ライフサイエンスコーパス: cysteine residue

1 -bond between protonated D46 and a catalytic cysteine residue.

2 ovalent catalysis mediated by an active-site cysteine residue.

3 leotide chromophore and a strictly conserved cysteine residue.

4 it undergoes farnesylation at the C-terminal cysteine residue.

5 greement with the absence of a corresponding cysteine residue.

6 at the active site cysteine, but on a remote cysteine residue.

7 minal undecapeptide, which contains a single cysteine residue.

8 r transfer through sacrificing its catalytic cysteine residue.

9 in part through alkylation of a nonconserved cysteine residue.

10 ng-pong mechanism centered on an active site cysteine residue.

11 um atoms bind at N- and C-terminal catalytic cysteine residues.

12 ave ArsM orthologs with only three conserved cysteine residues.

13 e in proteins containing multiple endogenous cysteine residues.

14 s function is identification of the targeted cysteine residues.

15 les have an unusual conserved cleft with two cysteine residues.

16 de bond that is formed by the second pair of cysteine residues.

17 rgeting lysine, glutamine/aspartic acid, and cysteine residues.

18 the cell membrane through palmitoylation of cysteine residues.

19 able tryptic digestion without alkylation of cysteine residues.

20 to catalyze palmitate removal from cytosolic cysteine residues.

21 d, activity was dependent on the presence of cysteine residues.

22 iency, can lead to in vitro modifications on cysteine residues.

23 n identified in this study and include these cysteine residues.

24 composition of the sequences adjacent to the cysteine residues.

25 vcMMAE or mcMMAF on the alkylated interchain cysteine residues.

26 ed by alanine replacement of three conserved cysteine residues.

27 exposed or reduced interchain disulfide bond cysteine residues.

28 in its peptidic backbone two S-methylated l-cysteine residues.

29 ion (NCL) which can take place at N-(methyl)-cysteine residues.

30 forming direct interactions with active-site cysteine residues.

31 lecular disulfide bridge between consecutive cysteine residues.

32 lmon nuclei despite salmon protamine lacking cysteine residues.

33 xidative post-translational modifications of cysteine residues.

34 ested disulfide bonds and motifs of adjacent cysteine residues.

35 haracterized ArsM to date has four conserved cysteine residues.

36 thyltransferase requiring only two conserved cysteine residues.

37 which is ligated by one histidine and three cysteine residues.

38 only the second, third and fourth conserved cysteine residues.

39 rticular, oxidation of mitochondrial protein cysteine residues.

40 e introduction of spin labels via engineered cysteine residues.

41 ed by S-palmitoylation at four juxtamembrane cysteine residues.

42 lic phosphatases by oxidation of active site cysteine residues.

43 The mutation of cysteine residue 107 in NDUFB10 impaired oxidation and e

44 specific S-nitrosylation of VLCAD mutants at cysteine residue 237.

45 inhibitor, PRN694, which covalently binds to cysteine residues 442 of ITK and 350 of RLK and blocks k

46 eable thiol ligands, and the track a line of cysteine residues 6 A apart within an alpha-haemolysin p

47 he posttranslational modification of protein cysteine residues, a process called S-sulfhydration.

48 ification in which palmitic acid is added to cysteine residues, allowing association with different c

49 ignificant flexibility in the positioning of cysteine residues, although the propensity to form cyste

50 ed by maleimide coupling of NOTA to a unique cysteine residue and chelation of (18)F-AlF.

51 1Ser substitution affects a highly conserved cysteine residue and is predicted by molecular modeling

52 ied by S-glutathionylation at this conserved cysteine residue and that either endogenously synthesize

53 itor, 3-bromopyruvate, also targets the same cysteine residue and that our electrophilic quinazolines

54 d in-situ with N-ethylmaleimide to block the cysteine residue and to enhance its lipophilic propertie

55 method using thiol-ene reactions between two cysteine residues and an alpha,omega-diene in high yield

56 thalimide (NPSP), reacts with free thiols in cysteine residues and attaches a chromogenic benzenesele

57 et light which photo-reverses S-nitrosylated cysteine residues and by co-incubations with cytochalasi

58 UV light, which photoreverses S-nitrosylated cysteine residues and by co-incubations with the antioxi

59 Ps express both surface attachment-promoting cysteine residues and FLAG-tag antibody binding peptides

60 cant reduction in HCN currents by binding to cysteine residues and forming S-nitrosothiol complexes.

