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1 d mutations in the gene Grxcr1 (glutaredoxin cysteine-rich 1) in five independent allelic strains of
2 ritically dependent on palmitoylation of its cysteine-rich (173)CCPCC(177) motif and are also highly
5 d levels of connective tissue growth factor, cysteine-rich 61, collagen I (COL1A2), and collagen III
8 een ORF31 and ORF24, (ii) the amino-terminal cysteine-rich and carboxyl-terminal basic domains of ORF
9 double-ring "head," in which the N-terminal cysteine-rich and fibronectin II domains were folded bac
12 mutagenesis of ADAMTS-4 identified that the cysteine-rich and spacer domains are responsible for bin
13 structs showed that membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10 mediate
15 of a rigid module formed by the disintegrin, cysteine-rich, and epidermal growth factor-like domains.
16 terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind substrates and
18 s to up-regulate the target genes, including cysteine-rich angiogenic inducer 61 (CYR61), connective
20 increasing expression of protein CYR61 (the cysteine-rich angiogenic inducer 61, or CCN1) in colonic
22 xins delta-SVIE and MrVIA), nodule-specific, cysteine-rich antimicrobial peptides (NCR), and a malari
24 inding regions of LRP consist of clusters of cysteine-rich approximately 40-residue complement-like r
28 and both auxiliary clusters are housed in a cysteine-rich C-terminal domain, termed SPASM domain, th
30 ectivity brought about by alterations in the cysteine-rich carboxy-terminal domains of the ligands.
34 receptors (FRalpha, FRbeta and FRgamma) are cysteine-rich cell-surface glycoproteins that bind folat
37 allothionein genes (CMT1 and CMT2), encoding cysteine-rich Cu binding and detoxifying proteins, whose
39 ehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich) domain using engineered glycans
41 cognized a protein complex consisting of the cysteine-rich (CysR), fibronectin-like type II (FnII), a
42 Def1 and MtDef4 from Medicago spp. are small cysteine-rich defensins with potent antifungal activity
43 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show th
44 y, homozygous deletion of src homology 3 and cysteine rich domain 3 (Stac3) in mice results in comple
46 r domain (ECD) of Fz, in particular its CRD (cysteine rich domain), as critical for nonautonomous Fz-
49 y LGR5 and RNF43, with its rod module of the cysteine-rich domain (CRD) contacting LGR5 and a hairpin
51 ular protease-associated (PA) domain and the cysteine-rich domain (CRD) of frizzled and the intracell
52 Wnt cis-unsaturated fatty acyl groups by the cysteine-rich domain (CRD) of FZD receptors remains elus
53 Wnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain
55 the conserved Wnt-binding site known as the cysteine-rich domain (CRD), with the highest affinity to
62 ises three immunoglobulin-like domains and a cysteine-rich domain (Fz-CRD) related to those in Frizzl
63 ering analyses of Norrin in complex with Fz4 cysteine-rich domain (Fz4CRD), of this complex bound wit
66 and fish null for the protein Stac3 (SH3 and cysteine-rich domain 3) but did not establish the functi
69 ession and purification of soluble mouse Fz8 cysteine-rich domain and human LRP6 extracellular domain
70 ges formed at C349/C356 and C465/C468 of the cysteine-rich domain are necessary for the enhancement o
71 Akt prevents binding of Rubicon (RUN domain cysteine-rich domain containing beclin1-interacting prot
72 a catalytically inactive PARP6 mutant, or a cysteine-rich domain deletion mutant that has significan
74 ring mutation in the evolutionally conserved cysteine-rich domain had more severe defects in ER exit
75 es localized to the N-terminal extracellular cysteine-rich domain has been described, a functional ro
77 ary, we present extensive mapping of WNT-FZD cysteine-rich domain interactions complemented by analys
79 ncatalytic spacer domain of ADAMTS-4 and the cysteine-rich domain of ADAMTS-5, blocking activity agai
82 developed by interchanging loops between the cysteine-rich domain of ASIP and the cysteine-rich domai
85 d on structural studies of the TWEAK-binding cysteine-rich domain of Fn14, several homology models of
87 s are mediated by an HS-binding motif in the cysteine-rich domain of HHIP1 that is required for its l
90 ngly, a truncated form of Smo that lacks the cysteine-rich domain of the ECD localizes to the cilium
92 for ROR1/ROR2 heterooligomerization and the cysteine-rich domain or intracellular proline-rich domai
93 cipated architecture in which the C-terminal cysteine-rich domain partially occludes the enzyme activ
94 axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute
96 structure of this newly characterized small cysteine-rich domain suggests potential involvement of J
98 ansferase domain, ankyrin repeat domain, and cysteine-rich domain) were unnecessary for G9a coactivat
99 is coupled to the transmembrane domain via a cysteine-rich domain, and LBD closure seems to be the fi
105 e closed-open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane doma
108 t interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc e
109 2 encodes four N-terminal scavenger receptor cysteine-rich domains and the highly conserved C-termina
112 ar, both containing three scavenger receptor cysteine-rich domains in their extracellular regions.
