ライフサイエンスコーパス: cyclopropyl

1 clusive migration of the boracycle (hexynyl, cyclopropyl).

2 = methyl, benzyl, t-butyl, 1-adamantyl, and cyclopropyl.

3 f the previously reported full agonist 1-(5- cyclopropyl-1,2,4-oxadiazol-3-yl)-12,12a-dihydroimidazo[

4 e carbonyl group of the partial agonist 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-[(dimethylamino)carb

5 l inhibitors, which are represented by N-[(5-cyclopropyl-1,2-oxazol-3-yl)methyl]adamantan-1-amine (WJ

6 clopropyl trimethylsilylmethyl ketone gave 1-cyclopropyl-1-trimethylsilylethylene, a product of exclu

7 , enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole has the (1S,2S) absolute confi

8 , enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole with the absolute configuratio

9 Treatment of the 6-N-cyclopropyl-2',3'-di-O-isopropylideneadenosine 5'-aldehy

10 luation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-me

11 ous effectors and the allosteric activator 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyr

12 -cGMP or the NO-independent sGC stimulator 5-cyclopropyl-2[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b] pyr

13 is of the corresponding chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-benzothiadiazine 1,1-dioxides

14 In addition, TTA-Q4 [(S)-4-(6-chloro-4-cyclopropyl-3-(2,2-difluoroethyl)-2-oxo-1,2,3,4-tetrahyd

15 enamide, and beta-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to

16 analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and beta-m

17 ibitor properties of several 1-methyl- and 1-cyclopropyl-4-aryl-1,2,3,6-tetrahydropyridine derivative

18 n to being an inhibitor, the corresponding 1-cyclopropyl-4-benzyl-1,2,3,6-tetrahydropyridine species

19 cterization of LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxo

20 ) potentiator, LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxo

21 Previous studies have established that 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine is an ef

22 arboxyphenylglycine (MCPG) and/or (RS)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) (group III a

23 eceptor (mGluR) II/III antagonist (RS)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) and by the b

24 ade of group III mGluRs with 300 microM (RS)-cyclopropyl-4-phosphonophenylglycine (CPPG) facilitated

25 h the mGluR6 receptor antagonist (R,S)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG).

26 he agonist with the mGluR6 antagonist (RS)-a-cyclopropyl-4-phosphonophenylglycine (CPPG).

27 The group III mGluR antagonist (R,S)-cyclopropyl-4-phosphonophenylglycine (CPPG, 300 microm)

28 tropic glutamate receptor antagonist (R,S)-a-cyclopropyl-4-phosphonophenylglycine had no effect on th

29 etabotropic glutamate antagonist, (RS)-alpha-cyclopropyl-4-phosphonophenylyglycine (CPPG), blocked li

30 An mGluR antagonist, (RS)-alpha-cyclopropyl-4-phosphonophenylyglycine (CPPG), blocked th

31 inolone 6, 8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4-quinolone-3-carboxyli c acid, but not to e

32 ters and cytotoxic agents with (12R,13S,15S)-cyclopropyl 5-methylpyridine epothilone A (11) as the mo

33 quent iodo- or protiodestannylation gave 6-N-cyclopropyl-5'-deoxy-5'-(iodomethylene)adenosine 8b or i

34 desirable in vitro biological profile was 9-cyclopropyl-6-fluoro-8-methoxy-7-(2-methylpyridin-4-yl)-

35 riment), the most potent compound was 11m (4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-1,2,4-be

36 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazi

37 4-cyclopropyl-7-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiaz

38 to readily react with various donor-acceptor cyclopropyl acid chlorides, with complete regioselectivi

39 sponding alpha-silylcyclopentenols or (alpha-cyclopropyl)acylsilanes favor the [1,4]-pathway by ortho

40 he formation of two more CC bonds, affording cyclopropyl alcohol boronate esters with three new stere

41 intermediates in the synthesis of versatile cyclopropyl alcohol boronate esters, which are valuable

42 s enable the synthesis of a diverse array of cyclopropyl alcohol building blocks with high enantio- a

43 ve methods for the synthesis of a variety of cyclopropyl alcohols are reported.

44 disubstituted cyclopropyl alcohols, and anti-cyclopropyl alcohols from achiral precursors.

