ライフサイエンスコーパス: cytidine deaminase

1 ass switch recombination (activation-induced cytidine deaminase).

2 d deoxyguanosine resistant to degradation by cytidine deaminase.

3 ically required in the reaction catalyzed by cytidine deaminase.

4 re shown to interact with activation-induced cytidine deaminase.

5 or of transcription 3 and activation-induced cytidine deaminase.

6 ulating the expression of activation-induced cytidine deaminase.

7 on of dG:dU mismatches by activation-induced cytidine deaminase.

8 he B cell-specific factor activation-induced cytidine deaminase.

9 nsity that are targets of activation-induced cytidine deaminase.

10 of Dnd1 is related to Apobec1 activity as a cytidine deaminase.

11 similar to the action of activation-induced cytidine deaminase.

12 , and Blimp-1, and of the activation-induced cytidine deaminase.

13 f DNA breaks initiated by activation-induced cytidine deaminase.

14 inhibits the activity of activation-induced cytidine deaminase.

15 to a defective BLM and the downregulation of cytidine deaminase.

16 receptors are damaged by activation-induced cytidine deaminase.

17 targeting activity of the activation-induced cytidine deaminase.

18 of the tumor stroma, and down-regulation of cytidine deaminase.

19 nding motif that shares characteristics with cytidine deaminases.

20 ein B mRNA-editing enzyme complex) family of cytidine deaminases.

21 l immunity afforded by the APOBEC3 family of cytidine deaminases.

22 ociation with lineage-specific expression of cytidine deaminases.

23 tivating host antiviral factors, the APOBEC3 cytidine deaminases.

24 (A3B), a member of the AID/APOBEC family of cytidine deaminases.

25 d major source of mutation in cancer, APOBEC cytidine deaminases.

26 lieved, and that this is largely due to host cytidine deaminases.

27 Expression of cytidine deaminase, a dC-catabolizing enzyme, in leukemi

28 The human APOBEC3 family consists of seven cytidine deaminases (A3A to A3H), some of which display

29 Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged i

30 se findings indicate that activation-induced cytidine deaminase acting on V-region sequences is suffi

31 self-regulating aspect of activation-induced cytidine deaminase action that is conserved in evolution

32 The DNA cytidine deaminase activation-induced deaminase (AID) ca

33 ctors contains residues conserved with known cytidine deaminase active sites; however, some PPR editi

34 A3FDelta2 and A3FDelta2-4 displayed reduced cytidine deaminase activity and moderate antiviral activ

35 We also queried the data for cytidine deaminase activity on the viral genome, which c

36 Moreover, whether APOBEC3G cytidine deaminase activity transcends to processing cel

37 ect cells and demonstrated that it possesses cytidine deaminase activity, as expected.

38 ations, and mutations associated with APOBEC cytidine deaminase activity.

39 uplex and, despite the bound RNA, has potent cytidine deaminase activity.

40 d functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damag

41 The cytidine deaminase AID hypermutates immunoglobulin genes

42 obulin class-switch recombination (CSR), the cytidine deaminase AID induces double-strand breaks into

43 ription factors and Aicda (which encodes the cytidine deaminase AID) and thus silenced B cell-specifi

44 riven expression of AICDA (which encodes the cytidine deaminase AID), the immunoglobulin receptor CD2

45 We previously showed that the cytidine deaminases AID and APOBEC1 can deaminate 5-meth

46 nal pattern suggestive of activation-induced cytidine deaminase (AID) activity.

47 While both activation-induced cytidine deaminase (AID) and 53BP1 have been associated

48 on of the genomic mutator activation-induced cytidine deaminase (AID) and AID-dependent DNA double-st

49 ed to the Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dependent fashion.

50 Fs ectopically expressing activation-induced cytidine deaminase (AID) and observed an excess of AID s

51 ed the expression of both activation-induced cytidine deaminase (AID) and of germline transcripts of

52 osine deaminases, such as activation-induced cytidine deaminase (AID) and other members of the APOBEC

53 n of DSBs is initiated by activation-induced cytidine deaminase (AID) and requires base excision repa

54 tudies have reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (T

55 The discovery of activation-induced cytidine deaminase (AID) and the use of murine models to

56 y, it has been shown that activation-induced cytidine deaminase (AID) contributes to the demethylatio

57 Activation-induced cytidine deaminase (AID) converts cytosine into uracil t

58 genome rearrangements via activation-induced cytidine deaminase (AID) followed by base excision repai