113 e in cultured retinal axons, suggesting that cysteine-rich domains interact with and activate an inhi
114 myocilin to the surface of cells expressing cysteine-rich domains of different Frizzled and sFRPs.
116 ng purified WNTs, we show that different FZD cysteine-rich domains prefer to bind to distinct WNTs wi
126 growth, thereby linking the redox status of cysteine-rich envelope proteins with progression of the
130 modified through the removal or addition of cysteine-rich extracellular domains to produce a panel o
131 Gp340 is a member of the scavenger receptor cysteine-rich family of innate immune molecules and also
132 L1 belongs to the group B scavenger receptor cysteine-rich family of proteins, where the CD163-L1 gen
135 one of these families, the nodule-specific, cysteine-rich gene family, is specific to the galegoid l
136 ction of the intestinal mucin MUC2, a large, cysteine-rich glycoprotein that forms the protective muc
138 sitively charged residues at the base of the cysteine-rich head and two variant residues in the dorsa
139 fluorometry to investigate movements in the cysteine-rich head domain of the rat P2X1R (A118-I125) t
141 lobes coordinated by positive charge on the cysteine-rich head region and residues in the adjacent d
142 oximately 135-fold in chimeras replacing the cysteine-rich head, and the dorsal fin region below it i
143 etric beta-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5
144 d and disulfide linked form) is a 32-residue cysteine-rich host-defense peptide, expressed and releas
145 bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique
147 cassette bound to brain endothelium and the cysteine-rich interdomain region 1 inhibited binding of
148 ge extracellular ectodomains made from CIDR (cysteine-rich interdomain regions) and DBL (Duffy-bindin
149 ual cysteine residues within the non-amyloid cysteine-rich Kringle-like domain stabilizes the disulfi
150 ofibril-associated glycoproteins (MAGPs) are cysteine-rich low molecular weight components of the fib
154 a large nuclear protein that shares a novel cysteine rich motif with known transcription factors.
155 critically depends on palmitoylation of its cysteine-rich motif (-CCPCC-) and is modulated by the me
156 ssociation is because of palmitoylation of a cysteine-rich motif, CCPCC, located within the catalytic
158 mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmemb
160 domains that are protease-resistant and has cysteine-rich N and C termini responsible for polymeriza
163 vent that is induced by host nodule-specific cysteine rich (NCR) antimicrobial peptides and requires
165 onstrate that NFS2 encodes a nodule-specific cysteine-rich (NCR) peptide that acts to promote bacteri
167 able of degrading a range of nodule-specific cysteine-rich (NCR) peptides encoded by M. truncatula.