45 lopropanation provides syn-cis-disubstituted cyclopropyl alcohols in 42-70% yield, 88-97% ee, and > 1

46 Workup with TBAF affords the anti-cyclopropyl alcohols in one pot in 60-82% yield, 89-99%

47 ith allyl bromides to generate the allylated cyclopropyl alcohols without loss of enantio- or diaster

48 cyclopropyl alcohols, syn-cis-disubstituted cyclopropyl alcohols, and anti-cyclopropyl alcohols from

49 In the synthesis of vinyl cyclopropyl alcohols, hydroboration of enynes is followe

50 For the synthesis of cis-disubstituted cyclopropyl alcohols, in situ generated (Z)-vinyl zinc r

51 nt the first one-pot approaches to syn-vinyl cyclopropyl alcohols, syn-cis-disubstituted cyclopropyl

52 Because direct cyclopropanation provides syn-cyclopropyl alcohols, the intermediate allylic alkoxides

53 lkoxide-directed cyclopropanation to provide cyclopropyl alcohols.

54 to in situ cyclopropanation to furnish vinyl cyclopropyl alcohols.

55 In an alternate pathway, the cyclopropyl aldehyde acts as a mechanism-based irreversi

56 When reacted with cAD, the cyclopropyl aldehyde produces 1-octadecene as the rearra

57 ols, such as 2-methylcyclopropylmethanol, to cyclopropyl aldehydes using tert-butyl hydroperoxide as

58 This reaction forms 1-cyclopropyl alkylamine derivatives in high yield and wit

59 amolecular Pd-catalyzed functionalization of cyclopropyl alpha-amino acid-derived benzamides proceeds

60 -Alder reaction of highly reactive beta,beta-cyclopropyl-alpha,beta-unstaturated N-acyloxazolidinones

61 onoamine oxidase, namely, phenylhydrazine, N-cyclopropyl-alpha-methylbenzylamine, and 1-phenylcyclopr

62 In the case of N-cyclopropyl-alpha-methylbenzylamine, masses correspondin

63 nylhydrazine was 10 times more potent than N-cyclopropyl-alpha-methylbenzylamine, which was much more

64 vior was also observed for other secondary N-cyclopropyl amides.

65 During the biosynthesis of the cyclopropyl amino acid coronamic acid from l-allo-Ile by

66 sequent steps in the formation of this novel cyclopropyl amino acid.

67 The cyclopropyl amino acids derived from ketones proved to b

68 Cyclopropyl analogue 4 was identified as a CYP11B1 inhib

69 -we postulated that the corresponding carba "cyclopropyl" analogue would be a potent retaining beta-g

70 with DENSPM and (2R,10R)-(HO)(2)DENSPM, both cyclopropyl analogues diminished ornithine decarboxylase

71 yclic replacements of the thiazoline ring or cyclopropyl analogues of the core diene segment.

72 The cyclopropyl analogues were alternative substrates.

73 6)-(2,5-dichlorobenzyl) and N(6)-(2-phenyl-1-cyclopropyl) analogues 20 and 33 (1000), and the N(6)-(3

74 es also confirmed the importance of both the cyclopropyl and 5-methylpyridine moieties in conferring

75 is, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, F

76 To probe the mechanism of the reaction, cyclopropyl and epoxy substrate analogues, designed to b

77 In both structures the alkyl substituents, cyclopropyl and isopropyl, are found to be orientated aw

78 Content of cyclopropyl and omega-cyclohexyl fatty acids of microbia

79 The use of cyclopropyl and thioether substrates support the radical

80 Cyclopropyl and vinyl boronic acids undergo very slow pr

81 ted ionization (MAI), the mechanism by which cyclopropyl and vinylidene carbenoids react with nucleop

82 yl, 5-iodo-2-methoxybenzyl, trans-2-phenyl-1-cyclopropyl, and 2,2-diphenylethyl.

83 Contributions from saturated, unsaturated, cyclopropyl, and branched bacterial fatty acids to the d

84 ings have been developed with both potassium cyclopropyl- and alkoxymethyltrifluoroborates.

85 Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl ch

86 chanisms of these HppE-catalyzed oxidations, cyclopropyl- and methylenecyclopropyl-containing compoun

87 n, and Wayner, the radical anions of several cyclopropyl- and oxiranyl-containing carbonyl compounds

88 ing of a wide variety of aryl-, heteroaryl-, cyclopropyl-, and vinylboronic acids with high selectivi

89 ichiometric amounts of zinc bromide produces cyclopropyl arenes in good to excellent yields.

90 macrolactone, the sugar callipeltose, and a cyclopropyl bearing chain.

91 trans-Cyclopropyl beta-amino acid derivatives can be synthesiz

92 al cyclopropane derivatives, including alpha-cyclopropyl-beta-amino acids.

