ライフサイエンスコーパス: cystamine

1 inhibitors of tTG (monodansylcadaverine and cystamine).

2 more than a hundred times more potently than cystamine.

3 ium ionophore and prevented by the inhibitor cystamine.

4 formation is inhibited by the TG inhibitor, cystamine.

5 NA complex via a disulfide bond, 2'-deoxy-6-(cystamine)-2-aminopurine (d6Cys2AP) was synthesized and

6 H induces perihematomal tTG upregulation and cystamine, a tTG inhibitor, reduces ICH-induced brain sw

7 Cysteamine and cystamine also augmented basal intracellular cysteamine

8 Cystamine also decreased HIV-1 protein expression in CBM

9 We previously reported that cystamine and a metabolic cystine precursor inactivate P

10 arent KI = 1.1 mM), and it is inactivated by cystamine and buthionine sulfoximine.

11 d monocyte/macrophage cultures revealed that cystamine and cysteamine possess significant antiviral p

12 y state percentage yields of cysteamine from cystamine and pantethine during the transit through OHSC

13 ubstrate specificity, and inhibition by GSH, cystamine, and transition state analog sulfoximines.

14 in the pathogenesis of HD, and they identify cystamine as a potential therapeutic strategy for treati

15 sized via degradation of a N,N'-bis(acryloyl)cystamine (BAC) cross-linked core out of a non-degradabl

16 fferent amounts of poly(triethylenetetramine/cystamine bisacrylamide) (p(TETA/CBA) and its pegylated

17 lated counterpart, poly(triethylenetetramine/cystamine bisacrylamide)- poly(ethylene glycol) (p(TETA/

18 The bioreducible cationic polymer poly(cystamine bisacrylamide-diamino hexane) (p(CBA-DAH)) was

19 led onto a gold quartz crystal electrode via cystamine bond.

20 noxalin-1-one (ODQ), methylene blue (M-BLU), cystamine (CYS)), L-ARG had only excitatory effects, whe

21 cyclase inhibitors methylene blue (M-BLU) or cystamine (CYS), NO donors had only excitatory effects,

22 oxadiazolo[4,3, -a]quinoxalin-1-one (ODQ) or cystamine (CYS); (ii) the adenylate cyclase inhibitors n

23 We therefore studied the actions of cystamine, cysteamine and several reference thiol agents

24 ontrast, the reduced forms of disulfiram and cystamine, diethyl dithiocarbamate and cysteamine, respe

25 armacological treatment with mithramycin and cystamine down-regulates ESET gene expression and reduce

26 after the appearance of abnormal movements, cystamine extended survival, reduced associated tremor a

27 Cystamine given intraperitoneally entered brain where it

28 with the thiol cysteamine and its disulfide cystamine have demonstrated dramatic cytoprotection in e

29 s with net charges, oxidized glutathione and cystamine, however, the apparent Bronsted coefficients w

30 s with other GCL, buthionine sulfoximine and cystamine inactivate the Arabidopsis enzyme but with ina

31 spectrometric analysis of peptide digests of cystamine-inactivated, carbamidomethylated PKCepsilon de

32 These studies suggest that cystamine inactivates the enzyme by blocking substrate a

33 gamma-GCS renders the enzyme insensitive to cystamine inactivation without significantly affecting t

34 glutaminase inhibitors dansyl-cadaverine and cystamine, indicating that apoptosis of Mphi is dependen

35 Additionally, cystamine inhibited caspase-3 activity to the same exten

36 In situ cystamine inhibited in a concentration-dependent manner

37 or an antisense for tTG, demonstrating that cystamine inhibits caspase activity independently of any

38 In this study we show that cystamine inhibits recombinant active caspase-3 in a con

39 Similarly to the mammalian enzyme, cystamine is a time-dependent, irreversible inhibitor of

40 At low concentrations cystamine is an uncompetitive inhibitor of caspase-3 act

41 t has been suggested by several studies that cystamine labels an active site Cys residue essential fo

42 Thus, these observations indicate that cystamine may have the potential to limit HIV-1 replicat

43 However, it has been suggested that cystamine may inhibit other thiol-dependent enzymes in a

44 These findings demonstrate that cystamine may prolong neuronal survival and delay the on

45 The IC(50) for cystamine-mediated inhibition of caspase-3 activity in v

46 ly and efficiently leads to cysteamine (half-cystamine) modification of a single site on Gbeta, likel

47 f silver underpotentially deposited onto the cystamine modified-Au-electrode surface is used as the r

48 This inhibitory effect of cystamine occurred with all five HIV-1 strains (both lab

49 The inhibitory effects of cystamine on HIV-1 did not appear to be caused by toxici

50 The effects of cystamine on the human immunodeficiency virus (HIV-1) ex

51 fter ICH and the effects of a tTG inhibitor, cystamine, on ICH-induced brain edema and neurological d

52 ng the enzymes reported to be inactivated by cystamine, only one Cys residue is invariant (Cys-319 in

53 traperitoneally with either a tTG inhibitor, cystamine, or vehicle.

54 s approach we have tracked the metabolism of cystamine, pantethine and CoA in the extracellular space

55 Finally, treatment with cystamine resulted in a robust increase in the levels of

56 mice with the pan-transglutaminase inhibitor cystamine resulted in significantly diminished CIA patho

57 D mice, using the transglutaminase inhibitor cystamine, significantly extended survival, improved bod

58 Cystamine suppressed HIV-1 expression in CBMDM and lymph

59 and [3H]-thymidine incorporation at doses of cystamine that inhibit the virus.

60 A literature search identified cystamine, thiamine disulfide, and disulfiram as compoun

61 The addition of cystamine to cultures of HIV-1 chronically infected CBMD

62 stration of the TGase competitive inhibitor, cystamine, to transgenic mice expressing exon 1 of hunti

63 topathic effect (CPE), respectively, whereas cystamine-treated cultures lacked the giant syncytia or

64 Cystamine treatment attenuated ICH-induced brain swellin

65 Unexpectedly, cystamine treatment increased transcription of one of th

66 Cystamine treatment normalized transglutaminase and GGEL

67 fected CBMDM or lymphocyte cultures (without cystamine treatment) demonstrated giant syncytium format

68 h with 5.7 at % Br that further reacted with cystamine under microwave irradiation, resulting in a pr

69 profibrotic pantothenic acid and pro-oxidant cystamine, we tested this pathway in the pathophysiology

70 Oxidized dithiothreitol and cystamine were reduced to a lesser degree.

71 Similarly administration of cystamine, which can inhibit transglutaminase, prolonged