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1 ic inhibitor of calpain, a calcium-dependent cysteine protease.
2 equently exposed the mice to ovalbumin and a cysteine protease.
3 inant Dpi showed inhibitory activity against cysteine protease.
4 ion as novel regulators of the secreted SpeB cysteine protease.
5 ragment was generated by a calcium-dependent cysteine protease.
6 y functioning both as a scaffold protein and cysteine protease.
7 of SERA6 by PfSUB1 converts it to an active cysteine protease.
8 es, including speB, which encodes a secreted cysteine protease.
9 perturbs the active site of this papain-like cysteine protease.
10 ed to be cleaved by cathepsin B, a lysosomal cysteine protease.
11 aragine endopeptidase (AEP), a key endosomal cysteine protease.
12 ational maturation of SpeB, an extracellular cysteine protease.
13 hese results strongly suggest that SpvD is a cysteine protease.
14 D is an inhibitor of lysosomal and secreted cysteine proteases.
15 elucidate novel inhibitors of the falcipain cysteine proteases.
16 ective for cathepsins B and Z, two lysosomal cysteine proteases.
17 yzed possible adjuvant function of exogenous cysteine proteases.
18 posure of cystatin domains for inhibition of cysteine proteases.
19 us enhancing PMC's inhibitory ability toward cysteine proteases.
20 CLD is unable to function as an inhibitor of cysteine proteases.
21 repeating units, each capable of inhibiting cysteine proteases.
22 been exploited as inhibitors for serine and cysteine proteases.
23 hat are crucial to the enzymatic activity of cysteine proteases.
24 blocks delta-secretase but not other related cysteine proteases.
25 covery for other classes of disease-relevant cysteine proteases.
26 was blocked almost completely by inhibiting cysteine proteases.
27 RAMP were rapidly cleaved by released amebic cysteine proteases.
28 cysteine, an arrangement found in productive cysteine proteases.
29 paraginase is degraded by leukemic lysosomal cysteine proteases.
30 rall protein fold reminiscent of other plant cysteine proteases.
31 is activation of calpains-calcium-dependent cysteine proteases.
32 ity of inhibition against calpain over other cysteine proteases.
33 e Y283 is highly conserved among papain-like cysteine proteases.
34 e cytosol upon inhibition of serine, but not cysteine, proteases.
35 nfection, RIP3 is cleaved by the CVB-encoded cysteine protease 3C(pro), which serves to abrogate RIP3
36 wn to contain four domains: an N-terminal, a cysteine protease, a peptidoglycan-binding and an SH3 ba
38 ine protease inhibitor but not inhibitors of cysteine proteases, acid proteases, metalloproteases, or
40 d granularity, demonstrating that control of cysteine protease activity by CF is critical for normal
42 with the mature form, demonstrating that the cysteine protease activity critically contributes to the
43 and reveals increased inflammation-regulated cysteine protease activity in atheromata and stent-induc
47 elatively small group of proteins, most with cysteine protease activity that target several key prote
50 erimental AAA pathogenesis and that enhanced cysteine protease activity, due to the lack of CystC, fa
57 s, 7F and E3, that specifically inhibit TcdB cysteine protease and glucosyltransferase activities, re
58 time that toxin autoprocessing occurs after cysteine protease and glucosyltransferase domains transl
60 retion of certain toxins, including the SpeB cysteine protease and the streptolysin O (SLO) cytolysin
63 ideas for inhibitor design for papain-family cysteine proteases and strategies to progress drug disco
64 s of the N-terminal glucosyltransferase, the cysteine protease, and the C-terminal repeat region can
65 in the gut with the primary proteases being cysteine proteases, and alkaline (8 to 9) in the saliva
66 ts a new clade of previously uncharacterized cysteine proteases, and the dependence of S. aureus on L
67 a member of the papain/cathepsin L family of cysteine proteases, and the major cysteine protease of t
71 Previous studies revealed that endosomal cysteine proteases are host factors for ebolavirus Zaire
72 efore, the activities of these two lysosomal cysteine proteases are important in host defense against
76 zation of limited enzymatic digestion with a cysteine protease as compared to the recently published
77 s strongly suggest that the use of endosomal cysteine proteases as host factors for entry is a genera
79 ium and support further investigation of the cysteine proteases as virulence factors in vivo and as p
80 mine a nonredundant subset of the serine and cysteine proteases as well as the barnase-barstar and Ra
81 s the biogenesis of SpeB, the major secreted cysteine protease, at a post-translational level, suscep
85 reasing LC3-II availability by silencing the cysteine protease ATG4B or acute trehalose exposure incr
88 Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a pr
90 species (ROS) emission and activation of the cysteine protease calpain are required for DOX-induced m
92 t functions of a ubiquitous Ca(2+)-dependent cysteine protease, calpain-2, and of the calpain substra
94 e CAPN1 gene, encoding the calcium dependent cysteine protease calpain1 (mu-calpain), was identified.