61 s groups (COG) 1900, possesses two conserved cysteine residues and is often found in genomic contexts

62 al infectivity by >100-fold and included two cysteine residues and neighboring residues.

63 Three cysteine residues and one disulfide bond conserved withi

64 brane protein 3 is S-fatty acylated on three cysteine residues and site-specific modification of high

65 tylated on multiple sites including those on cysteine residues and that deubiquitylation of these sit

66 of these exported proteins contain multiple cysteine residues and that several membrane-bound oxidor

67 vrFom2 is a small, secreted protein with two cysteine residues and weak similarity to secreted protei

68 A, and DsrE2 bind sulfur atoms via conserved cysteine residues, and experimental evidence is provided

69 These cysteine residues are conserved in all four desmoglein f

70 ntified cleavage site between two juxtaposed cysteine residues are distinct from those of presently k

71 st, MTSET has no effect on channels in which cysteine residues are engineered into intracellular regi

72 Disulfide bonds between cysteine residues are essential to the structure and fol

73 As some of these cysteine residues are highly conserved within the RGS fa

74 We found that the cysteine residues are not essential for the formation of

75 Cysteine residues are subject to diverse modifications,

76 Vicinal disulfides between sequence-adjacent cysteine residues are very rare and rather startling str

77 ps that are able to interact covalently with cysteine residues, as exemplified by its effect on NF-ka

78 palmitate moiety is covalently attached to a cysteine residue at position 175, which is part of an am

79 The cysteine residue at the C-terminal of the substrate was

80 The OPH signal peptide contains an invariant cysteine residue at the junction of the signal peptidase

81 el coiled-coil with two absolutely conserved cysteine residues at its apex.

82 mic one another by substituting the variable cysteine residues at position III in the protein.

83 vo and in vitro and identified two conserved cysteine residues at positions 54 and 56 as palmitoylati

84 The positional preference of cysteine residues at the N terminus in the tetrapeptides

85 ron transfer was mediated by an array of six cysteine residues at the very C-terminal end, which also

86 the MutL-beta interaction by engineering two cysteine residues at variable positions of the interface

87 prediction is then focused on the remaining cysteine residues based on SVR training.

88 with an HDAC, the thiol of a conserved HDAC cysteine residue becomes covalently tagged with the prom

89 conjugation takes place nonhomogeneously to cysteine residues both on the light and heavy chains.

90 experiments produced similar results of many cysteine residues bound to N-acetylglucosamine (GlcNAc).

91 ation through covalent modification of KEAP1 cysteine residues, but such electrophilic compounds lack

92 olipids and modification of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance chann

93 ttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation.

94 ants with point mutations of two of the four cysteine residues, C111 and C112, in domain B and found

95 During topology mapping, we discovered two cysteine residues (C187 and C293) located on opposite si

96 R domain of FisR through the three conserved cysteine residues (C53, C64 and C71), FisR activates the

97 which contains five palmitoylation sites at cysteine residues (C58, C59, C60, C95, and C101), was a

98 the alpha-helix with the former peroxidatic cysteine residue C61 by six residues.

99 MOM)-OH, peptides containing a Bhc-protected cysteine residue can be easily prepared.

100 D1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfid

101 of a pair of hydrogen atoms from juxtaposed cysteine residues, contrasts with the substantial change

102 on electrode surfaces through an engineered cysteine residue coupled with impedimetric detection fac

103 The ten internal cysteine residues crucial to functional structure format

104 DD) or a highly conserved transmembrane (TM) cysteine residue (Cys(259)) implicated in receptor dimer

105 mology-based structural modeling predicted a cysteine residue (Cys-298) in position to form a disulfi

106 Mutation of a conserved cysteine residue (Cys-85) preserves FMO but suppresses T

107 ergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys-264 and Cys-265.

108 BlArsM has six cysteine residues (Cys10, Cys11, Cys145, Cys193, Cys195

109 SpArsR has two conserved cysteine residues, Cys101 and Cys102.

110 covalent bond between TTN and a PP1-specific cysteine residue, Cys127.

