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1 cture by three disulfide bonds, which form a cystine knot.
2  is the presence of a stabilizing C-terminal cystine knot.
3 lpha-helical structures commonly observed in cystine knots.
4 8-82, and 32-84; the last three comprise the cystine knot, a structure also seen in a variety of grow
5                                              Cystine knot alpha-amylase inhibitors are cysteine-rich,
6                   Similar to other knottins, cystine knot alpha-amylase inhibitors are highly resista
7 n together, our results expand membership of cystine knot alpha-amylase inhibitors in the Apocynaceae
8                           Here, we show that cystine knot alpha-amylase inhibitors named alstotides d
9 oline bonds, characteristics shared by other cystine knot alpha-amylase inhibitors.
10 toms of several residues in the beta-subunit cystine knot, alpha-subunit loop 2, and the small seatbe
11 harmacologically active C-C-CC-C-C inhibitor cystine knot and CC-C-C motifs (168 and 44 toxins, respe
12  are those contained within the beta-subunit cystine knot and reveal that a disulfide exchange occurr
13 s between backbone atoms of the beta-subunit cystine knot and the tensor loop with backbone atoms in
14 reversibly with parts of the NH(2) terminus, cystine knot, and loop 2 of the hCG beta-subunit.
15 it potentiates formation of the beta-subunit cystine knot, and second, contacts between alpha-subunit
16 o a homogeneous product, retains the desired cystine knot architecture, functions as an antagonist, a
17                    Thus, individual bonds of cystine knot are important for secretion and heterodimer
18 e that all three "X" residues within the hCG cystine knots are collectively, but not individually, re
19                                          Two cystine knots are energetically preferred; however, all
20 ng of panitide L3 showed that it possesses a cystine knot arrangement similar to cyclotides.
21 l end-to-end cyclic backbone combined with a cystine knot arrangement, making them exceptionally stab
22 e leptin receptor contained several distinct cystine knots as well as 10 free cysteines.
23                          Whether the two non-cystine knot bonds 7-31 and 59-87 could form independent
24 fide bonds, collectively known as the cyclic cystine knot (CCK) motif.
25 t form a knotted structure known as a cyclic cystine knot (CCK).
26                               The C-terminal cystine knot (CK) (CTCK) domain in von Willebrand factor
27                                              Cystine knots consist of three intertwined disulfide bri
28 receptor associations that are determined by cystine-knot containing subdomains.
29 otein that shares similarity with a class of cystine knot-containing factors including dan, cerberus,
30 CG) is a heterodimeric member of a family of cystine knot-containing proteins that contain the consen
31 insight into the folding mechanisms of other cystine knot-containing proteins.
32 shares 81% identity, macaque (m)CG-beta is a cystine knot-containing subunit that assembles with an a
33                              Mutation of non-cystine knot disulfide bond 7-31, bond 59-87, or both (l
34                 Furthermore, mutation of the cystine knot disulfide bonds resulted in multiple foldin
35 l receptor ectodomain (ECD) with the Spatzle cystine knot domain dimer.
36                               The C-terminal cystine knot domain dimerizes end-to-end in a manner pre
37  by two loops presented by a well-structured cystine knot domain within AGRP(87-132).
38 e AGRP analogue designed to contain only the cystine knot domain.
39 that Hi1a comprises two homologous inhibitor cystine knot domains separated by a short, structurally
40 d here for the first time between the D4 and cystine-knot domains form a stem.
41 factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequ
42 uence patterns similar to those found in the cystine knot family of proteins.
43                It is the first member of the cystine knot family to have a defined function in invert
44 is predicted bursicon protein belongs to the cystine knot family, which includes vertebrate transform
45 he cytokine Spatzle, a dimeric ligand of the cystine knot family.
46                    ASIP adopts the inhibitor cystine knot fold and, along with AgRP, are the only kno
47 cture with each monomer adopting a conserved cystine knot fold.
48 s similar in structure to IL-17F, adopting a cystine-knot fold.
49 disulfide exchange event crucial for CG-beta cystine knot formation and attainment of CG-beta assembl
50 ariant Gly residue is required for efficient cystine knot formation and subunit folding.
51 ide rearrangement is an essential feature of cystine knot formation during CG-beta folding.
52                                              Cystine knot formation proceeded through a 1-disulfide i
53 pathway and that 59-87 forms during or after cystine knot formation.
54                   Neurotrophin-3 (NT-3) is a cystine knot growth factor that promotes the survival, p
55 mily members adopt a monomer fold typical of cystine knot growth factors, despite lacking the disulfi
56 ain noncovalently associated with the mature cystine-knot growth factor domain after processing.
57 on, to our knowledge the first heterodimeric cystine knot hormone found in insects, consists of two p
58 ucture is consistent with two models for the cystine knot; however, the poor density for the majority
59 the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-term
60 8, and are shown to belong to the inhibitory cystine knot (ICK) family of peptide toxins interacting
61  region of AGRP(87-132) adopts the inhibitor cystine knot (ICK) fold previously identified for numero
62  of the three-disulfide-containing inhibitor cystine knot (ICK) motif found widely in animals and pla
63 MR spectroscopy revealed a classic inhibitor cystine knot (ICK) motif.
64 pattern C-C-CC-C-C that forms the inhibitory cystine knot (ICK) or knottin motif.
65  reported to adopt a well-defined inhibitory cystine knot (ICK) scaffold structure.
