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1 cture by three disulfide bonds, which form a cystine knot.
2 is the presence of a stabilizing C-terminal cystine knot.
3 lpha-helical structures commonly observed in cystine knots.
4 8-82, and 32-84; the last three comprise the cystine knot, a structure also seen in a variety of grow
7 n together, our results expand membership of cystine knot alpha-amylase inhibitors in the Apocynaceae
10 toms of several residues in the beta-subunit cystine knot, alpha-subunit loop 2, and the small seatbe
11 harmacologically active C-C-CC-C-C inhibitor cystine knot and CC-C-C motifs (168 and 44 toxins, respe
12 are those contained within the beta-subunit cystine knot and reveal that a disulfide exchange occurr
13 s between backbone atoms of the beta-subunit cystine knot and the tensor loop with backbone atoms in
15 it potentiates formation of the beta-subunit cystine knot, and second, contacts between alpha-subunit
16 o a homogeneous product, retains the desired cystine knot architecture, functions as an antagonist, a
18 e that all three "X" residues within the hCG cystine knots are collectively, but not individually, re
21 l end-to-end cyclic backbone combined with a cystine knot arrangement, making them exceptionally stab
29 otein that shares similarity with a class of cystine knot-containing factors including dan, cerberus,
30 CG) is a heterodimeric member of a family of cystine knot-containing proteins that contain the consen
32 shares 81% identity, macaque (m)CG-beta is a cystine knot-containing subunit that assembles with an a
39 that Hi1a comprises two homologous inhibitor cystine knot domains separated by a short, structurally
41 factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequ
44 is predicted bursicon protein belongs to the cystine knot family, which includes vertebrate transform
49 disulfide exchange event crucial for CG-beta cystine knot formation and attainment of CG-beta assembl
55 mily members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfi
57 on, to our knowledge the first heterodimeric cystine knot hormone found in insects, consists of two p
58 ucture is consistent with two models for the cystine knot; however, the poor density for the majority
59 the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-term
60 8, and are shown to belong to the inhibitory cystine knot (ICK) family of peptide toxins interacting
61 region of AGRP(87-132) adopts the inhibitor cystine knot (ICK) fold previously identified for numero
62 of the three-disulfide-containing inhibitor cystine knot (ICK) motif found widely in animals and pla
66 s identified that AGRP contains an inhibitor cystine knot (ICK) structural fold, and that is the firs
67 da venatoria toxin 2 (HpTx2) is an inhibitor cystine knot (ICK)-gating modifier toxin that selectivel
72 ion to synthesize dimers of integrin-binding cystine knot (knottin) miniproteins with low-picomolar b
73 d illuminated with a fluorescent, engineered cystine knot (knottin) peptide that binds with high affi
74 d to engineer a small, disulfide-constrained cystine knot (knottin) peptide that bound to alpha(v)bet
77 ons that cystine residues of the hCG subunit cystine knots make in folding, assembly, and bioactivity
80 ma pruriens, that conforms to the inhibitory cystine knot motif and which modifies activation kinetic
81 residue C-terminal extension with a modified cystine knot motif found in multisubunit external cell s
82 the mutant structures suggests a role of the cystine knot motif in protein folding rather than in the
84 ein hormone alpha-subunit (GPH-alpha) form a cystine knot motif that stabilizes a three-loop antipara
85 monomeric and consists of an eight-membered cystine knot motif with a fold similar to transforming g
86 tides from three different classes of cyclic cystine knot motif-containing cyclotides: Mobius (M), tr
89 re, their end-to-end cyclic structure with a cystine-knot motif represents a molecular structure of a
90 ssue growth factor (CCN2/CTGF) to C-terminal cystine knot motifs present in key angiogenic regulators
91 ere substituted by swapping their respective cystine knot motifs, the resulting chimeras appeared to
94 From these studies we conclude that: (i) the cystine knot of GPH-alpha is necessary and sufficient fo
97 d and allows for the proper oxidation of the cystine knot of type III collagen after the short triple
98 was found to adopt the so-called "inhibitor cystine knot" or "knottin" fold stabilized by three disu
99 toxin guangxitoxin-1E (GxTX), an inhibitory cystine knot peptide that binds selectively to Kv2-type
102 f the Agouti-related protein (AgRP), a 4-kDa cystine-knot peptide with four disulfide bonds and four
110 e V-ATPase of pea albumin 1b (PA1b), a small cystine knot protein that shows exquisitely selective in
111 ocus on Drosophila bursicon, a heterodimeric cystine-knot protein that activates the G protein-couple
112 We have found that the structurally related cystine-knot protein, nerve growth factor beta (NGFbeta)
114 ved trio of disulfide bonds shared among all cystine knot proteins, but the remaining two putative di
116 is a neuropeptide hormone consisting of two cystine-knot proteins (burs alpha and burs beta), respon
119 cule supports the hypothesis that indeed the cystine knot region possesses the melanocortin receptor
121 equence of either the alpha- or beta-subunit cystine knot resulted in non-native disulfide bond forma
122 7-31, bond 59-87, or both (leaving only the cystine knot) resulted in an efficiently secreted foldin
123 own as cyclotides that possess a macrolactam-cystine knot scaffold imparting exceptional physiologica
124 cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in em
127 ions from several venoms and characterized a cystine knot toxin called JZTx-27 from the venom of tara
128 hypothesize parallel evolution of inhibitor cystine knot toxins from Araneomorphae and Mygalomorphae
131 ot disulfide bonds and demonstrated that the cystine knot was necessary and sufficient for efficient
132 d not form when all cysteine residues of the cystine knot were converted to alanine, suggesting that
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