59 s studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but ha

60 Finally, we find that activation-induced cytidine deaminase (AID) induces the rearrangement of ma

61 Activation-induced cytidine deaminase (AID) initiates Ab class-switch recom

62 Activation-induced cytidine deaminase (AID) initiates antibody gene diversi

63 Activation-induced cytidine deaminase (AID) initiates both class switch rec

64 Activation-induced cytidine deaminase (AID) initiates both somatic hypermut

65 Activation-induced cytidine deaminase (AID) initiates class switch recombin

66 Activation-induced cytidine deaminase (AID) initiates CSR and SHM by deamin

67 Activation-induced cytidine deaminase (AID) initiates CSR by promoting deam

68 Activation-induced cytidine deaminase (AID) initiates CSR by promoting DNA

69 mmunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of im

70 Activation-induced cytidine deaminase (AID) initiates DNA double-strand bre

71 Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) h

72 The DNA deaminase activation-induced cytidine deaminase (AID) initiates somatic hypermutation

73 Activation-induced cytidine deaminase (AID) instigates mutations and DNA br

74 Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme tha

75 Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme tha

76 Activation-induced cytidine deaminase (AID) is a key enzyme for antibody-me

77 Activation-induced cytidine deaminase (AID) is a key regulator of class swi

78 Activation-induced cytidine deaminase (AID) is a mutator enzyme that initia

79 Activation-induced cytidine deaminase (AID) is a mutator enzyme that target

80 Activation-induced cytidine deaminase (AID) is an enzyme essential for the

81 Activation-induced cytidine deaminase (AID) is critical in normal B cells t

82 Activation-induced cytidine deaminase (AID) is essential for class-switch r

83 PURPOSE OF REVIEW: Activation-induced cytidine deaminase (AID) is expressed in germinal center

84 Activation-induced cytidine deaminase (AID) is induced in B cells during an

85 Activation-induced cytidine deaminase (AID) is required for somatic hypermu

86 Activation-induced cytidine deaminase (AID) is required for somatic hypermu

87 Activation-induced cytidine deaminase (AID) mediates cytosine deamination a

88 tected GC B cells against activation-induced cytidine deaminase (AID) mutagenesis, facilitated cell c

89 B cells with constitutive activation-induced cytidine deaminase (AID) mutator activity.

90 The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes

91 SH requires the activation-induced cytidine deaminase (AID) protein and transcription of th

92 The activation induced cytidine deaminase (AID) protein is known to initiate so

93 t targeting of the enzyme activation-induced cytidine deaminase (AID) results in the accumulation of

94 ion (CSR) is initiated by activation-induced cytidine deaminase (AID) that catalyzes numerous DNA cyt

95 diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that a

96 The ability of activation-induced cytidine deaminase (AID) to efficiently mediate class-sw

97 ul R loops, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R

98 on-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions

99 Likewise, recruitment of activation-induced cytidine deaminase (AID) to S regions is critical for CS

100 on-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the su

101 ed with less targeting of activation-induced cytidine deaminase (AID) to the Igh locus.

102 ically inactive dCas9 to recruit variants of cytidine deaminase (AID) with MS2-modified sgRNAs, we ca

103 e we report the fusion of activation-induced cytidine deaminase (AID) with nuclease-inactive clustere

104 the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3gamma targets this enzym

105 nal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator.

106 the expression levels of activation-induced cytidine deaminase (AID), a key player in B-cell respons

107 , we apply this screen to activation-induced cytidine deaminase (AID), a poorly soluble protein that

108 RNA and protein levels of activation-induced cytidine deaminase (AID), a protein essential for SHM an

109 The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remode

110 e B cell specific enzyme, activation-induced cytidine deaminase (AID), and can be replicated in non-B

111 tion (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell differentiatio

112 genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene trans

113 itch recombination (CSR), activation-induced cytidine deaminase (AID), and stability of E47 mRNA.

114 f that machinery, such as activation-induced cytidine deaminase (AID), as well as factors central to

115 s in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral

116 eration and expression of activation-induced cytidine deaminase (AID), DNA repair enzymes, and post-c

117 DNA lesions initiated by activation-induced cytidine deaminase (AID), in the absence of mammalian-ty

118 The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutatio

119 One family member, activation-induced cytidine deaminase (AID), selectively introduces uracil

120 ion (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to

121 These biomarkers are activation-induced cytidine deaminase (AID), the enzyme of class switch rec

122 Activation-induced cytidine deaminase (AID), the enzyme responsible for ind

123 Activation-induced cytidine deaminase (AID), the enzyme-mediating class-swi

124 Activation-induced cytidine deaminase (AID), which functions in antibody di

125 pathway, thereby inducing activation-induced cytidine deaminase (AID), which is critical for class sw

