ライフサイエンスコーパス: cyclosome

1 activation of the anaphase-promoting complex/cyclosome.

2 ndependent of the anaphase-promoting complex/cyclosome.

3 C5 subunit of the anaphase promoting complex/cyclosome.

4 activation of the anaphase-promoting complex/cyclosome.

5 ll to inhibit the anaphase-promoting complex/cyclosome.

6 inhibition of the anaphase-promoting complex/cyclosome.

7 ubiquitin to the anaphase-promoting complex/cyclosome.

8 regulators by the anaphase-promoting complex/cyclosome.

9 ents of the anaphase-promoting complex (APC)/cyclosome.

10 inhibition of the anaphase-promoting complex/cyclosome.

11 t shown in other systems to regulate the APC cyclosome.

12 C2 subunit of the anaphase promoting complex/cyclosome.

13 the fission yeast anaphase promoting complex/cyclosome.

14 inhibition of the anaphase-promoting complex/cyclosome.

15 ubiquitin ligase anaphase-promoting complex/cyclosome.

16 radation by anaphase-promoting complex (APC)/cyclosome, a multisubunit ubiquitin ligase.

17 Apc10 does not co-sediment with the 20S APC-cyclosome, a ubiquitin ligase for B-type cyclins, and in

18 inhibitor of the anaphase-promoting complex/cyclosome, a ubiquitin ligase required for anaphase onse

19 trol is the anaphase-promoting complex (APC)/cyclosome, a ubiquitin ligase whose activation by Cdc20

20 ich Bruno and the anaphase-promoting complex/cyclosome act together to restrict the accumulation of t

21 ion by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly aft

22 ) inhibits APC/C (anaphase-promoting complex/cyclosome) activity during S and G2 phases, and is belie

23 activation of the anaphase-promoting complex/cyclosome also requires an intact polo box.

24 uitin ligase, the anaphase-promoting complex/cyclosome, also targets cyclin B1, thereby causing inact

25 of Cdc25p by the anaphase-promoting complex/cyclosome, an E3 ubiquitin ligase.

26 pathway, and it involves the activity of the cyclosome/anaphase promoting complex (APC).

27 Finally, hBUBR1 was associated with the cyclosome/anaphase-promoting complex (APC) in mitoticall

28 The anaphase promoting complex/cyclosome and its activator Cdh1 (APC/C(Cdh1)) restrains

29 gase APC/C(Cdh1) (anaphase-promoting complex/cyclosome and its activator Cdh1).

30 APC/C(Cdc20) (the anaphase-promoting complex/cyclosome and its coactivator Cdc20, a large ubiquitin l

31 the APC/C(Cdh1) (anaphase-promoting complex/cyclosome and its coactivator Cdh1) E3 ubiquitin ligase

32 eraction with the anaphase promoting complex/cyclosome and the disposition of a putative destruction

33 tin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20 (cell division cycl

34 inhibitor of the anaphase-promoting complex/cyclosome, and cyclin A.

35 kinase PLK1, the anaphase-promoting complex/cyclosome, and the proteasome that, when inhibited, resu

36 ubunits of the anaphase promoting complex or cyclosome, and, here, we show that one of the genes, emb

37 totic form of the anaphase-promoting complex/cyclosome (APC(Cdc20)).

38 activation of the anaphase-promoting complex/cyclosome (APC(Cdh1)) has the necessary characteristics

39 The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin li

40 substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit.

41 gase known as the anaphase-promoting complex/cyclosome (APC) plays a key role in the regulation of mi

42 The anaphase-promoting complex/cyclosome (APC) ubiquitin ligase is activated by Cdc20 a

43 he ability of the anaphase-promoting complex/cyclosome (APC), an E3 ubiquitin ligase, to trigger cycl

44 NG E3s, including anaphase-promoting complex/cyclosome (APC), catalyze polyubiquitination by sequenti

45 tisubunit 1.2-MDa anaphase-promoting complex/cyclosome (APC), which controls cell division by ubiquit

46 by inhibiting the anaphase promoting complex/cyclosome (APC).

47 ognized by the anaphase-promoting complex or cyclosome (APC).

