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1 ts are reversed by the anti-oxidant N-Acetyl Cysteine.
2 ) is significantly lower than a non-pi-clamp cysteine.
3 of sodium L-ascorbate, DL-Dithiothreitol or cysteine.
4 litate palmitoyl group transfer to substrate cysteine.
5 nces with four amino acids downstream of the cysteine.
6 e addition of diacylglycerol to an invariant cysteine.
7 us of aspartic acid and at the N-terminus of cysteine.
8 hur originates from intake of methionine and cysteine.
9 to retain the highly conserved undecapeptide cysteine.
10 the catalytically indispensable active-site cysteine.
11 oxidation and reduction of their active site cysteine.
12 ce assay for visual chiral discrimination of cysteine.
13 tion and thiol deprotonation of beta-subunit cysteines.
14 bonds in nested patterns and closely spaced cysteines.
15 rotein ligations with no influence on native cysteines.
16 the disulfide bond between the two conserved cysteines.
17 revealed a posttranslational modification on cysteine 328 (C328) by the oxidative adduct malondialdeh
19 es (ROS) in podocytes and that NAC (N-acetyl-cysteine), a potent antioxidant, significantly eliminate
20 ective CysSSH synthesis from the substrate L-cysteine, a reaction catalyzed by prokaryotic and mammal
21 required site-specific labeling of nonnative cysteines, a labor-intensive process occasionally result
25 thiols now allows determination of modified cysteines across the proteome and identification of thos
26 riking biases, such as the (near) absence of cysteine and aspartic peptidases and peptidase inhibitor
29 presence of physiological concentrations of cysteine and glutathione, while those with longer sulfur
32 n was dependent on essential redox-sensitive cysteine and lysine residues within N-terminus of channe
34 id Mixture 1, Gelatin Peptone N3, N-Acetyl-L-Cysteine and Pluronic F-68) were assayed in order to imp
35 for serine and histidine tRNAs, while minor cysteine and selenocysteine tRNA species may have a modi
38 n which adds 16-carbon palmitate to specific cysteines and contributes to various biological function
39 er radical SAM proteins, HemW contains three cysteines and one SAM coordinating an [4Fe-4S] cluster,
40 the enzyme; then it oxidizes the peroxidatic cysteine, and finally, the rate-limiting disulfide bond
43 experiments demonstrated that the first two cysteines are necessary for McpM to inhibit susceptible
48 ntaining a caspase recruitment domain (ASC), cysteine aspartase (caspase)-1, and interleukin (IL)-1be
51 r major protease mechanistic classes-serine, cysteine, aspartyl, and metallo-proteases-and develop a
52 is facilitated by palmitoylation of a single cysteine at position 739 within the large intracellular
55 y of Cys-tRNA(Cys) synthesis (tRNA-dependent cysteine biosynthesis) to prevent challenge of translati
61 covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor prote
62 troduced the HCM mutation E56G into a single-cysteine (C16) hVELC construct and substituted it for th
64 composite material consisting of N-acetyl-L-cysteine capped CdAgTe quantum dots (NAC-CdAgTe QDs) and
65 sensor is developed to detect DA based on l-cysteine capped Mn doped ZnS quantum dots (l-cys ZnS:Mn
67 vestigate the relationship between exogenous cysteine, cellular metabolism, cellular localization, an
70 the chemical reaction of [C2mim][OAc] with a cysteine-containing biomolecules can be tuned or even su
71 alysis of four small organic molecules and a cysteine-containing peptide we could postulate a general
72 ate to and are stabilized by a wide range of cysteine-containing peptides and the assembly of iron-su
73 xtensive persulfide formation is apparent in cysteine-containing proteins in Escherichia coli and mam
76 alytical system is based on the oxidation of cysteine (CSH) with hydrogen peroxide (H2O2) enzymatical
78 lectrophiles through covalent binding at its cysteine (Cys) thiol group, followed by stepwise catalyz
80 ein kinases changing in abundance, including cysteine (Cys)-rich receptor-like kinases (CRKs) that ar
81 inactivation through oxidation of a critical cysteine (Cys195) in the third transmembrane helix of Or
82 containing 3, interleukins 1beta and 6, and cysteine-cysteine chemokine ligand 5 [CCL5]) and profibr
84 hydrogen bonding between an aspartate and a cysteine (D156-O...S-C128) that would define a direct-cu
90 n is intimately tied to the function of both cysteine dioxygenases (CDOs) and nitrile hydratases (NHa
91 00 s(-1)) and quantify the energetics of the cysteine disulfide redox-reaction (reversible potentials
93 analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determin
95 showed that modification of a conserved BiP cysteine during stress beneficially alters BiP chaperone
96 st, miropin uniquely blocked many serine and cysteine endopeptidases of disparate architecture and su
97 tical role for the N glycosylation sites and cysteines for the structure and function of the amino te
99 -4-methylpentan-2-one-N-(l-gamma-glutamyl)-l-cysteine (gammaGluCys-4MMP) but at too low concentration
100 phosphatidylethanolamine to this N-terminal cysteine, generating a mature, triacylated lipoprotein.