97 vation of an intracellular caspase-1/calpain cysteine protease cascade degraded filamin, thereby seve
99 flammasome assembly is the activation of the cysteine protease caspase-1, which activates the pro-inf
105 lly identified the inhibitor-binding site in cysteine protease cathepsin B, a potential drug target a
106 that Xenopus 2F3 cells apically express the cysteine protease cathepsin B, as indicated by two-dimen
108 (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a
111 for cardiovascular disease and the lysosomal cysteine protease cathepsin K plays a critical role in c
112 We demonstrate an unprecedented role for the cysteine protease Cathepsin L (CTSL) in the degradation
117 calpain with high selectivity versus related cysteine protease cathepsins, other proteases, and recep
118 V. dahliae genes encoding a Ca(2+)-dependent cysteine protease (Clp-1) and an isotrichodermin C-15 hy
119 hages with the arginine- and lysine-specific cysteine protease complex (RgpA-Kgp complex), produced b
120 We found that disrupting a VAC-localized cysteine protease compromised VAC digestive function and
124 el in which to study RIBEs, and identify the cysteine protease CPR-4, a homologue of human cathepsin
126 almonella (S) carrying plasmids encoding the cysteine protease cruzipain (Cz) protects against Trypan
128 recombinant enzyme with characteristics of a cysteine protease, demonstrating that SERA5 can bind pep
132 main for inactivating host Rho GTPases and a cysteine protease domain for the delivery of the effecto
135 in, a Ca(2+)- and Zn(2+)-binding papain-like cysteine protease domain within the nonstructural replic
136 l hexakisphosphate (InsP(6)) by an intrinsic cysteine protease domain, located next to the glucosyltr
137 ve mechanisms to fine-tune the activity of a cysteine protease dubbed RD21 (RESPONSIVE TO DESICCATION
138 he activity of EspL defines a family of T3SS cysteine protease effectors found in a range of bacteria
141 ity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables quantification of diff
142 rly demonstrate that Amb a 11 is a bona fide cysteine protease exhibiting a strong allergenicity.
143 n unusually specific endosomal and lysosomal cysteine protease, expressed at high levels in the PTCs
149 of pro-Amb a 11 shows an overall typical C1A cysteine protease fold with a network of molecular inter
151 spases (MCPs) are members of a new family of cysteine proteases found in plants, fungi, and protozoa
153 This study provides the first analysis of a cysteine protease from the digestive fluid of a carnivor
154 se Clan CE, which includes distantly related cysteine proteases from eukaryotes, pathogenic bacteria,
157 n system in rice by combining Brassica napus cysteine-protease gene (BnCysP1) with anther-specific P1
159 rity to proteins from the NlpC/P60 family of cysteine proteases, having its secondary structure eleme
160 with putative domains for methyltransferase, cysteine protease, helicase and RNA-dependent RNA polyme
161 present a middle-down approach employing the cysteine protease IdeS under reducing conditions to obta
163 esiccation 21), a granulin domain-containing cysteine protease implicated in stress responses and def
164 rphyromonas gingivalis, secretes gingipains, cysteine proteases implicated as the main factors in the
165 s protein degradation by a calcium-dependent cysteine protease in response to unsaturated fatty acids
166 n underappreciated role of the SspB and ScpA cysteine proteases in modulating S. aureus biofilm archi
167 article describes a novel role for Giardia's cysteine proteases in pathogenesis and how Giardia's dis
169 vealed a high structural homology with known cysteine proteases, including the mite Der p 1 allergen.
171 )/Arg(15)) had modest adverse effects on the cysteine protease inhibition but conferred potent activi
173 ough proteasome inhibition and not serine or cysteine protease inhibition, likely through positive ch
177 er cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of t
178 s efficiently inhibited by both the covalent cysteine protease inhibitor E-64 and the reversible sele
179 DeltasigB mutant through the addition of the cysteine protease inhibitor E-64 or by using Staphostati
181 ile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at no
182 Collectively, these results indicate that a cysteine protease inhibitor from bacterial origin could
185 structural analysis between the hCLD and the cysteine protease inhibitor stefin A showed why the hCLD
186 lution as well as complexes with the general cysteine protease inhibitor trans-epoxysuccinyl-l-leucyl
188 t the helminth immunomodulator AvCystatin, a cysteine protease inhibitor, induces a novel regulatory
189 the cystatin B (CysB) gene, an intracellular cysteine protease inhibitor, lead to this human disease.
190 l-characterized apoplastic effector EPIC1, a cysteine protease inhibitor, was also secreted from haus
194 d tolerance of antiherbivory defenses (i.e., cysteine protease inhibitors) expressed in soybean folia
195 1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upre
196 ecific member of the cystatin superfamily of cysteine protease inhibitors, forms amyloid in vitro sug
200 ream of CTSB, a gene encoding cathepsin B, a cysteine protease involved in keratinocyte homeostasis.