48 e known as the anaphase-promoting complex or cyclosome (APC/C [2]).

49 regulates the anaphase-promoting complex or cyclosome (APC/C complex) that mediates the ubiquitinati

50 by inhibiting the anaphase-promoting complex/cyclosome (APC/C(Cdc20)) [2].

51 Activation of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) by Cdc20 is delayed by the spin

52 f CDC20-activated anaphase-promoting complex/cyclosome (APC/C(CDC20)).

53 erentiation, high anaphase-promoting complex/cyclosome (APC/C) activity degrades key E2F targets to l

54 s to suppress the anaphase-promoting complex/cyclosome (APC/C) activity early in prometaphase, thereb

55 d on separase and anaphase-promoting complex/cyclosome (APC/C) activity, which also triggers the acqu

56 inhibitor of the anaphase-promoting complex/cyclosome (APC/C) after knockdown of the mitotic cyclins

57 hich inhibits the anaphase-promoting complex/cyclosome (APC/C) and blocks anaphase onset.

58 oactivator of the anaphase-promoting complex/cyclosome (APC/C) and contributes to mitotic exit and G1

59 inhibition of the anaphase-promoting complex/cyclosome (APC/C) and delayed degradation of its substra

60 ctivity of the anaphase-promoting complex or cyclosome (APC/C) and delays the onset of anaphase.

61 achine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and deg

62 Fzr regulates the anaphase-promoting complex/cyclosome (APC/C) and is expressed at the mitotic-to-end

63 sociates with the anaphase-promoting complex/cyclosome (APC/C) and is required to activate the APC/C

64 s mediated by the anaphase-promoting complex/cyclosome (APC/C) and its associated specificity factors

65 that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two partner E2s, UBE2C (aka UB

66 tosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint com

67 quitylated by the anaphase-promoting complex/cyclosome (APC/C) and then subjected to proteasomal degr

68 catalyzed by the anaphase-promoting complex/cyclosome (APC/C) and ubiquitin-conjugating enzyme H10 (

69 le time after the anaphase-promoting complex/cyclosome (APC/C) becomes active, raising the question w

70 activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20.

71 s mediated by the anaphase-promoting complex/cyclosome (APC/C) bound to its regulator Cdh1p/Hct1p.

72 Activation of the anaphase-promoting complex/cyclosome (APC/C) by Cdc20 is critical for the metaphase

73 activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is cr

74 ctivity of the anaphase-promoting complex or cyclosome (APC/C) by phosphorylating its activator Cdc20

75 that Arabidopsis anaphase-promoting complex/cyclosome (APC/C) coactivator genes CDC20 and CCS52B (CD

76 in interacts with anaphase promoting complex/cyclosome (APC/C) coactivators Cdc20 and Cdh1 to mediate

77 The anaphase-promoting complex or cyclosome (APC/C) comprises a multisubunit ubiquitin lig

78 The anaphase-promoting complex/cyclosome (APC/C) controls a variety of cellular process

79 ligase called the anaphase-promoting complex/cyclosome (APC/C) controls mitotic exit.

80 y proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister chromatid segregation,

81 The anaphase-promoting complex/cyclosome (APC/C) controls the onset of anaphase by targ

82 estruction by the anaphase promoting complex/cyclosome (APC/C) during meiosis I (MI) exit.

83 ovel role for the anaphase-promoting complex/cyclosome (APC/C) during this process.

84 The anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase functions with the

85 activator of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase.

86 substrates by the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase.

87 G(1) phase by the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase.

88 activation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase.

89 mutants in the anaphase-promoting complex or cyclosome (APC/C) exhibit defects in germline proliferat

90 by inhibiting the anaphase-promoting complex/cyclosome (APC/C) from targeting key proteins for ubiqui

91 ligase called the anaphase-promoting complex/cyclosome (APC/C) from ubiquitinylating proteins whose d

92 A and B-restrain anaphase-promoting complex/cyclosome (APC/C) function, whereas the late-destroyed c

93 g connection: the Anaphase Promoting Complex/Cyclosome (APC/C) has a second function in controlling l

94 onstrate that the anaphase-promoting complex/cyclosome (APC/C) in complex with Cdh1 has an unexpected

95 activation of the anaphase-promoting complex/cyclosome (APC/C) in interphase, resulting in failure of

96 activation of the anaphase-promoting complex/cyclosome (APC/C) in mitosis.