111 We show that one natural cysteine residue, Cys327, out of three, has an enhanced

112 ointed the source of the quenching action to cysteine residues (Cys49 and Cys353) situated near two l

113 nfluenzae response to formaldehyde, with two cysteine residues (Cys54 and Cys71) identified to be imp

114 a modification of a unique, highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

115 idopsis (Arabidopsis thaliana) revealed that cysteine residues, CysI and CysII, are both involved in

116 208 new conotoxins displaying odd numbers of cysteine residues derived from known conotoxin motifs.

117 s proteins that are spin-labeled on a single cysteine residue display spin-echo decays with a single

118 Palmitoylation at a membrane proximal cysteine residue enables Fas to localize to lipid raft m

119 2) that disulfide bonds form between single cysteine residues experimentally introduced into an extr

120 lasso peptide microcin J25 (MccJ25) with two cysteine residues followed by cleavage of the peptide wi

121 Cd-MsrA mutants give a view of the essential cysteine residues for catalysis.

122 folds into a collagen triple helix, and the cysteine residues form disulfide bridges between the dif

123 Alanine substitution of cysteine residues forming the C-terminal disulfide bridg

124 s10, Cys145 and Cys195) align with conserved cysteine residues found in most ArsMs.

125 ative coupling of glutathione (GSH) to PRDX2 cysteine residues (i.e., protein glutathionylation) occu

126 ing chemical reagents specific for lysine or cysteine residues, identification of gas-phase fragmenta

127 ized so far contain evolutionarily conserved cysteine residues implicated in protochlorophyllide (Pch

128 , Pin p 1 contains the typical skeleton of 8 cysteine residues, important for its alpha-helixes enric

129 eat and contained an extra repetitive-domain cysteine residue in 1Dx5 that was important for understa

130 demonstrate the in situ labeling of a buried cysteine residue in BSA during extensional stress.

131 s resulting from the thiol reactivity of the cysteine residue in LR.

132 reductase, independently of H2O2 A conserved cysteine residue in OxyR2 is critical for this function.

133 evealed a diacylglycerol modification at the cysteine residue in position 16 for both nFAD-I and rFAD

134 ubstrate, which is coordinated by a peptidyl-cysteine residue in the bound state.

135 eakage of a thioether linkage to a conserved cysteine residue in the bulk protein structure.

136 ociated with substitutions of this conserved cysteine residue in the GPS motif have also been reporte

137 ds involving the acquired Cys39 and the only cysteine residue in the wild-type (M) sequence (Cys232).

138 f a palmitic chain via a thioester bond to a cysteine residue in weakly or nonencephalitogenic or neu

139 directly by binding to free thiol groups of cysteine residues in a chemical reaction called S-nitros

140 es have identified isozyme-specific reactive cysteine residues in brain glycogen phosphorylase (bGP).

141 using CLH-3b channels engineered with single-cysteine residues in CBS2 indicate that V228L, Y529A, an

142 Mutational analysis of cysteine residues in CNPYb identified differential depen

143 Cysteine residues in cytosolic proteins are maintained i

144 structures, as XEEL lacks the corresponding cysteine residues in hIntL-1 that stabilize the disulfid

145 y bound to GlcNAc through the side chains of cysteine residues in human cells, and the current discov

146 the C-terminal and N-terminal ends and TapA cysteine residues in its ability to promote the assembly

147 The BST-2 ectodomain encodes three cysteine residues in its N-terminal half, each of which

148 an lead to the non-enzymatic modification of cysteine residues in multiple proteins (succination) and

149 ew approach enabled us to selectively modify cysteine residues in native, unprotected peptides with a

150 rmolecular disulfide bonds between conserved cysteine residues in neurexins and CA10.

151 low molecular weight thiols are attached to cysteine residues in peptides via disulfide bonds.

152 ve shown that iron-sulfur clusters hosted by cysteine residues in proteins are readily disrupted by n

153 The sulfhydration of cysteine residues in proteins is an important mechanism

154 Measuring oxidation of cysteine residues in proteins is difficult using standar

155 Missense mutations that introduce or remove cysteine residues in receptor tyrosine kinases are belie

156 agent was developed to selectively alkylate cysteine residues in situ.

