ライフサイエンスコーパス: cytidine

1 igns four nucleotides upstream of the edited cytidine.

2 lling with the combination of vancomycin and cytidine.

3 in methanol solution is identical to that of cytidine.

4 obtained by the co-addition of either UMP or cytidine.

5 f exogenous CTP or its nucleoside precursor, cytidine.

6 con that had a high content of guanidine and cytidine.

7 ed to methylated and other modified forms of cytidine.

8 synthesized from suitably protected 5'-O-DMT cytidines.

9 ride, and the binding of ribonuclease A with cytidine 2'-monophosphate within reaction volumes of app

10 oxy-2',4'-difluorouridine (2',4'-diF-rU) and cytidine (2',4'-diF-rC) nucleosides.

11 The nucleotide cytidine 5' triphosphate (CTP) is a precursor required f

12 ficiency include phophoglucomutase 3 (PGM3), cytidine 5' triphosphate synthase 1 (CTPS1), nuclear fac

13 sis on the pressor and bradycardic effect of cytidine 5'-diphosphocholine (CDP-choline).

14 We demonstrated that Q5LIW1 is inhibited by cytidine 5'-monophospho-3-deoxy-D-manno-2-octulosonic ac

15 or cytosine, 1-methylcytosine, cytidine, and cytidine 5'-phosphate, and also for cytosine residues in

16 and microarray data generated on 5-azadeoxy-cytidine (5-Aza) treated HT-29 colon cancer cells with a

17 i are hypersensitive to killing by exogenous cytidine, adenosine, or guanosine, whereas wild-type cel

18 Gemcitabine is a modified cytidine analog having two fluorine atoms at the 2'-posi

19 Here, we show that the nonmethylable cytidine analog zebularine induces a DNA damage response

20 pectral changes and quenching of fluorescent cytidine analogs, we also established a mechanism for th

21 ty over related enzymes and synergize with a cytidine analogue against leukemic cells.

22 was modest, the triphosphate of a 2'-oxetane cytidine analogue demonstrated potent intrinsic biochemi

23 the design and synthesis of a new tricyclic cytidine analogue, 8-diethylamino-tC (8-DEA-tC), that re

24 The cytidine analogues azacytidine and 5-aza-2'-deoxycytidin

25 To expand the arsenal of fluorescent cytidine analogues for the detection of genetic material

26 ibitors that enhance the cytotoxic effect of cytidine analogues in leukemia cells.

27 cytarabine and various structurally related cytidine analogues, such as 2'deoxycytidine and gemcitab

28 on and are resistant to treatment with other cytidine analogues.

29 Monomethylations of cytidine and adenosine are common post-transcriptional m

30 ed with four different C5-functionalized LNA cytidine and C8-functionalized LNA adenosine monomers.

31 e distribution, with a strong preference for cytidine and guanosine, and identified hotspots of ribon

32 n criteria are outlined and the syntheses of cytidine and uridine azo dye analogues derived from 6-am

33 eding 3' splice sites while adapting to both cytidine and uridine nucleotides with nearly equivalent

34 ng some other nucleosides such as guanosine, cytidine and uridine, the excellent specificity of this

35 to some other nucleosides such as guanosine, cytidine and uridine.

36 ytic C-terminal domain (CTD) that deaminates cytidine, and a N-terminal domain (NTD) that binds to ss

37 imilar rates for cytosine, 1-methylcytosine, cytidine, and cytidine 5'-phosphate, and also for cytosi

38 but not with doxorubicin or arabinofuranosyl cytidine (Ara-C).

39 ery of the antimitotic drug arabinofuranosyl cytidine (AraC) blunted food intake, body weight gain, a

40 In angiosperm organelles, cytidines are converted to uridines by a deamination rea

41 The edited cytidines are often flanked by inverted repeats, but are

42 al specific nucleoside kinase is involved in cytidine as well as uridine salvage.