97 are essential for anaphase promoting complex/cyclosome (APC/C) inhibition.

98 cumulation of the anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 and the concomitant blo

99 The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to

100 Expression of the anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 is required for the acc

101 The anaphase promoting complex/cyclosome (APC/C) inhibitor Emi2 is another recent focus

102 Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor.

103 The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin

104 The anaphase-promoting complex/cyclosome (APC/C) is a conserved multisubunit E3 ubiquit

105 The anaphase-promoting complex/cyclosome (APC/C) is a conserved multisubunit ubiquitin

106 The anaphase-promoting complex/cyclosome (APC/C) is a conserved ubiquitin ligase that h

107 The anaphase-promoting complex or cyclosome (APC/C) is a conserved, multisubunit E3 ubiqui

108 The anaphase-promoting complex or cyclosome (APC/C) is a large E3 RING-cullin ubiquitin li

109 The anaphase promoting complex/cyclosome (APC/C) is a large multi-subunit E3 ubiquitin

110 The anaphase-promoting complex/cyclosome (APC/C) is a large multimeric cullin-RING E3 u

111 The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin l

112 The anaphase-promoting complex/cyclosome (APC/C) is a large multisubunit complex that r

113 The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls m

114 The anaphase-promoting complex/cyclosome (APC/C) is a member of the RING family of E3 u

115 The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligas

116 The anaphase-promoting complex or cyclosome (APC/C) is a multiprotein subunit E3 ubiquitin

117 The anaphase-promoting complex/cyclosome (APC/C) is a protein-ubiquitin ligase (E3) tha

118 The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase essential for th

119 The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that polyubiquit

120 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase composed of

121 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase in the ubiqu

122 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase mediating ta

123 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase, well known

124 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that

125 The anaphase-promoting complex/cyclosome (APC/C) is an essential ubiquitin ligase that

126 The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions

127 The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin lig

128 inhibition of the anaphase-promoting complex/cyclosome (APC/C) is responsible for this arrest.

129 The anaphase-promoting complex/cyclosome (APC/C) is the ubiquitin ligase essential to m

130 The anaphase-promoting complex or cyclosome (APC/C) is the ubiquitin ligase that regulates

131 on of cyclin B by anaphase-promoting complex/cyclosome (APC/C) is, in part, due to elevated levels of

132 The anaphase promoting complex/cyclosome (APC/C) mediates the metaphase-to-anaphase tra

133 The anaphase-promoting complex/cyclosome (APC/C) promotes anaphase onset and mitotic ex

134 For example, the anaphase-promoting complex/cyclosome (APC/C) promotes the exit from mitosis via des

135 The anaphase-promoting complex/cyclosome (APC/C) regulates multiple stages of the cell

136 The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation

137 CDKs and the anaphase promoting complex/cyclosome (APC/C) restrict licensing to G1 phase by dire

138 We show that the anaphase-promoting complex/cyclosome (APC/C) specifically interacts with microtubul

139 similar to known Anaphase-Promoting Complex/Cyclosome (APC/C) substrates to identify additional puta

140 t times after the anaphase-promoting complex/cyclosome (APC/C) switches from binding Cdc20 to Cdh1.

141 n of cut2p, an anaphase-promoting complex or cyclosome (APC/C) target.

142 uitin ligase, the anaphase-promoting complex/cyclosome (APC/C) targets Ams2 for destruction in G(1).

143 tween pRB and the anaphase-promoting complex/cyclosome (APC/C) that controls p27(Kip1) stability by t

144 ich activates the anaphase-promoting complex/cyclosome (APC/C) that triggers anaphase and mitotic exi

145 activation of the anaphase-promoting complex/cyclosome (APC/C) throughout the spindle and the cytopla

146 ter activates the anaphase-promoting complex/cyclosome (APC/C) to destroy cyclins.

