyzed hydro-, sila-, and stannastannation of cyclopropenes to give multisubstituted cyclopropylstanna

80 n-metal-catalyzed rearrangement of silylated cyclopropenes to the corresponding allenes is described.

81 Furthermore, some of the cyclopropene units were metabolically introduced into ce

82 Remarkably, the cyclopropenes used in these transformations differ by th

83 eo- and enantioselective hydroformylation of cyclopropenes was demonstrated.

84 ydrostannation reaction of 3,3-disubstituted cyclopropenes was demonstrated.

85 tion of dichlorocarbene to 1,2-disubstituted cyclopropenes were calculated using hybrid density funct

86 The cyclopropenes were converted into alkynylcyclopropenyliu

87 Interestingly, disubstituted cyclopropenes were found to present zero-order kinetics,

88 ent access to a variety of 1-(silyloxymethyl)cyclopropenes, which are not easily available via tradit

89 The small size and selective reactivity of cyclopropenes will facilitate efforts to tag diverse col

90 review of copper mediated carbometalation of cyclopropenes will follow.

91 ral oxa- and azabicycles, cyclobutenes and a cyclopropene with an alkyl- or aryl-substituted enol eth

92 cycloaddition by uncatalyzed reaction of the cyclopropene with isoquinolinium or pyridinium methylide

93 he context of the ring-opening metathesis of cyclopropenes with aldehydes using a simple hydrazine ca

94 in the Diels-Alder reactions of substituted cyclopropenes with butadiene were explored with M06-2X d

95 atalyzed carbozincation of 3,3-disubstituted cyclopropenes with diorganozinc reagents.

96 is a Cu-catalyzed directed carbozincation of cyclopropenes with organozinc reagents prepared by I/Mg/

97 ons of the cycloalkenes, cyclohexene through cyclopropene, with a series of dienes--1,3-dimethoxybuta

98 The key features of our cyclopropenes, with their unique C-1 linkage to BRD-4-ta