101 e potential interference from ascorbic acid, cysteine, glutamic acid, and glucose was also studied, a
103 erately added to various flour types since l-Cysteine has enabled favorable baking conditions such as
104 Group F TabZIPs contain the group-defining cysteine-histidine-rich motifs, which are the predicted
112 ed to be energy-dependent and is enhanced by cysteine in diverse species of bacteria under aerobic an
113 res efficiently inserted serine, alanine and cysteine in response to stop and sense codons, depending
116 determine the enantiomeric excess (ee) of D-cysteine in the whole range of ee values (from -100% to
123 vealing that a central core of palmitoylated cysteines is essential for aggregation of ANCL CSPalpha
124 ribed carbon-sulfur lyase SUR1 in processing cysteine-isothiocyanate conjugates, as well as the S-met
125 lent linkages between lectin molecules and a cysteine layer immobilized over gold-coated TiO2 butterf
126 wild-type hCNT1 and the corresponding TMs of cysteine-less NupC(C-) yielded results that validate the
128 geting of the catalytic subunit of glutamate cysteine ligase (Gclc) blocked GSH production specifical
129 quinone 1, glutathione reductase, glutamate-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin
131 a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, ther
132 r, or an extra amine group such as arginine, cysteine, lysine, methionine, and tryptophan had the str
135 e a model to explain the interplay between l-cysteine metabolism, H2S production, and oxidative stres
138 Comparison of N-linked glycosylation and cysteine mutant replication kinetics identified disparat
141 nd the application of ROS scavenger N-acetyl cysteine (NAC) completely blocked these effects by S17 i
142 on with acetyl-L-carnitine (LAC) or acetyl-N-cysteine (NAC) rapidly increases xCT and activates a net
143 rocess, an isoprenoid group is attached to a cysteine near the C terminus of a substrate protein by p
146 ing the polyhistidine tail to include a free cysteine on each protomer of model BG505 NFL trimers to
147 oxidation to a disulfide with a neighboring cysteine or dissociation upon reduction of Fe(3+)- to Fe
148 ino acids (4R)-hydroxyproline and proline by cysteine or homocysteine, which reduces the preorganizat
150 ered by depleting the cell of the amino acid cysteine, or by inhibiting the phospholipid hydroperoxid
151 od was shown to be highly chemoselective for cysteine over other potentially nucleophilic residues, a
154 tional importance of conserved extracellular cysteine pairs in CSF3R and suggest the necessity for br
155 e further showed that disruption of original cysteine pairs in the CSF3R extracellular domain resulte
156 Phytocystatins are reversible inhibitors of cysteine peptidases that are found naturally in plants.
157 sfer of the sulfane sulfur from an SQR-bound cysteine persulfide intermediate to a small-molecule acc
162 calpain with high selectivity versus related cysteine protease cathepsins, other proteases, and recep
163 ve mechanisms to fine-tune the activity of a cysteine protease dubbed RD21 (RESPONSIVE TO DESICCATION
164 he activity of EspL defines a family of T3SS cysteine protease effectors found in a range of bacteria
165 ity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables quantification of diff
167 ile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at no
171 opeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor pr
172 n of the gene encoding cathepsin S (Ctss), a cysteine protease that cleaves invariant chains and prod
173 al extension also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage.
174 n system in rice by combining Brassica napus cysteine-protease gene (BnCysP1) with anther-specific P1
175 erility, the coding region of Brassica napus cysteine protease1 (BnCysP1) was isolated from developin
177 article describes a novel role for Giardia's cysteine proteases in pathogenesis and how Giardia's dis
178 a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory p
179 c peptide sequence for the inhibition of the cysteine proteases rhodesain of Trypanosoma brucei rhode
180 to investigate the substrate specificity of cysteine proteases, serine proteases and metalloproteina
182 Cathepsin S is one of the most important cysteine proteinases and plays key roles in nematodes an
184 reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleuki
185 eficient T cells with metabolically active L-cysteine rescued mTOR activation and proliferation but n
188 itor, 3-bromopyruvate, also targets the same cysteine residue and that our electrophilic quinazolines
189 eat and contained an extra repetitive-domain cysteine residue in 1Dx5 that was important for understa
191 reductase, independently of H2O2 A conserved cysteine residue in OxyR2 is critical for this function.