147 twork anchors the anaphase-promoting complex/cyclosome (APC/C) to the mitotic spindle and poles.

148 s mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase [1].

149 cycles by the anaphase-promoting complex or cyclosome (APC/C) ubiquitin ligase depends on its coacti

150 SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cycl

151 a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 cond

152 The anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is known to target th

153 The anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated

154 ike kinase 1, the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase plays an essential ro

155 ked to the active anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase, suggesting that pRB-

156 ystem acts on the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase, which targets for de

157 s mediated by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase.

158 activator of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase.

159 that inhibits the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase.

160 substrates by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin-protein ligase.

161 ed, the E3 ligase anaphase promoting complex/cyclosome (APC/C) ubiquitylates securin for proteolysis,

162 and inhibits the anaphase-promoting complex/cyclosome (APC/C) until all chromosomes are properly att

163 MCC inhibits the anaphase-promoting complex/cyclosome (APC/C) until the checkpoint is satisfied.

164 ed binding of the anaphase-promoting complex/cyclosome (APC/C) with its activator Cdc20, and the dela

165 interact with the anaphase promoting complex/cyclosome (APC/C)(Cdc20) and to displace the BubR1 SAC c

166 An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that in

167 y activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase ta

168 The anaphase-promoting complex or cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, i

169 activators of the anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase.

170 ive regulators of anaphase-promoting complex/cyclosome (APC/C), a multisubunit ubiquitin E3 ligase th

171 controlled by the Anaphase Promoting Complex/Cyclosome (APC/C), a specific E3 ubiquitin ligase that i

172 substrates of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase essential for mito

173 d in vivo, on the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mito

174 substrate of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mito

175 s strategy to the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls sist

176 MCC inhibits the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets for d

177 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), accumulates on DNA breaks in a BubR1

178 The anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase responsible fo

179 e activity of the Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase.

180 activator of the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase.

181 The anaphase-promoting complex/cyclosome (APC/C), an essential ubiquitin protein ligase

182 , inhibits the anaphase-promoting complex or cyclosome (APC/C), and delays anaphase onset to prevent

183 , inhibits the anaphase-promoting complex or cyclosome (APC/C), and prevents premature sister chromat

184 s, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset.

185 substrates of the anaphase-promoting complex/cyclosome (APC/C), by APC/C coactivators and indicate a

186 activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitina

187 regulator, the anaphase-promoting complex or cyclosome (APC/C), in the regulation of cell fate throug

188 The anaphase-promoting complex, or cyclosome (APC/C), is a ubiquitin ligase that selectivel

189 transitions, the anaphase-promoting complex/cyclosome (APC/C), is an E3 ubiquitin ligase.

190 uitin ligase, the anaphase-promoting complex/cyclosome (APC/C), promotes exit from mitosis by directi

191 activator of the anaphase-promoting complex/cyclosome (APC/C), promotes Smk1 activation during meios

192 uitin ligase, the anaphase-promoting complex/cyclosome (APC/C), regulates critical cellular processes

193 C1 subunit of the anaphase-promoting complex/cyclosome (APC/C), resulting in G(2)/M cell cycle arrest

194 inhibitors of the anaphase-promoting complex/cyclosome (APC/C), such as the early mitotic inhibitor 1

195 and inhibits the anaphase-promoting complex/cyclosome (APC/C), the E3 ubiquitin ligase that initiate

196 activator of the anaphase-promoting complex/cyclosome (APC/C), the E3 ubiquitin ligase whose activit

197 d inhibits the anaphase-promoting complex or cyclosome (APC/C), thus ensuring accurate chromosome seg

198 ctivity of the anaphase-promoting complex or cyclosome (APC/C), thus preventing precocious chromosome

199 he Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to delay anaphase, thereby preventing

200 s mediated by the anaphase-promoting complex/cyclosome (APC/C), whereas degradation of TbCPC1 and TbC

201 3) subunit of the anaphase promoting complex/cyclosome (APC/C), which results in the polyubiquitinati

202 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), which, together with its substrate ad

203 ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), whose action is necessary for anaphas

204 uitylation by the anaphase-promoting complex/cyclosome (APC/C)-cadherin 1 (Cdh1), an E3 ubiquitin lig

205 ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C)-Cdc20 that triggers the metaphase-anap

206 lts indicate that anaphase-promoting complex/cyclosome (APC/C)-Cdh1 specifically targets EYA1 for deg

207 is degraded in an anaphase-promoting complex/cyclosome (APC/C)-dependent manner.