93 rgo asymmetric, intramolecular silylation of cyclopropyl C-H bonds in high yields and with high enant

94 antioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-pro

95 50) = 0.19 +/- 0.03 nM) > 4-{3-[6-amino-9-(5-cyclopropyl-carbamoyl-3,4-dihydroxytetrahydrofuran-2-yl

96 ng the delocalized C2-C1-O system in the key cyclopropyl-carbene intermediate, which is enhanced by t

97 bene character as compared with that of free cyclopropyl carbenes.

98 used cyclohexa-1,3-dienes upon acid-promoted cyclopropyl carbinol ring opening.

99 zed ring-opening cyclization of (hetero)aryl cyclopropyl carbinols to form alpha-alkylidene-gamma-but

100 arbinol substituents determine the extent of cyclopropyl carbinyl cation formation.

101 TfOH then catalyzes the formation of cyclopropyl carbinyl cations, which undergo ring opening

102 ive charge located in the same region as the cyclopropyl carbinyl group; that S-thiolo-diphosphates o

103 The cyclopropyl carbinyl intermediate of the stepwise pathwa

104 The stabilization of the cyclopropyl carbinyl radical cation by substituents corr

105 urface, whereas unstabilized or destabilized cyclopropyl carbinyl radical cations are not minima on t

106 halo-Mannich-type reaction is reported using cyclopropyl carbonyl-derived enolates and sulfonyl-prote

107 3-(6-[([1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl) amino]-3-methyl-2-pyridinyl)-benzo

108 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methy l-2-pyridinyl]-benzo

109 The adenosine A2 receptor agonist 5'-(N-cyclopropyl)-carboxamidoadenosine (1 microM), although c

110 The intermediate cyclopropyl cation undergoes substantial ring opening si

111 ay crystallographic studies which showed the cyclopropyl chain to adopt very differing conformations

112 Both cyclopropyl compounds reduced putrescine and spermidine

113 dicated that the (S)- and (R)-isomers of the cyclopropyl-containing analogues were efficiently conver

114 lithiation-borylation reaction to attach the cyclopropyl-containing side chain.

115 We describe the synthesis of two cyclopropyl-containing tripeptide analogues, delta-(l-al

116 h an excess of LiCu(n-Bu)(2) to generate the cyclopropyl cuprate.

117 ive bacteria, while C16:1, C16:0, C18:1, and cyclopropyl cyC17:0 and cyC19:0 were significant in Gram

118 either 1,25(OH)2D3,1,24-dihydroxy-22-ene-24-cyclopropyl D3 (analog BT) or 25-hydroxy-16-ene-23-yne-D

119 ft, whereas analog BT (1, 25-(OH)2-22-ene-24-cyclopropyl-D3), which binds to the vitamin D receptor w

120 aches: a diphenyl C60 alcohol (5) based on a cyclopropyl derivative of Bingel and a diisopropyl cyclo

121 um parvum infections in vivo compared to the cyclopropyl derivative, which in turn is superior to the

122 acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which

123 gn approach, hydroxamates derived from trans-cyclopropyl dicarboxylate were examined as potential TNF

124 ing a cyclopropyl ring, 14,15-epoxy-[9,10,11-cyclopropyl]-eicosa-5Z,7E,13E-trienoic acid.

125 It was found that only the beta-cyclopropyl enantiomer 2a, but not the alpha-enantiomer

126 Synthesis of both the (1R,2R)- and (1S, 2S)-cyclopropyl enantiomers of the most potent racemic compo

127 sis of alkyl, alkenyl, aryl, heteroaryl, and cyclopropyl ethers, mixed O,O-acetals, and S,S,O-orthoes

128 Cyclopropyl fatty acids (about 0.1% of milk fat) were de

129 ienski olefination reagents 1-fluoropropyl, (cyclopropyl)fluoromethyl, 1-fluoro-2-methyl-2-propenyl,

130 discovery was the rational substitution of N-cyclopropyl for N-methoxy in 1a, a previously reported c

131 obutanone DA adducts to synthetically useful cyclopropyl functional handles is described.

132 panation yielded a library of N-O containing cyclopropyl-fused bicyclic intermediates.

133 the potential of this methodology for making cyclopropyl-fused heterocycles.