126 omes who are deficient in activation-induced cytidine deaminase (AID), which is required for class-sw

127 instability in B cells as activation-induced cytidine deaminase (AID), which mediates this process, i

128 mutation are initiated by activation-induced cytidine deaminase (AID), which preferentially recognize

129 +) B cells stimulated for activation-induced cytidine deaminase (AID)-dependent IgH class switch reco

130 B lymphocytes induced for activation-induced cytidine deaminase (AID)-dependent IgH class switching.

131 o rapid proliferation and activation-induced cytidine deaminase (AID)-dependent remodeling of immunog

132 eliberate introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand br

133 he B-cell mutator protein activation-induced cytidine deaminase (AID).

134 of targeted DNA damage by activation-induced cytidine deaminase (AID).

135 geting of the DNA mutator activation-induced cytidine deaminase (AID).

136 K 293 cells co-expressing activation-induced cytidine deaminase (AID).

137 ntial activity of the DNA activation-induced cytidine deaminase (AID).

138 genes is initiated by the activation-induced cytidine deaminase (AID).

139 itch regions and requires activation-induced cytidine deaminase (AID).

140 bulin (Ig) genes requires activation-induced cytidine deaminase (AID).

141 tic hypermutation require activation-induced cytidine deaminase (AID).

142 nsiently-expressed enzyme Activation-induced cytidine Deaminase (AID).

143 tations introduced by the activation-induced cytidine deaminase (AID).

144 of cytidine to uracil by activation-induced cytidine deaminase (AID).

145 re, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic

146 The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is

147 ous and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the in

148 CSR is initiated by activation-induced cytidine deaminase, an enzyme that produces multiple DNA

149 in B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in

150 found a synthetic lethal interaction between cytidine deaminase and microtubule-associated protein Ta

151 esponsible for recruiting activation-induced cytidine deaminase and promoting its activity.

152 eamination of cytidine by activation-induced cytidine deaminase and subsequent DNA repair generates m

153 autoreactivity, expresses activation-induced cytidine deaminase and T-bet, and exhibits evidence of s

154 indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutat

155 Here we engineered programmable cytidine deaminases and test if we could introduce site-

156 dinated DNA demethylation pathway, utilizing cytidine deaminases and thymidine glycosylases, has been

157 in both the nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); wh

158 formation, expression of activation-induced cytidine deaminase, and affinity maturation.

159 lly defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision re

160 llicular dendritic cells, activation-induced cytidine deaminase, and IL-21(+)PD1(+) follicular helper

161 in binds a zinc metal ion, as expected for a cytidine deaminase, and is potentially the catalytic com

162 oliferation, induction of activation-induced cytidine deaminase, and the production of circle and ger

163 zyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated

164 edominant mutation signature associated with cytidine deaminase APOBEC, which correlates with the upr

165 more controversially, the activation-induced cytidine deaminase/APOBEC deaminases have the capacity t

166 We found that two cytidine deaminases (apobec2a and apobec2b) were express

167 The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are

168 The APOBEC3 family comprises seven cytidine deaminases (APOBEC3A [A3A] to A3H), which are e

169 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated wi

170 We recently showed that the DNA cytidine deaminase APOBEC3B accounts for up to half of t

171 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C

172 Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) ar

173 Human cytidine deaminases APOBEC3F (A3F) and APOBEC3G (A3G) in

174 The human cytidine deaminase APOBEC3G (A3G) is an innate restricti

175 Functional analyses identified the cytidine deaminase APOBEC3G as a barrier for chimpanzee-

176 It functions as an adaptor that binds to the cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) an

177 nfectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) fo

178 The human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) po

179 The enzymatic reaction of cytidine deaminase appears to be a distinct example.

180 es, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosyla

181 Cytidine deaminases are single stranded DNA mutators div

182 vation with expression of activation-induced cytidine deaminase, as well as local differentiation of

183 tion of U:G mismatches by activation-induced cytidine deaminase but differ in their subsequent mutage

184 The Apobec3 family of cytidine deaminases can inhibit the replication of retro

185 veral members of the human APOBEC3 family of cytidine deaminases can potently restrict retroviruses s

186 The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retrov

187 in such cells is attributed to a mycoplasma cytidine deaminase causing rapid drug catabolism.