168 pproximately 600 of them are nodule-specific cysteine-rich (NCR) peptides produced in the rhizobium-i
169 rentiation is driven by host nodule-specific cysteine-rich (NCR) peptides that orchestrate the adapta
170 ber of antimicrobial peptides, called nodule cysteine-rich (NCR) peptides, to control the outcome of
171 der control by an arsenal of nodule-specific cysteine-rich (NCR) peptides, which induce the bacteria
174 expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes
177 Inhibition of the enzyme by this 66-mer cysteine-rich peptide is mediated by its C-terminal sequ
178 clinical relevance of this hepatic ~2.8 kDa cysteine-rich peptide is rapidly increasing, since alter
182 s process is orchestrated by nodule-specific cysteine-rich peptides (NCRs) delivered into developing
184 ibes chemistry that is broadly applicable to cysteine-rich peptides and the influence of a fourth dis
185 es a new element of structural diversity for cysteine-rich peptides as well as increased protease res
186 rminus for the capture reaction, which makes cysteine-rich peptides ideal candidates for the entropy-
187 as likely due to the coordination of Zn with cysteine-rich peptides in the root endodermis, suggestin
189 Defensins are short cationic, amphiphilic, cysteine-rich peptides that constitute the front-line im
193 SMYD2 domains including the MYND domain, the cysteine-rich post-SET domain, and the C-terminal domain
194 Cystine knot alpha-amylase inhibitors are cysteine-rich, proline-rich peptides found in the Amaran
196 ied a conserved GPI-linked parasite protein, Cysteine-rich protective antigen (CyRPA) as an interacti
201 B silencing leads to increased expression of cysteine-rich protein 61 (CCN1/CYR61) known to mediate a
203 bronectin 1 (FN1), interleukin-1beta (IL1B), cysteine-rich protein 61 (CYR61), and jagged-1 (JAG1), t
205 ke molecule alpha (Relm-alpha) is a secreted cysteine-rich protein belonging to a newly defined famil
206 ns in the gene coding for reversion-inducing cysteine-rich protein containing Kazal motifs (Reck).
207 efficient modification of acceptor sites in cysteine-rich protein domains before disulfide bond form
210 wth factor-like (EGF) repeats are also small cysteine-rich protein motifs that can be O-glycosylated
212 ilitates the import and oxidative folding of cysteine-rich protein substrates into the mitochondrial
214 the tumor suppressor gene reversion-inducing cysteine-rich protein with kazal motifs (RECK) by two ke
215 nd Western blot analysis, reversion-inducing cysteine-rich protein with kazal motifs (Reck) was ident
216 an inactivating lesion in reversion-inducing cysteine-rich protein with Kazal motifs [reck; also know
217 the Notch activator RECK (reversion-inducing cysteine-rich protein with kazal motifs) by releasing it
218 he membrane protein RECK (Reversion-inducing cysteine-rich protein with kazal motifs) controls breast
220 press such a large, highly glycosylated, and cysteine-rich protein, limiting structural studies to LR
222 Metallothioneins are a family of small, cysteine rich proteins that have been implicated in a ra
224 cluding the major outer membrane protein and cysteine-rich proteins (OmcA and OmcB), constitute the o
225 llothioneins (MTs) are low-molecular-weight, cysteine-rich proteins believed to play a role in cytoso
227 ners with the oxidoreductase Mia40 to import cysteine-rich proteins in the mitochondrial intermembran
228 ing of Mia40 and Erv1 mediates the import of cysteine-rich proteins into the mitochondrial intermembr
229 s the hair and nails by binding and altering cysteine-rich proteins of hair and nails or by means of
231 bz linker can be applied to the synthesis of cysteine-rich proteins such the cyclotides Kalata B1 and
234 ordin-like (KCP) protein, one of a family of cysteine-rich proteins, suppresses TGF-beta signaling by
237 alysis revealed the activation of members of cysteine-rich receptor-like kinase (CRK) genes in the ba
239 ions in either the core region (K41A) or the cysteine-rich region (C30G) of Tat abrogated its ability
241 roximity to the glutamate binding domain and cysteine-rich region (R375G and G396V) show both decreas
242 ADAM17 revealed that within its disintegrin/cysteine-rich region are two highly conserved, vicinal c
245 we find that a few basic amino acids in the cysteine-rich region of SNAP25 and SNAP23 are essential
246 well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutation
248 pidermal growth factor (EGF)-like domains, a cysteine-rich region which includes a domain of eight cy
249 replication initiation factor, followed by a cysteine-rich region, predicted to fold as a Zn knuckle.