134 ion of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase

135 We report a facile approach to a cyclopropyl-fused pyrrolidine, which contains four stere

136 Our previous studies showed that N-(cyclopropyl)glycine (CPG) acts as a mechanism-based inac

137 The present study demonstrates that N-(cyclopropyl)glycine (CPG) is a mechanism-based inhibitor

138 Reactions proceeding through cyclopropyl gold(I) carbene-like intermediates are ideal

139 lectrophilic species with a highly distorted cyclopropyl gold(I) carbene-like structure, which can re

140 takes place stepwise, first by formation of cyclopropyl gold(I) carbenes, followed by a ring expansi

141 The key intermediates are cyclopropyl gold(I) carbenes, which have been independen

142 han related radicals that do not contain the cyclopropyl group (e.g., k = 1.1 x 10(6) s(-1) in CH3CN

143 ne group of 7 or inclusion of an olefinic or cyclopropyl group also reduced potency.

144 ond in position Delta9, 10, or 11 and Delta9 cyclopropyl group can activate TRPV1 with efficacy simil

145 ther cycloalkyls, the sp(2) character of the cyclopropyl group can confer improved H-bonding characte

146 ed that enantiomer 2a with a 11 beta,12 beta-cyclopropyl group exists as two populations of diastereo

147 Both the selective cleavage of the cyclopropyl group from the aromatic amine nitrogen and n

148 N-nitrosoaniline by specific cleavage of the cyclopropyl group from the nitrogen.

149 erically defined analogues of 7 containing a cyclopropyl group in place of the branched carbon were l

150 t contains a unique moiety in which a chiral cyclopropyl group is flanked by triene and enal chromoph

151 this deficiency and identify the fate of the cyclopropyl group lost upon N-dealkylation, we have inve

152 ylation only; no loss or ring-opening of the cyclopropyl group occurred.

153 ty of 3 seems to be interactions between the cyclopropyl group of 3 and the backbone of Phe495 and Me

154 ntramolecular abstraction of a beta-H of the cyclopropyl group to form either methane or mesitylene f

155 Our studies show that the cyclopropyl group undergoes reversible general-acid/base

156 Potency was enhanced with a 9-cyclopropyl group, the duration of action was improved w

157 D using a fatty aldehyde that incorporates a cyclopropyl group, which can act as a radical clock.

158 uence trapping of nucleophiles by the A-ring cyclopropyl group.

159 efully consider the chirality of substituted cyclopropyl groups as radical reporting groups in studie

160 clude asymmetric substitution, olefinic, and cyclopropyl groups.

161 bstituent was in the order tert-butyl > or = cyclopropyl > 2,4-difluorophenyl > ethyl approximately c

162 electrophiles, except allylic, benzylic, and cyclopropyl halides where single-electron-transfer proce

163 ubfamily of these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydr

164 (1R,2R)-4-(2-(5,5-Dimethylhex-1-ynyl)cyclopropyl)imidazole (32) is one of the most potent his

165 nally, under peroxidatic conditions, 1a (R = cyclopropyl) inactivates HRP with concurrent formation o

166 conformational free energy landscape for the cyclopropyl inhibitors show a strong bias for the (4)H3

167 We demonstrate that tomato cyclopropyl isomerase (SlCPI), an enzyme involved in ste

168 Four new tetramines, the two cyclopropyl isomers, the trans-cyclobutyl isomer, and th

169 zed aldol addition reaction using a strained cyclopropyl ketenethioacetal, (2) an efficient enyne rin

170 ediated regioselective ring expansion of the cyclopropyl ketone.

171 te HBr reagents in ring-opening reactions of cyclopropyl ketones as well as of 2,2-difluorocyclopropy

172 symmetric [3 + 2] photocycloaddition of aryl cyclopropyl ketones that enables the enantiocontrolled c

173 Using SnCl4 as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cyclization to

174 In contrast, the cyclopropyl ketones underwent homoconjugate addition wit

175 his reaction, ortho-disubstituted phenyl and cyclopropyl ketones were recognized as crucial structura

176 heteroaromatic, alpha,beta-unsaturated, and cyclopropyl ketones, affording high reactivity (up to 1,

177 nnel that instead leads to the corresponding cyclopropyl ketones.

178 of the allylic diazoesters 16a-d to give the cyclopropyl lactones 17a-d in high enantiomeric excess.

179 ne carboxylic acid 22 and the diastereomeric cyclopropyl lactones 32a,b featured diastereoselective i

180 Cyclopropyl malonoyl peroxide (1), which can be prepared

181 ethyl series are observed with a series of N-cyclopropyl mechanism based inactivators.