188 s and identified that L306 in the C-terminal cytidine deaminase (CD) domain contributed to its core l

189 Cytidine deaminase (CDA) binds the inhibitor zebularine

190 Cytidine deaminase (CDA) catalyzes the deamination of cy

191 CYTIDINE DEAMINASE (CDA) catalyzes the deamination of cy

192 new possibilities for anti-cancer treatment.Cytidine deaminase (CDA) deficiency leads to genome inst

193 (18)F-FAC tumor uptake is also influenced by cytidine deaminase (CDA), a determinant of resistance to

194 m revealed that TAMs induced upregulation of cytidine deaminase (CDA), the enzyme that metabolizes th

195 DNMT1 and tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapi

196 erivatives were synthesized as inhibitors of cytidine deaminase (CDA).

197 that the susceptible cell lines overexpress cytidine deaminase (CDA).

198 belongs to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids.

199 ent the crystal structure of a tRNA-specific cytidine deaminase, CDAT8, which has the cytidine deamin

200 on of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteo

201 V regions, expression of activation-induced cytidine deaminase, clonal H chain switch, and an invert

202 man APOBEC3 protein family of polynucleotide cytidine deaminases contributes to intracellular defense

203 c mice (quasimonoclonal, activation-induced [cytidine] deaminase-Cre-tamoxifen-dependent estrogen rec

204 identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitut

205 Tau is overexpressed in cytidine deaminase-deficient cells, and its depletion wo

206 ere Tau functions in maintaining survival of cytidine deaminase-deficient cells, and ribosomal DNA tr

207 germline IgM produced in activation-induced cytidine deaminase-deficient mice (aicda(-/-)) provided

208 uracil N-glycosylase and activation-induced cytidine deaminase-deficient mice.

209 Igs and hypermutated IgM (activation-induced cytidine deaminase-deficient), or fully agammaglobulemic

210 to mount dominant IgM and activation-induced cytidine deaminase-dependent IgG anti-FtL responses that

211 lated high frequencies of activation-induced cytidine deaminase-dependent IgH locus chromosomal break

212 neous loss of MSH6 and of activation-induced cytidine deaminase did not appreciably affect the surviv

213 Human APOBEC3H (A3H) has one cytidine deaminase domain (CDD) and inhibits the replica

214 fic cytidine deaminase, CDAT8, which has the cytidine deaminase domain linked to a tRNA-binding THUMP

215 nd that conserved catalytic residues in both cytidine deaminase domains are required for RNA editing.

216 e engineered base editors containing mutated cytidine deaminase domains that narrow the width of the

217 because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both re

218 We engineered fusions of CRISPR/Cas9 and a cytidine deaminase enzyme that retain the ability to be

219 Members of the APOBEC3 (A3) family of cytidine deaminase enzymes act as host defense mechanism

220 Several adenosine or cytidine deaminase enzymes deaminate transcript sequence

221 associated with increased activation-induced cytidine deaminase expression, and correlate with increa

222 ation ex vivo by altering activation-induced cytidine deaminase expression.

223 eaminase is unique within the zinc-dependent cytidine deaminase family as being allosterically regula

224 f these findings to the wider zinc-dependent cytidine deaminase family is also discussed.

225 We find that APOBEC2, a member of the cytidine deaminase family of DNA/RNA editing enzymes, is

226 polypeptide-like-3 (APOBEC3) innate cellular cytidine deaminase family, particularly APOBEC3F and APO

227 A3G is another member of the cytidine deaminases family predominantly expressed in ly

228 Using cytidine deaminase fused to Cas9 nickase, up to 28% of s

229 -mediated ablation of the activation-induced cytidine deaminase gene required for class switch recomb

230 pts and to upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and

231 show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in in

232 support functional GL7(+)/activation-induced cytidine deaminase(+) germinal centers.

233 itical to both processes, activation-induced cytidine deaminase, has been identified, it remains uncl

234 oduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and

235 s recently proposed for the APOBEC family of cytidine deaminases in generating particular genome-wide

236 tion, as it shows sequence similarities with cytidine deaminases in other organisms.

237 the miR-155 target Aicda (activation-induced cytidine deaminase) in this process and, in combination

238 r-like tumors arose by an activation-induced cytidine deaminase-independent pathway.

239 3B activity, providing new insights into how cytidine deaminase-induced mutagenesis might be activate

240 dministration of tetrahydrouridine (a potent cytidine deaminase inhibitor).

241 Activation-induced cytidine deaminase initiates DNA ds break formation by d

242 ptide-like (APOBEC) proteins are a family of cytidine deaminases involved in various important biolog

243 n activated B cells where activation-induced cytidine deaminase is highly expressed.