43 A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a mod

44 These proteins convert cytidine bases to uridine bases in retroviral DNA.

45 unction mutants accumulating high amounts of cytidine but also CMP, cytosine, and some uridine in see

46 somatic hypermutation (SHM), deamination of cytidine by activation-induced cytidine deaminase and su

47 Plant RNA editosomes modify cytidines (C) to uridines (U) at specific sites in plast

48 Plant RNA editing modifies cytidines (C) to uridines (U) at specific sites in the t

49 e units for healthy volunteers (P = .02) and cytidine concentrations were 1.44 (0.95-1.73) relative u

50 nal pattern suggestive of activation-induced cytidine deaminase (AID) activity.

51 ed to the Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dependent fashion.

52 Fs ectopically expressing activation-induced cytidine deaminase (AID) and observed an excess of AID s

53 n of DSBs is initiated by activation-induced cytidine deaminase (AID) and requires base excision repa

54 tudies have reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (T

55 Activation-induced cytidine deaminase (AID) converts cytosine into uracil t

56 Activation-induced cytidine deaminase (AID) initiates Ab class-switch recom

57 Activation-induced cytidine deaminase (AID) initiates both class switch rec

58 Activation-induced cytidine deaminase (AID) initiates both somatic hypermut

59 Activation-induced cytidine deaminase (AID) initiates class switch recombin

60 Activation-induced cytidine deaminase (AID) initiates CSR by promoting deam

61 The DNA deaminase activation-induced cytidine deaminase (AID) initiates somatic hypermutation

62 Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme tha

63 Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme tha

64 Activation-induced cytidine deaminase (AID) is a key regulator of class swi

65 Activation-induced cytidine deaminase (AID) is a mutator enzyme that target

66 Activation-induced cytidine deaminase (AID) is critical in normal B cells t

67 Activation-induced cytidine deaminase (AID) is essential for class-switch r

68 Activation-induced cytidine deaminase (AID) mediates cytosine deamination a

69 B cells with constitutive activation-induced cytidine deaminase (AID) mutator activity.

70 The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes

71 SH requires the activation-induced cytidine deaminase (AID) protein and transcription of th

72 The activation induced cytidine deaminase (AID) protein is known to initiate so

73 ion (CSR) is initiated by activation-induced cytidine deaminase (AID) that catalyzes numerous DNA cyt

74 The ability of activation-induced cytidine deaminase (AID) to efficiently mediate class-sw

75 ul R loops, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R

76 on-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions

77 Likewise, recruitment of activation-induced cytidine deaminase (AID) to S regions is critical for CS

78 on-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the su

79 ed with less targeting of activation-induced cytidine deaminase (AID) to the Igh locus.

80 ically inactive dCas9 to recruit variants of cytidine deaminase (AID) with MS2-modified sgRNAs, we ca

81 e we report the fusion of activation-induced cytidine deaminase (AID) with nuclease-inactive clustere

82 the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3gamma targets this enzym

83 nal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator.

84 the expression levels of activation-induced cytidine deaminase (AID), a key player in B-cell respons

85 The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remode

86 tion (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell differentiatio

87 genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene trans

88 f that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to

89 s in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral

90 eration and expression of activation-induced cytidine deaminase (AID), DNA repair enzymes, and post-c

91 ion (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to

92 These biomarkers are activation-induced cytidine deaminase (AID), the enzyme of class switch rec

93 Activation-induced cytidine deaminase (AID), the enzyme responsible for ind

94 Activation-induced cytidine deaminase (AID), the enzyme-mediating class-swi

95 Activation-induced cytidine deaminase (AID), which functions in antibody di

96 +) B cells stimulated for activation-induced cytidine deaminase (AID)-dependent IgH class switch reco

97 eliberate introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand br

98 of cytidine to uracil by activation-induced cytidine deaminase (AID).

99 he B-cell mutator protein activation-induced cytidine deaminase (AID).

100 ntial activity of the DNA activation-induced cytidine deaminase (AID).