208 oint prevents the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of cyclin B and s

209 GPC1 inhibits the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of mitotic cyclin

210 atic cells, where anaphase-promoting complex/cyclosome (APC/C)-mediated proteasomal destruction remov

211 e is regulated by anaphase-promoting complex/cyclosome (APC/C)-mediated protein degradation.

212 l attachment with anaphase-promoting complex/cyclosome (APC/C)-mediated securin and cyclin B1 destruc

213 s mediated by the anaphase-promoting complex/cyclosome (APC/C)-targeted ubiquitination and proteolysi

214 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).

215 ubunits of the anaphase-promoting complex or cyclosome (APC/C).

216 activator of the anaphase-promoting complex/cyclosome (APC/C).

217 activator of the anaphase-promoting complex/cyclosome (APC/C).

218 uitination by the Anaphase-Promoting Complex/Cyclosome (APC/C).

219 ry subunit of the anaphase-promoting complex/cyclosome (APC/C).

220 on depends on the anaphase-promoting complex/cyclosome (APC/C).

221 regulator of the Anaphase-Promoting Complex/Cyclosome (APC/C).

222 st subunit of the anaphase-promoting complex/cyclosome (APC/C).

223 on through the anaphase promoting complex or cyclosome (APC/C).

224 to inactivate the Anaphase Promoting Complex/Cyclosome (APC/C).

225 activation of the anaphase-promoting complex/cyclosome (APC/C).

226 ociation with the anaphase promoting complex/cyclosome (APC/C).

227 activator of the anaphase-promoting complex/cyclosome (APC/C).

228 d inhibits the anaphase-promoting complex or cyclosome (APC/C).

229 activation of the anaphase-promoting complex/cyclosome (APC/C).

230 es (CDKs) and the anaphase promoting complex/cyclosome (APC/C).

231 a subunit of the anaphase-promoting complex/cyclosome (APC/C).

232 mponent of the anaphase-promoting complex or cyclosome (APC/C).

233 of Mad2 with the anaphase promoting complex/cyclosome (APC/C).

234 ubunits of the anaphase-promoting complex or cyclosome (APC/C).

235 component of the anaphase-promoting complex/cyclosome (APC/C).

236 ligase termed the anaphase promoting complex/cyclosome (APC/C).

237 c activity of the anaphase-promoting complex/cyclosome (APC/C).

238 receptors for the Anaphase Promoting Complex/Cyclosome (APC/C).

239 ubiquitin ligase anaphase promoting complex/cyclosome (APC/C).

240 ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C).

241 of the E3 ligase anaphase promoting complex/cyclosome (APC/C).

242 rved regulator of anaphase promoting complex/cyclosome (APC/C).

243 ssociation of the anaphase-promoting complex/cyclosome (APC/C).

244 hich inhibits the anaphase-promoting complex/cyclosome (APC/C).

245 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).

246 1, indicating that Cks1 is not essential for cyclosome/APC activity.

247 activities at the kinetochore and regulating cyclosome/APC activity.

248 totic regulators Clb2 and Pds1 depend on the cyclosome/APC and the 26S proteasome.

249 mechanisms that modulate the activity of the cyclosome/APC.

250 x) and the APC/C (anaphase promoting complex/cyclosome), are vital in ensuring the temporal order of

251 , an inhibitor of anaphase-promoting complex/cyclosome, are elevated in Plk1-depleted cells.

252 meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates

253 h inhibits the anaphase-promoting complex or cyclosome bound to Cdc20 (APC/C(Cdc20)) to delay anaphas

254 ediated by the anaphase-promoting complex or cyclosome bound to Cdh1 (APC/C(Cdh1)), resulting in accu

255 inhibitor of the anaphase-promoting complex/cyclosome bound to its specificity factor, Cdc20.