244 The APOBEC3 family of cytidine deaminases is part of the innate host defense t

245 However, a role for the APOBEC family of cytidine deaminases is proposed.

246 (PPR) protein SLO2, which lacks a C-terminal cytidine deaminase-like DYW domain, interacts in vivo wi

247 eoside transporters, and it was resistant to cytidine deaminase-mediated degradation.

248 ntrations of gemcitabine, synergizing with a cytidine deaminase-mediated mechanism of action.

249 ous, and likely caused by activation-induced cytidine deaminase-mediated somatic hypermutation, as sh

250 ACI antibody could induce activation-induced cytidine deaminase mRNA in those with mutations.

251 c antibody showed loss of activation-induced cytidine deaminase mRNA induction in all mutation-bearin

252 APOBEC cytidine deaminases mutate cancer genomes by converting

253 The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range

254 In SHM, activation-induced cytidine deaminase mutates the V region of the Ig genes

255 Nucleic acid cytidine deaminases of the activation-induced deaminase

256 Several antiviral cytidine deaminases of the human APOBEC3 (hA3) family ha

257 drouridine (THU), a competitive inhibitor of cytidine deaminase, on the pharmacokinetics and pharmaco

258 Activation-induced cytidine deaminase, one of the APOBEC members, was repor

259 2- to 6-fold increase for activation-induced cytidine deaminase, PAX5, and the nonexcised rearranged

260 The APOBEC3 cytidine deaminases play a critical role in host-mediate

261 The activation-induced cytidine deaminase protein induces genome-wide DNA break

262 Inhibition of cytidine deaminase raised the levels of activated gemcit

263 report extensive computer simulations of the cytidine deaminase reaction and its temperature dependen

264 he structural gene encoding the RNA-specific cytidine deaminase responsible for production of apolipo

265 Single-strand DNA-specific APOBEC cytidine deaminase(s) are major source(s) of mutation in

266 strate of some single strand-specific APOBEC cytidine deaminases, similar to the mutations that can t

267 nized individual to study activation-induced cytidine deaminase targeting and found that hypermutatio

268 r with A3G, it is considered the most potent cytidine deaminase targeting HIV.

269 APOBEC3G (A3G) is a cytidine deaminase that catalyzes deamination of deoxycy

270 Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues

271 Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication.

272 APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses.

273 downstream effector APOBEC3, an IFN-induced cytidine deaminase that introduces lethal mutations duri

274 APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by i

275 APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency

276 Human APOBEC3A is a single-stranded DNA cytidine deaminase that restricts viral pathogens and en

277 APOBEC3G (A3G) is a host cytidine deaminase that serves as a potent intrinsic inh

278 e catalytic subunit 3 (APOBEC-3) enzymes are cytidine deaminases that are broadly and constitutively

279 e earliest-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate specif

280 The AID / APOBEC genes are a family of cytidine deaminases that have evolved in vertebrates, an

281 The human APOBEC3 proteins are DNA cytidine deaminases that impede the replication of many

282 APOBEC3F (A3F) is a member of the family of cytidine deaminases that is often coexpressed with APOBE

283 otein B editing complex 3 family members are cytidine deaminases that play important roles in intrins

284 ed with overexpression of activation-induced cytidine deaminase, the hotspot length increases even fu

285 t essential for targeting activation-induced cytidine deaminase to S regions, as was suggested.

286 ssibilities, we used a chemical inhibitor of cytidine deaminase to stabilize and thereby artificially

287 Base editing relies on recruitment of cytidine deaminases to introduce changes (rather than do

288 gs for cancer tissues presenting concomitant cytidine deaminase underexpression and Tau upregulation

289 Members of the APOBEC3 family of cytidine deaminases vary in their proportions of a virio

290 regulate transcription of activation-induced cytidine deaminase via Akt, repression of epsilonGLT and

291 signature attributed to the APOBEC family of cytidine deaminases, whereas others are confined to a si

292 on (CSR) is instigated by activation-induced cytidine deaminase, which converts cytosines in switch r

293 ation (CSR) is induced by activation-induced cytidine deaminase, which initiates a cascade of events

294 Mice deficient in activation-induced cytidine deaminase, which produce only IgM, were protect

295 e host enzymes in the APOBEC3 (A3) family of cytidine deaminases, which act on CC (APOBEC3G) and TC (

296 t studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil du

297 EC3 activity of Vif variants against several cytidine deaminases will help reveal the requirement for

298 sent the crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site a

299 APOBEC3G is a cytidine deaminase with two homologous domains and restr

300 or stromal remodeling and down-regulation of cytidine deaminase without depletion of tumor stromal co