101 of targeted DNA damage by activation-induced cytidine deaminase (AID).

102 nsiently-expressed enzyme Activation-induced cytidine Deaminase (AID).

103 tations introduced by the activation-induced cytidine deaminase (AID).

104 re, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic

105 The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is

106 s and identified that L306 in the C-terminal cytidine deaminase (CD) domain contributed to its core l

107 CYTIDINE DEAMINASE (CDA) catalyzes the deamination of cy

108 new possibilities for anti-cancer treatment.Cytidine deaminase (CDA) deficiency leads to genome inst

109 m revealed that TAMs induced upregulation of cytidine deaminase (CDA), the enzyme that metabolizes th

110 DNMT1 and tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapi

111 that the susceptible cell lines overexpress cytidine deaminase (CDA).

112 erivatives were synthesized as inhibitors of cytidine deaminase (CDA).

113 on of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteo

114 because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both re

115 se findings indicate that activation-induced cytidine deaminase acting on V-region sequences is suffi

116 ctors contains residues conserved with known cytidine deaminase active sites; however, some PPR editi

117 We also queried the data for cytidine deaminase activity on the viral genome, which c

118 ect cells and demonstrated that it possesses cytidine deaminase activity, as expected.

119 ations, and mutations associated with APOBEC cytidine deaminase activity.

120 uplex and, despite the bound RNA, has potent cytidine deaminase activity.

121 d functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damag

122 ription factors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell-specifi

123 in B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in

124 found a synthetic lethal interaction between cytidine deaminase and microtubule-associated protein Ta

125 eamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates m

126 autoreactivity, expresses activation-induced cytidine deaminase and T-bet, and exhibits evidence of s

127 edominant mutation signature associated with cytidine deaminase APOBEC, which correlates with the upr

128 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated wi

129 We recently showed that the DNA cytidine deaminase APOBEC3B accounts for up to half of t

130 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C

131 Functional analyses identified the cytidine deaminase APOBEC3G as a barrier for chimpanzee-

132 The enzymatic reaction of cytidine deaminase appears to be a distinct example.

133 es, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosyla

134 in such cells is attributed to a mycoplasma cytidine deaminase causing rapid drug catabolism.

135 nd that conserved catalytic residues in both cytidine deaminase domains are required for RNA editing.

136 e engineered base editors containing mutated cytidine deaminase domains that narrow the width of the

137 We engineered fusions of CRISPR/Cas9 and a cytidine deaminase enzyme that retain the ability to be

138 Several adenosine or cytidine deaminase enzymes deaminate transcript sequence

139 associated with increased activation-induced cytidine deaminase expression, and correlate with increa

140 ation ex vivo by altering activation-induced cytidine deaminase expression.

141 eaminase is unique within the zinc-dependent cytidine deaminase family as being allosterically regula

142 f these findings to the wider zinc-dependent cytidine deaminase family is also discussed.

143 polypeptide-like-3 (APOBEC3) innate cellular cytidine deaminase family, particularly APOBEC3F and APO

144 Using cytidine deaminase fused to Cas9 nickase, up to 28% of s

145 -mediated ablation of the activation-induced cytidine deaminase gene required for class switch recomb

146 pts and to upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and

147 dministration of tetrahydrouridine (a potent cytidine deaminase inhibitor).

148 ACI antibody could induce activation-induced cytidine deaminase mRNA in those with mutations.

149 c antibody showed loss of activation-induced cytidine deaminase mRNA induction in all mutation-bearin

150 The activation-induced cytidine deaminase protein induces genome-wide DNA break

151 report extensive computer simulations of the cytidine deaminase reaction and its temperature dependen

152 Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues

153 Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication.

154 downstream effector APOBEC3, an IFN-induced cytidine deaminase that introduces lethal mutations duri

155 APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by i

156 APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency

157 t essential for targeting activation-induced cytidine deaminase to S regions, as was suggested.

