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1 purified antisera raised against recombinant cystatin M.
2                  We reported previously that cystatin M, a potent endogenous inhibitor of lysosomal c
3                         Both forms of native cystatin M also occurred intracellularly.
4 omal cysteine proteases, as both recombinant cystatin M and E64 were able to block these processes.
5                            Cystatins such as cystatin M are potent endogenous protein inhibitors of l
6                                   We propose cystatin M as a novel candidate tumor suppressor gene fo
7                     Here, we report that the Cystatin M (CST6) tumor suppressor gene is concurrently
8             Here, we examined the effects of cystatin M expression on malignant properties of human b
9                                          The cystatin M fusion protein displayed inhibitory activity
10 owever, appeared to be unaltered between the cystatin M group and the control group.
11 hemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost.
12  reaction, we found consistent expression of cystatin M in normal human breast epithelial cells, wher
13                                              Cystatin M is expressed by normal mammary cells and a va
14                                              Cystatin M is expressed in normal and premalignant human
15                        Loss of expression of cystatin M is likely associated with the progression of
16  This study provides the first evidence that cystatin M may play important roles in safeguarding agai
17                    An N-glycosylated form of cystatin M of 20-22 kDa was co-immunoprecipitated and ac
18                                       Native cystatin M protein of approximately 14.5 kDa is secreted
19 nt with the mRNA differential expression, no cystatin M protein was detected in metastatic mammary ep
20                                   The mature cystatin M protein was produced in Escherichia coli as a
21 ated and accounted for about 30-40% of total cystatin M protein.
22 mplanted with breast cancer cells expressing cystatin M show significantly delayed primary tumor grow
23  Experimental metastasis assays suggest that cystatin M suppressed tumor cell proliferation at the se
24                                              Cystatin M was found to significantly reduce in vitro: c
25               Complete loss of expression of cystatin M was observed in two of three IDCs from stage
26 nd to encode a novel protein, which we named cystatin M, with 40% homology to human family 2 cystatin

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