157 Alkylation of cysteine residues in TG2 or inhibition of endothelial NO

158 Two critical cysteine residues in the copper-A site (Cu(A)) on subuni

159 Cysteine residues in the double-stranded beta-helix fold

160 The cysteine residues in the ERp5 active sites are not requi

161 ctively, as measured by the accessibility of cysteine residues in the extracellular and cytoplasmic p

162 dual point mutations created at histidine or cysteine residues in the extracellular domain of CaR att

163 We identified two cysteine residues in the juxtamembrane (intracellular an

164 Replacement of any of the cysteine residues in the NCR169 peptide with serine rend

165 s a guardian of the reduced state of its own cysteine residues in the oxidizing environment of the mi

166 functional analysis of the role of reactive cysteine residues in the protein.

167 ity ligation assay with chemical labeling of cysteine residues in the sulfenic acid state, we visuali

168 erved region unusually rich in histidine and cysteine residues in the TMA-L1 region of eukaryotic chl

169 ognition, as missense mutations in conserved cysteine residues in this domain do not affect the catal

170 Linkage of the DOTA-based LBT to a cysteine residue induces pseudo-contact shifts (PCS) for

171 is hypothesis we have introduced 11 pairs of cysteine residues into Complex I; in each pair one is in

172 n (HA) trimer, termed HA3-SS, by introducing cysteine residues into the HA stem to covalently bridge

173 a) residues (in this instance, from a unique cysteine residue introduced by site-directed mutagenesis

174 In contrast, several pairs of cysteine residues introduced at other interfaces of N:M

175 sulfhydryl labelling by PEGylation of novel cysteine residues introduced into a cysteine-less WcaJ.

176 bridges formed between pairs of pore-lining cysteine residues introduced into different transmembran

177 d VKORL form disulfide-linked oligomers, the cysteine residues involved in the oligomerization appear

178 nzyme kinetics experiments validate that the cysteine residue is covalently appended with the TAP pro

179 Today, oxidation of cysteine residues is a well-recognized posttranslational

180 ial ferredoxins, while its ligation to three cysteine residues is reminiscent of enzymes such as acon

181 reviously reported that any one of the three cysteine residues is sufficient to produce functional BS

182 S-sulfhydration (forming -S-SH adducts from cysteine residues) is a newly defined oxidative posttran

183 forming the carboxymethyl derivative of the cysteine residues, is proposed.

184 oach utilizes conjugation to native antibody cysteine residues, it is widely applicable and enables h

185 -terminal region around the highly conserved cysteine residues known to be involved in regulation by

186 y modified by a palmitoyl lipid group at the cysteine residue linked with RP.

187 ite of covalent modification was mapped to a cysteine residue located in a region of V-ATPase subunit

188 the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase

189 region forms a three-helical bundle with two cysteine residues located at positions 191 and 192 in th

190 ide bond formation, depends on two conserved cysteine residues located in the C-terminal region.

191 Here, we show that two additional cysteine residues located in the non-helical head domain

192 r results have identified oxidation of TRPA1 cysteine residues, most likely by peroxynitrite, as a no

193 hepatoma cells and stably modifies specific cysteine residues (namely, Cys-257, -273, -288, -434, -4

194 SETD8 (MS453), which specifically modifies a cysteine residue near the inhibitor binding site, has an

195 Engineered cysteine residues near the primary electron donor (P) of

196 re protein of 48 amino acids (including four cysteine residues) not previously identified in associat

197 e loss of a thioether linkage to a conserved cysteine residue occurs, and the phycocyanobilin reactio

198 of the 1Ax1 gene corresponding to the extra cysteine residue of 1Dx5 was substituted by a cysteine c

199 ggest that an oxidative modification of this cysteine residue of Cox11 stimulates Cox19 binding, poin

200 It was concluded that the extra cysteine residue of mutant 1Ax1 subunit plays a positive

201 ansfer of a nitric oxide (NO) group from the cysteine residue of one protein to another].

202 holipid to the amine group of the N-terminal cysteine residue of the apolipoprotein.