256 cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip

257 inhibition of the anaphase-promoting complex/cyclosome by a kinetochore-derived "wait anaphase" signa

258 tion inhibits the anaphase-promoting complex/cyclosome (Cdc20-APC/C), thereby preventing the proteoly

259 le is achieved by anaphase-promoting complex/cyclosome(Cdh1) (APC/C(Cdh1)), a multisubunit E3 ubiquit

260 cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner.

261 1 also binds with anaphase-promoting complex/cyclosome co-activators Cdc20 and Cdh1.

262 nant forms of the anaphase-promoting complex/cyclosome, cohesin, and kinetochore complexes.

263 by the proteasome via the anaphase-promoting cyclosome complex (APC/c) pathway.

264 st targets of the anaphase-promoting complex/cyclosome complex, a set of genes whose expression is pr

265 ox-containing and anaphase-promoting complex/cyclosome complexes.

266 t with a small molecule inhibitor of the APC/cyclosome could sensitize otherwise paclitaxel-resistant

267 inding of CDH1 to anaphase promoting complex/cyclosome decreased, resulting in an attenuation of anap

268 aded in an APC/C (anaphase-promoting complex/cyclosome)-dependent manner.

269 on of separase by anaphase-promoting complex/cyclosome-dependent degradation of cyclin B1.

270 The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of

271 binding with the anaphase-promoting complex/cyclosome E3 ubiquitin ligase component APC-2 protein.

272 trate that APC/C (anaphase-promoting complex/cyclosome) enzyme is active in ES cells but attenuated b

273 e complex; APC/C (anaphase promoting complex/cyclosome) facilitates the cell cycle stage-specific deg

274 c20 activates the anaphase-promoting complex/cyclosome in a substrate-specific manner.

275 inhibition of the anaphase-promoting complex/cyclosome, in part by a newly identified protein, Emi2 (

276 Cdc20 binding and anaphase-promoting complex/cyclosome inhibition: a destruction box (D box) and a ph

277 The anaphase-promoting complex (APC) or cyclosome is a multisubunit ubiquitin-protein ligase tha

278 , geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

279 ortex form of the Anaphase Promoting Complex/Cyclosome is inactive.

280 Thus, the anaphase-promoting complex/cyclosome is likely to be required for all metaphase-to-

281 demonstrates that anaphase promoting complex/cyclosome is required not only in proliferating cells bu

282 ation of the anaphase-promoting complex (APC/cyclosome) is involved in the TGF-beta signaling pathway

283 The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collab

284 activator of the anaphase-promoting complex/cyclosome, is excluded from interphase nuclei, but enter

285 We show that cyclosome-mediated degradation of cdc13p and cig2p is ne

286 bination with the anaphase-promoting complex/cyclosome mutation bimE7.

287 vity of the anaphase-promoting complex (APC)/cyclosome needs to be tightly regulated for proper cell

288 conserved multisubunit complex known as the cyclosome or anaphase-promoting complex is involved in c

289 -promoting complex (APC/C, also known as the cyclosome) regulates the ubiquitin-dependent proteolysis

290 a-solenoid folds composed of 9-11 proteasome/cyclosome repeats, each approximately 40 residues long a

291 protein sequences containing the proteasome/cyclosome repeats.

292 component of the anaphase-promoting complex/cyclosome, required for the metaphase-to-anaphase transi

293 activator of the anaphase-promoting complex/cyclosome that initiates anaphase onset by ordering the

294 ng subunit of the anaphase-promoting complex/cyclosome that regulates multiple steps in meiotic devel

295 ts with the anaphase-promoting complex (APC)/cyclosome through the noncatalytic domain of Plo1 and th

296 ely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise

297 t Cdc20, of APC (anaphase-promoting complex)/cyclosome ubiquitin ligase reduced the level of Dnmt1 in

298 uitination by the anaphase-promoting complex/cyclosome ubiquitin ligase, acting in conjunction with t

299 to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtub

300 activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent prote