158 ssibilities, we used a chemical inhibitor of cytidine deaminase to stabilize and thereby artificially

159 gs for cancer tissues presenting concomitant cytidine deaminase underexpression and Tau upregulation

160 sent the crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site a

161 APOBEC3G is a cytidine deaminase with two homologous domains and restr

162 or stromal remodeling and down-regulation of cytidine deaminase without depletion of tumor stromal co

163 Single-strand DNA-specific APOBEC cytidine deaminase(s) are major source(s) of mutation in

164 the miR-155 target Aicda (activation-induced cytidine deaminase) in this process and, in combination

165 Expression of cytidine deaminase, a dC-catabolizing enzyme, in leukemi

166 formation, expression of activation-induced cytidine deaminase, and affinity maturation.

167 lly defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision re

168 in binds a zinc metal ion, as expected for a cytidine deaminase, and is potentially the catalytic com

169 oliferation, induction of activation-induced cytidine deaminase, and the production of circle and ger

170 V regions, expression of activation-induced cytidine deaminase, clonal H chain switch, and an invert

171 oduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and

172 Activation-induced cytidine deaminase, one of the APOBEC members, was repor

173 ed with overexpression of activation-induced cytidine deaminase, the hotspot length increases even fu

174 on (CSR) is instigated by activation-induced cytidine deaminase, which converts cytosines in switch r

175 ation (CSR) is induced by activation-induced cytidine deaminase, which initiates a cascade of events

176 identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitut

177 Tau is overexpressed in cytidine deaminase-deficient cells, and its depletion wo

178 ere Tau functions in maintaining survival of cytidine deaminase-deficient cells, and ribosomal DNA tr

179 Igs and hypermutated IgM (activation-induced cytidine deaminase-deficient), or fully agammaglobulemic

180 lated high frequencies of activation-induced cytidine deaminase-dependent IgH locus chromosomal break

181 3B activity, providing new insights into how cytidine deaminase-induced mutagenesis might be activate

182 (PPR) protein SLO2, which lacks a C-terminal cytidine deaminase-like DYW domain, interacts in vivo wi

183 eoside transporters, and it was resistant to cytidine deaminase-mediated degradation.

184 of the tumor stroma, and down-regulation of cytidine deaminase.

185 d deoxyguanosine resistant to degradation by cytidine deaminase.

186 ically required in the reaction catalyzed by cytidine deaminase.

187 re shown to interact with activation-induced cytidine deaminase.

188 or of transcription 3 and activation-induced cytidine deaminase.

189 ulating the expression of activation-induced cytidine deaminase.

190 on of dG:dU mismatches by activation-induced cytidine deaminase.

191 he B cell-specific factor activation-induced cytidine deaminase.

192 nsity that are targets of activation-induced cytidine deaminase.

193 to a defective BLM and the downregulation of cytidine deaminase.

194 receptors are damaged by activation-induced cytidine deaminase.

195 targeting activity of the activation-induced cytidine deaminase.

196 c mice (quasimonoclonal, activation-induced [cytidine] deaminase-Cre-tamoxifen-dependent estrogen rec

197 belongs to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids.

198 Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged i

199 indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutat

200 Here we engineered programmable cytidine deaminases and test if we could introduce site-

201 Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) ar

202 nfectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) fo

203 Cytidine deaminases are single stranded DNA mutators div

204 The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retrov

205 man APOBEC3 protein family of polynucleotide cytidine deaminases contributes to intracellular defense

206 show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in in

207 s recently proposed for the APOBEC family of cytidine deaminases in generating particular genome-wide

208 ptide-like (APOBEC) proteins are a family of cytidine deaminases involved in various important biolog

209 APOBEC cytidine deaminases mutate cancer genomes by converting

210 The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range

211 Several antiviral cytidine deaminases of the human APOBEC3 (hA3) family ha

212 e catalytic subunit 3 (APOBEC-3) enzymes are cytidine deaminases that are broadly and constitutively