182 Solvolysis of 1-(trimethylsilylmethyl)cyclopropyl mesylate in CD(3)CO(2)D gives ring-opened pr

183 n of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)iso indolin-1-one

184 ions, provides exclusively the corresponding cyclopropyl methyl ketones.

185 N9-propyl and N9-cyclopropyl methyl substitutions did not afford further

186 substitutions (Me, Et, (n)()Pr, (i)()Pr, and cyclopropyl methyl) at the oxime moiety are preferred fo

187 on-fluorination of n-propyl, 5-hexenyl, and (cyclopropyl)methyl PT-sulfones proceeded under homogeneo

188 lowed by analogues such as 7a, with an N-bis(cyclopropyl)methyl-N-propylamino side chain, and analogu

189 eceptor antagonist (NBI27914 [5-chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-tric

190 N1-ethyl-N11-[(cyclopropyl)methyl]-4,8,-diazaundecane (CPENSpm) is a po

191 e, the bromine was substituted to generate a cyclopropyl MIDA derivative.

192 the Ir(III)-tethered DNA assembly containing cyclopropyl-modified bases provides a unique model syste

193 Installation of a cyclopropyl moiety at either the 3,4- or 4,5-position of

194 The cyclopropyl moiety in (18)F-FCPHA does have a significan

195 This fatty acid, containing a cyclopropyl moiety in the beta,gamma-position, was desig

196 uggesting that the conjugative effect of the cyclopropyl moiety is minimal.

197 ered ether followed by addition of a further cyclopropyl moiety, affecting only one of the two bicycl

198 avine, a complex ergot alkaloid containing a cyclopropyl moiety.

199 of the chanoclavine-I intermediate to form a cyclopropyl moiety.

200 uption of and configurational changes in the cyclopropyl moiety; disruption, oxidation, and configura

201 ed the selective KCC2 inhibitor VU0463271 [N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyri

202 A group of N-cyclopropyl-N-alkylanilines has been synthesized, and th

203 Unexpectedly, N-benzyl-N-cyclopropyl-N-methylamine (4) was found not to inactivat

204 as been studied using the probe substrates N-cyclopropyl-N-methylaniline (2a) and N-(1'-methylcyclopr

205 Although the SET oxidation of N-cyclopropyl-N-methylaniline (3) by horseradish peroxidas

206 ion, we have investigated the oxidation of N-cyclopropyl-N-methylaniline (3) by horseradish peroxidas

207 a), and application of mechanistic probes (N-cyclopropyl-N-methylaniline (CMA) and (p-methoxyphenyl)-

208 like the hydroxylated DENSPM compounds, both cyclopropyl norspermines substantially upregulated sperm

209 n, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid methyl ester and bryostatin 1

210 oits the energetics of such an intermediate, cyclopropyl-p-benzoquinone (CPBQ) is shown to be a speci

211 In the present study, a series of N-alkyl-N-cyclopropyl-p-chloroaniline probes have been used to exa

212 ided that the ethyl group always prefers the cyclopropyl position as in 3a, the 1-ethyl-5-methylsemib

213 xidase leads exclusively to ring-opened (non-cyclopropyl) products, P450 oxidation of 3 leads to form

214 lactone reduction and cyclization, afforded cyclopropyl pyran 1.

215 oaddition reactions of the synthesized spiro-cyclopropyl pyrazolones with phenyl isothiocyanate and b

216 tolerated in this reaction including vinyl, cyclopropyl, pyridyl, aryl, benzyl, and nitro groups.

217 odent parasite Plasmodium chabaudi with seco-cyclopropyl pyrrolo indole analogs.

218 ld also be attenuated by treatment with seco-cyclopropyl pyrrolo indole analogs.

219 Discussed herein is cyclopropyl quinone methide formation from a pyrido[1,2-

220 [Chemical structure: see text] A cyclopropyl quinone methide is formed by elimination of

221 icted electron affinities show that only the cyclopropyl radical tends to bind electrons among the hy

222 e electrocyclic ring-opening reaction of the cyclopropyl radical.

223 f 1,5-enyne substrates revealed an uncovered cyclopropyl rearrangement that gives rise to [3,6,5,7] t

224 R affinity, and those larger or smaller than cyclopropyl reduced A(1)AR selectivity.

225 The cyclopropyl reporter group imparts a 35-fold acceleratio

226 Consequently, the cyclopropyl ring addresses multiple roadblocks that can

227 itor of AdoHcy hydrolase not modified with a cyclopropyl ring at 6-amino group, also inhibited T. bru

228 gical chlorination is a cryptic strategy for cyclopropyl ring formation.