192 of the 1Ax1 gene corresponding to the extra cysteine residue of 1Dx5 was substituted by a cysteine c
195 rc homology 2 (SH2) or SH3 domains or of the cysteine residue that undergoes LPS-induced palmitoylati
196 pically have severe effects, mutation of the cysteine residue to alanine has minor effects on overall
198 or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphata
200 R domain of FisR through the three conserved cysteine residues (C53, C64 and C71), FisR activates the
201 strategy, we identified 1,276 S-nitrosylated cysteine residues [S-nitrosothiol (SNO)] on 491 proteins
204 Vicinal disulfides between sequence-adjacent cysteine residues are very rare and rather startling str
206 experiments produced similar results of many cysteine residues bound to N-acetylglucosamine (GlcNAc).
209 d VKORL form disulfide-linked oligomers, the cysteine residues involved in the oligomerization appear
212 ins through site-selective bis-alkylation of cysteine residues present as disulfides under mild and b
214 ding bulls and humans, also contain multiple cysteine residues that form intra- and interprotamine su
215 amino acid motif and including six conserved cysteine residues that form intramolecular disulfide bon
217 d histidine and intact histidine, lysine, or cysteine residues were discovered and characterized from
218 is approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable s
219 nteractions through covalent modification of cysteine residues within the RGS domain that are located
220 of a pair of hydrogen atoms from juxtaposed cysteine residues, contrasts with the substantial change
221 ing chemical reagents specific for lysine or cysteine residues, identification of gas-phase fragmenta
222 oach utilizes conjugation to native antibody cysteine residues, it is widely applicable and enables h
223 y, our data support that the seven conserved cysteine residues, present within the SPASM domain, are
224 y depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if pres
225 oxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (mAb) scaffo
226 conjugated with biotin via native lysine and cysteine residues, under native-MS and solution conditio
234 5-aminoacid peptide guanylin containing four cysteine residues; the net simulation time using Amber f
238 ber of antimicrobial peptides, called nodule cysteine-rich (NCR) peptides, to control the outcome of
239 isingly, Loxl3 N-terminal scavenger receptor cysteine-rich (SRCR) repeats, rather than the C-terminal
243 Binding of a modulatory antibody to the cysteine-rich domain liberates the catalytic domain from
244 cipated architecture in which the C-terminal cysteine-rich domain partially occludes the enzyme activ
247 s process is orchestrated by nodule-specific cysteine-rich peptides (NCRs) delivered into developing
248 ibes chemistry that is broadly applicable to cysteine-rich peptides and the influence of a fourth dis
250 wth factor-like (EGF) repeats are also small cysteine-rich protein motifs that can be O-glycosylated
251 nd Western blot analysis, reversion-inducing cysteine-rich protein with kazal motifs (Reck) was ident
253 well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutation
254 opsis thaliana) that has similarities to the cysteine-rich zinc-binding domain of DnaJ chaperones.
256 ptide macrocyclization through perfluoroaryl-cysteine SNAr chemistry to improve the ability of peptid
257 protein secreted protein acidic and rich in cysteine (SPARC) is up-regulated and expressed intracell
258 We therefore conclude that germline ENPP1 cysteine-specific mutations, primarily affecting the mel
259 k, water-dispersible N-acetylcysteine- and l-cysteine-stabilized palladium nanoparticles are introduc
260 products with high sensitivity, we developed cysteine-stable isotope labeling using amino acids in ce
262 f the neighbouring leucine-116 (L116) in the cysteine-string domain cause CSPalpha to form high molec
263 The importance of specific residues in the cysteine-string domain was investigated, revealing that
264 ggregates is linked to palmitoylation of the cysteine-string domain, however the regions of the mutan
268 blocking (or oxidation) of GAPDH active site cysteines suppressed GAPDH/Ape1 interaction and potentia
269 11 nM) is comparable to that of the E. coli cysteine synthase complex (K d 6 nM), and both complex
270 an effectively displace CysE from pre-formed cysteine synthase complexes, enabling toxin activation e
271 ng arsenate reductase (HAC1), gamma-glutamyl-cysteine synthetase (gamma-ECS), phytochelatin synthase
275 e repressor by introduction of an additional cysteine that allows for three-coordinate As(III) bindin
277 sents the first characterization of unpaired cysteines that mediate both gain- and loss-of-function p
278 etreatment with the ROS scavenger N-acetyl-L-cysteine, the ERK1/2 inhibitor UO126, or ERK1/2 siRNA kn
280 we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targeted, systemic,
285 n through the analysis of knock-in mice with cysteine-to-alanine substitution at the palmitoylated re
286 nt strain of L. monocytogenes expressing the cysteine-to-alanine variant of LLO was able to infect an
287 ession of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and s
289 enocysteine residues were replaced mainly by cysteine, tryptophan and arginine in a codon-specific ma
290 ficant effect on several compounds (proline, cysteine, tryptophan, phenylalanine, alpha-terpineol and
292 tects E. coli against oxidative stress via l-cysteine utilization and H2S-mediated sequestration of f
295 tion mass spectrometry (HRMS) revealing that cysteine was the preferred nucleophile for acrylamide el
298 inetics of the interactions between L- and D-cysteine with CdTe QDs led to chiral recognition of thes
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