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1 the inner mitochondrial side chain cleavage cytochrome P-450.
2 ite is the smallest yet observed for a human cytochrome P-450.
3 nstrated that metabolism was due to PHS, not cytochrome P-450.
4 tion of a number of genes, including certain cytochrome P-450s.
5 lytic system and the eukaryotic machinery of cytochromes P-450.
6 osynthesis of aflatoxin B(1) are mediated by cytochromes P-450.
8 lymorphisms in two maternal metabolic genes, cytochrome P-450 1A1 (CYP1A1) MspI and epoxide hydrolase
10 suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relati
12 tase with NADH in reconstitution assays with cytochrome P-450 1A2 and with squalene monooxygenase.
13 wn to counteract B(a)P-mediated induction of cytochrome P-450 1B1, a prototypical AhR target gene.
14 gamma coactivator-1alpha (PGC-1alpha), CAR, cytochrome P-450 2b10 (Cyp2b10), UDP-glucuronosyltransfe
16 pha-2 urinary globulin, alpha-1 antitrypsin, cytochrome P-450 2C13, L-type 6-phosphofructo-2-kinase,
17 nts of the enzyme that metabolizes warfarin, cytochrome P-450 2C9 (CYP2C9), and of a key pharmacologi
19 chrome P-450 2D6, encoded by the polymorphic cytochrome P-450 2D6 gene (CYP2D6), oxidizes tamoxifen t
22 trates and inhibitors, only chlorzoxazone, a cytochrome P-450 2E1 (CYP2E1) substrate, showed any sign
25 GPx, lower GSH, and increased expression of cytochrome P-450 2E1, consistent with increased hepatic
26 potent glucocorticoids dexamethasone [strong cytochrome P-450 3A (CYP3A) inducer] or triamcinolone ac
27 e erythromycin is extensively metabolized by cytochrome P-450 3A (CYP3A) isozymes, commonly used medi
29 he first study to use catalytically distinct cytochromes P-450 3A from the same species in the elucid
33 -Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P-450 4A/4F-derived metabolite of the membran
34 ealed that rat cerebral microvessels express cytochrome P-450 4A1, 4A2, 4A3, and 4A8 isoforms, some o
35 uctase, farnesyl pyrophosphate synthase, and cytochrome P-450-51, were decreased in liver by fasting
36 This established the product of fkbD as the cytochrome P-450 9-deoxo-FK506 hydroxylase, which is res
37 teins show homologies to other known CYP-150 cytochrome P-450 and [3Fe-4S] ferredoxin enzymes and may
38 multiple xenobiotic response genes, such as cytochrome P-450 and glutathione S-transferases, potenti
39 activation by NDO is different from that by cytochrome P-450 and other monooxygenases, which oxidize
40 tabolizing enzymes, such as by inhibition of cytochrome P-450 and/or by induction of phase II detoxif
41 se absorption and metabolism are mediated by cytochrome P-450 and/or P-glycoprotein should require cl
42 oI gene encodes a protein with similarity to cytochrome P-450s and was able to complement mutations i
45 minobenzotriazole to determine the effect of cytochrome P-450 blockade on inflammatory responses by a
46 f electron transfer and substrate binding to cytochrome P-450 BM3 from Bacillus megaterium and its co
48 he mechanism of hydrocarbon hydroxylation by cytochromes P-450(cam) (CYP101) and P-450(BM3) (CYP102).
49 ts of hNPR-A-mediated signal transduction on cytochrome P-450 cholesterol monooxygenase side-chain cl
50 ersion of cholesterol to pregnenolone (i.e., cytochrome P-450 cholesterol monooxygenase side-chain cl
55 equirements for selectively inhibiting human cytochrome P-450 (CYP) 2A6, the major nicotine metaboliz
56 Efavirenz and nelfinavir are metabolized by cytochrome P-450 (CYP) 2B6 and CYP2C19, respectively, wi
57 ure, nesiritide for acute heart failure, and cytochrome P-450 (CYP) 2C19 genotyping for the acute cor
59 transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effe
63 oholic steatohepatitis (NASH) affect hepatic cytochrome P-450 (CYP) protein expression and activity,
65 ctivity of the carcinogen activating enzymes cytochrome P-450 (CYP)1A1/CYP1A2 in microsomes and intac
67 n oxidative cleavage reaction catalyzed by a cytochrome P(450) (CYP) expressed predominantly in the l
68 omplex that transactivates expression of the cytochrome P-450 CYP1A1 gene and other genes in the diox
70 nobarbital-responsive enhancer module of the cytochrome P-450 Cyp2b10 gene, contains two potential nu
73 a 10-aa motif consistent with its role as a cytochrome P-450 (CyP450) enzyme and is similar to a num
76 rt the isolation and characterization of the cytochrome P-450 CYP82Y1, which catalyzes the 1-hydroxyl
78 Cytochrome P-450 2D is a subfamily of the cytochrome P-450-dependent mixed function oxidase system
79 concentration inhibits the lipoxygenase and cytochrome P-450-dependent pathways of arachidonic acid
80 se results suggest that the integrity of the cytochrome P-450 enzyme system plays an important role i
83 Much of the detoxification is performed by cytochrome P-450 enzymes, many of which have broad subst
86 cells with cyclooxygenase, lipoxygenase, or cytochrome P-450 epoxygenase inhibitors did not reverse
88 yeicosatrienoic acids (EETs) are products of cytochrome P-450 epoxygenase that possess important vaso
89 of NO synthase, but not of cyclooxygenase or cytochrome P-450 epoxygenase, significantly attenuated t
90 ntial fatty acid arachidonate is oxidized by cytochrome P-450 epoxygenases to four epoxyeicosatrienoi
92 AhR-regulated genes include members of the cytochrome P-450 family that are known to oxidize B[a]P
95 sponse elements present in steroid-inducible cytochrome P-450 genes and is expressed in tissues in wh
96 sociation was found between genotypes of the cytochrome P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1
97 ase is the electron transfer partner for the cytochromes P-450, heme oxygenase, and squalene monooxyg
98 facilitate catalytic activity of microsomal cytochromes P-450 heterologously expressed in E. coli.