250 lves domains in the N terminus of anosmin-1 (cysteine-rich region, whey acidic protein-like domain an
251 nsus as TTYRAA and determine that two tandem cysteine rich regions are required for high-affinity DNA
252 s of both the human and Xenopus laevis RecQ4 cysteine-rich regions, and showed by NMR spectroscopy th
254 ocation of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized b
255 either the N-terminal myristoylation nor the cysteine-rich RING H2 domain of rapsyn is required for i
256 wing the identification of the male (S-locus Cysteine Rich/S-locus Protein 11) and female (S Receptor
258 -locus receptor kinase (SRK) and the S-locus cysteine-rich (SCR) genes, as well as unlinked modifier
259 e (SRK) [1] by pollen coat-localized S-locus cysteine-rich (SCR) ligand [2-5] and the resulting rejec
260 d the other encoding its ligand, the S-locus cysteine-rich (SCR) protein, which is localized in the p
263 Connective tissue growth factor (CTGF) is a cysteine-rich secreted matricellular protein involved in
264 ike molecule (RELM)-beta, belongs to a novel cysteine-rich secreted protein family named FIZZ/RELM.
267 wn that allurin is a truncated member of the Cysteine-Rich Secretory Protein (CRISP) family, whose me
268 ssion of a human CAP superfamily member, the cysteine-rich secretory protein 2 (CRISP2), rescues the
270 unctional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis r
271 of action, the CAP protein superfamily [i.e. cysteine-rich secretory proteins (CRISP), antigen 5, and
273 R-1/Sc7 (SCP/TAPS) domain, also known as the cysteine-rich secretory proteins/antigen 5/pathogenesis-
274 protein tablysin-15 is a member of the CAP (cysteine-rich secretory, antigen 5, and pathogenesis-rel
275 efensin-related Defcr-rs genes that code for cysteine-rich sequence 4C (CRS4C) peptides that have a u
276 monstrate that noncatalytic thrombospondin-1/cysteine-rich/spacer domains are principal modifiers of
278 the expression of secreted protein, acidic, cysteine rich (SPARC), myocilin, angiopoietin-like facto
280 ns is present, containing scavenger receptor cysteine-rich (SRCR) and C-type lectin domains, which fu
282 the substitution of CD163 scavenger receptor cysteine-rich (SRCR) domain 5 with a homolog of human CD
283 he presence of the fourth scavenger receptor-cysteine-rich (SRCR) domain of LOXL2, which is also the
284 to result in between 7-20 scavenger-receptor cysteine-rich (SRCR) domains within each SAG molecule.
286 isingly, Loxl3 N-terminal scavenger receptor cysteine-rich (SRCR) repeats, rather than the C-terminal
287 o-receptors belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a mu
291 protein with sequence homology to vertebrate Cysteine-rich transmembrane BMP regulator 1 (Crim1).
292 o span 22 kb including exons 14-17 of CRIM1 (cysteine-rich transmembrane bone morphogenetic protein (
294 ysis, we identify a hitherto uncharacterized cysteine-rich, transmembrane (TM) module, CYSTM, found i
295 hrough molecular dynamics simulations on the cysteine-rich trypsin inhibitor MCoTI-II with three disu
296 l of exon 2 of the Sep15 gene coding for the cysteine-rich UDP-glucose:glycoprotein glucosyltransfera
298 ns, adipose differentiation-related protein, cysteine-rich with epidermal growth factor-like domains
300 opsis thaliana) that has similarities to the cysteine-rich zinc-binding domain of DnaJ chaperones.
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