213 e earliest-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate specif

214 The AID / APOBEC genes are a family of cytidine deaminases that have evolved in vertebrates, an

215 otein B editing complex 3 family members are cytidine deaminases that play important roles in intrins

216 Base editing relies on recruitment of cytidine deaminases to introduce changes (rather than do

217 Members of the APOBEC3 family of cytidine deaminases vary in their proportions of a virio

218 in both the nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); wh

219 zyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated

220 strate of some single strand-specific APOBEC cytidine deaminases, similar to the mutations that can t

221 signature attributed to the APOBEC family of cytidine deaminases, whereas others are confined to a si

222 t studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil du

223 (A3B), a member of the AID/APOBEC family of cytidine deaminases.

224 d major source of mutation in cancer, APOBEC cytidine deaminases.

225 lieved, and that this is largely due to host cytidine deaminases.

226 nding motif that shares characteristics with cytidine deaminases.

227 ociation with lineage-specific expression of cytidine deaminases.

228 tivating host antiviral factors, the APOBEC3 cytidine deaminases.

229 ages of cDNA synthesis, as well as excessive cytidine deamination (hypermutation) of the DNAs that ar

230 lation and enzymatic basis of RNA editing by cytidine deamination are incompletely understood.

231 normalities but demonstrated elevated global cytidine deamination at deaminase intrinsic binding site

232 No viruses showed evidence of cytidine deamination by mouse or human APOBEC3s.

233 In spite of this in vitro activity, cytidine deamination by virion-packaged APOBEC3 of MMTV

234 troviruses during replication as a result of cytidine deamination of minus-strand DNA transcripts.

235 Our data suggest that while APOBEC3-mediated cytidine deamination of MMTV may occur, it is not the ma

236 ombination (CSR) via transcription-dependent cytidine deamination of single-stranded DNA targets.

237 APOBEC3 restricts its viral targets through cytidine deamination of viral DNA during reverse transcr

238 L/6)) and knockout mice to determine whether cytidine deamination was important for APOBEC3's anti-MM

239 se transcription as well as the induction of cytidine deamination within nascent viral cDNA.

240 , gene conversion or switch recombination by cytidine deamination within the immunoglobulin loci.

241 ases away from the positions of AID-mediated cytidine deamination, suggesting DNA end resection befor

242 GSDA belongs to the cytidine/deoxycytidylate deaminase family of proteins to

243 ion of a new radical species and a "trapped" cytidine derivative that can break down to cytosine.

244 covery of 80% of the G* and reduction of the cytidine derivative, proposed to be 3'-keto-deoxycytidin

245 hosphatidylcholine (PC) biosynthesis via the cytidine diphosphate (CDP)-choline pathway at the expens

246 Cytidine diphosphate diacylglycerol (CDP-DAG) is a centr

247 respiring rat liver mitochondria with [(14)C]cytidine diphosphate leads to accumulation of radiolabel

248 ing greater partitioning of choline into the cytidine diphosphate-choline (CDP-choline) PC biosynthet

249 mice with the DNA-demethylating agent 5-aza-cytidine distinctly enhanced the antitumor response, int

250 21 nt and with the adenosine adjacent to the cytidine-guanosine (CG) dinucleotide motif led to a sign

251 Cytidine hydrolysis in cda mutants is likely caused by N

252 denine in a DNA oligonucleotide and 8.15 for cytidine in a tertiary structure element from beet weste

253 cleotides and found the lowest affinity to 5'cytidine in correlation with the translational stress-re

254 aminases mutate cancer genomes by converting cytidines into uridines within ssDNA during replication.