66 s identified that AGRP contains an inhibitor cystine knot (ICK) structural fold, and that is the firs
67 da venatoria toxin 2 (HpTx2) is an inhibitor cystine knot (ICK)-gating modifier toxin that selectivel
68             These results suggested that the cystine knot is critical for the intracellular integrity
69                   The conserved motif of the cystine knot is CX3CP.
70                                          The cystine knot is N-terminal to the collagen triple helix
71                                   This novel cystine knot is present in type IX collagen, too.
72 ion to synthesize dimers of integrin-binding cystine knot (knottin) miniproteins with low-picomolar b
73 d illuminated with a fluorescent, engineered cystine knot (knottin) peptide that binds with high affi
74 d to engineer a small, disulfide-constrained cystine knot (knottin) peptide that bound to alpha(v)bet
75         Norrin (Norrie Disease Protein) is a cystine-knot like growth factor.
76 ugh disulfide bonds between their C-terminal cystine knot-like (CK) domains.
77 ons that cystine residues of the hCG subunit cystine knots make in folding, assembly, and bioactivity
78                                          The cystine-knot miniproteins present in tomato fruit (TCMPs
79 cular disulfide bonds, three of which form a cystine knot motif (10-60, 28-82, and 32-84).
80 ma pruriens, that conforms to the inhibitory cystine knot motif and which modifies activation kinetic
81 residue C-terminal extension with a modified cystine knot motif found in multisubunit external cell s
82 the mutant structures suggests a role of the cystine knot motif in protein folding rather than in the
83                                 The modified cystine knot motif stabilizes cell-bound trimers upon Ca
84 ein hormone alpha-subunit (GPH-alpha) form a cystine knot motif that stabilizes a three-loop antipara
85  monomeric and consists of an eight-membered cystine knot motif with a fold similar to transforming g
86 tides from three different classes of cyclic cystine knot motif-containing cyclotides: Mobius (M), tr
87  C-term VHv1.1 represents a new and distinct cystine knot motif.
88 de peptide was consistent with an inhibitory cystine knot motif.
89 re, their end-to-end cyclic structure with a cystine-knot motif represents a molecular structure of a
90 ssue growth factor (CCN2/CTGF) to C-terminal cystine knot motifs present in key angiogenic regulators
91 ere substituted by swapping their respective cystine knot motifs, the resulting chimeras appeared to
92                              Conversely, the cystine knot mutants were inefficiently secreted (<25%).
93 utants was greater than 95%, whereas for the cystine knot mutants, it was 20-40%.
94 From these studies we conclude that: (i) the cystine knot of GPH-alpha is necessary and sufficient fo
95                                          The cystine knot of Spz binds the concave face of the Toll l
96                                   First, the cystine knot of the alpha-subunit potentiates formation
97 d and allows for the proper oxidation of the cystine knot of type III collagen after the short triple
98  was found to adopt the so-called "inhibitor cystine knot" or "knottin" fold stabilized by three disu
99  toxin guangxitoxin-1E (GxTX), an inhibitory cystine knot peptide that binds selectively to Kv2-type
100                                        These cystine knot peptide tracers, in particular (18)F-fluoro
101                            A yeast-displayed cystine-knot peptide library was generated by substituti
102 f the Agouti-related protein (AgRP), a 4-kDa cystine-knot peptide with four disulfide bonds and four
103        ProTx-II and huwentoxin-IV (HWTX-IV), cystine knot peptides from tarantula venoms, preferentia
104                                              Cystine knot peptides were labeled with N-succinimidyl-4
105                         Here, we evaluated 2 cystine knot peptides, R01 and S02, previously engineere
106                             Four macrocyclic cystine-knot peptides of 29-31 residues, kalata, circuli
107                                       Mutant cystine-knot peptides were screened in a high-throughput
108 as characterized recently as a heterodimeric cystine knot protein in Drosophila melanogaster.
109 ligand is the human nerve growth factor-like cystine knot protein Spatzle.
110 e V-ATPase of pea albumin 1b (PA1b), a small cystine knot protein that shows exquisitely selective in
111 ocus on Drosophila bursicon, a heterodimeric cystine-knot protein that activates the G protein-couple
112  We have found that the structurally related cystine-knot protein, nerve growth factor beta (NGFbeta)
113  endoproteinase Lys-C, resulting in a stable cystine-knot protein.
114 ved trio of disulfide bonds shared among all cystine knot proteins, but the remaining two putative di
115 ling and the structure and function of other cystine knot proteins.
116  is a neuropeptide hormone consisting of two cystine-knot proteins (burs alpha and burs beta), respon
117 x ligands, including the family of mammalian cystine-knot proteins.
118             Comparison with other classes of cystine knots provides indication that C-term VHv1.1 rep
119 cule supports the hypothesis that indeed the cystine knot region possesses the melanocortin receptor
120 esidues 991 to 1032 including the C-terminal cystine knot region, to 2.3A resolution.
121 equence of either the alpha- or beta-subunit cystine knot resulted in non-native disulfide bond forma
122  7-31, bond 59-87, or both (leaving only the cystine knot) resulted in an efficiently secreted foldin
123 own as cyclotides that possess a macrolactam-cystine knot scaffold imparting exceptional physiologica
124 cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in em
125              GVIIJ[C24S] adopts an inhibitor cystine knot structure, with two antiparallel beta-stran
126                                    The eight cystine knot topologies that are characterized by exclus
127 ions from several venoms and characterized a cystine knot toxin called JZTx-27 from the venom of tara
128  hypothesize parallel evolution of inhibitor cystine knot toxins from Araneomorphae and Mygalomorphae
129 cysteine-stabilized alpha/beta and inhibitor cystine knot types of fold.
130 hered gonadotropins bearing mutations in the cystine knot was increased significantly.
131 ot disulfide bonds and demonstrated that the cystine knot was necessary and sufficient for efficient
132 d not form when all cysteine residues of the cystine knot were converted to alanine, suggesting that
133 aring single cysteine residue mutants in the cystine knot were significantly reduced.

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