203 ate is not due to irreversible reaction with cysteine residues of C/EBPbeta.

204 t in Cox4i2(-/-) PASMCs and was dependent on cysteine residues of Cox4i2.

205 lysis showed that ACR-adducts were formed on cysteine residues of some synaptic proteins.

206 disulfide bond between two highly conserved cysteine residues of SUN2 and KASH2 is crucial for the s

207 benzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by

208 Thus, compounds that target the cysteine residues of tau may prove useful in halting the

209 eptide that involves the four closely spaced cysteine residues of the heavy chain.

210 luorophores because the lysine, arginine and cysteine residues of viral proteins are labelled simulta

211 the loop sequence between the two conserved cysteine residues of VKORL affects its activity, support

212 Yvc1p has nine cysteine residues, of which eight are located in the cyt

213 The presence of an S-sulfhydration-modified cysteine residue on cytosolic ascorbate peroxidase was d

214 d formation through attack of an active site cysteine residue on the benzo[d]isothiazol-3(2H)-one cor

215 of sigma receptors results in oxidation of a cysteine residue on VMAT2, which decreases transporter f

216 Specifically, fumarate covalently modifies cysteine residues on iron regulatory protein 2 (IRP2), r

217 ing a linker-payload to native or engineered cysteine residues on the antibody.

218 ein we establish the importance of a pair of cysteine residues, one from AMG 416 and the other from t

219 map the sites of S-acylation on IRAP to two cysteine residues, one of which is predicted to lie in t

220 chment of 4,4'-bis(maleimido)azobenzene to a cysteine residue (P329C) introduced into each second tra

221 We then introduced cysteine residue pairs to the N- and C- termini of the c

222 utants, suggesting that the first N-terminal cysteine residue plays an important role in protein-memb

223 nts with single or multiple substitutions of cysteine residues points to a spatial and temporal hiera

224 ins through site-selective bis-alkylation of cysteine residues present as disulfides under mild and b

225 y, our data support that the seven conserved cysteine residues, present within the SPASM domain, are

226 We show here that addition of a cysteine residue prolongs the plasma half-life of iRGD a

227 Fatty acylation of cysteine residues provides spatial and temporal control

228 s found to abstract the sulfur atom from the cysteine residue, providing an alternative way to transf

229 cylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking and fun

230 ulfide-bond bridging in the presence of free cysteine residues relative to established maleimide func

231 , the role of this highly conserved reactive cysteine residue remains largely unknown.

232 firming that the C-terminal, redox-sensitive cysteine residues reside within the intermembrane space

233 utation or modification of the two conserved cysteine residues resulted in loss of transport activity

234 Mutation of the conserved cysteine residues revealed that the Cys22-Cys28 disulfid

235 idation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH).

236 NO reacts with cysteine residues (S-nitrosylation) on hyperpolarization

237 strategy, we identified 1,276 S-nitrosylated cysteine residues [S-nitrosothiol (SNO)] on 491 proteins

238 These cysteine residues serve as a dimerization domain and bin

239 ABSTRACT: The modification of cysteine residues (substituted for D43 and T47) by 2-ami

240 H4-mimicking peptide, containing a lysine to cysteine residue substitution (K12C), resulted in acetyl

241 existence of ArsMs with only three conserved cysteine residues suggest that the ability to methylate

242 ost focus has been on targeting binding-site cysteine residues, targeting nucleophilic lysine residue

243 chrome P450 (CYP) superfamily conserve a key cysteine residue that coordinates the heme iron.

244 t, confirming Cys-797 as the redox-sensitive cysteine residue that regulates kinase activity.

245 rc homology 2 (SH2) or SH3 domains or of the cysteine residue that undergoes LPS-induced palmitoylati

246 is regulated by palmitoylation of C-terminal cysteine residues that allows Golgi localization.

247 r the activity of channels containing single cysteine residues that are engineered into the short int

248 pyridyldithiol reagent preferentially labels cysteine residues that are more basic and hydrophobic.

249 tely 5 d, to unambiguously identify specific cysteine residues that are transiently and reversibly ox

250 This oxidation event involves one or more cysteine residues that become oxidized to sulfenic acid

251 e quite different, notably ABri contains two cysteine residues that can form disulfide bonds.

