ライフサイエンスコーパス: cyclops

1 tants for the nodal-related genes squint and cyclops.

2 ase A rescues the phenotypes associated with cyclops.

3 mozygotes displays axial defects and reduced cyclops and mesodermal gene expression, and penetrance o

4 down embryos displayed reduced expression of cyclops and mesodermal genes, axial defects similar to N

5 2 are expressed in the left heart field; and cyclops and pitx2 are expressed in the left gut primordi

6 thway leads to zebrafish endoderm formation: Cyclops and Squint activate receptors such as TARAM-A; O

7 e also show that the Nodal-related molecules Cyclops and Squint and the transmembrane protein Oep are

8 ndoderm formation requires the Nodal signals Cyclops and Squint and their cofactor One-eyed pinhead (

9 The nodal-related genes cyclops and squint are expressed at the blastoderm margi

10 First, overexpression of cyclops and squint at different doses leads to the induc

11 that Bon functions exclusively downstream of cyclops and squint signaling.

12 Here we test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth

13 pression patterns of the nodal-related genes cyclops and squint.

14 In sum, these data show the power of CYCLOPS and temporal reconstruction in bridging basic ci

15 ator of symbiotic (transmitted via CCaMK and CYCLOPS) and hormonal (gibberellin) signals.

16 expression, including the Nodal-related gene cyclops, and body axis dorsalization.

17 is analysis places RAM1 downstream of CCaMK, CYCLOPS, and DELLA because ectopic expression of RAM1 re

18 ed in the early zebrafish embryo, squint and cyclops; antiSOX3c-injection leads to an increase in the

19 zebrafish Nodal-related proteins Squint and Cyclops are required in the YSL for endoderm and head me

20 se genes, and a second nodal-related factor, cyclops, are also expressed in the overlying marginal bl

21 The cyclops b16 mutation deletes ventral midline cells in th

22 Functional promoter studies revealed that CYCLOPS binds in a sequence-specific manner to a motif w

23 Whereas different levels of both Squint and Cyclops can induce different downstream genes, we find t

24 onclude that the activation of ERN1 by CCaMK/CYCLOPS complex is an important step controlling IT-medi

25 These CYCLOPS (copy number alterations yielding cancer liabili

26 copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabili

27 In the zebrafish mutant cyclops (Cyc(b16)), most embryos have two partial retina

28 wo Nodal-related proteins - Squint (Sqt) and Cyclops (Cyc) - are expressed during germ-layer specific

29 brafish nodal-related genes squint (sqt) and cyclops (cyc) [3] [4] [5], dorsal marginal cells adopt n

30 activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterni

31 e report that the zebrafish squint (sqt) and cyclops (cyc) genes have essential, although partly redu

32 Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal

33 loating head (flh, a Not homeobox gene), and cyclops (cyc) play direct and essential roles in the dev

34 ion is present in one-eyed pinhead (oep) and cyclops (cyc) zebrafish mutants, the pattern is altered.

35 acterized three gamma-ray induced alleles of cyclops (cyc), a gene required for development of midlin

36 ng boz, sqt and a second nodal-related gene, cyclops (cyc).

37 In cyclops (cyc-) mutants, which develop with a partial def

38 A cyclops-dependent midline domain, associated with the pr

39 However, in squint;cyclops double mutants, which lack Nodal function and po

40 cyclops embryos showed essentially normal Lim3 expressio

41 From this structure, CYCLOPS estimates the phase of each sample.

42 autoregulation, whereas other factors induce cyclops expression in ventrolateral cells.

43 ced Foxd3 function results in a reduction of cyclops expression, and subsequent mesodermal and axial

44 jection leads to an increase in the level of cyclops expression.

45 cts left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm.

46 oderm require different levels of squint and cyclops function.

47 We validated SF3B1 as a CYCLOPS gene and found that human cancer cells harboring

48 Wild-type cyclops gene function is required for these morphogeneti

49 Differential regulation of the cyclops gene in these cells contributes to the different

50 One CYCLOPS gene, PSMC2, encodes an essential member of the

51 f a point source of Nodal ligands Squint and Cyclops in a non-cell autonomous manner.