104 e to iNOS and human and rat liver microsomal cytochrome P-450 induced a high spin, type I spectra, wh
107 to 24 h; 2) alpha-naphthoflavone, an AhR and cytochrome P-450 inhibitor, blocks DMBA-induced apoptosi
108 utathione (GSH), dithiothreitol (DTT) and by cytochrome P-450 inhibitors (clotrimazole and miconazole
110 evented by cyclo-oxygenase, lipoxygenase, or cytochrome P-450 inhibitors and was mimicked by 5,8,11,1
111 was completely suppressed in the presence of cytochrome P-450 inhibitors, piperonylbutoxide and carbo
112 A 4-hydroxylase is a unique, highly specific cytochrome P-450 isoenzyme, whose expression is regulate
113 , through differential inhibition of hepatic cytochrome P-450 isoenzymes, affect CY metabolism and co
115 General cytochrome P-450 inhibitors and cytochrome P-450 isoform-selective substrates and inhibi
120 roduct of Streptomyces sp. strain C5 doxA, a cytochrome P-450-like protein, to be daunorubicin C-14 h
122 ntegrative model suggests that both CIF from cytochrome P-450 metabolism and secretion-like coupling
125 to acute hypertension would be prevented if cytochrome P-450 metabolism were inhibited by cobalt chl
126 roviral therapy, but their susceptibility to cytochrome P(450) metabolism reduces their systemic avai
130 abolites of arachidonic acid (AA), formed by cytochrome P-450 monooxygenase (P450), are endothelium-d
132 nidulans stcL gene is predicted to encode a cytochrome P-450 monooxygenase and is located within a c
134 eicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase metabolism of arachidonic
135 In summary, we believe the presence of the cytochrome P-450 monooxygenase system in glial cells of
136 e rat glioma C6 cell line contains an active cytochrome P-450 monooxygenase system which can be induc
137 that with soluble methane monooxygenase and cytochrome P-450 monooxygenase, which produce chloral hy
140 cosatrienoic acids (EETs) are synthesized by cytochrome P-450 monooxygenases and released into the bl
143 en reading frames and code for a novel brain cytochrome P-450 (P-450) belonging to the CYP2D subfamil
145 fluence hepatic expression of CYP3A or other cytochromes P-450 (P-450s) because Pgp can transport end
147 arbon dibenzo[a,l]pyrene (DB[a,l]P) by human cytochrome P-450 (P450) 1A1 and 1B1 was investigated in
149 lls with a cyclophosphamide (CPA)-activating cytochrome P-450 (P450) gene provides the capacity for l
150 abolite produced by either a lipoxygenase or cytochrome P-450 pathway, to act as a potent indirect mo
154 electron reduction of DZQ and AZQ by NADPH: cytochrome P-450 reductase at physiological pH therefore
156 nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase); 3) changes in molecules inv
157 was exposed to the flavin-containing enzyme cytochrome P-450 reductase, both semiquinone and superox
161 nts and reducing systems ascorbate (Asc) and cytochrome P(450) reductase (CPR), measure rate constant
163 is recombinant domain contains the catalytic cytochrome P-450 site for arginine oxidation by molecula
164 3H]cortico-sterone to [3H]aldosterone (i.e., cytochrome P-450 steroid 11 beta-monooxygenase/aldostero
166 an important regulator of the expression of cytochrome P-450 steroidogenic enzymes in cultured cells
167 First, we compiled a database of known human cytochrome P-450 substrates, products, and nonsubstrates
168 eductase and oxidase components of bacterial cytochrome P-450 systems, which allow catabolism or anab
171 ydroxylating monooxygenase and by analogy to cytochrome P-450, the accumulation of a reduced and acti
172 f eight opium poppy chemotypes revealed four cytochrome P-450s, three from the CYP82 and one from the
173 acid hydroperoxides are metabolized by CYP74 cytochrome P-450s to various oxylipins that play importa
175 These are reminiscent of the mechanism of cytochrome P-450, where a heme iron stabilizes the activ
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