255 These analogues were more emissive than cytidine (lambdaem 398-420 nm, Phi 0.009-0.687), and exc

256 motif, a cap analog (m(7)GTP), and a capped cytidine (m(7)GpppC), resolved to 2.6, 1.8 and 1.7 A, re

257 ate diphosphohydrolase 5/ adenylate kinase 1/cytidine monophosphate kinase 1 axis and the mitochondri

258 n unprecedented ability to attach a terminal cytidine monophosphate to cognate precursor peptide in c

259 The cytidine monophosphate-binding site in the C-terminal al

260 e structure and function of the prototypical cytidine monophosphate-Kdo-dependent alpha-Kdo glycosylt

261 Cytidine monophosphate-N-acetylneuraminate hydroxylase (

262 , 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxyla

263 induce anti-Neu5Gc antibody when grafted in cytidine monophosphate-N-acetylneuraminic acid hydroxyla

264 ere we focused on the function of Drosophila cytidine monophosphate-sialic acid synthetase (CSAS), th

265 Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxyla

266 Levels of the precursor molecule cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac

267 of AML patients receiving treatment with the cytidine nucleoside analogue cytarabine.

268 Thus, AML cells have increased cytidine nucleoside kinase activity that regulates mtDNA

269 armacokinetics of a series of 4'-substituted cytidine nucleosides.

270 ng of ribonuclease A (RNaseA, 13.7 kDa) with cytidine nucleotide ligands and the binding of lysozyme

271 250 muM MPA) and upregulation of uridine and cytidine nucleotides (p < 0.001 at 24 h; 5 muM MPA) occu

272 f seven enzymes that catalyze deamination of cytidine nucleotides to uridine nucleotides (C-to-U) in

273 APOBEC3A, which is known to deaminate cytidines of single-stranded DNA and to inhibit viruses

274 als, and humans modifies genomically encoded cytidine or adenosine nucleotides to uridine or inosine,

275 NAs, dCas9-AID-P182X (AIDx) directly changed cytidines or guanines to the other three bases independe

276 ynthesized para-substituted phenyl-imidazolo-cytidine ((Ph)ImC) analogues 5a-g and established a rela

277 nds suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which

278 y DNA hypermethylation of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in g

279 and the Toll-like receptor 9 (TLR9) agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG)

280 ccount for discrimination against methylated cytidine residues.

281 ase inhibitor, dCas9-AIDx converted targeted cytidines specifically to thymines, creating specific po

282 sis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue (1,3-diaza-2-oxo-phen

283 High frequency of cytidine to thymidine conversions was identified in the

284 and test if we could introduce site-specific cytidine to thymidine transitions in the absence of targ

285 lls and are initiated through deamination of cytidine to uracil by activation-induced cytidine deamin

286 tion-induced deaminase (AID), which converts cytidine to uracil within the Ig variable (IgV) regions.

287 DEAMINASE (CDA) catalyzes the deamination of cytidine to uridine and ammonia in the catabolic route o

288 ttern resembles the deamination signature of cytidine to uridine carried out by members of the APOBEC

289 found to be the main specificity factors of cytidine to uridine RNA editing.

290 breaks, and mediate the direct conversion of cytidine to uridine, thereby effecting a C-->T (or G-->A

291 able deaminases effectively convert specific cytidines to thymidines with 13% efficiency in Escherich

292 ss switch recombination (CSR) by deaminating cytidines to uridines at V region (V) genes and switch (

293 ion with the DNA methylation inhibitor 5-aza-cytidine, to activate an early skeletal muscle transcrip

294 d complementary DNA sequences, we discovered cytidine-to-uridine RNA editing in position 32 of two nu

295 ects of inhibiting viral cDNA production and cytidine-to-uridine-driven hypermutation of this cDNA.

296 herichia coli is allosterically inhibited by cytidine triphosphate.

297 nd betaine in alcohol-fed mice and decreased cytidine, uracil, fumarate, creatine phosphate, creatine

298 sugars, and, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine.

299 The resulting 'base editors' convert cytidines within a window of approximately five nucleoti

300 ls can tolerate high doses of these modified cytidines without any deleterious effects on physiology.