229 m ion formed by SET oxidation of 3 undergoes cyclopropyl ring fragmentation exclusively to generate a

230 enzyme, CmaC, catalyses the formation of the cyclopropyl ring from the gamma-Cl-l-allo-isoleucine pro

231 substituent derived from the cleavage of the cyclopropyl ring in CPG.

232 tly, there has been an increasing use of the cyclopropyl ring in drug development to transition drug

233 onformationally restricted structures have a cyclopropyl ring in the interfacial region of the phosph

234 formed in the photolysis via opening of the cyclopropyl ring is 2-methyl-5-isopropylcyclopent-2-enon

235 e little-known chiroptical contribution of a cyclopropyl ring linked to polyene systems.

236 eview will focus on the contributions that a cyclopropyl ring makes to the properties of drugs contai

237 The inner cyclopropyl ring of 3 was assembled with trans geometry

238 ark apparatus, where the aldol condensation, cyclopropyl ring opening followed by cyclization took pl

239 ument the presence of general-acid-catalyzed cyclopropyl ring opening near neutrality and to assess t

240 This step is followed by rapid cyclopropyl ring opening to produce an iminium ion with

241 p undergoes C2 methylation in the absence of cyclopropyl ring opening, disfavoring mechanisms that in

242 hed ene and Diels-Alder products without any cyclopropyl ring opening, that of 3 carrying the ultrafa

243 radical clock afforded products derived from cyclopropyl ring opening.

244 arrangement of bicyclo-beta-ketoester having cyclopropyl ring to access fused tricyclic gamma-butyrol

245 m hydrolysis of a novel epoxide containing a cyclopropyl ring, 14,15-epoxy-[9,10,11-cyclopropyl]-eico

246 t on the rate of nucleophile trapping by the cyclopropyl ring.

247 the enamine and the sigma*C-C orbital of the cyclopropyl ring.

248 the effect of substituents at both aryl and cyclopropyl rings.

249 ent conditions of 0.049 microM while the N-6-cyclopropyl-Sal-AMS 16 led to improved potency and to a

250 activity from the opposite enantiomer of the cyclopropyl scaffolds, which display almost superimposab

251 ew class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted benzene

252 esulted in cyclopropanation to form the anti-cyclopropyl silyl ether.

253 l-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available al

254 utational studies (B3LYP/6-31G) suggest that cyclopropyl stabilization of carbenes is more effective

255 cycloisomerase (EC ) to convert pentacyclic cyclopropyl sterols to conventional tetracyclic sterols.

256 studies and elucidating the in vivo roles of cyclopropyl sterols.

257 ogy model characterized distinct hydrophobic cyclopropyl subpockets, the larger "A" forming contacts

258 a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position.

259 ength of the straps connecting adjacent meso-cyclopropyl substituents decreases (the opposite of the

260 The resulting cyclopropyl substituted allenes derived from acyloxy mig

261 of highly functionalized cyclohexenones from cyclopropyl substituted propargyl esters.

262 The cyclopropyl-substituted alkynylcarbene complex Cp(CO)(2)

263 This is a general phenomenon and a number of cyclopropyl-substituted benzophenones, including 4-(endo

264 nthesis and biological evaluation of novel 4-cyclopropyl-substituted pyridothiadiazine dioxides was p

265 adical was observed, but, unlike other alpha-cyclopropyl-substituted radicals, this showed no propens

266 yl moiety of 6 and (2) hydroxyl, acetyl, and cyclopropyl substitutions on the butylamide linking chai

267 A cyclopropyl substrate analogue inactivates both enzymes

268 nes, and nitriles, forming the corresponding cyclopropyl sulfones under mild conditions in high yield

269 r 4 h gives a variety of (enantiopure) trans-cyclopropyl sulfones with high diastereoselectivity.

270 ugh a gold(I)-catalyzed alkoxycyclization of cyclopropyl-tethered 1,6-enynes.

271 ium salt of the tosylhydrazone derivative of cyclopropyl trimethylsilylmethyl ketone gave 1-cycloprop

272 We also showed that beta-cyclopropyl-Trp undergoes C2 methylation in the absence

273 that conformational strain induced through a cyclopropyl unit may add to the armory of tight-binding

274 derived from carbonylative C-C activation of cyclopropyl ureas can be "captured" by pendant nucleophi

275 The order of stability of the cyclopropyl-X radicals was calculated to be X = CH2 >> X

276 The relative rate of ring opening for cyclopropyl-X radicals X = CH2 to X = O was calculated t