201 a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory p
205 is required for cleavage by the periplasmic cysteine protease LapG and release of the adhesin from t
207 TecA and other bacterial homologs bear a cysteine protease-like catalytic triad, which inactivate
208 osome biogenesis requires Autophagy 4 (Atg4) cysteine protease-mediated processing of ubiquitin-like
209 equires a previously unrecognized tripartite cysteine protease motif in EspL (Cys47, His131, Asp153)
210 Consistent with these in vitro results, a cysteine protease noncleavable mutant, TcdB-L543A, delay
212 previously reported that LapG, a periplasmic cysteine protease of P. fluorescens, cleaves the N termi
214 ed the possibility that cruzipain, the major cysteine protease of T. cruzi, is responsible for trunca
215 family of cysteine proteases, and the major cysteine protease of the protozoan Trypanosoma cruzi, th
217 inhibitor of the major secreted cathepsin L cysteine proteases of F. hepatica, FhCL1 and FhCL2, and
226 rradiated, it releases 1, which inhibits the cysteine proteases papain and cathepsins B, K and L up t
230 cloned, expressed and purified this putative cysteine protease (PCP), which presented autoproteolytic
233 increasing body of evidence for papain-like cysteine proteases (PLCPs) being central hubs in plant i
234 E(-/-)) mice to examine directly the role of cysteine protease/protease inhibitor imbalance in AAA fo
235 al extension also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage.
237 Mutant analysis suggested the role of the cysteine protease RESPONSE TO DROUGHT21A-LIKE1 in beta-o
239 c peptide sequence for the inhibition of the cysteine proteases rhodesain of Trypanosoma brucei rhode
240 duced senescence in Arabidopsis, including a cysteine protease (SAG12) and three flavonoid biosynthes
242 to investigate the substrate specificity of cysteine proteases, serine proteases and metalloproteina
243 hase, surface M1 protein cleavage by the GAS cysteine protease SpeB eliminated Fg binding and relieve
245 found that elimination of production of the cysteine protease SpeB was not necessary for emergence o
247 t of the chromosomally encoded streptococcal cysteine protease (speB) in the MGAS5005 Deltasrv backgr
250 s that specifically target the extracellular cysteine proteases SspB and ScpA (called Staphopains).
252 obes that specifically target three distinct cysteine protease subfamilies: aleurain-like proteases,
254 sub-micromolar inhibition activities against cysteine proteases such as papain and calpain as well as
255 uickly in the lungs of naive mice exposed to cysteine proteases, such as bromelain and papain, as a m
256 etected members of the transglutaminase-like cysteine protease superfamily, and all possess a non-can
257 omal activity via inhibition of trypanosomal cysteine proteases, TbCatB and rhodesain, through alkyla
260 opeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor pr
261 n of the gene encoding cathepsin S (Ctss), a cysteine protease that cleaves invariant chains and prod
262 n this dysfunction of cathepsin S (Cat-S), a cysteine protease that degrades elastic fibers and activ
263 ffector domain (MCFVv) is an autoproteolytic cysteine protease that induces rounding of various cell
264 ogenic exotoxin B (SpeB) is an extracellular cysteine protease that is a critical virulence factor ma
266 M4 was found to interact with cathepsin C, a cysteine protease that plays an important role in bacter
268 mediated by activated cathepsin B (CatB), a cysteine protease that translocates to the cell surface
269 ic dyad that is characteristic of C11-family cysteine proteases that are conserved in multiple pathog
270 ular activity of calpains, calcium-activated cysteine proteases that are known to contribute to cell
273 entified cathepsins L and Z as the lysosomal cysteine proteases that digest polyQ proteins and peptid
277 p a family of Ca(2+)-dependent intracellular cysteine proteases that include ubiquitously expressed m
281 The MJD family of DUBs consists of four cysteine proteases that share a catalytic "Josephin" dom
282 d the hypothesis that activation of specific cysteine proteases, the caspases, during C. trachomatis
283 theses for the exclusive binding of FhKT1 to cysteine proteases, the importance of the Leu(15) in anc
284 Using selective inhibitors of either PKG or cysteine proteases to separately inhibit the sequential
285 rt a model in which GP cleavage by endosomal cysteine proteases unmasks the binding site for NPC1, an
287 prolines and that actin-related proteins and cysteine proteases were highly enriched in the group.
289 ns, which are calcium-dependent nonlysosomal cysteine proteases, were activated upon ATP stimulation
290 y levels of these enzymes, in particular the cysteine proteases, were increased in a rot mutant.
291 also activates calpain, a calcium-dependent cysteine protease, which has been shown to play a critic
292 s dependent on the autoactivation of a toxin cysteine protease, which is promoted by the allosteric c
293 iquitin-like conjugation system and the ATG4 cysteine proteases, which are implicated in the formatio
294 alpain-1 and calpain-2, are Ca(+2)-dependent cysteine proteases, which have been associated with nume
295 Calpains are calcium-dependent intracellular cysteine proteases, which include ubiquitously expressed
296 C-cleavage, is mediated by the activity of a cysteine protease whose activity is independent from tha
299 ubstrate for cathepsin H (CtsH), a lysosomal cysteine protease with a strong aminopeptidase activity.
300 that plant MCPs are arginine/lysine-specific cysteine proteases with caspase-like processing activiti
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