252 addition to the four disulfide bond-forming cysteine residues that define the traditional chemokine

253 at Tim17 contains a pair of highly conserved cysteine residues that form a structural disulfide bond

254 emokine fold, CCL28 possesses two additional cysteine residues that form a third disulfide bond.

255 ding bulls and humans, also contain multiple cysteine residues that form intra- and interprotamine su

256 amino acid motif and including six conserved cysteine residues that form intramolecular disulfide bon

257 ur genetic and biochemical data identify the cysteine residues that form the binding site as Cys132,

258 ADC) comprised of drug-linkers conjugated to cysteine residues that have been engineered into heavy c

259 by mouse macrophages, lacks three conserved cysteine residues that have been shown to form disulfide

260 es in the core of DSD were replaced by eight cysteine residues that serve as ligands to the [4Fe-4S]

261 tional analysis of TRPA1 mutants showed that cysteine residues that were oxidized by STZ were importa

262 Because covalent inhibitors target a cysteine residue, the effects of its oxidation on enzyme

263 y depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if pres

264 5-aminoacid peptide guanylin containing four cysteine residues; the net simulation time using Amber f

265 ent protein bridge by reacting with a nearby cysteine residue through proximity-enabled bioreactivity

266 e spontaneous oxidation of the Hha conserved cysteine residue to a -SOxH-containing species (sulfenic

267 lular aqueous accessibility of an endogenous cysteine residue to a membrane-impermeant sulfhydryl rea

268 pically have severe effects, mutation of the cysteine residue to alanine has minor effects on overall

269 ition that was dependent on the oxidation of cysteine residues to form disulfide bonds at a highly co

270 Class A methylases use two cysteine residues to methylate sp(2)-hybridized carbon c

271 rom predisposition of the intein's catalytic cysteine residues to oxidative and nitrosative modificat

272 Exposure of cysteine residues to ROS in the presence of glutathione

273 donating the sulfur atom of their exclusive cysteine residues to the substrate.

274 oxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (mAb) scaffo

275 aled minimal epimerization of the C-terminal cysteine residue under basic conditions used for Fmoc de

276 conjugated with biotin via native lysine and cysteine residues, under native-MS and solution conditio

277 niques, which leave the sensitive network of cysteine residues undisturbed.

278 ociated with dynamic reversible oxidation of cysteine residues via sequential sulfenylation and S-glu

279 lysis, and the subsequent incorporation of a cysteine residue was achieved by native chemical ligatio

280 work, unexpected protein S-GlcNAcylation on cysteine residues was observed to extensively exist in h

281 Differential labeling of cysteine residues was successfully demonstrated with nat

282 the high binding affinity of As(III) toward cysteine residues, we reasoned that the highly conserved

283 d histidine and intact histidine, lysine, or cysteine residues were discovered and characterized from

284 her this model can be extrapolated to GAT-1, cysteine residues were introduced at positions 359 and 4

285 Sec22 homodimers in cellular membranes when cysteine residues were positioned in the SNARE motif or

286 ine-free monomeric form of BST-2, individual cysteine residues were reintroduced at various locations

287 or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphata

288 assing four mutations that replace or create cysteine residues, which are most likely critical for ma

289 ) methylation activities have four conserved cysteine residues, which are thought to be essential for

290 ling molecules through oxidation of critical cysteine residues, which led to the notion that initiati

291 ompromised by acquired mutation of C797, the cysteine residue with which they form a key covalent bon

292 is approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable s

293 risingly, although pertussis toxin targets a cysteine residue within the alpha subunit of inhibitory

294 Our findings suggest that cysteine residues within p38alpha act as redox sensors t

295 reversible S-glutathionylation at conserved cysteine residues within TAZ.

296 stigated whether the conserved extracellular cysteine residues within the amino terminus of gK contri

297 emonstrate that coordination of zinc ions by cysteine residues within the CRD is required for the str

298 ers generated by H2O2 metabolism oxidize two cysteine residues within the GDE2 enzymatic domain, whic

299 Mutagenesis of individual cysteine residues within the non-amyloid cysteine-rich K

300 nteractions through covalent modification of cysteine residues within the RGS domain that are located