52 lso investigate the potential involvement of cyclops in the hh signaling pathway and conclude that al

53 on in the symbiosis signaling pathway mutant cyclops/ipd3, indicating an intersection between DELLA a

54 tivity range of the short-range Nodal signal Cyclops is not regulated by Lefty activity.

55 such as sonic hedgehog and one-eyed-pinhead, cyclops is required for ventral midline patterning of th

56 tx2, ectopic pitx2c in other regions induces cyclops, lefty2 and goosecoid expression.

57 itx2 are expressed in the left diencephalon; cyclops, lefty2 and pitx2 are expressed in the left hear

58 embryos, L-R asymmetric expression of Nodal/cyclops, Lefty2/antivin, and Pitx2 does not occur in the

59 Here, we report that the cyclops locus encodes the nodal-related protein Ndr2, a

60 he brain, including the previously described cyclops locus.

61 In embryos lacking both squint and cyclops, members of the nodal group of TGF-beta related

62 We conclude that these observations in the cyclops mutant are compatible with mechanisms of pattern

63 signaling pathway and conclude that although cyclops mutant cells can respond to hh signaling, neithe

64 m3 expression in no tail, floating head, and cyclops mutant embryos, all of which have midline defect

65 sion of RAM1 restores arbuscule formation in cyclops mutants and in the presence of suppressive gibbe

66 y the Nodal pathway, behave normal in squint;cyclops mutants but exhibit defective motility in one-ey

67 f dorsal mesendoderm induction in squint and cyclops mutants suggests that dorsal marginal cells can

68 omite and optic stalk defects in no tail and cyclops mutants that lack midline structures that normal

69 In cyclops mutants, corresponding cells failed to move ante

70 The cyclops mutation leads to a loss of medial floor plate a

71 e downstream transcription factors including CYCLOPS, NIN, and ERN1 were not required for this respon

72 of pitx2c midline expression is dependent on cyclops (nodal) and schmalspur, but not no tail (brachyu

73 cyclops (nodal), lefty1 and pitx2 are expressed in the l

74 nes implicated in laterality of the viscera (cyclops/nodal, antivin/lefty and pitx2) are coexpressed

75 in oep eliminate the response to Squint and Cyclops overexpression but are suppressed by expression

76 on in the initiation codon and rescue of the cyclops phenotype by expression of ndr2 RNA, here rename

77 ygotes or hypomorphic alleles) results in a 'cyclops' phenotype, where mid-dorsal head epidermis is t

78 ided expression domains of downstream genes (cyclops, pitx2, lefty1 and lefty2) are severely downregu

79 In contrast, while Znr1/Cyclops reproducibly induces mesodermal and neural marke

80 Dorsal expression of cyclops requires Nodal-dependent autoregulation, whereas

81 ntified zebrafish nodal-related factor, Znr1/Cyclops, reveals distinct inductive properties of each l

82 echnologies Group AQUAtracka, Turner Designs Cyclops, Satlantic SUNA and WET Labs, Inc.

83 sis demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm pat

84 ch as those mutated in the zebrafish mutants cyclops, squint and one-eyed pinhead (oep), cause HPE.

85 deficient embryos (Antivin overexpressing or cyclops;squint double mutants), which show extensive AP

86 ted with reduced wnt8 expression, as seen in cyclops;squint mutants.

87 ype by expression of ndr2 RNA, here renamed "cyclops." Thus, in interaction with other molecules impl

88 hat activates RAM1 expression via binding of CYCLOPS to a cis element in the RAM1 promoter.

89 wo zebrafish nodal-related genes, squint and cyclops, to manipulate genetically the levels and timing

90 in reduction is suppressed in bozozok;squint;cyclops triple mutants, and is associated with reduced w

91 ithm, cyclic ordering by periodic structure (CYCLOPS), uses evolutionary conservation and machine lea

92 We validated CYCLOPS using temporally ordered mouse and human data an